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  • 1 University of Oxford Worcester College Oxford UK
  • 2 National and Kapodistrian University of Athens Laboratory of Physiology, Medical School PO Box 65257 GR-15401 Athens Greece
  • 3 University of Glasgow College of Medical, Veterinary and Life Sciences Glasgow UK
  • 4 University College London (UCL) Institute of Neurology London UK
  • 5 National and Kapodistrian University of Athens Laboratory of Anatomy, Medical School Athens Greece
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Cholecystokinin (CCK) is a neuropeptide that is (among others) reportedly involved in the pathophysiology of psychiatric disorders. The excitatory role of CCK in negative affective emotions as well as in aversive reactions, antisocial behaviors and memories, has been indicated by numerous electrophysiological, neurochemical and behavioral methodologies on both animal models for anxiety and human studies. The current review article summarizes the existing experimental evidence with regards to the role of CCK in the induction of aggressive behavior, and: (a) synopsizes the anatomical circuits through which it could potentially mediate all types of aggressive behavior, as well as (b) highlights the potential use of these experimental evidence in the current research quest for the clinical treatment of mood and anxiety disorders.

  • Abelson JL, Nesse RM: Pentagastrin infusions in patients with panic disorder. I. Symptoms and cardiovascular responses. Biol. Psychiatry 36, 73–83 (1994)

    Nesse RM , 'Pentagastrin infusions in patients with panic disorder. I. Symptoms and cardiovascular responses ' (1994 ) 36 Biol. Psychiatry : 73 -83.

    • Search Google Scholar
  • Abramov U, Raud S, Kõks S, Innos J, Kurrikoff K, Matsui T, Vasar E: Targeted mutation of CCK2 receptor gene antagonises behavioural changes induced by social isolation in female, but not in male mice. Behav. Brain Res. 155, 1–11 (2004)

    Vasar E , 'Targeted mutation of CCK2 receptor gene antagonises behavioural changes induced by social isolation in female, but not in male mice ' (2004 ) 155 Behav. Brain Res. : 1 -11.

    • Search Google Scholar
  • Adamec R: Transmitter systems involved in neural plasticity underlying increased anxiety and defense — implications for understanding anxiety following traumatic stress. Neurosci. Biobehav. Rev. 21, 755–765 (1997)

    Adamec R , 'Transmitter systems involved in neural plasticity underlying increased anxiety and defense — implications for understanding anxiety following traumatic stress ' (1997 ) 21 Neurosci. Biobehav. Rev. : 755 -765.

    • Search Google Scholar
  • Adamec RE, Shallow T, Budgell J: Blockade of CCKB but not CCKA receptors before and after the stress of predator exposure prevents lasting increases in anxiety-like behavior: implications for anxiety associated with posttraumatic stress disorder. Behav. Neurosci. 111, 435–449 (1997)

    Budgell J , 'Blockade of CCKB but not CCKA receptors before and after the stress of predator exposure prevents lasting increases in anxiety-like behavior: implications for anxiety associated with posttraumatic stress disorder ' (1997 ) 111 Behav. Neurosci. : 435 -449.

    • Search Google Scholar
  • Agnati LF, Fuxe K, Giardino L, Calza L, Zoli M, Battistini N, Benfenati F, Vanderhaeghen JJ, Guidolin D, Ruggeri M et al.: Evidence for cholecystokinin-dopamine receptor interactions in the central nervous system of the adult and old rat. Studies on their functional meaning. Ann. N. Y. Acad. Sci. 448, 315–333 (1985)

    Ruggeri M , 'Evidence for cholecystokinin-dopamine receptor interactions in the central nervous system of the adult and old rat. Studies on their functional meaning ' (1985 ) 448 Ann. N. Y. Acad. Sci. : 315 -333.

    • Search Google Scholar
  • Allikmets L, Vasar E: Adaptational changes in GABA, benzodiazepine and cholecystokinin receptors elicited by long-term haloperidol administration. Sov. Med. Rev. G. Neuropharm. 1, 101–126 (1990)

    Vasar E , 'Adaptational changes in GABA, benzodiazepine and cholecystokinin receptors elicited by long-term haloperidol administration ' (1990 ) 1 Sov. Med. Rev. G. Neuropharm. : 101 -126.

    • Search Google Scholar
  • Aluoja A, Shlik J, Vasar V, Kingisepp PH, Jagomägi K, Vasar E, Bradwejn J: Emotional and cognitive factors connected with response to cholecystokinin tetrapeptide in healthy volunteers. Psychiatry Res. 66, 59–67 (1997)

    Bradwejn J , 'Emotional and cognitive factors connected with response to cholecystokinin tetrapeptide in healthy volunteers ' (1997 ) 66 Psychiatry Res. : 59 -67.

    • Search Google Scholar
  • Becker C, Thièbot MH, Touitou Y, Hamon M, Cesselin F, Benoliel JJ: Enhanced cortical extracellular levels of cholecystokinin-like material in a model of anticipation of social defeat in the rat. J. Neurosci. 21, 262–269 (2001)

    Benoliel JJ , 'Enhanced cortical extracellular levels of cholecystokinin-like material in a model of anticipation of social defeat in the rat ' (2001 ) 21 J. Neurosci. : 262 -269.

