Authors:
Bakhtawar Usman Department of Microbiology, Kohat University of Science & Technology (KUST), Kohat, Khyber Pakhtunkhwa, Pakistan

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Abdul Rehman Department of Microbiology, Kohat University of Science & Technology (KUST), Kohat, Khyber Pakhtunkhwa, Pakistan

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Iffat Naz Department of Biology, Scientific Unit, Deanship of Educational Services, Qassim University, Buraidah, 51452, Qassim, Kingdom of Saudi Arabia (KSA)

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Muhammad Anees Department of Microbiology, Kohat University of Science & Technology (KUST), Kohat, Khyber Pakhtunkhwa, Pakistan

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https://orcid.org/0000-0001-7886-195X
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Abstract

Dermatophytosis is a major health problem all over the world including Pakistan. This is the first report of detection of dermatophytes and their antifungal drug resistance in the Northern and Western parts of Pakistan. A total of 154 samples were collected from different hospitals of Khyber Pakhtunkhwa, and out of them 136 samples were found positive. Tinea corporis (35%) was the most predominant type of infection followed by Tinea capitis (22%). The fungi identified in Tinea corporis infection types were identified as Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum. The fungi identified in Tinea capitis included Trichophyton violaceum, T. mentagrophytes, Microsporum ferrugineum. The gender wise distribution showed both males (52%) and females (48%) were infected with the fungi. More cases belonged to the rural parts of the country. Age wise distribution showed that the infection was more prevalent in the children and the prevalence decreased with the increase in age. The positive samples were checked against two antifungal agents: fluconazole and nystatin. Among 136 positive samples, none of the isolates showed resistance to nystatin while 7% of the samples showed resistance to fluconazole. The resistant isolates were then identified by amplifying the 18S rRNA gene, using universal primers (ITS1, ITS4). Among the 9 resistant isolates, 5 isolates were identified as Trichophyton spp., 3 as Microsporum spp. and 1 as Epidermophyton spp.

  • 1.

    White TC. , Findley K , Dawson TL , Scheynius A , Boekhout T , Cuomo CA , Saunders CW . Fungi on the skin: dermatophytes and Malassezia. Cold Spring Harbor Perspect Med 2014; 4(8): a019802.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 2.

    Oliveira LDQD . Influence of the essential oils of Cinnamomum cassia and Cymbopogon flexuosus on susceptibility and virulence factors in yeasts of the Cryptococcus neoformans complex; 2017.

    • Search Google Scholar
    • Export Citation
  • 3.

    Gnat S , Łagowski D , Nowakiewicz A . Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections. J Appl Microbiol 2020; 129(2): 212232.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4.

    Martinez-Rossi NM , Bitencourt TA , Peres NT , Lang EA , Gomes EV , Quaresemin NR , Rossi A . Dermatophyte resistance to antifungal drugs: mechanisms and prospectus. Front Microbiol 2018; 9: 1108.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5.

    Teklebirhan G , Bitew A . Prevalence of dermatophytic infection and the spectrum of dermatophytes in patients attending a tertiary hospital in Addis Ababa, Ethiopia. Int J Microbiol 2015.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6.

    Kim SH , Cho SH , Youn SK , Park JS , Choi JT , Bak YS , Kim YK . Epidemiological characterization of skin fungal infections between the years 2006 and 2010 in Korea. Osong Public Health Res Perspect 2015; 6(6): 341345.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7.

    Achterman RR , White TC . Dermatophyte virulence factors: identifying and analyzing genes that may contribute to chronic or acute skin infections. Int J Microbiol 2012.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 8.

    Bassiri-Jahromi S . Epidemiological trends in zoophilic and geophilic fungi in Iran. Clin Exp Dermatol Clin Dermatol 2013; 38(1): 1319.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 9.

    Lockhart SR , Guarner J . Emerging and reemerging fungal infections. Semin Diagn Pathol 2019; 36(3): 177181.

  • 10.

    Attal RO , Deotale V , Yadav A . Tinea capitis among primary school children: a clinic mycological study in a rural hospital in central India. Int J Curr Res Rev 2017; 9(23): 25.

    • Search Google Scholar
    • Export Citation
  • 11.

    Husain MA , Alam MN , Joarder Y , Ferdous M . Correlation between clinical and mycological diagnosis of onychomycosis. J Pak Assoc Dermatol 2018; 27(3): 220225.

