Gaffen SL, Hajishengallis G. A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17. J Dent Res 2008; 87(9): 817–828. https://doi.org/10.1177/154405910808700908.

Gaffen SL, Hajishengallis G. A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17. J Dent Res 2008; 87(9): 817–828. https://doi.org/10.1177/154405910808700908.)| false
• Search Google Scholar
• Export Citation

Eskan MA, Jotwani R, Abe T, Chmelar J, Lim JH, Liang S, et al. The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nat Immunol 2012; 13(5): 465–473. https://doi.org/10.1038/ni.2260.

Eskan MA, Jotwani R, Abe T, Chmelar J, Lim JH, Liang S, et al. The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nat Immunol 2012; 13(5): 465–473. https://doi.org/10.1038/ni.2260.)| false
• Search Google Scholar
• Export Citation

Moore WE, Holdeman LV, Smibert RM, Hash DE, Burmeister JA, Ranney RR. Bacteriology of severe periodontitis in young adult humans. Infect Immun 1982; 38(3): 1137–1148. https://doi.org/10.1128/iai.38.3.1137-1148.1982.

Moore WE, Holdeman LV, Smibert RM, Hash DE, Burmeister JA, Ranney RR. Bacteriology of severe periodontitis in young adult humans. Infect Immun 1982; 38(3): 1137–1148. https://doi.org/10.1128/iai.38.3.1137-1148.1982.)| false
• Search Google Scholar
• Export Citation

Socransky SS. Microbiology of periodontal disease-present status and future considerations. J Periodontol 1977; 48(9): 497–504. https://doi.org/10.1902/jop.1977.48.9.497.

Socransky SS. Microbiology of periodontal disease-present status and future considerations. J Periodontol 1977; 48(9): 497–504. https://doi.org/10.1902/jop.1977.48.9.497.)| false
• Search Google Scholar
• Export Citation

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486(7402): 207–214. https://doi.org/10.1038/nature11234.

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486(7402): 207–214. https://doi.org/10.1038/nature11234.)| false
• Search Google Scholar
• Export Citation

Acharya A, Chan Y, Kheur S, Jin LJ, Watt RM, Mattheos N. Salivary microbiome in non-oral disease: a summary of evidence and commentary. Arch Oral Biol 2017; 83: 169–173. https://doi.org/10.1016/j.archoralbio.2017.07.019.

Acharya A, Chan Y, Kheur S, Jin LJ, Watt RM, Mattheos N. Salivary microbiome in non-oral disease: a summary of evidence and commentary. Arch Oral Biol 2017; 83: 169–173. https://doi.org/10.1016/j.archoralbio.2017.07.019.)| false
• Search Google Scholar
• Export Citation

Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol 2018; 16(12): 745–759.

Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol 2018; 16(12): 745–759.)| false
• Search Google Scholar
• Export Citation

Finlay BB. Cellular microbiology in the 21st century. Future Microbiol 2006; 1(4): 359–361.

Finlay BB. Cellular microbiology in the 21st century. Future Microbiol 2006; 1(4): 359–361.)| false
• Search Google Scholar
• Export Citation

Hajishengallis G, Darveau RP, Curtis MA. The keystone-pathogen hypothesis. Nat Rev Microbiol 2012; 10(10): 717–725.

Hajishengallis G, Darveau RP, Curtis MA. The keystone-pathogen hypothesis. Nat Rev Microbiol 2012; 10(10): 717–725.)| false
• Search Google Scholar
• Export Citation

Schenkein HA, Papapanou PN, Genco R, Sanz M. Mechanisms underlying the association between periodontitis and atherosclerotic disease. Periodontol 2000 2020; 83(1): 90–106. https://doi.org/10.1111/prd.12304.

Schenkein HA, Papapanou PN, Genco R, Sanz M. Mechanisms underlying the association between periodontitis and atherosclerotic disease. Periodontol 2000 2020; 83(1): 90–106. https://doi.org/10.1111/prd.12304.)| false
• Search Google Scholar
• Export Citation

Nanci A, Bosshardt DD. Structure of periodontal tissues in health and disease. Periodontol 2000 2006; 40: 11–28. https://doi.org/10.1111/j.1600-0757.2005.00141.x.

Nanci A, Bosshardt DD. Structure of periodontal tissues in health and disease. Periodontol 2000 2006; 40: 11–28. https://doi.org/10.1111/j.1600-0757.2005.00141.x.)| false
• Search Google Scholar
• Export Citation

Parahitiyawa NB, Jin LJ, Leung WK, Yam WC, Samaranayake LP. Microbiology of odontogenic bacteremia: beyond endocarditis. Clin Microbiol Rev 2009; 22(1): 46–64. Table of Contents. https://doi.org/10.1128/CMR.00028-08.

Parahitiyawa NB, Jin LJ, Leung WK, Yam WC, Samaranayake LP. Microbiology of odontogenic bacteremia: beyond endocarditis. Clin Microbiol Rev 2009; 22(1): 46–64. Table of Contents. https://doi.org/10.1128/CMR.00028-08.)| false
• Search Google Scholar
• Export Citation

Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol 1998; 25(2): 134–144. https://doi.org/10.1111/j.1600-051x.1998.tb02419.x.

Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol 1998; 25(2): 134–144. https://doi.org/10.1111/j.1600-051x.1998.tb02419.x.)| false
• Search Google Scholar
• Export Citation

Lamont RJ, Jenkinson HF. Subgingival colonization by Porphyromonas gingivalis. Oral Microbiol Immunol 2000; 15(6): 341–9. https://doi.org/10.1034/j.1399-302x.2000.150601.x.

