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  • 1 Eskisehir Osmangazi University, Medical Faculty Department of Physiology Meselik Kampusu 26480 Eskisehir Turkey
  • | 2 Eskisehir Osmangazi University Department of Pharmacology, Medical Faculty Eskisehir Turkey
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Objectives: Des-Arg9-bradykinin and bradykinin-potentiating peptide C (BPPC) may contribute to the regulation of cardiovascular function. Therefore, we studied effects of these peptides on coronary perfusion pressure (CPP), heart rate, left ventricular developed pressure (LVDP) and maximum rate of increase of left ventricular pressure (+dP/dtmax). Methods: The isolated rat hearts were perfused with modified Krebs-Henseleit solution. Results: Infusion of 10, 100 and 1000 nM Des-Arg9-bradykinin decreased CPP (−13.6, −14.8 and −19.0%), LVDP (−16.5, −21.0 and −30.7%) and +dP/dtmax (−11.8, −17.8 and −23.7%), respectively (p < 0.001). Ten or 100 nM Des-Arg9-bradykinin did not alter heart rate, but 1000 nM increased it (+11.3%, p < 0.01). One, 10 and 100 nM BBPC reduced CPP (−16.3, −28.5 and −47.5%), LVDP (−12.6, −19.6 and −21.3%) and +dP/dtmax (−8.7, −18.6 and −20.3%), respectively (p < 0.001). BPPC increased heart rate at 1 nM (+9.6%, p < 0.05 ) and at 10 nM (+14.2%, p < 0.01), however 100 nM decreased it (−15.3%, p < 0.001). Conclusions: This study evidences that Des-Arg9-bradykinin and BPPC possess vasodilatory effect with modest negative inotropic action. Furthermore, high-dose of Des-Arg9-bradykinin and low-dose of BPPC may produce a tachycardic action, but high dose of BBPC may cause a bradycardic action.

  • Aptecar E, Lecorvoisier P, Teiger E, Garot P, Dupouy P, Sediame S, Vermes E, Loisance D, Hittinger L, Dubois-Rande JL, Montagne O: Coronary vasomotor response to the selective B1-kinin-receptor agonist Des-Arg9-bradykinin in humans. J. Heart Lung Transplant. 25, 187–194 (2006)

    Montagne O , 'Coronary vasomotor response to the selective B1-kinin-receptor agonist Des-Arg9-bradykinin in humans ' (2006 ) 25 J. Heart Lung Transplant. : 187 -194.

    • Search Google Scholar
  • Baydoun AR, Woodward B: Effects of bradykinin in the rat isolated perfused heart: role of kinin receptors and endothelium-derived relaxing factor. Br. J. Pharmacol. 103, 1829–1833 (1991)

    Woodward B , 'Effects of bradykinin in the rat isolated perfused heart: role of kinin receptors and endothelium-derived relaxing factor ' (1991 ) 103 Br. J. Pharmacol. : 1829 -1833.

    • Search Google Scholar
  • Canadian Council on Animal Care (1984): Guide to the Care and Use of Experimental Animals. CCAC, Ottawa, 2, 176–187

    '' (1984 ) 2 Guide to the Care and Use of Experimental Animals : 176 -187.

  • Chahine R, Adam A, Yamaguchi N, Nadeau R: Effects of bradykinin and Des-Arg9-bradykinin on the ischemic rat heart. Agents Actions 38, 103–109 (1992)

    Nadeau R , 'Effects of bradykinin and Des-Arg9-bradykinin on the ischemic rat heart ' (1992 ) 38 Agents Actions : 103 -109.

    • Search Google Scholar
  • Cote J, Savard M, Bovenzi V, Belanger S, Morin J, Neugebauer W, Larouche A, Dubuc C, Gobeil F Jr: Novel kinin B1 receptor agonists with improved pharmacological profiles. Peptides 30, 788–795 (2009)

    Gobeil F , 'Novel kinin B1 receptor agonists with improved pharmacological profiles ' (2009 ) 30 Peptides : 788 -795.

