View More View Less
  • 1 Institute of Botany Žaliuju Ežeru 49 LT-08406 Vilnius Lithuania
  • | 2 Kaunas University of Medicine A. Mickevičiaus 9 LT-44307 Kaunas Lithuania
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $692.00

This study, carried out in 2004–2005, describes the variation of hypericin and flavonoid contents in different samples of Hypericum maculatum . Flowering tops of H. maculatum were collected and analysed for hypericin and flavonoids using HPLC. The contents of hypericin ranged from 0.35–0.95 mg/g; flavonoid contents varied as follows: hyperoside — 16.66–40.89 mg/g, quercitrin — 0.00 to 1.07 mg/g and quercetin — 1.46–4.96 mg/g. The study indicated that flavonoid rutin was absent from the flavonoid pattern of H. maculatum , or present only in trace amounts (0.00–0.67 mg/g), however, H. maculatum is one of the most important sources of hyperoside. The samples of H. maculatum which accumulated high levels of flavonoids seem to be promising for further propagation.

  • Bagdonaite, E. and Radušiene, J. (2002): Analysis of variation of phenotypical characters in Hypericum maculatum Crantz wild populations. — Biologija1 : 46–49.

    Radušiene J. , 'Analysis of variation of phenotypical characters in Hypericum maculatum Crantz wild populations ' (2002 ) 1 Biologija : 46 -49.

    • Search Google Scholar
  • Bagdonaite, E., Zygmunt, B. and Radušiene, J. (2001): Morphological and chemical evaluation of St. John’s wort (Hypericum perforatum L.) populations from Lithuania. — Herba Pol.47 : 294–303.

    Radušiene J. , 'Morphological and chemical evaluation of St. John’s wort (Hypericum perforatum L.) populations from Lithuania ' (2001 ) 47 Herba Pol. : 294 -303.

    • Search Google Scholar
  • Bombardelli, E. and Morazzoni, P. (1995): Hypericum perforatum. — Fitoterapia66 : 43–68.

    Morazzoni P. , 'Hypericum perforatum ' (1995 ) 66 Fitoterapia : 43 -68.

  • Brantner, A., Kartnig, T. and Quehenberger, F. (1994): Comparative phytochemical investigations of Hypericum perforatum L. and Hypericum maculatum Crantz. — Sci. Pharm.62 : 261–276.

    Quehenberger F. , 'Comparative phytochemical investigations of Hypericum perforatum L. and Hypericum maculatum Crantz ' (1994 ) 62 Sci. Pharm. : 261 -276.

    • Search Google Scholar
  • Çirak, C., Sağlam, B., Ayan, A. K. and Kevseroğlu, K. (2006): Morphogenetic and diurnal variation of hypericin in some Hypericum species from Turkey during the course of ontogenesis. — Biochem. Syst. Ecol.34 : 1–13.

    Kevseroğlu K. , 'Morphogenetic and diurnal variation of hypericin in some Hypericum species from Turkey during the course of ontogenesis ' (2006 ) 34 Biochem. Syst. Ecol. : 1 -13.

    • Search Google Scholar
  • Constantine, G. H. and Karchesy, J. (1998): Variations in hypericin concentrations in Hypericum perforatum L. and commercial products. — Pharm. Biol.36 : 365–367.

    Karchesy J. , 'Variations in hypericin concentrations in Hypericum perforatum L. and commercial products ' (1998 ) 36 Pharm. Biol. : 365 -367.

    • Search Google Scholar
  • Crockett, S. L., Schaneberg, B. and Khan, A. (2005): Phytochemical profiling of new and old world Hypericum (St. John’s Wort) species. — Phytochem. Anal.16 : 479–485.

    Khan A. , 'Phytochemical profiling of new and old world Hypericum (St. John’s Wort) species ' (2005 ) 16 Phytochem. Anal. : 479 -485.

    • Search Google Scholar
  • Galambosi, B. (1993): Considerations and experiences regarding the cultivation of medicinal wildflowers in Finland. — Aquilo. Ser. Bot.31 : 161–166.

    Galambosi B. , 'Considerations and experiences regarding the cultivation of medicinal wildflowers in Finland ' (1993 ) 31 Aquilo. Ser. Bot. : 161 -166.

