Authors:
Zaineb Hamzaoui University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES09, Tunis 1007, Tunisia

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Sana Ferjani University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES09, Tunis 1007, Tunisia

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Lamia Kanzari University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES09, Tunis 1007, Tunisia
Charles Nicolle Hospital, Laboratory of Microbiology, Tunis 1006, Tunisia

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Roua Ben Ali National Center Chalbibelkahia of Pharmacovigilance of Tunis, Laboratory of Clinical Pharmacology, 9 Avenue Dr. Zouhaier Essafi 1006 Bab Souika, Tunis, Tunisia

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Latifa Charaa Charles Nicolle Hospital, Laboratory of Microbiology, Tunis 1006, Tunisia

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Ichrak Landolsi Charles Nicolle Hospital, Laboratory of Microbiology, Tunis 1006, Tunisia

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Ines Medini National Center Chalbibelkahia of Pharmacovigilance of Tunis, Laboratory of Clinical Pharmacology, 9 Avenue Dr. Zouhaier Essafi 1006 Bab Souika, Tunis, Tunisia

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Sarra Chammam National Center Chalbibelkahia of Pharmacovigilance of Tunis, Laboratory of Clinical Pharmacology, 9 Avenue Dr. Zouhaier Essafi 1006 Bab Souika, Tunis, Tunisia

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Salma Abid University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES09, Tunis 1007, Tunisia
Charles Nicolle Hospital, Laboratory of Microbiology, Tunis 1006, Tunisia

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Asma Ferjani University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES09, Tunis 1007, Tunisia
Charles Nicolle Hospital, Laboratory of Microbiology, Tunis 1006, Tunisia

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Dhouha Kebaier University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES09, Tunis 1007, Tunisia
Charles Nicolle Hospital, Laboratory of Microbiology, Tunis 1006, Tunisia

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Ahmed Fakhfakh University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES09, Tunis 1007, Tunisia
Charles Nicolle Hospital, Laboratory of Microbiology, Tunis 1006, Tunisia

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Zoubeir Bouslah University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES09, Tunis 1007, Tunisia
Charles Nicolle Hospital, Laboratory of Microbiology, Tunis 1006, Tunisia

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Mouna Ben Sassi National Center Chalbibelkahia of Pharmacovigilance of Tunis, Laboratory of Clinical Pharmacology, 9 Avenue Dr. Zouhaier Essafi 1006 Bab Souika, Tunis, Tunisia
University of Tunis El Manar, Faculty of Medicine of Tunis, LR16SP02, 1007 Tunis, Tunisia

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Sameh Trabelsi National Center Chalbibelkahia of Pharmacovigilance of Tunis, Laboratory of Clinical Pharmacology, 9 Avenue Dr. Zouhaier Essafi 1006 Bab Souika, Tunis, Tunisia
University of Tunis El Manar, Faculty of Medicine of Tunis, LR16SP02, 1007 Tunis, Tunisia

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Ilhem Boutiba-Ben Boubaker University of Tunis El Manar, Faculty of Medicine of Tunis, LR99ES09, Tunis 1007, Tunisia
Charles Nicolle Hospital, Laboratory of Microbiology, Tunis 1006, Tunisia

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Abstract

The JN.1 sub-variant is a new variant of the SARS-CoV-2 Omicron strain, derived from the BA.2.86 sub-variant. It was first detected in late 2023 and has quickly spread to many countries, becoming the most prevalent variant in some regions. JN.1 exhibits a unique mutation (L455S) in the spike protein compared to the BA.2.86 lineage, which may affect its transmissibility and immune evasion capabilities. JN.1 has been designated as a “variant of interest” by the World Health Organization due to its rapidly increasing spread and is being closely monitored for its impact on the COVID-19 pandemic. This study describes the emergence of SARS-CoV-2 JN.1 sub-variant in Tunisia, and reports its mutation profiles.

Nasopharyngeal samples collected over a four-month period (October 2023 to January 2024) were subjected to RNA extraction and real-time RT-PCR confirmation of SARS-CoV-2 infection. The whole-genome sequencing was performed by an iSeq 100 sequencer and COVIDSeq kit reagents (Illumina, USA).