    • Search Google Scholar
  • Becker C, Zeau B, Rivat C, Blugeot A, Hamon M, Benoliel JJ: Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin. Mol. Psychiatry 13, 1079–1092 (2008)

    Benoliel JJ , 'Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin ' (2008 ) 13 Mol. Psychiatry : 1079 -1092.

    • Search Google Scholar
  • Beinfeld MC, Meyer DK, Eskay RL, Jensen RT, Brownstein MJ: The distribution of cholecystokinin immunoreactivity in the central nervous system of the rat as determined by radioimmunoassay. Brain Res. 212, 51–57 (1981)

    Brownstein MJ , 'The distribution of cholecystokinin immunoreactivity in the central nervous system of the rat as determined by radioimmunoassay ' (1981 ) 212 Brain Res. : 51 -57.

    • Search Google Scholar
  • Beinfeld MC: An introduction to neuronal cholecystokinin. Peptides 22, 1197–1200 (2001)

    Beinfeld MC , 'An introduction to neuronal cholecystokinin ' (2001 ) 22 Peptides : 1197 -1200.

    • Search Google Scholar
  • Bhatnagar S, Viau V, Chu A, Soriano L, Meijer OC, Dallman MF: A cholecystokinin-mediated pathway to the paraventricular thalamus is recruited in chronically stressed rats and regulates hypothalamic-pituitary-adrenal function. J. Neurosci. 20, 5564–5573 (2000)

    Dallman MF , 'A cholecystokinin-mediated pathway to the paraventricular thalamus is recruited in chronically stressed rats and regulates hypothalamic-pituitary-adrenal function ' (2000 ) 20 J. Neurosci. : 5564 -5573.

    • Search Google Scholar
  • Biró E, Sarnyai Z, Penke B, Szabó G, Telegdy G: Role of endogenous corticotropin-releasing factor in mediation of neuroendocrine and behavioral responses to cholecystokinin octapeptide sulfate ester in rats. Neuroendocrinology 57, 340–345 (1993)

    Telegdy G , 'Role of endogenous corticotropin-releasing factor in mediation of neuroendocrine and behavioral responses to cholecystokinin octapeptide sulfate ester in rats ' (1993 ) 57 Neuroendocrinology : 340 -345.

    • Search Google Scholar
  • Blair RJ: The roles of orbital frontal cortex in the modulation of antisocial behavior. Brain Cogn. 55, 198–208 (2004)

    Blair RJ , 'The roles of orbital frontal cortex in the modulation of antisocial behavior ' (2004 ) 55 Brain Cogn. : 198 -208.

    • Search Google Scholar
  • Bowers ME, Choi DC, Ressler KJ: Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide Y. Physiol. Behav. 107, 699–710 (2012)

    Ressler KJ , 'Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide Y ' (2012 ) 107 Physiol. Behav. : 699 -710.

    • Search Google Scholar
  • Bradwejn J, Koszycki D, Couëtoux du Tertre A, van Megen H, den Boer J, Westenberg H: The panicogenic effects of cholecystokinin-tetrapeptide are antagonized by L-365,260, a central cholecystokinin receptor antagonist, in patients with panic disorder. Arch. Gen. Psychiatry 51, 486–493 (1994)

    Westenberg H , 'The panicogenic effects of cholecystokinin-tetrapeptide are antagonized by L-365,260, a central cholecystokinin receptor antagonist, in patients with panic disorder ' (1994 ) 51 Arch. Gen. Psychiatry : 486 -493.

    • Search Google Scholar
  • Bradwejn J, Koszycki D, Meterissian G: Cholecystokinin-tetrapeptide induces panic attacks in patients with panic disorder. Can. J. Psychiatry 35, 83–85 (1990)

    Meterissian G , 'Cholecystokinin-tetrapeptide induces panic attacks in patients with panic disorder ' (1990 ) 35 Can. J. Psychiatry : 83 -85.

    • Search Google Scholar
  • Bradwejn J, Koszycki D, Paradis M, Reece P, Hinton J, Sedman A: Effect of CI-988 on cholecystokinin tetrapeptide-induced panic symptoms in healthy volunteers. Biol. Psychiatry 38, 742–746 (1995)

    Sedman A , 'Effect of CI-988 on cholecystokinin tetrapeptide-induced panic symptoms in healthy volunteers ' (1995 ) 38 Biol. Psychiatry : 742 -746.

    • Search Google Scholar
  • Bradwejn J, Koszycki D, Shriqui C: Enhanced sensitivity to cholecystokinin tetrapeptide in panic disorder. Clinical and behavioral findings. Arch. Gen. Psychiatry 48, 603–610 (1991)

    Shriqui C , 'Enhanced sensitivity to cholecystokinin tetrapeptide in panic disorder. Clinical and behavioral findings ' (1991 ) 48 Arch. Gen. Psychiatry : 603 -610.

