Acta Microbiologica et Immunologica Hungarica
Volume/Issue:
Volume 71: Issue 2
Epidemiological and bacterial profile of childhood meningitis in Tunisia
Authors:
Sarra Dhraief Laboratory of Microbiology, Children's Hospital Bechir Hamza of Tunis, Tunisia

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Khaoula Meftah Laboratory of Microbiology, Children's Hospital Bechir Hamza of Tunis, Tunisia
Tunis El Manar University, Faculty of Medicine of Tunis, LR18ES39, Tunis, Tunisia

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https://orcid.org/0000-0003-3312-8265
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Samar Mhimdi Laboratory of Microbiology, Children's Hospital Bechir Hamza of Tunis, Tunisia
Tunis El Manar University, Faculty of Medicine of Tunis, LR18ES39, Tunis, Tunisia

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Houyem Khiari Tunis El Manar University, Faculty of Medicine of Tunis, LR18ES39, Tunis, Tunisia
Department of Epidemiology and Biostatistics, Salah Azaiz Institute, Tunis, Tunisia

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Firas Aloui Laboratory of Microbiology, Children's Hospital Bechir Hamza of Tunis, Tunisia
Tunis El Manar University, Faculty of Medicine of Tunis, LR18ES39, Tunis, Tunisia

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Aida Borgi Tunis El Manar University, Faculty of Medicine of Tunis, LR18ES39, Tunis, Tunisia
Pediatric Intensive Care Unit, Children's Hospital Bechir Hamza of Tunis, Tunisia

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Sondes Haddad-Boubaker Laboratory of Clinical Virology, WHO Regional Reference Laboratory for Poliomyelitis and Measles for the EMR, Institute Pasteur of Tunis, University of Tunis El Manar, Tunis, Tunisia

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Amani Brik Laboratory of Microbiology, Children's Hospital Bechir Hamza of Tunis, Tunisia

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Khaled Menif Tunis El Manar University, Faculty of Medicine of Tunis, LR18ES39, Tunis, Tunisia
Pediatric Intensive Care Unit, Children's Hospital Bechir Hamza of Tunis, Tunisia

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Amel Kechrid Laboratory of Microbiology, Children's Hospital Bechir Hamza of Tunis, Tunisia

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Aida Bouafsoun Laboratory of Microbiology, Children's Hospital Bechir Hamza of Tunis, Tunisia

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Hanen Smaoui Laboratory of Microbiology, Children's Hospital Bechir Hamza of Tunis, Tunisia
Tunis El Manar University, Faculty of Medicine of Tunis, LR18ES39, Tunis, Tunisia

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Pages:
148–154
Online Publication Date:
21 May 2024
Publication Date:
02 Jul 2024
Article Category:
Research Article
DOI:
https://doi.org/10.1556/030.2024.02208
Keywords:
children; bacterial meningitis; antimicrobial resistance; vaccination; Tunisia
Restricted access

Abstract

The worldwide burden of disease of bacterial meningitis remains high, despite the decreasing incidence following introduction of routine vaccination campaigns.

The aim of our study was to evaluate the epidemiological and bacteriological profile of paediatric bacterial meningitis (BM) in Tunisian children, during the period 2003–2019, following the implementation of Haemophilus influenzae type b (Hib) vaccine (April 2011) and before 10-valent pneumoccocal conjugate vaccine (PCV10) introduction to the childhood immunization program.

All bacteriologically confirmed cases of BM admitted to children's hospital of Tunis were recorded (January 2003 to April 2019). Serogroups of Neisseria meningitidis (Nm) and serotypes of Streptococcus pneumoniae (Sp) and H. influenzae (Hi) and antibiotic resistance were determined using conventional and molecular methods.