    • Search Google Scholar
  • Girzu, M. A., Carnat, A., Fraisse, D., Carnat, A. P. and Lamaison, J. L. (2000): Flavonoid and dianthranoid levels of the St. John’s wort flowering tops. — Annal. Pharm. Francaises58 : 341–345.

    Lamaison J. L. , 'Flavonoid and dianthranoid levels of the St. John’s wort flowering tops ' (2000 ) 58 Annal. Pharm. Francaises : 341 -345.

    • Search Google Scholar
  • Kirakosyan, A., Kaufman, P., Warber, S., Zick, S., Aaronson, K., Bolling, S. and Chang, S. C. (2004): Applied environmental stresses to enhance the levels of polyphenolics in leaves of hawthorn plants. — Physiol. Plant.121 : 182–186.

    Chang S. C. , 'Applied environmental stresses to enhance the levels of polyphenolics in leaves of hawthorn plants ' (2004 ) 121 Physiol. Plant. : 182 -186.

    • Search Google Scholar
  • Kitanov, G. (1995): Dynamics and contents of tannins and flavonoids in Hypericum perforatum L. and Hypericum maculatum Crantz. — Farmacia5–6 : 13–17.

    Kitanov G. , 'Dynamics and contents of tannins and flavonoids in Hypericum perforatum L. and Hypericum maculatum Crantz ' (1995 ) 5–6 Farmacia : 13 -17.

    • Search Google Scholar
  • Kitanov, G. (2000): The dynamics and content of hypericins in Hypericum perforatum L. and Hypericum maculatum Crantz growing in Bulgaria. — Acta Pharm.50 : 65–68.

    Kitanov G. , 'The dynamics and content of hypericins in Hypericum perforatum L. and Hypericum maculatum Crantz growing in Bulgaria ' (2000 ) 50 Acta Pharm. : 65 -68.

    • Search Google Scholar
  • Kitanov, G. M. and Nikolov, N. Tz. (1991): Phenolic constituents of Hypericum maculatum. — Fitoterapia62 : 92.

    Nikolov N. Tz. , 'Phenolic constituents of Hypericum maculatum ' (1991 ) 62 Fitoterapia : 92 -.

    • Search Google Scholar
  • Kovács, G., Kuzovkina, I. N., Szőke, É. and Kursinszki, L. (2004): HPLC determination of flavonoids in hairy-root cultures of Scutellaria baicalensis Georgi. — Chromatographia60 : 81–85.

    Kursinszki L. , 'HPLC determination of flavonoids in hairy-root cultures of Scutellaria baicalensis Georgi ' (2004 ) 60 Chromatographia : 81 -85.

    • Search Google Scholar
  • Kurth, H. and Spreemann, R. (1998): Phytochemical characterization of various St. John’s wort extracts. — Advances in Therapy15 : 117–128.

    Spreemann R. , 'Phytochemical characterization of various St. John’s wort extracts ' (1998 ) 15 Advances in Therapy : 117 -128.

    • Search Google Scholar
  • Liu, F. F., Ang, C. Y. W., Heinze, T. M., Rankin, J. D., Beger, R. D., Freeman, J. P. and Lay, J. O. Jr. (2000): Evaluation of major active components in St. John’s wort dietary supplements by high-performance liquid chromatography with photodiode array detection and electrospray mass spectrometric confirmation. — J. Chromatogr. A888 : 85–92.

    Lay J. O. , 'Evaluation of major active components in St. John’s wort dietary supplements by high-performance liquid chromatography with photodiode array detection and electrospray mass spectrometric confirmation ' (2000 ) 888 J. Chromatogr. A : 85 -92.

    • Search Google Scholar
  • Mártonfi, P., Repčák, M. and Mihoková, L. (1996): Hypericum maculatum Crantz subsp. maculatum x H. perforatum L. (Hypericaceae): corroboration of natural hybridization by secondary metabolite analysis. — Folia Geobot. Phytotax.31 : 245–250.

    Mihoková L. , 'Hypericum maculatum Crantz subsp. maculatum x H. perforatum L. (Hypericaceae): corroboration of natural hybridization by secondary metabolite analysis ' (1996 ) 31 Folia Geobot. Phytotax. : 245 -250.