Mutation analysis, using the NextClade platform and GISAID database, revealed the presence of JN.1 in 15 out of 80 positive cases (18.75%) during the study period.

The emergence of JN.1 highlights the ongoing evolution of SARS-CoV-2 and the need for continued surveillance and research to better understand the characteristics and impact of emerging variants.

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    Quarleri J, Delpino MV, Galvan V. Anticipating the future of the COVID-19 pandemic: insights into the emergence of SARS-CoV-2 variant JN.1 and its projected impact on older adults. GeroScience 2024. s11357-024-01066–7. https://doi.org/10.1007/s11357-024-01066-7.

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    Focosi D, Spezia PG, Gueli F, Maggi F. The Era of the FLips: how spike mutations L455F and F456L (and A475V) are shaping SARS-CoV-2 evolution. Viruses 2023; 16: 3. https://doi.org/10.3390/v16010003.

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Senior editors

Editor-in-Chief: Prof. Dóra Szabó (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Managing Editor: Dr. Béla Kocsis (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Co-editor: Dr. Andrea Horváth (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)

Editorial Board

  • Prof. Éva ÁDÁM (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Sebastian AMYES (Department of Medical Microbiology, University of Edinburgh, Edinburgh, UK.)
  • Dr. Katalin BURIÁN (Institute of Clinical Microbiology University of Szeged, Szeged, Hungary; Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary.)
  • Dr. Orsolya DOBAY (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Ildikó Rita DUNAY (Institute of Inflammation and Neurodegeneration, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany)
  • Prof. Levente EMŐDY(Department of Medical Microbiology and Immunology, University of Pécs, Pécs, Hungary.)
  • Prof. Anna ERDEI (Department of Immunology, Eötvös Loránd University, Budapest, Hungary, MTA-ELTE Immunology Research Group, Eötvös Loránd University, Budapest, Hungary.)
  • Prof. Éva Mária FENYŐ (Division of Medical Microbiology, University of Lund, Lund, Sweden)
  • Prof. László FODOR (Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, Budapest, Hungary)
  • Prof. József KÓNYA (Department of Medical Microbiology, University of Debrecen, Debrecen, Hungary)
  • Prof. Yvette MÁNDI (Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary)
  • Prof. Károly MÁRIALIGETI (Department of Microbiology, Eötvös Loránd University, Budapest, Hungary)
  • Prof. János MINÁROVITS (Department of Oral Biology and Experimental Dental Research, University of Szeged, Szeged, Hungary)
  • Prof. Béla NAGY (Centre for Agricultural Research, Institute for Veterinary Medical Research, Budapest, Hungary.)
  • Prof. István NÁSZ (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Kristóf NÉKÁM (Hospital of the Hospitaller Brothers in Buda, Budapest, Hungary.)
  • Dr. Eszter OSTORHÁZI (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary)
  • Prof. Rozália PUSZTAI (Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary)
  • Prof. Peter L. RÁDY (Department of Dermatology, University of Texas, Houston, Texas, USA)
  • Prof. Éva RAJNAVÖLGYI (Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary)
  • Prof. Ferenc ROZGONYI (Institute of Laboratory Medicine, Semmelweis University, Budapest, Hungary)
  • Prof. Joseph G. SINKOVICS (The Cancer Institute, St. Joseph’s Hospital, Tampa, Florida, USA)
  • Prof. Júlia SZEKERES (Department of Medical Biology, University of Pécs, Pécs, Hungary.)
  • Prof. Mária TAKÁCS (National Reference Laboratory for Viral Zoonoses, National Public Health Center, Budapest, Hungary.)
  • Prof. Edit URBÁN (Department of Medical Microbiology and Immunology University of Pécs, Pécs, Hungary; Institute of Translational Medicine, University of Pécs, Pécs, Hungary.)