Lamont RJ, Jenkinson HF. Subgingival colonization by Porphyromonas gingivalis. Oral Microbiol Immunol 2000; 15(6): 341–9. https://doi.org/10.1034/j.1399-302x.2000.150601.x.)| false
• Search Google Scholar
• Export Citation

Holt SC, Kesavalu L, Walker S, Genco CA. Virulence factors in Porphyromonas gingivalis. Periodontol 2000 1999; 20: 168–238.

Holt SC, Kesavalu L, Walker S, Genco CA. Virulence factors in Porphyromonas gingivalis. Periodontol 2000 1999; 20: 168–238.)| false
• Search Google Scholar
• Export Citation

Kobayashi-Sakamoto M, Isogai E, Hirose K. Porphyromonas gingivalis modulates the production of interleukin 8 and monocyte chemotactic protein 1 in human vascular endothelial cells. Curr Microbiol 2003; 46: 109–124.

Kobayashi-Sakamoto M, Isogai E, Hirose K. Porphyromonas gingivalis modulates the production of interleukin 8 and monocyte chemotactic protein 1 in human vascular endothelial cells. Curr Microbiol 2003; 46: 109–124.)| false
• Search Google Scholar
• Export Citation

Inomata M, Ishihara Y, Matsuyama T, Imamura T, Maruyama I, Noguchi T, et al. Degradation of vascular endothelial thrombomodulin by arginine- and lysine-specific cysteine proteases from Porphyromonas gingivalis. J Periodontol 2009; 80(9): 1511–7. https://doi.org/10.1902/jop.2009.090114.

Inomata M, Ishihara Y, Matsuyama T, Imamura T, Maruyama I, Noguchi T, et al. Degradation of vascular endothelial thrombomodulin by arginine- and lysine-specific cysteine proteases from Porphyromonas gingivalis. J Periodontol 2009; 80(9): 1511–7. https://doi.org/10.1902/jop.2009.090114.)| false
• Search Google Scholar
• Export Citation

Kim SR, Jeon HJ, Park HJ, Kim MK, Choi WS, Jang HO, et al. Glycyrrhetinic acid inhibits Porphyromonas gingivalis lipopolysaccharide-induced vascular permeability via the suppression of interleukin-8. Inflamm Res 2013; 62(2): 145–54. https://doi.org/10.1007/s00011-012-0560-5.

Kim SR, Jeon HJ, Park HJ, Kim MK, Choi WS, Jang HO, et al. Glycyrrhetinic acid inhibits Porphyromonas gingivalis lipopolysaccharide-induced vascular permeability via the suppression of interleukin-8. Inflamm Res 2013; 62(2): 145–54. https://doi.org/10.1007/s00011-012-0560-5.)| false
• Search Google Scholar
• Export Citation

Farrugia C, Stafford GP, Murdoch C. Porphyromonas gingivalis outer membrane vesicles increase vascular permeability. J Dent Res 2020; 99(13): 1494–501. https://doi.org/10.1177/0022034520943187.

Farrugia C, Stafford GP, Murdoch C. Porphyromonas gingivalis outer membrane vesicles increase vascular permeability. J Dent Res 2020; 99(13): 1494–501. https://doi.org/10.1177/0022034520943187.)| false
• Search Google Scholar
• Export Citation

Kadowaki T, Yoneda M, Okamoto K, Maeda K, Yamamoto K. Purification and characterization of a novel arginine- specific cysteine proteinase (argingipain) involved in the pathogenesis of periodontal disease from the culture supernatant of Porphyromonas gingivalis. J Biol Chem 1994; 269: 21371–2137.

Kadowaki T, Yoneda M, Okamoto K, Maeda K, Yamamoto K. Purification and characterization of a novel arginine- specific cysteine proteinase (argingipain) involved in the pathogenesis of periodontal disease from the culture supernatant of Porphyromonas gingivalis. J Biol Chem 1994; 269: 21371–2137.)| false
• Search Google Scholar
• Export Citation

Listgarten MA. Structure of the microbial flora associated with periodontal health and disease in man. A light and electron microscopic study. J Periodontol 1976; 47(1): 1–18. https://doi.org/10.1902/jop.1976.47.1.1.

Listgarten MA. Structure of the microbial flora associated with periodontal health and disease in man. A light and electron microscopic study. J Periodontol 1976; 47(1): 1–18. https://doi.org/10.1902/jop.1976.47.1.1.)| false
• Search Google Scholar
• Export Citation

Weinberg A, Holt SC. Chemical and biological activities of a 64-kilodalton outer sheath protein from Treponema denticola strains. J Bacteriol 1991; 173(21): 6935–6947. https://doi.org/10.1128/jb.173.21.6935-6947.1991.

Weinberg A, Holt SC. Chemical and biological activities of a 64-kilodalton outer sheath protein from Treponema denticola strains. J Bacteriol 1991; 173(21): 6935–6947. https://doi.org/10.1128/jb.173.21.6935-6947.1991.)| false
• Search Google Scholar
• Export Citation

Ishihara K. Virulence factors of Treponema denticola. Periodontol 2000 2010; 54(1): 117–135.

Ishihara K. Virulence factors of Treponema denticola. Periodontol 2000 2010; 54(1): 117–135.)| false
• Search Google Scholar
• Export Citation

Diamond G, Beckloff N, Ryan LK. Host defense peptides in the oral cavity and the lung: similarities and differences. J Dent Res 2008; 87(10): 915–927.