    • Search Google Scholar
  • El-Saadani MAM, El-Sayed MF: A bradykinin potentiating peptide from Egyptian cobra venom strongly affects rat atrium contractile force and cellular calcium regulation. Comp. Biochem. Physiol. 136, 387–395 (2003)

    El-Sayed MF , 'A bradykinin potentiating peptide from Egyptian cobra venom strongly affects rat atrium contractile force and cellular calcium regulation ' (2003 ) 136 Comp. Biochem. Physiol. : 387 -395.

    • Search Google Scholar
  • He M-X, Downey HF: Downregulation of ventricular contractile function during early ischemia is flow but not pressure dependent. Am. J. Physiol. 275, H1520–H1523 (1993)

    Downey HF , 'Downregulation of ventricular contractile function during early ischemia is flow but not pressure dependent ' (1993 ) 275 Am. J. Physiol. : H1520 -H1523.

    • Search Google Scholar
  • Ianzer D, Konno K, Marques-Porto R, Portaro FCV, Stöcklin R, de Camargo ACM, Pimenta DC: Identification of five new bradykinin potentiating peptides (BPPs) from Bothrops jararaca crude venom by using electrospray ionization tandem mass spectrometry after a two-step liquid chromatography. Peptides 25, 1085–1092 (2004)

    Pimenta DC , 'Identification of five new bradykinin potentiating peptides (BPPs) from Bothrops jararaca crude venom by using electrospray ionization tandem mass spectrometry after a two-step liquid chromatography ' (2004 ) 25 Peptides : 1085 -1092.

    • Search Google Scholar
  • Ianzer D, Santos RAS, Etelvino GM, Xavier CH, Santos JA, Mendes EP, Machado LT, Prezoto BC, Dive V, de Camargo ACM: Do the cardiovascular effects of angiotensin-converting enzyme (ACE) I involve ACEindependent mechanisms? New insights from proline-rich peptides of Bothrops jararaca. J. Pharmacol. Exp. Ther. 322, 795–805 (2007)

    Camargo ACM , 'Do the cardiovascular effects of angiotensin-converting enzyme (ACE) I involve ACEindependent mechanisms? New insights from proline-rich peptides of Bothrops jararaca ' (2007 ) 322 J. Pharmacol. Exp. Ther. : 795 -805.

    • Search Google Scholar
  • Ianzer D, Xavier CH, Fraga FC, Lautner RQ, Guerreiro JR, Machado LT, Mendes EP, de Camargo AC, Santos RA: BPP-5a produces a potent and long-lasting NO-dependent antihypertensive effect. Ther. Adv. Cardiovasc. Dis. 5, 281–295 (2011)

    Santos RA , 'BPP-5a produces a potent and long-lasting NO-dependent antihypertensive effect ' (2011 ) 5 Ther. Adv. Cardiovasc. Dis. : 281 -295.

    • Search Google Scholar
  • Ignjatovic T, Stanisavljevic S, Brovkovych V, Skidgel RA, Erdos EG: Kinin B1 receptors stimulate nitric oxide production in endothelial cells: Signaling pathways activated by angiotensin I-converting enzyme inhibitors and peptide ligands. Mol. Pharmacol. 66, 1310–1316 (2004)

    Erdos EG , 'Kinin B1 receptors stimulate nitric oxide production in endothelial cells: Signaling pathways activated by angiotensin I-converting enzyme inhibitors and peptide ligands ' (2004 ) 66 Mol. Pharmacol. : 1310 -1316.

    • Search Google Scholar
  • Lamontagne D, Nakhostine N, Couture R, Nadeau R: Mechanisms of kinin B1 receptor-induced hypotension in the anesthetized dog. J. Cardiovasc. Pharmacol. 28, 645–650 (1996)

    Nadeau R , 'Mechanisms of kinin B1 receptor-induced hypotension in the anesthetized dog ' (1996 ) 28 J. Cardiovasc. Pharmacol. : 645 -650.

    • Search Google Scholar
  • Lang NN, Cruden NL, Tse GH, Bloomfield P, Ludlam CA, Fox KA, Newby DE: Vascular B1 kinin receptors in patients with congestive heart failure. J. Cardiovasc. Pharmacol. 52, 438–444 (2008)

    Newby DE , 'Vascular B1 kinin receptors in patients with congestive heart failure ' (2008 ) 52 J. Cardiovasc. Pharmacol. : 438 -444.

