Acta Physiologica Hungarica
Volume/Issue:
Volume 100: Issue 4
The role of cholecystokinin in the induction of aggressive behavior: A focus on the available experimental data (review)
Authors: E. Katsouni, A. Zarros, N. Skandali, Stylianos Tsakiris 2 , and D. Lappas 5
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  • 1 University of Oxford Worcester College Oxford UK
  • 2 National and Kapodistrian University of Athens Laboratory of Physiology, Medical School PO Box 65257 GR-15401 Athens Greece
  • 3 University of Glasgow College of Medical, Veterinary and Life Sciences Glasgow UK
  • 4 University College London (UCL) Institute of Neurology London UK
  • 5 National and Kapodistrian University of Athens Laboratory of Anatomy, Medical School Athens Greece
DOI:
https://doi.org/10.1556/APhysiol.100.2013.4.1
Page Count:
361–377
Publication Date:
01 Dec 2013
Online Publication Date:
07 Dec 2013
Article Category:
Research Article
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Cholecystokinin (CCK) is a neuropeptide that is (among others) reportedly involved in the pathophysiology of psychiatric disorders. The excitatory role of CCK in negative affective emotions as well as in aversive reactions, antisocial behaviors and memories, has been indicated by numerous electrophysiological, neurochemical and behavioral methodologies on both animal models for anxiety and human studies. The current review article summarizes the existing experimental evidence with regards to the role of CCK in the induction of aggressive behavior, and: (a) synopsizes the anatomical circuits through which it could potentially mediate all types of aggressive behavior, as well as (b) highlights the potential use of these experimental evidence in the current research quest for the clinical treatment of mood and anxiety disorders.

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Cover Acta Physiologica Hungarica
Acta Physiologica Hungarica
Print ISSN:
0231-424X
Online ISSN:
1588-2683
Keywords:
cholecystokinin; CCK receptors; aggressive behavior; neuroanatomical circuits; dopamine; serotonin; neuromodulators; mood; anxiety disorders; stress; experimental data; nucleus accumbens

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