    • Search Google Scholar
    • Export Citation
  • 12.

    Ahsan U , Zaman T , Rashid T , Jahangir M . Cutaneous manifestations in 1000 Pakistani newborns. J Pak Assoc Dermatol 2010; 20(4): 199205.

    • Search Google Scholar
    • Export Citation
  • 13.

    Haroon TS , Qureshi AS , Alvi KH , Khan HZ , Lakhani S , Sherali A . A study of skin disease in Chitral. J Pak Med Assoc 1987; 37: 247250.

    • Search Google Scholar
    • Export Citation
  • 14.

    Thebo NK , Abro H , Soomro AQ , Anwer J , Suhail M . Isolation and identification of dermatophytes from Sindh, Pakistan. Pak J Bot 2006; 38(2): 493.

    • Search Google Scholar
    • Export Citation
  • 15.

    Mirza SH , Gardezi AH , Khan Y , Wiqar MA . Subcutaneous facial mycosis in a child due to Madurella mycetomatis. J Pak Med Assoc 2007; 57(9): 466.

    • Search Google Scholar
    • Export Citation
  • 16.

    Abbas SQ , Maan A , Iqbal J , Niaz M , Waqas M , Ahmed H , Liaqat A . A report of Paecilomyces variotii on human from Pakistan. Pak J Bot 2009; 41(1): 467472.

    • Search Google Scholar
    • Export Citation
  • 17.

    Yasmeen N , Khan MR . Spectrum of common childhood skin diseases: a single center experience. J Pak Med Assoc 2005; 55(1): 6063.

  • 18.

    Namboodiri MT , Pakshirajan K . Sustainable and green approach of chitosan production from Penicillium citrinum biomass using industrial wastewater as a cheap substrate. J Environ Manage 2019; 240: 431440.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 19.

    Bitew A . Dermatophytosis: prevalence of dermatophytes and non-dermatophyte fungi from patients attending Arsho advanced medical laboratory. Addis Ababa, Ethiopia: Dermatol Res Pract; 2018.

    • Search Google Scholar
    • Export Citation
  • 20.

    Suárez-Villota EY , Carmignotto AP , Brandão MV , Percequillo AR , Silva MJDJ . Systematics of the genus Oecomys (Sigmodontinae: Oryzomyini): molecular phylogenetic, cytogenetic and morphological approaches reveal cryptic species. Zool J Linn Soc 2018; 184(1): 182210.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 21.

    Feghali N , Albertin W , Tabet E , Rizk Z , Bianco A , Zara G , Budroni M . Genetic and phenotypic characterization of a Saccharomyces cerevisiae population of ‘Merwah’ white wine. Microorganisms 2019; 7(11): 492.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 22.

    Hasan TSS , Aleem S , Tabassum L . Clinical evaluation of efficacy of Majoon Ushba and Marham Gulabi in Qooba. Indian J Traditional Knowledge 2011; 10: 702705.

    • Search Google Scholar
    • Export Citation
  • 23.

    Zhan P , Liu W . The changing face of dermatophytic infections worldwide. Mycopathologia 2017; 182(1–2): 7786.

  • 24.

    Chen M , Xu Y , Hong N , Yang Y , Lei W , Du L , Liao W . Epidemiology of fungal infections in China. Front Med-Prc 2018; 12(1): 5875.

  • 25.

    Mashedi OM . Characterization and antifungal drug profile of Dermatophytes from clinical sources in Nairobi. Doctoral dissertation, Kenya: University of Nairobi; 2010.

    • Search Google Scholar
    • Export Citation
  • 26.

    Balakumar S , Rajan S , Thirunalasundari T , Jeeva S . Epidemiology of dermatophytosis in and around Tiruchirapalli, Tamilnadu, India. Asian Pac J Trop Dis 2012; 2(4): 286289.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 27.

    Naseri A , Fata A , Najafzadeh MJ , Shokri H . Surveillance of dermatophytosis in northeast of Iran (Mashhad) and review of published studies. Mycopathologia 2013; 176(3–4): 247253.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 28.