Diamond G, Beckloff N, Ryan LK. Host defense peptides in the oral cavity and the lung: similarities and differences. J Dent Res 2008; 87(10): 915–927.)| false
• Search Google Scholar
• Export Citation

Brissette CA, Pham TT, Coats SR, Darveau RP, Lukehart SA. Treponema denticola does not induce production of common innate immune mediators from primary gingival epithelial cells. Oral Microbiol Immunol 2008; 23: 474–481.

Brissette CA, Pham TT, Coats SR, Darveau RP, Lukehart SA. Treponema denticola does not induce production of common innate immune mediators from primary gingival epithelial cells. Oral Microbiol Immunol 2008; 23: 474–481.)| false
• Search Google Scholar
• Export Citation

Fenno JC, Tamura M, Hannam PM, Wong GW, Chan RA, McBride BC. Identification of a Treponema denticola OppA homologue that binds host proteins present in the subgingival environment. Infect Immun 2000 Apr; 68(4): 1884–92. https://doi.org/10.1128/IAI.68.4.1884-1892.2000.

Fenno JC, Tamura M, Hannam PM, Wong GW, Chan RA, McBride BC. Identification of a Treponema denticola OppA homologue that binds host proteins present in the subgingival environment. Infect Immun 2000 Apr; 68(4): 1884–92. https://doi.org/10.1128/IAI.68.4.1884-1892.2000.)| false
• Search Google Scholar
• Export Citation

Fenno JC, Hannam PM, Leung WK, Tamura M, Uitto VJ, McBride BC. Cytopathic effects of the major surface protein and the chymotrypsin like protease of Treponema denticola. Infect Immun 1998; 66(5): 1869–1877. https://doi.org/10.1128/IAI.66.5.1869-1877.1998.

Fenno JC, Hannam PM, Leung WK, Tamura M, Uitto VJ, McBride BC. Cytopathic effects of the major surface protein and the chymotrypsin like protease of Treponema denticola. Infect Immun 1998; 66(5): 1869–1877. https://doi.org/10.1128/IAI.66.5.1869-1877.1998.)| false
• Search Google Scholar
• Export Citation

Leung WK, Haapasalo M, Uitto V-J, Hannam PM, McBride BC. The surface proteinase of Treponema denticola may mediate attachment of the bacteria to epithelial cells. Anaerobe 1996; 2(1): 39–46.

Leung WK, Haapasalo M, Uitto V-J, Hannam PM, McBride BC. The surface proteinase of Treponema denticola may mediate attachment of the bacteria to epithelial cells. Anaerobe 1996; 2(1): 39–46.)| false
• Search Google Scholar
• Export Citation

Kimizuka R, Kato T, Ishihara K, Okuda K. Mixed infections with Porphyromonas gingivalis and Treponema denticola cause excessive inflammatory responses in a mouse pneumonia model compared with mono-infections. Microbes Infect 2003; 5(15): 1357–1362. https://doi.org/10.1016/j.micinf.2003.09.015.

Kimizuka R, Kato T, Ishihara K, Okuda K. Mixed infections with Porphyromonas gingivalis and Treponema denticola cause excessive inflammatory responses in a mouse pneumonia model compared with mono-infections. Microbes Infect 2003; 5(15): 1357–1362. https://doi.org/10.1016/j.micinf.2003.09.015.)| false
• Search Google Scholar
• Export Citation

Nixon CS, Steffen MJ, Ebersole JL. Cytokine responses to Treponema pectinovorum and Treponema denticola in human gingival fibroblasts. Infect Immun 2000; 68(9): 5284–92. https://doi.org/10.1128/IAI.68.9.5284-5292.2000.

Nixon CS, Steffen MJ, Ebersole JL. Cytokine responses to Treponema pectinovorum and Treponema denticola in human gingival fibroblasts. Infect Immun 2000; 68(9): 5284–92. https://doi.org/10.1128/IAI.68.9.5284-5292.2000.)| false
• Search Google Scholar
• Export Citation

Miyamoto M, Ishihara K, Okuda K. The Treponema denticola surface protease dentilisin degrades interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor alpha. Infect Immun 2006; 74(4): 2462–2467. https://doi.org/10.1128/IAI.74.4.2462-2467.2006.

Miyamoto M, Ishihara K, Okuda K. The Treponema denticola surface protease dentilisin degrades interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor alpha. Infect Immun 2006; 74(4): 2462–2467. https://doi.org/10.1128/IAI.74.4.2462-2467.2006.)| false
• Search Google Scholar
• Export Citation

Yamazaki T, Miyamoto M, Yamada S, Okuda K, Ishihara K. Surface protease of Treponema denticola hydrolyzes C3 and influences function of polymorphonuclear leukocytes. Microbes Infect 2006; 8(7): 1758–1763. https://doi.org/10.1016/j.micinf.2006.02.013.

Yamazaki T, Miyamoto M, Yamada S, Okuda K, Ishihara K. Surface protease of Treponema denticola hydrolyzes C3 and influences function of polymorphonuclear leukocytes. Microbes Infect 2006; 8(7): 1758–1763. https://doi.org/10.1016/j.micinf.2006.02.013.)| false
• Search Google Scholar
• Export Citation

Gross EL, Beall CJ, Kutsch SR, Firestone ND, Leys EJ, Griffen AL. Beyond Streptococcus mutans: dental caries onset linked to multiple species by 16S rRNA community analysis. PLoS One 2012; 7(10): e47722.