Among 388 cases, the most frequent species were Sp (51.3%), followed by Nm (27.5%) and Hi (16.8%). We observed a significant decrease in Hi BM rate during the conjugated Hib vaccine use period (P < 0.0001). The main pneumococcal serotypes were 14, 19F, 6B, 23F and 19A and the serotype coverage of PCV10, PCV13, PCV15 and PCV20 was 71.3 and 78.8%, 79.4 and 81.9% respectively. The most frequent Nm serogroup was B (83.1%). Most Hi strains were of serotype b (86.9%). High levels of resistance were found: Sp and Nm to penicillin (respectively 60.1 and 80%) and Hi to ampicillin (42.6%). All meningococcal and Hi isolates were susceptible to third-generation cephalosporins and 7.2% of pneumococcal strains had decreased susceptibility to these antibiotics.

The Hib conjugate vaccine decreased the rate of BM. Sp dominated the aetiology of BM in children in Tunisia. Conjugate vaccines introducing decreases not only BM cases but also antimicrobial resistance.

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Cover Acta Microbiologica et Immunologica Hungarica
Acta Microbiologica et Immunologica Hungarica A Quarterly of the Hungarian Academy of Sciences
Print ISSN:
1217-8950
Online ISSN:
1588-2640

Senior editors

Editor-in-Chief: Prof. Dóra Szabó (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Managing Editor: Dr. Béla Kocsis (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Co-editor: Dr. Andrea Horváth (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Editorial Board

  • Prof. Éva ÁDÁM (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Sebastian AMYES (Department of Medical Microbiology, University of Edinburgh, Edinburgh, UK.)
  • Dr. Katalin BURIÁN (Institute of Clinical Microbiology University of Szeged, Szeged, Hungary; Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary.)
  • Dr. Orsolya DOBAY (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Ildikó Rita DUNAY (Institute of Inflammation and Neurodegeneration, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany)
  • Prof. Levente EMŐDY(Department of Medical Microbiology and Immunology, University of Pécs, Pécs, Hungary.)
  • Prof. Anna ERDEI (Department of Immunology, Eötvös Loránd University, Budapest, Hungary, MTA-ELTE Immunology Research Group, Eötvös Loránd University, Budapest, Hungary.)
  • Prof. Éva Mária FENYŐ (Division of Medical Microbiology, University of Lund, Lund, Sweden)
  • Prof. László FODOR (Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, Budapest, Hungary)
  • Prof. József KÓNYA (Department of Medical Microbiology, University of Debrecen, Debrecen, Hungary)
  • Prof. Yvette MÁNDI (Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary)
  • Prof. Károly MÁRIALIGETI (Department of Microbiology, Eötvös Loránd University, Budapest, Hungary)
  • Prof. János MINÁROVITS (Department of Oral Biology and Experimental Dental Research, University of Szeged, Szeged, Hungary)
  • Prof. Béla NAGY (Centre for Agricultural Research, Institute for Veterinary Medical Research, Budapest, Hungary.)
  • Prof. István NÁSZ (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Kristóf NÉKÁM (Hospital of the Hospitaller Brothers in Buda, Budapest, Hungary.)
  • Dr. Eszter OSTORHÁZI (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Rozália PUSZTAI (Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary)
  • Prof. Peter L. RÁDY (Department of Dermatology, University of Texas, Houston, Texas, USA)
  • Prof. Éva RAJNAVÖLGYI (Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary)
  • Prof. Ferenc ROZGONYI (Institute of Laboratory Medicine, Semmelweis University, Budapest, Hungary)
  • Prof. Joseph G. SINKOVICS (The Cancer Institute, St. Joseph’s Hospital, Tampa, Florida, USA)
  • Prof. Júlia SZEKERES (Department of Medical Biology, University of Pécs, Pécs, Hungary.)
  • Prof. Mária TAKÁCS (National Reference Laboratory for Viral Zoonoses, National Public Health Center, Budapest, Hungary.)
  • Prof. Edit URBÁN (Department of Medical Microbiology and Immunology University of Pécs, Pécs, Hungary; Institute of Translational Medicine, University of Pécs, Pécs, Hungary.)

 

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Acta Microbiologica et Immunologica Hungarica
Language English
Size A4
Year of
Foundation		 1954
Volumes
per Year		 1
Issues
per Year		 4
Founder Magyar Tudományos Akadémia
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Address		 H-1051 Budapest, Hungary, Széchenyi István tér 9.
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ISSN 1217-8950 (Print)
ISSN 1588-2640 (Online)

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