    • Search Google Scholar
  • Brodin K, Rosén A, Iwarsson K, Ogren SO, Brodin E: Increased levels of substance P and cholecystokinin in rat cerebral cortex following repeated electroconvulsive shock and subchronic treatment with a serotonin uptake inhibitor. Acta Physiol. Scand. 136, 613–614 (1989)

    Brodin E , 'Increased levels of substance P and cholecystokinin in rat cerebral cortex following repeated electroconvulsive shock and subchronic treatment with a serotonin uptake inhibitor ' (1989 ) 136 Acta Physiol. Scand. : 613 -614.

    • Search Google Scholar
  • Burgdorf J, Panksepp J, Beinfeld MC, Kroes RA, Moskal JR: Regional brain cholecystokinin changes as a function of rough-and-tumble play behavior in adolescent rats. Peptides 27, 172–177 (2006)

    Moskal JR , 'Regional brain cholecystokinin changes as a function of rough-and-tumble play behavior in adolescent rats ' (2006 ) 27 Peptides : 172 -177.

    • Search Google Scholar
  • Coccaro EF, Bergeman CS, Kavoussi RJ, Seroczynski AD: Heritability of aggression and irritability: a twin study of the Buss-Durkee aggression scales in adult male subjects. Biol. Psychiatry 41, 273–284 (1997)

    Seroczynski AD , 'Heritability of aggression and irritability: a twin study of the Buss-Durkee aggression scales in adult male subjects ' (1997 ) 41 Biol. Psychiatry : 273 -284.

    • Search Google Scholar
  • Cohen H, Kaplan Z, Kotler M: CCK-antagonists in a rat exposed to acute stress: implication for anxiety associated with post-traumatic stress disorder. Depress. Anxiety 10, 8–17 (1999)

    Kotler M , 'CCK-antagonists in a rat exposed to acute stress: implication for anxiety associated with post-traumatic stress disorder ' (1999 ) 10 Depress. Anxiety : 8 -17.

    • Search Google Scholar
  • Crawley JN, Hommer DW, Skirboll LR: Topographical analysis of nucleus accumbens sites at which cholecystokinin potentiates dopamine-induced hyperlocomotion in the rat. Brain Res. 335, 337–341 (1985)

    Skirboll LR , 'Topographical analysis of nucleus accumbens sites at which cholecystokinin potentiates dopamine-induced hyperlocomotion in the rat ' (1985 ) 335 Brain Res. : 337 -341.

    • Search Google Scholar
  • Crawley JN, Stivers JA, Blumstein LK, Paul SM: Cholecystokinin potentiates dopamine-mediated behaviors: evidence for modulation specific to a site of coexistence. J. Neurosci. 5, 1972–1983 (1985)

    Paul SM , 'Cholecystokinin potentiates dopamine-mediated behaviors: evidence for modulation specific to a site of coexistence ' (1985 ) 5 J. Neurosci. : 1972 -1983.

    • Search Google Scholar
  • Crawley JN: Cholecystokinin-dopamine interactions. Trends Pharmacol. Sci. 12, 232–236 (1991)

    Crawley JN , 'Cholecystokinin-dopamine interactions ' (1991 ) 12 Trends Pharmacol. Sci. : 232 -236.

    • Search Google Scholar
  • Crawley JN: Subtype-selective cholecystokinin receptor antagonists block cholecystokinin modulation of dopamine-mediated behaviors in the rat mesolimbic pathway. J. Neurosci. 12, 3380–3391 (1992)

    Crawley JN , 'Subtype-selective cholecystokinin receptor antagonists block cholecystokinin modulation of dopamine-mediated behaviors in the rat mesolimbic pathway ' (1992 ) 12 J. Neurosci. : 3380 -3391.

    • Search Google Scholar
  • Daugé V, Beslot F, Matsui T, Roques BP: Mutant mice lacking the cholecystokinin 2 receptor show a dopaminedependent hyperactivity and a behavioral sensitization to morphine. Neurosci. Lett. 306, 41–44 (2001)

    Roques BP , 'Mutant mice lacking the cholecystokinin 2 receptor show a dopaminedependent hyperactivity and a behavioral sensitization to morphine ' (2001 ) 306 Neurosci. Lett. : 41 -44.

    • Search Google Scholar
  • Daugé V, Léna I: CCK in anxiety and cognitive processes. Neurosci. Biobehav. Rev. 22, 815–825 (1998)

    Léna I , 'CCK in anxiety and cognitive processes ' (1998 ) 22 Neurosci. Biobehav. Rev. : 815 -825.

    • Search Google Scholar
  • Daugé V, Sebret A, Beslot F, Matsui T, Roques BP: Behavioral profile of CCK2 receptor-deficient mice. Neuropsychopharmacology 25, 690–698 (2001)

    Roques BP , 'Behavioral profile of CCK2 receptor-deficient mice ' (2001 ) 25 Neuropsychopharmacology : 690 -698.