Gross EL, Beall CJ, Kutsch SR, Firestone ND, Leys EJ, Griffen AL. Beyond Streptococcus mutans: dental caries onset linked to multiple species by 16S rRNA community analysis. PLoS One 2012; 7(10): e47722.)| false
• Search Google Scholar
• Export Citation

Tanner ACR, Socransky SS, Goodson JM. Microbiota of periodontal pockets losing crestal alveolar bone. J Periodontal Res 1984; 19(3): 279–291.

Tanner ACR, Socransky SS, Goodson JM. Microbiota of periodontal pockets losing crestal alveolar bone. J Periodontal Res 1984; 19(3): 279–291.)| false
• Search Google Scholar
• Export Citation

Libermann TA, Baltimore D. Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol 1990; 10(5): 2327–2334.

Libermann TA, Baltimore D. Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol 1990; 10(5): 2327–2334.)| false
• Search Google Scholar
• Export Citation

Hajishengallis G, Martin M, Sojar HT, Sharma A, Schifferle RE, DeNardin E, et al. Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine induction. Clin Dign Lab Immunol 2002; 9(2): 403–411.

Hajishengallis G, Martin M, Sojar HT, Sharma A, Schifferle RE, DeNardin E, et al. Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine induction. Clin Dign Lab Immunol 2002; 9(2): 403–411.)| false
• Search Google Scholar
• Export Citation

Onishi S, Honma K, Liang S, Stathopoulou P, Kinane D, Hajishengallis G, et al. Toll-like receptor 2-mediated interleukin-8 expression in gingival epithelial cells by the Tannerella forsythia leucine-rich repeat protein BspA. Infect Immun 2008; 76(1): 198–205.

Onishi S, Honma K, Liang S, Stathopoulou P, Kinane D, Hajishengallis G, et al. Toll-like receptor 2-mediated interleukin-8 expression in gingival epithelial cells by the Tannerella forsythia leucine-rich repeat protein BspA. Infect Immun 2008; 76(1): 198–205.)| false
• Search Google Scholar
• Export Citation

Lee HR, Jun HK, Choi BK. Tannerella forsythia BspA increases the risk factors for atherosclerosis in ApoE−/− mice. Oral diseases 2014; 20(8): 803–8.

Lee HR, Jun HK, Choi BK. Tannerella forsythia BspA increases the risk factors for atherosclerosis in ApoE−/− mice. Oral diseases 2014; 20(8): 803–8.)| false
• Search Google Scholar
• Export Citation

Abusleme L, Dupuy AK, Dutzan N, Silva N, Burleson JA, Strausbaugh LD, et al. The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation. ISME J 2013; 7(5): 1016–1025.

Abusleme L, Dupuy AK, Dutzan N, Silva N, Burleson JA, Strausbaugh LD, et al. The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation. ISME J 2013; 7(5): 1016–1025.)| false
• Search Google Scholar
• Export Citation

Hong BY, Furtado Araujo MV, Strausbaugh LD, Terzi E, Ioannidou E, Diaz PI. Microbiome profiles in periodontitis in relation to host and disease characteristics. PloS One 2015; 10(5): e0127077.

Hong BY, Furtado Araujo MV, Strausbaugh LD, Terzi E, Ioannidou E, Diaz PI. Microbiome profiles in periodontitis in relation to host and disease characteristics. PloS One 2015; 10(5): e0127077.)| false
• Search Google Scholar
• Export Citation

Signat B, Roques C, Poulet P, Duffaut D. Fusobacterium nucleatum in periodontal health and disease. Curr Issues Mol Biol 2011; 13(2): 25–36.

Signat B, Roques C, Poulet P, Duffaut D. Fusobacterium nucleatum in periodontal health and disease. Curr Issues Mol Biol 2011; 13(2): 25–36.)| false
• Search Google Scholar
• Export Citation

Bradshaw DJ, Marsh PD, Watson GK, Allison C. Role of Fusobacterium nucleatum and coaggregation in anaerobe survival in planktonic and biofilm oral microbial communities during aeration. Infect Immun 1998; 66(10): 4729–4732.

Bradshaw DJ, Marsh PD, Watson GK, Allison C. Role of Fusobacterium nucleatum and coaggregation in anaerobe survival in planktonic and biofilm oral microbial communities during aeration. Infect Immun 1998; 66(10): 4729–4732.)| false
• Search Google Scholar
• Export Citation

Fardini Y, Wang X, Témoin S, Nithianantham S, Lee D, Shoham M, et al. Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity. Mol Microbiol 2011; 82(6): 1468–1480. https://doi.org/10.1111/j.1365-2958.2011.07905.x.

Fardini Y, Wang X, Témoin S, Nithianantham S, Lee D, Shoham M, et al. Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity. Mol Microbiol 2011; 82(6): 1468–1480. https://doi.org/10.1111/j.1365-2958.2011.07905.x.)| false
• Search Google Scholar
• Export Citation

Krisanaprakornkit S, Kimball JR, Weinberg A, Darveau RP, Bainbridge BW, Dale BA. Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun 2000; 68(5): 2907–2915. https://doi.org/10.1128/IAI.68.5.2907-2915.2000.

Krisanaprakornkit S, Kimball JR, Weinberg A, Darveau RP, Bainbridge BW, Dale BA. Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun 2000; 68(5): 2907–2915. https://doi.org/10.1128/IAI.68.5.2907-2915.2000.)| false
• Search Google Scholar
• Export Citation

Bhattacharyya S, Ghosh SK, Shokeen B, Eapan B, Lux R, Kiselar J, et al. FAD-I, a Fusobacterium nucleatum cell wall-associated diacylated lipoprotein that mediates human beta defensin 2 induction through Toll-like receptor-½ (TLR-½) and TLR-2/6. Infect Immun 2016; 84(5): 1446–1456.

