Department of Biological Sciences, University of Bergen, Bergen 5020, Norway
Search for other papers by Fatema Moni Chowdhury in
Current site
Google Scholar
PubMed
Search for other papers by Chowdhury Rafiqul Ahsan in
Current site
Google Scholar
PubMed
Search for other papers by Nils-Kåre Birkeland in
Current site
Google Scholar
PubMed
Abstract
The recent rise of antibiotic resistance and lack of an effective vaccine make the scenario of shigellosis alarming in developing countries like Bangladesh. In recent years, our group reported the vaccine efficacy of a non-pathogenic Escherichia albertii strain DM104 in different animal models, where an ocularly administered vaccine in the guinea pig eye model against Shigella dysenteriae type 4 challenge showed high protective efficacy and also induced a high titer of serum IgG against S. dysenteriae type 4 whole cell lysate (WCL) and LPS. In this study, we report further evaluation of the non-invasive and non-toxic environmental strain DM104 as a vaccine candidate against S. dysenteriae type 4 in mice model. Oral immunization of live DM104 bacterial strain demonstrated better protective immunity in mice model by showing 90% protection in mice against live S. dysenteriae type 4 lethal dose challenge and by inducing effective humoral and mucosal immune responses.
-
1.
Centers for Disease Control and Prevention . Notifiable diseases and mortality tables. Morb Mortal Wkly Rep 2015; 64(13): 544–561. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6431md.htm?s_cid=mm6431md_w.
-
2.
Chakraborty S , Harro C , DeNearing B , Bream J , Bauers N , Dally L , et al.. Evaluation of the safety, tolerability, and immunogenicity of an oral, inactivated whole-cell Shigella flexneri 2a vaccine in healthy adult subjects. Clin Vaccine Immunol 2016; 23(4): 315–325. https://cvi.asm.org/content/cdli/23/4/315.full.pdf.
-
3.
Chitradevi STS , Kaur G , Sivaramakrishna U , Singh D , Bansal A . Development of recombinant vaccine candidate molecule against Shigella infection. Vaccine 2016; 34: 5376–5383. https://pubmed.ncbi.nlm.nih.gov/27591952/.
-
4.
Rahman MZ , Sultana M , Khan SI , Birkeland NK . Serological cross-reactivity of environmental isolates of Enterobacter, Escherichia, Stenotrophomonas, and Aerococcus with Shigella spp.-specific antisera. Curr Microbiol 2007; 54: 63–67. https://link.springer.com/article/10.1007/s00284-006-0387-9.
-
5.
Azmuda N , Rahman MZ , Sultana M , Jenssen EL , Khan SI , Birkeland NK . Evidence of interspecies O antigen gene cluster transfer between Shigella boydii 15 and Escherichia fergusonii. APMIS 2012; 120: 959–966. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0463.2012.02926.x.
-
6.
Rahman MZ , Akter S , Azmuda N , Sultana M , Weill FX , Khan SI , et al.. Serological cross-reaction between O-antigens of Shigella dysenteriae type 4 and an environmental Escherichia albertii isolate. Curr Microbiol 2013; 67(5): 590–595. https://link.springer.com/article/10.1007%2Fs00284-013-0405-7.
-
7.
Chowdhury FM , Rahman MZ , Khan SI , Ahsan CR , Birkeland NK . An environmental Escherichia albertii strain, DM104, induces protective immunity to Shigella dysenteriae in guinea pig eye model. Curr Microbiol 2014; 68: 642–647. https://link.springer.com/article/10.1007/s00284-014-0522-y.
-
8.
Chowdhury FM , Rahman MZ , Sarkar MMH , Rabbi F , Khan SI , Ahsan CR , et al.. Protection against shigellosis caused by Shigella dysenteriae serotype 4 in guinea pigs using Escherichia albertii DM104 as a live vaccine candidate strain. Acta Microbiol Immunol Hung 2017; 9: 1–14. https://core.ac.uk/reader/85130555?utm_source=linkout.
-
9.
Chowdhury FM , Birkeland NK , Ahsan CR . Comparison of immunogenicity and protective efficacy of the intranasal and intraperitoneal immunization routes of Escherichia albertii strain DM104 in mouse model. Bangladesh J Microbiol 2020; 37(2): 38–41. https://www.banglajol.info/index.php/BJM/article/view/51208.
-
10.
Swain P , Nayak SK , Sahu A , Meher PK , Mishra BK . High antigenic cross-reaction among the bacterial species responsible for diseases of cultured freshwater fishes and strategies to overcome it for specific serodiagnosis. Comp Immunol Microbiol Infect Dis 2003; 26: 199–211. https://www.sciencedirect.com/science/article/abs/pii/S0147957102000590?via%3Dihub.
-
11.
Osorio M , Bray MD , Walker RI . Vaccine potential for inactivated shigellae. Vaccine 2007; 25: 1581–1592. https://www.sciencedirect.com/science/article/pii/S0264410X06012102?via%3Dihub.