    • Search Google Scholar
  • de Montigny C: Cholecystokinin tetrapeptide induces panic-like attacks in healthy volunteers. Preliminary findings. Arch. Gen. Psychiatry 46, 511–517 (1989)

    Montigny C , 'Cholecystokinin tetrapeptide induces panic-like attacks in healthy volunteers. Preliminary findings ' (1989 ) 46 Arch. Gen. Psychiatry : 511 -517.

    • Search Google Scholar
  • Del Bel EA, Guimarães FS: Social isolation increases cholecystokinin mRNA in the central nervous system of rats. Neuroreport 8, 3597–3600 (1997)

    Guimarães FS , 'Social isolation increases cholecystokinin mRNA in the central nervous system of rats ' (1997 ) 8 Neuroreport : 3597 -3600.

    • Search Google Scholar
  • Dornan WA, Malsbury CW: Peptidergic control of male rat sexual behavior: the effects of intracerebral injections of substance P and cholecystokinin. Physiol. Behav. 46, 547–556 (1989)

    Malsbury CW , 'Peptidergic control of male rat sexual behavior: the effects of intracerebral injections of substance P and cholecystokinin ' (1989 ) 46 Physiol. Behav. : 547 -556.

    • Search Google Scholar
  • Feldman RS, Meyer JS, Quenzer LF (1997): Principles of Neuropsychopharmacology. Sinauer Associates, Inc, Sunderland, MA, pp. 484–491

    Quenzer LF , '', in Principles of Neuropsychopharmacology , (1997 ) -.

  • Fukamauchi F, Takahashi R: Regional effects of apomorphine on rat brain cholecystokinin-8 like immunoreactivity following electrolytic lesions of the ventral tegmental area. Neuropeptides 11, 63–67 (1988)

    Takahashi R , 'Regional effects of apomorphine on rat brain cholecystokinin-8 like immunoreactivity following electrolytic lesions of the ventral tegmental area ' (1988 ) 11 Neuropeptides : 63 -67.

    • Search Google Scholar
  • Giardino L, Bettelli C, Pozza M, Calzà L: Regulation of CCK mRNA expression in the rat brain by stress and treatment with sertraline, a selective serotonin re-uptake inhibitor. Brain Res. 824, 304–307 (1999)

    Calzà L , 'Regulation of CCK mRNA expression in the rat brain by stress and treatment with sertraline, a selective serotonin re-uptake inhibitor ' (1999 ) 824 Brain Res. : 304 -307.

    • Search Google Scholar
  • González-Hernández T, Rodríguez M: Compartmental organization and chemical profile of dopaminergic and GABAergic neurons in the substantia nigra of the rat. J. Comp. Neurol. 421, 107–135 (2000)

    Rodríguez M , 'Compartmental organization and chemical profile of dopaminergic and GABAergic neurons in the substantia nigra of the rat ' (2000 ) 421 J. Comp. Neurol. : 107 -135.

    • Search Google Scholar
  • Gregg TR, Siegel A: Brain structures and neurotransmitters regulating aggression in cats: implications for human aggression. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 91–140 (2001)

    Siegel A , 'Brain structures and neurotransmitters regulating aggression in cats: implications for human aggression ' (2001 ) 25 Prog. Neuropsychopharmacol. Biol. Psychiatry : 91 -140.

    • Search Google Scholar
  • Griebel G, Perrault G, Sanger DJ: CCK receptor antagonists in animal models of anxiety: comparison between exploration tests, conflict procedures and a model based on defensive behaviours. Behav. Pharmacol. 8, 549–560 (1997)

    Sanger DJ , 'CCK receptor antagonists in animal models of anxiety: comparison between exploration tests, conflict procedures and a model based on defensive behaviours ' (1997 ) 8 Behav. Pharmacol. : 549 -560.

    • Search Google Scholar
  • Griebel G: Is there a future for neuropeptide receptor ligands in the treatment of anxiety disorders? Pharmacol. Ther. 82, 1–61 (1999)

    Griebel G , 'Is there a future for neuropeptide receptor ligands in the treatment of anxiety disorders? ' (1999 ) 82 Pharmacol. Ther. : 1 -61.

    • Search Google Scholar
  • Harro J, Jossan SS, Oreland L: Changes in cholecystokinin receptor binding in rat brain after selective damage of locus coeruleus projections by DSP-4 treatment. Naunyn Schmiedebergs Arch. Pharmacol. 346, 425–431 (1992)

    Oreland L , 'Changes in cholecystokinin receptor binding in rat brain after selective damage of locus coeruleus projections by DSP-4 treatment ' (1992 ) 346 Naunyn Schmiedebergs Arch. Pharmacol. : 425 -431.

    • Search Google Scholar
  • Harro J, Kiivet RA, Lang A, Vasar E: Rats with anxious or non-anxious type of exploratory behaviour differ in their brain CCK-8 and benzodiazepine receptor characteristics. Behav. Brain Res. 39, 63–71 (1990)

    Vasar E , 'Rats with anxious or non-anxious type of exploratory behaviour differ in their brain CCK-8 and benzodiazepine receptor characteristics ' (1990 ) 39 Behav. Brain Res. : 63 -71.