Bhattacharyya S, Ghosh SK, Shokeen B, Eapan B, Lux R, Kiselar J, et al. FAD-I, a Fusobacterium nucleatum cell wall-associated diacylated lipoprotein that mediates human beta defensin 2 induction through Toll-like receptor-½ (TLR-½) and TLR-2/6. Infect Immun 2016; 84(5): 1446–1456.)| false
• Search Google Scholar
• Export Citation

Gainet J, Chollet-Martin S, Brion M, Hakim J, Gougerot-Pocidalo MA, Elbim C. Interleukin-8 production by polymorphonuclear neutrophils in patients with rapidly progressive periodontitis: an amplifying loop of polymorphonuclear neutrophil activation. Lab Invest 1998; 78(6): 755–762.

Gainet J, Chollet-Martin S, Brion M, Hakim J, Gougerot-Pocidalo MA, Elbim C. Interleukin-8 production by polymorphonuclear neutrophils in patients with rapidly progressive periodontitis: an amplifying loop of polymorphonuclear neutrophil activation. Lab Invest 1998; 78(6): 755–762.)| false
• Search Google Scholar
• Export Citation

Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol 2015; 15(1): 30–44. https://doi.org/10.1038/nri3785.

Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol 2015; 15(1): 30–44. https://doi.org/10.1038/nri3785.)| false
• Search Google Scholar
• Export Citation

Valentine J, Saladyanant T, Ramsey K, Blake J, Morelli T, Southerland J, et al. Impact of periodontal intervention on local inflammation, periodontitis, and HIV outcomes. Oral Dis 2016; 22(Suppl 1): 87–97. https://doi.org/10.1111/odi.12419.

Valentine J, Saladyanant T, Ramsey K, Blake J, Morelli T, Southerland J, et al. Impact of periodontal intervention on local inflammation, periodontitis, and HIV outcomes. Oral Dis 2016; 22(Suppl 1): 87–97. https://doi.org/10.1111/odi.12419.)| false
• Search Google Scholar
• Export Citation

Nussbaum G, Shapira L. How has neutrophil research improved our understanding of periodontal pathogenesis? J Clin Periodontol 2011; 38(Suppl 11): 49–59. https://doi.org/10.1111/j.1600-051X.2010.01678.x.

Nussbaum G, Shapira L. How has neutrophil research improved our understanding of periodontal pathogenesis? J Clin Periodontol 2011; 38(Suppl 11): 49–59. https://doi.org/10.1111/j.1600-051X.2010.01678.x.)| false
• Search Google Scholar
• Export Citation

Potempa M, Potempa J, Kantyka T, Nguyen KA, Wawrzonek K, Manandhar SP, et al. Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3. Plos Pathog 2009 Mar; 5(2): e1000316.

Potempa M, Potempa J, Kantyka T, Nguyen KA, Wawrzonek K, Manandhar SP, et al. Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3. Plos Pathog 2009 Mar; 5(2): e1000316.)| false
• Search Google Scholar
• Export Citation

Popadiak K, Potempa J, Riesbeck K, Blom AM. Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system. J Immunol 2007; 178(11): 7242–7250.

Popadiak K, Potempa J, Riesbeck K, Blom AM. Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system. J Immunol 2007; 178(11): 7242–7250.)| false
• Search Google Scholar
• Export Citation

Imamura T. The role of gingipains in the pathogenesis of periodontal disease. J Periodontol 2003; 74(1): 111–118.

Imamura T. The role of gingipains in the pathogenesis of periodontal disease. J Periodontol 2003; 74(1): 111–118.)| false
• Search Google Scholar
• Export Citation

Amano A, Furuta N, Tsuda K. Host membrane trafficking for conveyance of intracellular oral pathogens. Periodontol 2000 2010; 52(1): 84–93.

Amano A, Furuta N, Tsuda K. Host membrane trafficking for conveyance of intracellular oral pathogens. Periodontol 2000 2010; 52(1): 84–93.)| false
• Search Google Scholar
• Export Citation

Takeuchi H, Furuta N, Morisaki I, Amano A. Exit of intracellular Porphyromonas gingivalis from gingival epithelial cells is mediated by endocytic recycling pathway. Cell Microbiol 2011; 13(5): 677–691.

Takeuchi H, Furuta N, Morisaki I, Amano A. Exit of intracellular Porphyromonas gingivalis from gingival epithelial cells is mediated by endocytic recycling pathway. Cell Microbiol 2011; 13(5): 677–691.)| false
• Search Google Scholar
• Export Citation

Helaine S, Cheverton AM, Watson KG, Faure LM, Matthews SA, Holden DW, et al. Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Science 2014; 343(6167): 204–208.

Helaine S, Cheverton AM, Watson KG, Faure LM, Matthews SA, Holden DW, et al. Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Science 2014; 343(6167): 204–208.)| false
• Search Google Scholar
• Export Citation

Pussinen PJ, Kopra E, Pietiäinen M, Lehto M, Zaric S, Paju S, et al. Periodontitis and cardiometabolic disorders: the role of lipopolysaccharide and endotoxemia. Periodontol 2000 2022; 89: 19–40.