 

Editorial Office:
Akadémiai Kiadó Zrt.
Budafoki út 187-187, A/3, H-1117 Budapest, Hungary

Editorial Correspondence:
Acta Microbiologica et Immunologica Hungarica
Institute of Medical Microbiology
Semmelweis University
P.O. Box 370
H-1445 Budapest, Hungary
Phone: + 36 1 459 1500 ext. 56101
Fax: (36 1) 210 2959
E-mail: amih@med.semmelweis-univ.hu

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  • Science Citation Index Expanded

2022  
Web of Science  
Total Cites
WoS
689
Journal Impact Factor 1.5
Rank by Impact Factor

Immunology (Q4)
Microbiology (Q4)

Impact Factor
without
Journal Self Cites
1.3
5 Year
Impact Factor
1.7
Journal Citation Indicator 0.34
Rank by Journal Citation Indicator

Immunology (Q4)
Microbiology (Q4)

Scimago  
Scimago
H-index
31
Scimago
Journal Rank
0.333
Scimago Quartile Score

Immunology and Microbiology (miscellaneous) (Q3)
Infectious Diseases (Q3)
Medicine (miscellaneous) (Q3)
Microbiology (medical) (Q3)

Scopus  
Scopus
Cite Score
2.8
Scopus
CIte Score Rank
General Immunology and Microbiology 29/53 (46th PCTL)
Infectious Diseases 186/304 (38th PCTL)
Microbiology 85/124 (31st PCTL)
Scopus
SNIP
0.484

2021  
Web of Science  
Total Cites
WoS
696
Journal Impact Factor 2,298
Rank by Impact Factor Immunology 141/161
Microbiology 118/136
Impact Factor
without
Journal Self Cites
2,143
5 Year
Impact Factor
1,925
Journal Citation Indicator 0,39
Rank by Journal Citation Indicator Immunology 146/177
Microbiology 129/157
Scimago  
Scimago
H-index
29
Scimago
Journal Rank
0,362
Scimago Quartile Score Immunology and Microbiology (miscellaneous) (Q3)
Medicine (miscellaneous) (Q3)
Scopus  
Scopus
Cite Score
3,6
Scopus
CIte Score Rank
General Immunology and Microbiology 26/56 (Q2)
Infectious Diseases 149/295 (Q3)
Microbiology (medical) 66/118 (Q3)
Scopus
SNIP
0,598

2020  
Total Cites 662
WoS
Journal
Impact Factor
2,048
Rank by Immunology 145/162(Q4)
Impact Factor Microbiology 118/137 (Q4)
Impact Factor 1,904
without
Journal Self Cites
5 Year 0,671
Impact Factor
Journal  0,38
Citation Indicator  
Rank by Journal  Immunology 146/174 (Q4)
Citation Indicator  Microbiology 120/142 (Q4)
Citable 42
Items
Total 40
Articles
Total 2
Reviews
Scimago 28
H-index
Scimago 0,439
Journal Rank
Scimago Immunology and Microbiology (miscellaneous) Q4
Quartile Score Medicine (miscellaneous) Q3
Scopus 438/167=2,6
Scite Score  
Scopus General Immunology and Microbiology 31/45 (Q3)
Scite Score Rank  
Scopus 0,760
SNIP
Days from  225
submission
to acceptance
Days from  118
acceptance
to publication
Acceptance 19%
Rate

2019  
Total Cites
WoS
485
Impact Factor 1,086
Impact Factor
without
Journal Self Cites
0,864
5 Year
Impact Factor
1,233
Immediacy
Index
0,286
Citable
Items
42
Total
Articles
40
Total
Reviews
2
Cited
Half-Life
5,8
Citing
Half-Life
7,7
Eigenfactor
Score
0,00059
Article Influence
Score
0,246
% Articles
in
Citable Items
95,24
Normalized
Eigenfactor
0,07317
Average
IF
Percentile
7,690
Scimago
H-index
27
Scimago
Journal Rank
0,352
Scopus
Scite Score
320/161=2
Scopus
Scite Score Rank
General Immunology and Microbiology 35/45 (Q4)
Scopus
SNIP
0,492
Acceptance
Rate
16%

 

Acta Microbiologica et Immunologica Hungarica
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Acta Microbiologica et Immunologica Hungarica
Language English
Size A4
Year of
Foundation
1954
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1217-8950 (Print)
ISSN 1588-2640 (Online)

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