    • Search Google Scholar
  • Harro J, Löfberg C, Rehfeld JF, Oreland L: Cholecystokinin peptides and receptors in the rat brain during stress. Naunyn Schmiedebergs Arch. Pharmacol. 354, 59–66 (1996)

    Oreland L , 'Cholecystokinin peptides and receptors in the rat brain during stress ' (1996 ) 354 Naunyn Schmiedebergs Arch. Pharmacol. : 59 -66.

    • Search Google Scholar
  • Harro J, Vasar E, Bradwejn J: CCK in animal and human research on anxiety. Trends Pharmacol. Sci. 14, 244–249 (1993)

    Bradwejn J , 'CCK in animal and human research on anxiety ' (1993 ) 14 Trends Pharmacol. Sci. : 244 -249.

    • Search Google Scholar
  • Hebb AL, Zacharko RM, Dominguez H, Laforest S, Gauthier M, Levac C, Drolet G: Changes in brain cholecystokinin and anxiety-like behavior following exposure of mice to predator odor. Neuroscience 116, 539–551 (2003)

    Drolet G , 'Changes in brain cholecystokinin and anxiety-like behavior following exposure of mice to predator odor ' (2003 ) 116 Neuroscience : 539 -551.

    • Search Google Scholar
  • Heidbreder CA, Weiss IC, Domeney AM, Pryce C, Homberg J, Hedou G, Feldon J, Moran MC, Nelson P: Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome. Neuroscience 100, 749–768 (2000)

    Nelson P , 'Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome ' (2000 ) 100 Neuroscience : 749 -768.

    • Search Google Scholar
  • Hökfelt T, Rehfeld JF, Skirboll L, Ivemark B, Goldstein M, Markey K: Evidence for coexistence of dopamine and CCK in meso-limbic neurones. Nature 285, 476–478 (1980)

    Markey K , 'Evidence for coexistence of dopamine and CCK in meso-limbic neurones ' (1980 ) 285 Nature : 476 -478.

    • Search Google Scholar
  • Iadarola MJ, Naranjo JR, Duchemin AM, Quach TT: Expression of cholecystokinin and enkephalin mRNA in discrete brain regions. Peptides 10, 687–692 (1989)

    Quach TT , 'Expression of cholecystokinin and enkephalin mRNA in discrete brain regions ' (1989 ) 10 Peptides : 687 -692.

    • Search Google Scholar
  • Jenck F, Martin JR, Moreau JL: Behavioral effects of CCKB receptor ligands in a validated simulation of panic anxiety in rats. Eur. Neuropsychopharmacol. 6, 291–298 (1996)

    Moreau JL , 'Behavioral effects of CCKB receptor ligands in a validated simulation of panic anxiety in rats ' (1996 ) 6 Eur. Neuropsychopharmacol. : 291 -298.

    • Search Google Scholar
  • Karler R, Calder LD, Chaudhry IA, Turkanis SA: Blockade of “reverse tolerance” to cocaine and amphetamine by MK-801. Life Sci. 45, 599–606 (1989)

    Turkanis SA , 'Blockade of “reverse tolerance” to cocaine and amphetamine by MK-801 ' (1989 ) 45 Life Sci. : 599 -606.

    • Search Google Scholar
  • Katsouni E, Sakkas P, Zarros A, Skandali N, Liapi C: The involvement of substance P in the induction of aggressive behavior. Peptides 30, 1586–1591 (2009)

    Liapi C , 'The involvement of substance P in the induction of aggressive behavior ' (2009 ) 30 Peptides : 1586 -1591.

    • Search Google Scholar
  • Kõks S, Männistö PT, Bourin M, Shlik J, Vasar V, Vasar E: Cholecystokinin-induced anxiety in rats: relevance of pre-experimental stress and seasonal variations. J. Psychiatry Neurosci. 25, 33–42 (2000)

    Vasar E , 'Cholecystokinin-induced anxiety in rats: relevance of pre-experimental stress and seasonal variations ' (2000 ) 25 J. Psychiatry Neurosci. : 33 -42.

    • Search Google Scholar
  • Kõks S, Volke V, Veraksits A, Rünkorg K, Sillat T, Abramov U, Bourin M, Huotari M, Männistö PT, Matsui T, Vasar E: Cholecystokinin 2 receptor-deficient mice display altered function of brain dopaminergic system. Psychopharmacology (Berl.) 158, 198–204 (2001)

    Vasar E , 'Cholecystokinin 2 receptor-deficient mice display altered function of brain dopaminergic system ' (2001 ) 158 Psychopharmacology (Berl.) : 198 -204.