Pussinen PJ, Kopra E, Pietiäinen M, Lehto M, Zaric S, Paju S, et al. Periodontitis and cardiometabolic disorders: the role of lipopolysaccharide and endotoxemia. Periodontol 2000 2022; 89: 19–40.)| false
• Search Google Scholar
• Export Citation

Sanz M, Ceriello A, Buysschaert M, Chapple I, Demmer RT, Graziani F, et al. Scientific evidence on the links between periodontal diseases and diabetes: consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. J Clin Periodontol 2018; 45(2): 138–149.

Sanz M, Ceriello A, Buysschaert M, Chapple I, Demmer RT, Graziani F, et al. Scientific evidence on the links between periodontal diseases and diabetes: consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. J Clin Periodontol 2018; 45(2): 138–149.)| false
• Search Google Scholar
• Export Citation

Herrera D, Sanz M, Shapira L, Brotons C, Chapple I, Frese T, et al. Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (EFP) and the European arm of the World Organization of Family Doctors (WONCA Europe). J Clin Periodontol 2023; 50(6): 819–841. https://doi.org/10.1111/jcpe.13807.

Herrera D, Sanz M, Shapira L, Brotons C, Chapple I, Frese T, et al. Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (EFP) and the European arm of the World Organization of Family Doctors (WONCA Europe). J Clin Periodontol 2023; 50(6): 819–841. https://doi.org/10.1111/jcpe.13807.)| false
• Search Google Scholar
• Export Citation

Taylor GW. Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective. Ann Periodontol. 2001; 6(1): 99–112. https://doi.org/10.1902/annals.2001.6.1.99.

Taylor GW. Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective. Ann Periodontol. 2001; 6(1): 99–112. https://doi.org/10.1902/annals.2001.6.1.99.)| false
• Search Google Scholar
• Export Citation

Polak D, Shapira L. An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J Clin Periodontol 2018; 45(2): 150–166.

Polak D, Shapira L. An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J Clin Periodontol 2018; 45(2): 150–166.)| false
• Search Google Scholar
• Export Citation

Casarin RC, Barbagallo A, Meulman T, Santos VR, Sallum EA, Nociti FH, et al. Subgingival biodiversity in subjects with uncontrolled type-2 diabetes and chronic periodontitis. J Periodontal Res 2013; 48(1): 30–6.

Casarin RC, Barbagallo A, Meulman T, Santos VR, Sallum EA, Nociti FH, et al. Subgingival biodiversity in subjects with uncontrolled type-2 diabetes and chronic periodontitis. J Periodontal Res 2013; 48(1): 30–6.)| false
• Search Google Scholar
• Export Citation

Mealey BL, Rethman MP. Periodontal disease and diabetes mellitus. Bidirectional relationship. Dent Today 2003; 22(4): 107–113.

Mealey BL, Rethman MP. Periodontal disease and diabetes mellitus. Bidirectional relationship. Dent Today 2003; 22(4): 107–113.)| false
• Search Google Scholar
• Export Citation

Benguigui C, Bongard V, Ruidavets JB, Chamontin B, Sixou M, Ferrières J, et al. Metabolic syndrome, insulin resistance, and periodontitis: a cross-sectional study in a middle-aged French population. J Clin Periodontol 2010; 37(7): 601–608.

Benguigui C, Bongard V, Ruidavets JB, Chamontin B, Sixou M, Ferrières J, et al. Metabolic syndrome, insulin resistance, and periodontitis: a cross-sectional study in a middle-aged French population. J Clin Periodontol 2010; 37(7): 601–608.)| false
• Search Google Scholar
• Export Citation

Tian J, Liu C, Zheng X, Jia X, Peng X, Yang R, et al. Porphyromonas gingivalis induces insulin resistance by increasing BCAA levels in mice. J Dental Res 2020; 99(7): 839–846. https://doi.org/10.1177/0022034520911037.

Tian J, Liu C, Zheng X, Jia X, Peng X, Yang R, et al. Porphyromonas gingivalis induces insulin resistance by increasing BCAA levels in mice. J Dental Res 2020; 99(7): 839–846. https://doi.org/10.1177/0022034520911037.)| false
• Search Google Scholar
• Export Citation

Ruiz HH, Ramasamy R, Schmidt AM. Advanced glycation end products: building on the concept of the “common soil” in metabolic disease. Endocrinology 2020; 161(1): 006.

Ruiz HH, Ramasamy R, Schmidt AM. Advanced glycation end products: building on the concept of the “common soil” in metabolic disease. Endocrinology 2020; 161(1): 006.)| false
• Search Google Scholar
• Export Citation

Grossi SG, Genco RJ. Periodontal disease and diabetes mellitus: a two‐way relationship. Ann Periodontol 1998 Jul; 3(1): 51–61.

Grossi SG, Genco RJ. Periodontal disease and diabetes mellitus: a two‐way relationship. Ann Periodontol 1998 Jul; 3(1): 51–61.)| false
• Search Google Scholar
• Export Citation

Chapple IL, Genco R, working group 2 of the joint EFP/AAP workshop. Diabetes and periodontal diseases: consensus report of the joint EFP/AAP workshop on periodontitis and systemic diseases. J Periodontol 2013; 84(4 Suppl): S106–S112.

Chapple IL, Genco R, working group 2 of the joint EFP/AAP workshop. Diabetes and periodontal diseases: consensus report of the joint EFP/AAP workshop on periodontitis and systemic diseases. J Periodontol 2013; 84(4 Suppl): S106–S112.)| false
• Search Google Scholar
• Export Citation

Costa PP, Trevisan GL, Macedo GO, Palioto DB, Souza SL, Grisi MF, et al. Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes. J Periodontol 2010; 81(3): 384–391.

