Authors:
Neşe İnal Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

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Gülşen Hazırolan Department of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

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Abstract

Leptotrichia species are fastidious anaerobic, fusiform, pencil-shaped Gram-negative bacilli that reside in microbiota of humans. Leptotrichia species have increasingly been recognized as an opportunistic pathogen in humans, mainly in the immunocompromised patient. Anaerobic organisms have rarely been isolated from blood cultures of pediatric patients. In our study, we isolated Leptotrichia trevisanii from central venous catheter culture of a five-year-old male patient. It was identified with both matrix-assisted laser desorption ionization time-of-flight mass spectrometry and confirmed via 16S rRNA gene sequencing. The early recognition of anaerobic bacteremia and administration of appropriate antimicrobial and play an important role preventing mortality and morbidity in children. In our study we report a rarely diagnosed case of L. trevisanii bacteremia in a pediatric patient.

  • [1]

    Eribe ERK , Paster BJ , Caugant DA , Dewhirst FE , Stromberg VK , Lacy GH , et al. Genetic diversity of Leptotrichia and description of Leptotrichia goodfellowii sp. nov., Leptotrichia hofstadii sp. nov., Leptotrichia shahii sp. nov. and Leptotrichia wadei sp. nov. Int J Syst Evol Microbiol. 2004; 54: 583-92.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [2]

    Cooreman S , Schuermans C , Van Schaeren J , Olive N , Wauters G , Verhaegen J , et al. Bacteraemia caused by Leptotrichia trevisanii in a neutropenic patient. Anaerobe. 2011; 17: 1-3.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [3]

    Couturier MR , Slechta ES , Goulston C , Fisher MA , Hanson KE . Leptotrichia bacteremia in patients receiving high-dose chemotherapy. J Clin Microbiol. 2012; 50: 1228-32.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [4]

    Kumagai J , Takiguchi Y , Shono K , Suruga Y , Akiba Y , Yamamoto K , et al. Acute myelogenous leukemia with Leptotrichia trevisanii bacteremia. Intern Med. 2013; 52: 2573-6.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [5]

    Tee W , Midolo P , Janssen PH , Kerr T , Dyall-Smith ML . Bacteremia due to Leptotrichia trevisanii sp. nov. Eur J Clin Microbiol Infect Dis. 2001; 20: 765-9.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [6]

    Higurashi Y , Tatsuno K , Fujimoto F , Kobayashi I , Ida K , Seto Y , et al. Two cases of bacteremia caused by Leptotrichia trevisanii in patients with febrile neutropenia. J Infect Chemother. 2013; 19: 1181-4.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [7]

    Dien Bard J , McElvania TeKippe E . Diagnosis of bloodstream infections in children. J Clin Microbiol. 2016; 54: 1418-24.

  • [8]

    Wu D , Hugenholtz P , Mavromatis K , Pukall R , Dalin E , Ivanova NN , et al. A phylogeny-driven genomic encyclopaedia of Bacteria and Archaea. Nature. 2009; 462: 1056-60.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [9]

    Simmon KE , Croft AC , Petti CA . Application of SmartGene IDNS software to partial 16S rRNA gene sequences for a diverse group of bacteria in a clinical laboratory. J Clin Microbiol. 2006; 44: 4400-6.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [10]

    Brook I. Bacteremia due to anaerobic bacteria in newborns. J perinatology: official J Calif Perinatal Assoc. 1990; 10: 351.

  • [11]

    Brook I. Pediatric anaerobic infections: diagnosis and management: CRC Press; 2001.

  • [12]

    Cho EH , Park KS , Yang M , Song DJ , Huh HJ , Ki CS , et al. Laboratory identification of Leptotrichia species isolated from bacteremia patients at a single institution. Ann Lab Med. 2017; 37: 272-6.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [13]

    Posteraro P , De Maio F , Menchinelli G , Palucci I , Errico FM , Carbone M , et al. First bloodstream infection caused by Prevotella copri in a heart failure elderly patient with Prevotella-dominated gut microbiota: a case report. Gut Pathog. 2019; 11: 44.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [14]

    Gajdacs M , Terhes G , Urban E . The incidence of bloodstream infections caused by anaerobic bacteria in a university hospital between 2005-2009 and 2013-2017. A retrospective, comparative study. Orv Hetil. 2020; 161: 797-803.

    • Search Google Scholar
    • Export Citation
  • [15]

    Demir Cuha M , Hazirolan G . Anaerobic bacteria isolated from blood cultures in Hacettepe university faculty of medicine hospital between 2017 and 2019: a three-year evaluation. Klimik Dergisi/Klimik J. 2020; 33: 286-91.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [16]

    Schrimsher JM , McGuirk JP , Hinthorn DR . Leptotrichia trevisanii sepsis after bone marrow transplantation. Emerg Infect Dis. 2013; 19: 1690-1.