    • Search Google Scholar
  • Li Q, Zhang J, Loro JF, Pfaffendorf M, van Zwieten PA: Bradykinin B2-receptor mediated positive chronotropic effect of bradykinin in isolated rat atria. J. Cardiovasc. Pharmacol. 32, 452–456 (1998)

    Zwieten PA , 'Bradykinin B2-receptor mediated positive chronotropic effect of bradykinin in isolated rat atria ' (1998 ) 32 J. Cardiovasc. Pharmacol. : 452 -456.

    • Search Google Scholar
  • Loro JF, Zhang J, Pfaffendorf M, van Zwieten PA: Positive chronotropic activity of bradykinin in the pithed normotensive rat. Fundam. Clin. Pharmacol. 12, 77–81 (1998)

    Zwieten PA , 'Positive chronotropic activity of bradykinin in the pithed normotensive rat ' (1998 ) 12 Fundam. Clin. Pharmacol. : 77 -81.

    • Search Google Scholar
  • Ma TKW, Kam KKH, Yan BP, Lan Y-Y: Renin-angiotensin-aldosteron system blockade for cardiovascular diseases: current status. Br. J. Pharmacol. 160, 1273–1292 (2010)

    Lan Y-Y , 'Renin-angiotensin-aldosteron system blockade for cardiovascular diseases: current status ' (2010 ) 160 Br. J. Pharmacol. : 1273 -1292.

    • Search Google Scholar
  • Madeddu P, Emanueli C, Varoni MV, Demontis MP, Anania V, Gorioso N, Chao J: Regulation of bradykinin B2 receptor expression by estrogen. Br. J. Pharmacol. 121, 1763–1769 (1997)

    Chao J , 'Regulation of bradykinin B2 receptor expression by estrogen ' (1997 ) 121 Br. J. Pharmacol. : 1763 -1769.

    • Search Google Scholar
  • Murayama N, Michel GH, Yanoshita R, Samejima Y, Saguchi K, Ohi H, Fujita Y, Higuchi S: cDNA cloning of bradykinin-potentiating peptides-C-type natriuretic peptide precursor, and characterization of novel peptide Leu3-blomhotin from the venom of Agkistrodon blomhoffi. Eur. J. Biochem. 267, 4075–4080 (2000)

    Higuchi S , 'cDNA cloning of bradykinin-potentiating peptides-C-type natriuretic peptide precursor, and characterization of novel peptide Leu3-blomhotin from the venom of Agkistrodon blomhoffi ' (2000 ) 267 Eur. J. Biochem. : 4075 -4080.

    • Search Google Scholar
  • Nakhostine N, Ribuot C, Lamontagne D, Nadeau R, Couture R: Mediation by B1 and B2 receptors of vasodepressor responses to intravenously administered kinins in anaesthetized dogs. Br. J. Pharmacol. 110, 71–76 (1993)

    Couture R , 'Mediation by B1 and B2 receptors of vasodepressor responses to intravenously administered kinins in anaesthetized dogs ' (1993 ) 110 Br. J. Pharmacol. : 71 -76.

    • Search Google Scholar
  • Ni A, Yin H, Agata J, Yang Z, Chao L, Chao J: Overexpression of kinin B1 receptors induces hypertensive response to Des-Arg9-bradykinin and susceptibility to inflammation. J. Biol. Chem. 278, 219–225 (2003)

    Chao J , 'Overexpression of kinin B1 receptors induces hypertensive response to Des-Arg9-bradykinin and susceptibility to inflammation ' (2003 ) 278 J. Biol. Chem. : 219 -225.

    • Search Google Scholar
  • Parenti A, Morbidelli L, Ledda F, Granger HJ, Ziche M: The bradykinin/B1 receptor promotes angiogenesis by up-regulation of endogenous FGF-2 in endothelium via nitric oxide synthase pathway. FASEB J. 15, 1487–1489 (2001)

    Ziche M , 'The bradykinin/B1 receptor promotes angiogenesis by up-regulation of endogenous FGF-2 in endothelium via nitric oxide synthase pathway ' (2001 ) 15 FASEB J. : 1487 -1489.