Costa PP, Trevisan GL, Macedo GO, Palioto DB, Souza SL, Grisi MF, et al. Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes. J Periodontol 2010; 81(3): 384–391.)| false
• Search Google Scholar
• Export Citation

D’Aiuto F, Gkranias N, Bhowruth D, Khan T, Orlandi M, Suvan J, et al.. Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, single-centre, investigator-masked, randomised trial. Lancet Diabetes Endocrinol 2018; 6(12): 954–965.

D’Aiuto F, Gkranias N, Bhowruth D, Khan T, Orlandi M, Suvan J, et al.. Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, single-centre, investigator-masked, randomised trial. Lancet Diabetes Endocrinol 2018; 6(12): 954–965.)| false
• Search Google Scholar
• Export Citation

Park JH, Kim SH, Kim SJ, Kim JW. Recovery from chronic periodontal disease is associated with lower risk for incident diabetes. J Clin Periodontol 2022; 49(9): 862–871.

Park JH, Kim SH, Kim SJ, Kim JW. Recovery from chronic periodontal disease is associated with lower risk for incident diabetes. J Clin Periodontol 2022; 49(9): 862–871.)| false
• Search Google Scholar
• Export Citation

Allen EM, Matthews JB, O' Halloran DJ, Griffiths HR, Chapple IL. Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis. J Clin Periodontol 2011; 38(10): 894–901. https://doi.org/10.1111/j.1600-051X.2011.01764.x.

Allen EM, Matthews JB, O' Halloran DJ, Griffiths HR, Chapple IL. Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis. J Clin Periodontol 2011; 38(10): 894–901. https://doi.org/10.1111/j.1600-051X.2011.01764.x.)| false
• Search Google Scholar
• Export Citation

Engebretson S, Kocher T. Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta-analysis. J Clin Periodontol 2013; 40(Suppl 14): S153–S163. https://doi.org/10.1111/jcpe.12084.

Engebretson S, Kocher T. Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta-analysis. J Clin Periodontol 2013; 40(Suppl 14): S153–S163. https://doi.org/10.1111/jcpe.12084.)| false
• Search Google Scholar
• Export Citation

Babaev EA, Balmasova IP, Mkrtumyan AM, Kostryukova SN, Vakhitova ES, Il’ina EN, et al. Metagenomic analysis of gingival sulcus microbiota and pathogenesis of periodontitis associated with type 2 diabetes mellitus. Bull Exp Biol Med 2017; 163(6): 718–721.

Babaev EA, Balmasova IP, Mkrtumyan AM, Kostryukova SN, Vakhitova ES, Il’ina EN, et al. Metagenomic analysis of gingival sulcus microbiota and pathogenesis of periodontitis associated with type 2 diabetes mellitus. Bull Exp Biol Med 2017; 163(6): 718–721.)| false
• Search Google Scholar
• Export Citation

Shi B, Lux R, Klokkevold P, Chang M, Barnard E, Haake S, et al.. The subgingival microbiome associated with periodontitis in type 2 diabetes mellitus. ISME J 2020; 14(2): 519–530. https://doi.org/10.1038/s41396-019-0544-3.

Shi B, Lux R, Klokkevold P, Chang M, Barnard E, Haake S, et al.. The subgingival microbiome associated with periodontitis in type 2 diabetes mellitus. ISME J 2020; 14(2): 519–530. https://doi.org/10.1038/s41396-019-0544-3.)| false
• Search Google Scholar
• Export Citation

Mahalakshmi K, Krishnan P, Krishna Baba MG, Dhivyapriya V, Arumugam SB. “Association of periodontopathic anaerobic bacterial co-occurrence to atherosclerosis” – a cross-sectional study. Anaerobe 2017 Apr 1; 44: 66–72.

Mahalakshmi K, Krishnan P, Krishna Baba MG, Dhivyapriya V, Arumugam SB. “Association of periodontopathic anaerobic bacterial co-occurrence to atherosclerosis” – a cross-sectional study. Anaerobe 2017 Apr 1; 44: 66–72.)| false
• Search Google Scholar
• Export Citation

Takahashi Y, Davey M, Yumoto H, Gibson FC III, Genco CA. Fimbria-dependent activation of pro-inflammatory molecules in Porphyromonas gingivalis infected human aortic endothelial cells. Cell Microbiol 2006; 8: 738–757.

Takahashi Y, Davey M, Yumoto H, Gibson FC III, Genco CA. Fimbria-dependent activation of pro-inflammatory molecules in Porphyromonas gingivalis infected human aortic endothelial cells. Cell Microbiol 2006; 8: 738–757.)| false
• Search Google Scholar
• Export Citation

Giacona MB, Papapanou PN, Lamster IB, Rong LL, D’Agati VD, Schmidt AM, et al. Porphyromonas gingivalis induces its uptake by human macrophages and promotes foam cell formation in vitro. FEMS Microbiol Lett 2004; 241(1): 95–101.

Giacona MB, Papapanou PN, Lamster IB, Rong LL, D’Agati VD, Schmidt AM, et al. Porphyromonas gingivalis induces its uptake by human macrophages and promotes foam cell formation in vitro. FEMS Microbiol Lett 2004; 241(1): 95–101.)| false
• Search Google Scholar
• Export Citation

Tonetti MS, D’Aiuto F, Nibali L, Donald A, Storry C, Parkar M, et al. Treatment of periodontitis and endothelial function. N Engl J Med 2007; 356(9): 911–920. https://doi.org/10.1056/NEJMoa063186.