    Pontes ZBVDS , Oliveira ACD , Guerra FQS , Pontes LRDA , Santos JPD . Distribution of dermatophytes from soils of urban and rural areas of cities of Paraiba State, Brazil. Rev Do Inst Med Trop SP 2013; 55(6): 377383.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 29.

    Akcaglar S , Ener B , Toker SC , Ediz B , Tunali S , Tore O . A comparative study of dermatophyte infections in Bursa, Turkey. Med Mycol 2011; 49(6): 602607.

    • Search Google Scholar
    • Export Citation
  • 30.

    Agarwal RK , Gupta S , Mittal G , Khan F , Roy S , Agarwal A . Antifungal susceptibility testing of dermatophytes by agar-based disk diffusion method. Int J Curr Microbiol Appl Sci 2015; 4(3): 430436.

    • Search Google Scholar
    • Export Citation
  • 31.

    Khatri PK , Kachhawa D , Maurya V , Meena S , Bora A , Rathore L , Khullar S . Antifungal resistance pattern among dermatophytes in Western Rajasthan. Int J Curr Microbiol Appl Sci 2017; 6: 499509.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 32.

    Habeb KA , Maikhan HK , Rachid SK . Molecular identification of dermatophytes among clinical isolates. Asian J Nat Appl Sci 2016; 5(2): 111.

    • Search Google Scholar
    • Export Citation
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Senior editors

Editor-in-Chief: Prof. Dóra Szabó (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Managing Editor: Dr. Béla Kocsis (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Co-editor: Dr. Andrea Horváth (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Editorial Board

  • Prof. Éva ÁDÁM (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Sebastian AMYES (Department of Medical Microbiology, University of Edinburgh, Edinburgh, UK.)
  • Dr. Katalin BURIÁN (Institute of Clinical Microbiology University of Szeged, Szeged, Hungary; Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary.)
  • Dr. Orsolya DOBAY (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Ildikó Rita DUNAY (Institute of Inflammation and Neurodegeneration, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany)
  • Prof. Levente EMŐDY(Department of Medical Microbiology and Immunology, University of Pécs, Pécs, Hungary.)
  • Prof. Anna ERDEI (Department of Immunology, Eötvös Loránd University, Budapest, Hungary, MTA-ELTE Immunology Research Group, Eötvös Loránd University, Budapest, Hungary.)
  • Prof. Éva Mária FENYŐ (Division of Medical Microbiology, University of Lund, Lund, Sweden)
  • Prof. László FODOR (Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, Budapest, Hungary)
  • Prof. József KÓNYA (Department of Medical Microbiology, University of Debrecen, Debrecen, Hungary)
  • Prof. Yvette MÁNDI (Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary)
  • Prof. Károly MÁRIALIGETI (Department of Microbiology, Eötvös Loránd University, Budapest, Hungary)
  • Prof. János MINÁROVITS (Department of Oral Biology and Experimental Dental Research, University of Szeged, Szeged, Hungary)
  • Prof. Béla NAGY (Centre for Agricultural Research, Institute for Veterinary Medical Research, Budapest, Hungary.)
  • Prof. István NÁSZ (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Kristóf NÉKÁM (Hospital of the Hospitaller Brothers in Buda, Budapest, Hungary.)
  • Dr. Eszter OSTORHÁZI (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Rozália PUSZTAI (Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary)
  • Prof. Peter L. RÁDY (Department of Dermatology, University of Texas, Houston, Texas, USA)
  • Prof. Éva RAJNAVÖLGYI (Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary)
  • Prof. Ferenc ROZGONYI (Institute of Laboratory Medicine, Semmelweis University, Budapest, Hungary)
  • Prof. Joseph G. SINKOVICS (The Cancer Institute, St. Joseph’s Hospital, Tampa, Florida, USA)
  • Prof. Júlia SZEKERES (Department of Medical Biology, University of Pécs, Pécs, Hungary.)
  • Prof. Mária TAKÁCS (National Reference Laboratory for Viral Zoonoses, National Public Health Center, Budapest, Hungary.)
  • Prof. Edit URBÁN (Department of Medical Microbiology and Immunology University of Pécs, Pécs, Hungary; Institute of Translational Medicine, University of Pécs, Pécs, Hungary.)

 

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Acta Microbiologica et Immunologica Hungarica
Language English
Size A4
Year of
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1954
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia
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ISSN 1217-8950 (Print)
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