  • [17]

    Shah HN , Olsen I , Bernard K , Finegold SM , Gharbia S , Gupta RS . Approaches to the study of the systematics of anaerobic, gram-negative, non-sporeforming rods: current status and perspectives. Anaerobe. 2009; 15: 179-94.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [18]

    Bizzini A , Jaton K , Romo D , Bille J , Prod'hom G , Greub G . Matrix-assisted laser desorption ionization - time of flight mass spectrometry as an alternative to 16S rRNA gene sequencing for identification of difficult-to-identify bacterial strains. J Clin Microbiol. 2011; 49: 693-6.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [19]

    Martín-Gutiérrez G , Rodríguez N , Lepe JA , Parody R , Torres MJ , Aznar J . Rapid identification of a Leptotrichia trevisanii catheter-related bloodstream infection using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. JMM Case Rep. 2015; 2.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [20]

    Hou H , Chen Z , Tian L , Sun Z . Leptotrichia trevisanii bacteremia in a woman with systemic lupus erythematosus receiving high-dose chemotherapy. BMC Infect Dis. 2018; 18: 661.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [21]

    Sabater Cabrera C , Fernández Blázquez A , García Carús E . Bacteremia due to Leptotrichia trevisanii after an allogeneic bone marrow transplant. Enfermedades Infecciosas y Microbiologia Clinica (English Ed). 2017; 35: 389-90.

    • Search Google Scholar
    • Export Citation
  • [22]

    Mora-Palma JC , Rodriguez-Oliver AJ , Navarro-Mari JM , Gutierrez-Fernandez J . Emergent genital infection by Leptotrichia trevisanii. Infection. 2019; 47: 111-4.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [23]

    Fontanals D , Garcia-Miralles C , Ballester R , Cochs B , Orellana R , Capilla S . Chorioamnionitis due to Leptotrichia trevisanii. Anaerobe. 2018; 49: 18-20.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • [24]

    Rodriguez-Sanchez B , Marin M , Sanchez-Carrillo C , Cercenado E , Ruiz A , Rodriguez-Creixems M , et al. Improvement of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry identification of difficult-to-identify bacteria and its impact in the workflow of a clinical microbiology laboratory. Diagn Microbiol Infect Dis. 2014; 79: 1-6.

    • Crossref
    • Search Google Scholar
    • Export Citation
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Senior editors

Editor-in-Chief: Prof. Dóra Szabó (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Managing Editor: Dr. Béla Kocsis (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Co-editor: Dr. Andrea Horváth (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Editorial Board

  • Prof. Éva ÁDÁM (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Sebastian AMYES (Department of Medical Microbiology, University of Edinburgh, Edinburgh, UK.)
  • Dr. Katalin BURIÁN (Institute of Clinical Microbiology University of Szeged, Szeged, Hungary; Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary.)
  • Dr. Orsolya DOBAY (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Ildikó Rita DUNAY (Institute of Inflammation and Neurodegeneration, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany)
  • Prof. Levente EMŐDY(Department of Medical Microbiology and Immunology, University of Pécs, Pécs, Hungary.)
  • Prof. Anna ERDEI (Department of Immunology, Eötvös Loránd University, Budapest, Hungary, MTA-ELTE Immunology Research Group, Eötvös Loránd University, Budapest, Hungary.)
  • Prof. Éva Mária FENYŐ (Division of Medical Microbiology, University of Lund, Lund, Sweden)
  • Prof. László FODOR (Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, Budapest, Hungary)
  • Prof. József KÓNYA (Department of Medical Microbiology, University of Debrecen, Debrecen, Hungary)
  • Prof. Yvette MÁNDI (Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary)
  • Prof. Károly MÁRIALIGETI (Department of Microbiology, Eötvös Loránd University, Budapest, Hungary)
  • Prof. János MINÁROVITS (Department of Oral Biology and Experimental Dental Research, University of Szeged, Szeged, Hungary)
  • Prof. Béla NAGY (Centre for Agricultural Research, Institute for Veterinary Medical Research, Budapest, Hungary.)
  • Prof. István NÁSZ (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Kristóf NÉKÁM (Hospital of the Hospitaller Brothers in Buda, Budapest, Hungary.)
  • Dr. Eszter OSTORHÁZI (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Rozália PUSZTAI (Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary)
  • Prof. Peter L. RÁDY (Department of Dermatology, University of Texas, Houston, Texas, USA)
  • Prof. Éva RAJNAVÖLGYI (Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary)
  • Prof. Ferenc ROZGONYI (Institute of Laboratory Medicine, Semmelweis University, Budapest, Hungary)
  • Prof. Joseph G. SINKOVICS (The Cancer Institute, St. Joseph’s Hospital, Tampa, Florida, USA)
  • Prof. Júlia SZEKERES (Department of Medical Biology, University of Pécs, Pécs, Hungary.)
  • Prof. Mária TAKÁCS (National Reference Laboratory for Viral Zoonoses, National Public Health Center, Budapest, Hungary.)
  • Prof. Edit URBÁN (Department of Medical Microbiology and Immunology University of Pécs, Pécs, Hungary; Institute of Translational Medicine, University of Pécs, Pécs, Hungary.)

 

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Acta Microbiologica et Immunologica Hungarica
Language English
Size A4
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Foundation
1954
Volumes
per Year
1
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per Year
4
Founder Magyar Tudományos Akadémia
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ISSN 1217-8950 (Print)
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