Tonetti MS, D’Aiuto F, Nibali L, Donald A, Storry C, Parkar M, et al. Treatment of periodontitis and endothelial function. N Engl J Med 2007; 356(9): 911–920. https://doi.org/10.1056/NEJMoa063186.)| false
• Search Google Scholar
• Export Citation

Le Sage F, Meilhac O, Gonthier MP. Anti-inflammatory and antioxidant effects of polyphenols extracted from Antirhea borbonica medicinal plant on adipocytes exposed to Porphyromonas gingivalis and Escherichia coli lipopolysaccharides. Pharmacol Res 2017; 119: 303–312. https://doi.org/10.1016/j.phrs.2017.02.020.

Le Sage F, Meilhac O, Gonthier MP. Anti-inflammatory and antioxidant effects of polyphenols extracted from Antirhea borbonica medicinal plant on adipocytes exposed to Porphyromonas gingivalis and Escherichia coli lipopolysaccharides. Pharmacol Res 2017; 119: 303–312. https://doi.org/10.1016/j.phrs.2017.02.020.)| false
• Search Google Scholar
• Export Citation

Lassenius M. Bacterial endotoxins in type 1 diabetes PhD thesis. Dissertations of the University of Helsinki; 29/2016. http://urn.fi/URN:ISBN:978-951-51-2104-.

Lassenius M. Bacterial endotoxins in type 1 diabetes PhD thesis. Dissertations of the University of Helsinki; 29/2016. http://urn.fi/URN:ISBN:978-951-51-2104-.)| false
• Search Google Scholar
• Export Citation

Kumar KR, Ranganath V, Naik R, Banu S, Nichani AS. Assessment of high-sensitivity C-reactive protein and lipid levels in healthy adults and patients with coronary artery disease, with and without periodontitis--a cross-sectional study. J Periodontal Res 2014 Dec; 49(6): 836–44. https://doi.org/10.1111/jre.12172.

Kumar KR, Ranganath V, Naik R, Banu S, Nichani AS. Assessment of high-sensitivity C-reactive protein and lipid levels in healthy adults and patients with coronary artery disease, with and without periodontitis--a cross-sectional study. J Periodontal Res 2014 Dec; 49(6): 836–44. https://doi.org/10.1111/jre.12172.)| false
• Search Google Scholar
• Export Citation

Schenkein HA, Loos BG. Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. J Clin Periodontol 2013; Suppl 14(014): S51–S69. https://doi.org/10.1111/jcpe.12060.

Schenkein HA, Loos BG. Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. J Clin Periodontol 2013; Suppl 14(014): S51–S69. https://doi.org/10.1111/jcpe.12060.)| false
• Search Google Scholar
• Export Citation

Chandy S, Joseph K, Sankaranarayanan A, Issac A, Babu G, Wilson B, et al. Evaluation of C-reactive protein and fibrinogen in patients with chronic and aggressive periodontitis: a clinico biochemical study. J Clin Diagn Res 2017; 11(3): ZC41-ZC45.

Chandy S, Joseph K, Sankaranarayanan A, Issac A, Babu G, Wilson B, et al. Evaluation of C-reactive protein and fibrinogen in patients with chronic and aggressive periodontitis: a clinico biochemical study. J Clin Diagn Res 2017; 11(3): ZC41-ZC45.)| false
• Search Google Scholar
• Export Citation

Vidal F, Cordovil I, Figueredo CM, Fischer RG. Non-surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study. J Clin Periodontol 2013; 40(7): 681–687.

Vidal F, Cordovil I, Figueredo CM, Fischer RG. Non-surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study. J Clin Periodontol 2013; 40(7): 681–687.)| false
• Search Google Scholar
• Export Citation

Bokhari SA, Khan AA, Butt AK, Azhar M, Hanif M, Izhar M, et al. Non-surgical periodontal therapy reduces coronary heart disease risk markers: a randomized controlled trial. J Clin Periodontol 2012; 39(11): 1065–1074.

Bokhari SA, Khan AA, Butt AK, Azhar M, Hanif M, Izhar M, et al. Non-surgical periodontal therapy reduces coronary heart disease risk markers: a randomized controlled trial. J Clin Periodontol 2012; 39(11): 1065–1074.)| false
• Search Google Scholar
• Export Citation

Perumal R, Rajendran M, Krishnamurthy M, Ganji KK, Pendor SD. Modulation of P-selection and platelet aggregation in chronic periodontitis: a clinical study. J Indian Soc Periodontol 2014; 18(3): 293–300.

Perumal R, Rajendran M, Krishnamurthy M, Ganji KK, Pendor SD. Modulation of P-selection and platelet aggregation in chronic periodontitis: a clinical study. J Indian Soc Periodontol 2014; 18(3): 293–300.)| false
• Search Google Scholar
• Export Citation

Ford PJ, Gemmell E, Hamlet SM, Hasan A, Walker PJ, West MJ, et al. Cross-reactivity of GroEL antibodies with human heat shock protein 60 and quantification of pathogens in atherosclerosis. Oral Microbiol Immunol 2005; 20: 296–302.

Ford PJ, Gemmell E, Hamlet SM, Hasan A, Walker PJ, West MJ, et al. Cross-reactivity of GroEL antibodies with human heat shock protein 60 and quantification of pathogens in atherosclerosis. Oral Microbiol Immunol 2005; 20: 296–302.)| false
• Search Google Scholar
• Export Citation