-
12.
Ranallo RT , Thakkar S , Chen Q , Venkatesan MM . Immunogenicity and characterization of WRSF2G11: a second generation live attenuated Shigella flexneri 2a vaccine strain. Vaccine 2007; 25: 2269–2278. https://www.sciencedirect.com/science/article/pii/S0264410X06013065?via%3Dihub.
-
13.
Oliveira AF , Ruas LP , Cardoso SA , Soares SG , Roque-Barreira MC . Vaccination of mice with salmonella expressing VapA: mucosal and systemic Th1 responses provide protection against Rhodococcus equi infection. PLoS One 2010; 5: e8644. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008644.
-
14.
Mazumdar T , Anam K , Ali N . A mixed Th1/Th2 response elicited by a liposomal formulation of Leishmania vaccine instructs Th1 responses and resistance to Leishmania donovani in susceptible BALB/c mice. Vaccine 2004; 22: 1162–1171. https://www.sciencedirect.com/science/article/pii/S0264410X03007059?via%3Dihub.
-
15.
Cong H , Gu QM , Jiang Y , He SY , Zhou HY , Yang TT , et al.. Oral immunization with a live recombinant attenuated Salmonella typhimurium protects mice against Toxoplasma gondii. Parasite Immunol 2005; 27: 29–35. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-3024.2005.00738.x.
-
16.
Du A , Wang S . Efficacy of a DNA vaccine delivered in attenuated Salmonella typhimurium against Eimeria tenella infection in chickens. Int J Parasitol 2005; 35: 777–785. https://www.sciencedirect.com/science/article/abs/pii/S0020751905001049?via%3Dihub.
-
17.
Dong C , Flavell RA . Control of T helper cell differentiation – in search of master genes. Science’s stke 2000; 49: 1–5. https://stke.sciencemag.org/content/2000/49/pe1/tab-article-info.
-
18.
Way SS , Borczuk AC , Dominitz R , Goldberg MB . An essential role for gamma interferon in innate resistance to Shigella flexneri infection. Infect Immun 1998; 66: 1342–1348. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC108058/pdf/ii001342.pdf.
Editorial Office:
Akadémiai Kiadó Zrt.
Budafoki út 187-187, A/3, H-1117 Budapest, Hungary
Editorial Correspondence:
Acta Microbiologica et Immunologica Hungarica
Institute of Medical Microbiology
Semmelweis University
P.O. Box 370
H-1445 Budapest, Hungary
Phone: + 36 1 459 1500 ext. 56101
Fax: (36 1) 210 2959
E-mail: amih@med.semmelweis-univ.hu
Indexing and Abstracting Services:
- Biological Abstracts
- BIOSIS Previews
- CAB Abstracts
- CABELLS Journalytics
- Chemical Abstracts
- Global Health
- Index Medicus
- Index Veterinarius
- Medline
- Referativnyi Zhurnal
- SCOPUS
- Science Citation Index Expanded
| 2023 | |
|---|---|
| Web of Science | |
| Journal Impact Factor | 1.3 |
| Rank by Impact Factor | Q4 (Immunology) |
| Journal Citation Indicator | 0.31 |
| Scopus | |
| CiteScore | 2.3 |
| CiteScore rank | Q3 (Infectious Diseases) |
| SNIP | 0.389 |
| Scimago | |
| SJR index | 0.308 |
| SJR Q rank | Q3 |
| Acta Microbiologica et Immunologica Hungarica | |
|---|---|
| Publication Model | Hybrid |
| Submission Fee | none |
| Article Processing Charge | 1100 EUR/article (only for OA publications) |
| Regional discounts on country of the funding agency | World Bank Lower-middle-income economies: 50% World Bank Low-income economies: 100% |
| Further Discounts | Editorial Board / Advisory Board members: 50% Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100% |
| Subscription fee 2025 | Online subsscription: 772 EUR / 848 USD Print + online subscription: 860 EUR / 944 USD |
| Subscription Information | Online subscribers are entitled access to all back issues published by Akadémiai Kiadó for each title for the duration of the subscription, as well as Online First content for the subscribed content. |
| Purchase per Title | Individual articles are sold on the displayed price. |
| Acta Microbiologica et Immunologica Hungarica | |
|---|---|
| Language | English |
| Size | A4 |
| Year of Foundation |
1954 |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Magyar Tudományos Akadémia |
| Founder's Address |
H-1051 Budapest, Hungary, Széchenyi István tér 9. |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 1217-8950 (Print) |
| ISSN | 1588-2640 (Online) |
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Oct 2024 | 148 | 0 | 0 |
| Nov 2024 | 42 | 0 | 0 |
| Dec 2024 | 42 | 0 | 0 |
| Jan 2025 | 45 | 0 | 0 |
| Feb 2025 | 57 | 0 | 0 |
| Mar 2025 | 33 | 0 | 0 |
| Apr 2025 | 0 | 0 | 0 |
Copyright Akadémiai Kiadó AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.