    • Search Google Scholar
  • Koszycki D, Zacharko RM, Le Melledo JM, Young SN, Bradwejn J: Effect of acute tryptophan depletion on behavioral, cardiovascular, and hormonal sensitivity to cholecystokinin-tetrapeptide challenge in healthy volunteers. Biol. Psychiatry 40, 648–655 (1996)

    Bradwejn J , 'Effect of acute tryptophan depletion on behavioral, cardiovascular, and hormonal sensitivity to cholecystokinin-tetrapeptide challenge in healthy volunteers ' (1996 ) 40 Biol. Psychiatry : 648 -655.

    • Search Google Scholar
  • Lang A, Harro J, Soosaar A, Kõks S, Volke V, Oreland L, Bourin M, Vasar E, Bradwejn J, Männistö PT: Role of N-methyl-D-aspartic acid and cholecystokinin receptors in apomorphine-induced aggressive behaviour in rats. Naunyn Schmiedebergs Arch. Pharmacol. 351, 363–370 (1995)

    Männistö PT , 'Role of N-methyl-D-aspartic acid and cholecystokinin receptors in apomorphine-induced aggressive behaviour in rats ' (1995 ) 351 Naunyn Schmiedebergs Arch. Pharmacol. : 363 -370.

    • Search Google Scholar
  • Lemaire M, Böhme GA, Piot O, Roques BP, Blanchard JC: CCK-A and CCK-B selective receptor agonists and antagonists modulate olfactory recognition in male rats. Psychopharmacology (Berl.) 115, 435–440 (1994)

    Blanchard JC , 'CCK-A and CCK-B selective receptor agonists and antagonists modulate olfactory recognition in male rats ' (1994 ) 115 Psychopharmacology (Berl.) : 435 -440.

    • Search Google Scholar
  • Lemaire M, Piot O, Roques BP, Böhme GA, Blanchard JC: Evidence for an endogenous cholecystokininergic balance in social memory. Neuroreport 3, 929–932 (1992)

    Blanchard JC , 'Evidence for an endogenous cholecystokininergic balance in social memory ' (1992 ) 3 Neuroreport : 929 -932.

    • Search Google Scholar
  • Levy AD, Kim JJ, Ellison GD: Chronic amphetamine alters D-2 but not D-1 agonist-induced behavioral responses in rats. Life Sci. 43, 1207–1213 (1988)

    Ellison GD , 'Chronic amphetamine alters D-2 but not D-1 agonist-induced behavioral responses in rats ' (1988 ) 43 Life Sci. : 1207 -1213.

    • Search Google Scholar
  • Luo B, Cheu JW, Siegel A: Cholecystokinin B receptors in the periaqueductal gray potentiate defensive rage behavior elicited from the medial hypothalamus of the cat. Brain Res. 796, 27–37 (1998)

    Siegel A , 'Cholecystokinin B receptors in the periaqueductal gray potentiate defensive rage behavior elicited from the medial hypothalamus of the cat ' (1998 ) 796 Brain Res. : 27 -37.

    • Search Google Scholar
  • Marshall FH, Barnes S, Hughes J, Woodruff GN, Hunter JC: Cholecystokinin modulates the release of dopamine from the anterior and posterior nucleus accumbens by two different mechanisms. J. Neurochem. 56, 917–922 (1991)

    Hunter JC , 'Cholecystokinin modulates the release of dopamine from the anterior and posterior nucleus accumbens by two different mechanisms ' (1991 ) 56 J. Neurochem. : 917 -922.

    • Search Google Scholar
  • Mattingly BA, Rowlett JK, Graff JT, Hatton BJ: Effects of selective D1 and D2 dopamine antagonists on the development of behavioral sensitization to apomorphine. Psychopharmacology (Berl.) 105, 501–507 (1991)

    Hatton BJ , 'Effects of selective D1 and D2 dopamine antagonists on the development of behavioral sensitization to apomorphine ' (1991 ) 105 Psychopharmacology (Berl.) : 501 -507.

    • Search Google Scholar
  • Meloy JR: Empirical basis and forensic application of affective and predatory violence. Aust. N. Z. J. Psychiatry 40, 539–547 (2006)

    Meloy JR , 'Empirical basis and forensic application of affective and predatory violence ' (2006 ) 40 Aust. N. Z. J. Psychiatry : 539 -547.

    • Search Google Scholar
  • Miyasaka K, Ichikawa M, Ohta M, Kanai S, Yoshida Y, Masuda M, Nagata A, Matsui T, Noda T, Takiguchi S, Takata Y, Kawanami T, Funakoshi A: Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor. J. Nutr. 132, 739–741 (2002)

    Funakoshi A , 'Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor ' (2002 ) 132 J. Nutr. : 739 -741.

    • Search Google Scholar
  • Molina-Hernandez M, Tellez-Alcantara P, Perez-Garcia J: Isolation rearing induced fear-like behavior without affecting learning abilities of Wistar rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1111–1123 (2001)

    Perez-Garcia J , 'Isolation rearing induced fear-like behavior without affecting learning abilities of Wistar rats ' (2001 ) 25 Prog. Neuropsychopharmacol. Biol. Psychiatry : 1111 -1123.