    • Search Google Scholar
  • Raidoo DM, Ramsaroop R, Naidoo S, Müller-Esterl W, Bhoola KD: Kinin receptors in human vascular tissue: their role in atheromatous disease. Immunopharmacology 36, 153–160 (1997)

    Bhoola KD , 'Kinin receptors in human vascular tissue: their role in atheromatous disease ' (1997 ) 36 Immunopharmacology : 153 -160.

    • Search Google Scholar
  • Rastaldo R, Paolocci N, Chiribiri A, Pena C, Gattullo D, Pagliaro P: Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect. Am. J. Physiol. 280, H2823–H2832 (2001)

    Pagliaro P , 'Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect ' (2001 ) 280 Am. J. Physiol. : H2823 -H2832.

    • Search Google Scholar
  • Schluter H, Mentrup D, Grosz I, Meyer HE, Spengler B, Kaufmann R, Zidek W: Identification of endogenous Des-Arg9-[Hyp3]-bradykinin in human plasma with post-source-decay matrix-assisted laser desorption/ ionization mass spectrometry. Anal. Biochem. 246, 15–19 (1997)

    Zidek W , 'Identification of endogenous Des-Arg9-[Hyp3]-bradykinin in human plasma with post-source-decay matrix-assisted laser desorption/ ionization mass spectrometry ' (1997 ) 246 Anal. Biochem. : 15 -19.

    • Search Google Scholar
  • Soares MR, Oliveira-Carvalho AL, Wermelinger LS, Zingali RB, Ho PL, Junqueirade-Azevedo ILM, Diniz MR: Identification of novel bradykinin-potentiating peptides and C-type natriuretic peptide from Lachesis muta venom. Toxicon 46, 31–38 (2005)

    Diniz MR , 'Identification of novel bradykinin-potentiating peptides and C-type natriuretic peptide from Lachesis muta venom ' (2005 ) 46 Toxicon : 31 -38.

    • Search Google Scholar
  • Su JB, Houel R, Heloire F, Barbe F, Beverelli F, Sambin L, Castaigne A, Berdeaux A, Crozatier B, Hittinger L: Stimulation of bradykinin B1 receptors induces vasodilation in conductance and resistance coronary vessels in conscious dogs: comparison with B2 receptor stimulation. Circulation 101, 1848–1853 (2000)

    Hittinger L , 'Stimulation of bradykinin B1 receptors induces vasodilation in conductance and resistance coronary vessels in conscious dogs: comparison with B2 receptor stimulation ' (2000 ) 101 Circulation : 1848 -1853.

    • Search Google Scholar
  • Tominaga M, Stewart JM: Synthesis and properties of new bradykinin potentiating peptides. J. Med. Chem. 18, 130–133 (1975)

    Stewart JM , 'Synthesis and properties of new bradykinin potentiating peptides ' (1975 ) 18 J. Med. Chem. : 130 -133.

    • Search Google Scholar
  • Vila-Petroff MG, Younes A, Egan J, Lakatta EG, Sollott SJ: Activation of distinct cAMP-dependent and cGMPdependent pathways by nitric oxide in cardiac myocytes. Circ. Res. 84, 1020–1031 (1999)

    Sollott SJ , 'Activation of distinct cAMP-dependent and cGMPdependent pathways by nitric oxide in cardiac myocytes ' (1999 ) 84 Circ. Res. : 1020 -1031.

    • Search Google Scholar
  • Xu J, Carretore OA, Sun Y, Shesely EG, Rhaleb N-E, Liu Y-H, Liao TD, Yang JJ, Bader M, Yang XP: Role of the kinin receptor in the regulation of cardiac function and remodeling after myocardial infarction. Hypertension 45, 747–753 (2005)

    Yang XP , 'Role of the kinin receptor in the regulation of cardiac function and remodeling after myocardial infarction ' (2005 ) 45 Hypertension : 747 -753.

    • Search Google Scholar

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