    • Search Google Scholar
  • Mártonfi, P., Repčák, M. and Zanvit, P. (2006): Secondary metabolites variation in Hypericum maculatum and its relatives. — Biochem. Syst. Ecol.34 : 56–59.

    Zanvit P. , 'Secondary metabolites variation in Hypericum maculatum and its relatives ' (2006 ) 34 Biochem. Syst. Ecol. : 56 -59.

    • Search Google Scholar
  • Mártonfi, P., Repčák, M., Ciccarelli, D. and Garbari, F. (2001): Hypericum perforatum L. — chemotype without rutin from Italy. — Biochem. Syst. Ecol.29 : 659–661.

    Garbari F. , 'Hypericum perforatum L. — chemotype without rutin from Italy ' (2001 ) 29 Biochem. Syst. Ecol. : 659 -661.

    • Search Google Scholar
  • Michelitsch, A., Biza, B., Wurglics, M., Schubert-Zsilavecz, M., Baumeister, A. and Likussar, W. (2000): Determination of hypericin in herbal medicine products by differential pulse polarography. — Phytochem. Anal.11 : 41–44.

    Likussar W. , 'Determination of hypericin in herbal medicine products by differential pulse polarography ' (2000 ) 11 Phytochem. Anal. : 41 -44.

    • Search Google Scholar
  • Osińska, E. and Weglarz, Z. (2000): Morphological, developmental and chemical variability of Hypericum genus. — Acta Hort.523 : 81–85.

    Weglarz Z. , 'Morphological, developmental and chemical variability of Hypericum genus ' (2000 ) 523 Acta Hort. : 81 -85.

    • Search Google Scholar
  • Pharmeuropa (2004): St. John’s wort dry extract, quantified. — Pharmeuropa16 : 97–98.

    Pharmeuropa , 'St. John’s wort dry extract, quantified ' (2004 ) 16 Pharmeuropa : 97 -98.

  • Pluhár, Zs., Rehák, O. and Németh, É. (2000): Comparative investigation on Hypericum perforatum L. populations of different origin. — Intl. J. Hort. Science6 : 56–60.

    Németh , 'Comparative investigation on Hypericum perforatum L. populations of different origin ' (2000 ) 6 Intl. J. Hort. Science : 56 -60.

    • Search Google Scholar
  • Radušiene, J. and Bagdonaite, E. (2002): Phenotypic variation in Hypericum perforatum L. and H. maculatum Crantz wild populations in Lithuania. — J. Herbs, Spices & Med. Plants9 : 345–351.

    Bagdonaite E. , 'Phenotypic variation in Hypericum perforatum L. and H. maculatum Crantz wild populations in Lithuania ' (2002 ) 9 J. Herbs, Spices & Med. Plants : 345 -351.

    • Search Google Scholar
  • Smelcerovic, A., Verma, V., Spiteller, M., Ahmad, S. M., Puri, S. C. and Qazi, G. H. (2006): Phytochemical analysis and genetic characterization of six Hypericum species from Serbia. — Phytochem.67 : 171–177.

    Qazi G. H. , 'Phytochemical analysis and genetic characterization of six Hypericum species from Serbia ' (2006 ) 67 Phytochem. : 171 -177.

    • Search Google Scholar
  • Umek, A., Kreft, S., Kartnig, T. and Heydel, B. (1999): Quantitative phytochemical analyses of six Hypericum species growing in Slovenia. — Planta Med.65 : 388–390.

    Heydel B. , 'Quantitative phytochemical analyses of six Hypericum species growing in Slovenia ' (1999 ) 65 Planta Med. : 388 -390.

    • Search Google Scholar
  • Walker, L., Sirvent, T., Gibson, D. and Vance, N. (2001): Regional differences in hypericin and pseudohypericin concentrations and five morphological traits among Hypericum perforatum plants in the northwestern United States. — Can. J. Bot.79 : 1248–1255.

    Vance N. , 'Regional differences in hypericin and pseudohypericin concentrations and five morphological traits among Hypericum perforatum plants in the northwestern United States ' (2001 ) 79 Can. J. Bot. : 1248 -1255.

    • Search Google Scholar

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jan 2021 1 1 1
Feb 2021 0 0 0
Mar 2021 6 0 0
Apr 2021 10 0 0
May 2021 2 0 0
Jun 2021 1 0 0
Jul 2021 0 0 0