    • Search Google Scholar
  • Moran TH, Robinson PH, Goldrich MS, McHugh PR: Two brain cholecystokinin receptors: implications for behavioral actions. Brain Res. 362, 175–179 (1986)

    McHugh PR , 'Two brain cholecystokinin receptors: implications for behavioral actions ' (1986 ) 362 Brain Res. : 175 -179.

    • Search Google Scholar
  • Moroji T, Hagino Y: A behavioral pharmacological study on CCK-8 related peptides in mice. Neuropeptides 8, 273–286 (1986)

    Hagino Y , 'A behavioral pharmacological study on CCK-8 related peptides in mice ' (1986 ) 8 Neuropeptides : 273 -286.

    • Search Google Scholar
  • Nelson RJ, Chiavegatto S: Aggression in knockout mice. ILAR J. 41, 153–162 (2000)

    Chiavegatto S , 'Aggression in knockout mice ' (2000 ) 41 ILAR J. : 153 -162.

  • Nelson RJ, Chiavegatto S: Molecular basis of aggression. Trends Neurosci. 24, 713–719 (2001)

    Chiavegatto S , 'Molecular basis of aggression ' (2001 ) 24 Trends Neurosci. : 713 -719.

  • Netto CF, Guimarães FS: Anxiogenic effect of cholecystokinin in the dorsal periaqueductal gray. Neuropsychopharmacology 29, 101–107 (2004)

    Guimarães FS , 'Anxiogenic effect of cholecystokinin in the dorsal periaqueductal gray ' (2004 ) 29 Neuropsychopharmacology : 101 -107.

    • Search Google Scholar
  • Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP: International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol. Rev. 51, 745–781 (1999)

    Roques BP , 'International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors ' (1999 ) 51 Pharmacol. Rev. : 745 -781.

    • Search Google Scholar
  • Panksepp J, Burgdorf J, Beinfeld MC, Kroes RA, Moskal JR: Brain regional neuropeptide changes resulting from social defeat. Behav. Neurosci. 121, 1364–1371 (2007)

    Moskal JR , 'Brain regional neuropeptide changes resulting from social defeat ' (2007 ) 121 Behav. Neurosci. : 1364 -1371.

    • Search Google Scholar
  • Panksepp J, Burgdorf J, Beinfeld MC, Kroes RA, Moskal JR: Regional brain cholecystokinin changes as a function of friendly and aggressive social interactions in rats. Brain Res. 1025, 75–84 (2004)

    Moskal JR , 'Regional brain cholecystokinin changes as a function of friendly and aggressive social interactions in rats ' (2004 ) 1025 Brain Res. : 75 -84.

    • Search Google Scholar
  • Panksepp J (1998): Affective Neuroscience: The Foundations of Human and Animal Emotions. Oxford University Press, New York

    Panksepp J , '', in Affective Neuroscience: The Foundations of Human and Animal Emotions , (1998 ) -.

    • Search Google Scholar
  • Pommier B, Beslot F, Simon A, Pophillat M, Matsui T, Dauge V, Roques BP, Noble F: Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system. J. Neurosci. 22, 2005–2011 (2002)

    Noble F , 'Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system ' (2002 ) 22 J. Neurosci. : 2005 -2011.

    • Search Google Scholar
  • Porreca F, Cowan A, Tallarida RJ: Differentiation of apomorphine from bromocriptine, piribidel and TRH by chronic administration in rats. Psychopharmacology (Berl.) 76, 70–74 (1982)

    Tallarida RJ , 'Differentiation of apomorphine from bromocriptine, piribidel and TRH by chronic administration in rats ' (1982 ) 76 Psychopharmacology (Berl.) : 70 -74.

    • Search Google Scholar
  • Radu D, Brodin E, Weber G, Lindefors N: Delayed stress-induced increase in tissue level of cholecystokinin in rat prefrontal cortex: modulation by microdialysis probe implantation and systemic ketamine. Brain Res. 908, 197–203 (2001)

    Lindefors N , 'Delayed stress-induced increase in tissue level of cholecystokinin in rat prefrontal cortex: modulation by microdialysis probe implantation and systemic ketamine ' (2001 ) 908 Brain Res. : 197 -203.

    • Search Google Scholar
  • Rasmussen K, Stockton ME, Czachura JF, Howbert JJ: Cholecystokinin (CCK) and schizophrenia: the selective CCKB antagonist LY262691 decreases midbrain dopamine unit activity. Eur. J. Pharmacol. 209, 135–138 (1991)

    Howbert JJ , 'Cholecystokinin (CCK) and schizophrenia: the selective CCKB antagonist LY262691 decreases midbrain dopamine unit activity ' (1991 ) 209 Eur. J. Pharmacol. : 135 -138.

    • Search Google Scholar
  • Rasmussen K: CCK, schizophrenia, and anxiety. CCK-B antagonists inhibit the activity of brain dopamine neurons. Ann. N. Y. Acad. Sci. 713, 300–311 (1994)

    Rasmussen K , 'CCK, schizophrenia, and anxiety. CCK-B antagonists inhibit the activity of brain dopamine neurons ' (1994 ) 713 Ann. N. Y. Acad. Sci. : 300 -311.

    • Search Google Scholar
  • Raud S, Rünkorg K, Veraksits A, Reimets A, Nelovkov A, Abramov U, Matsui T, Bourin M, Volke V, Kõks S, Vasar E: Targeted mutation of CCK2 receptor gene modifies the behavioural effects of diazepam in female mice. Psychopharmacology (Berl.) 168, 417–425 (2003)

    Vasar E , 'Targeted mutation of CCK2 receptor gene modifies the behavioural effects of diazepam in female mice ' (2003 ) 168 Psychopharmacology (Berl.) : 417 -425.

    • Search Google Scholar
  • Ravard S, Dourish CT: Cholecystokinin and anxiety. Trends Pharmacol. Sci. 11, 271–273 (1990)

    Dourish CT , 'Cholecystokinin and anxiety ' (1990 ) 11 Trends Pharmacol. Sci. : 271 -273.

  • Rehfeld JF: Cholecystokinin and panic disorder-three unsettled questions. Regul. Pept. 93, 79–83 (2000)

    Rehfeld JF , 'Cholecystokinin and panic disorder-three unsettled questions ' (2000 ) 93 Regul. Pept. : 79 -83.

    • Search Google Scholar
  • Seroczynski AD, Bergeman CS, Coccaro EF: Etiology of the impulsivity/aggression relationship: genes or environment? Psychiatry Res. 86, 41–57 (1999)

    Coccaro EF , 'Etiology of the impulsivity/aggression relationship: genes or environment? ' (1999 ) 86 Psychiatry Res. : 41 -57.

    • Search Google Scholar
  • Shayit M, Weller A: Cholecystokinin receptor antagonists increase the rat pup’s preference toward maternalodor and rug texture. Dev. Psychobiol. 38, 164–173 (2001)

    Weller A , 'Cholecystokinin receptor antagonists increase the rat pup’s preference toward maternalodor and rug texture ' (2001 ) 38 Dev. Psychobiol. : 164 -173.

    • Search Google Scholar
  • Shevelkin AV: Facilitation of defense reactions during the consumption of food in snails: the participation of glucose and gastrin/cholecystokinin-like peptide. Neurosci. Behav. Physiol. 24, 115–124 (1994)

    Shevelkin AV , 'Facilitation of defense reactions during the consumption of food in snails: the participation of glucose and gastrin/cholecystokinin-like peptide ' (1994 ) 24 Neurosci. Behav. Physiol. : 115 -124.

    • Search Google Scholar
  • Shlik J, Aluoja A, Vasar V, Vasar E, Podar T, Bradwejn J: Effects of citalopram treatment on behavioural, cardiovascular and neuroendocrine response to cholecystokinin tetrapeptide challenge in patients with panic disorder. J. Psychiatry Neurosci. 22, 332–340 (1997)

    Bradwejn J , 'Effects of citalopram treatment on behavioural, cardiovascular and neuroendocrine response to cholecystokinin tetrapeptide challenge in patients with panic disorder ' (1997 ) 22 J. Psychiatry Neurosci. : 332 -340.

    • Search Google Scholar
  • Shlik J, Vasar E, Bradwejn J: Cholecystokinin and psychiatric disorders: role in aetiology and potential of receptor antagonists in therapy. CNS Drugs 8, 134–152 (1997)

    Bradwejn J , 'Cholecystokinin and psychiatric disorders: role in aetiology and potential of receptor antagonists in therapy ' (1997 ) 8 CNS Drugs : 134 -152.

    • Search Google Scholar
  • Siegel A, Bhatt S, Bhatt R, Zalcman SS: The neurobiological bases for development of pharmacological treatments of aggressive disorders. Curr. Neuropharmacol. 5, 135–147 (2007)

    Zalcman SS , 'The neurobiological bases for development of pharmacological treatments of aggressive disorders ' (2007 ) 5 Curr. Neuropharmacol. : 135 -147.

    • Search Google Scholar
  • Siegel A, Roeling TA, Gregg TR, Kruk MR: Neuropharmacology of brain-stimulation-evoked aggression. Neurosci. Biobehav. Rev. 23, 359–389 (1999)

    Kruk MR , 'Neuropharmacology of brain-stimulation-evoked aggression ' (1999 ) 23 Neurosci. Biobehav. Rev. : 359 -389.

    • Search Google Scholar
  • Siegel A (2005): The Neurobiology of Aggression and Rage. CRC Press, Boca Raton

    Siegel A , '', in The Neurobiology of Aggression and Rage , (2005 ) -.

  • Siegel RA, Düker EM, Pahnke U, Wuttke W: Stress-induced changes in cholecystokinin and substance P concentrations in discrete regions of the rat hypothalamus. Neuroendocrinology 46, 75–81 (1987)

    Wuttke W , 'Stress-induced changes in cholecystokinin and substance P concentrations in discrete regions of the rat hypothalamus ' (1987 ) 46 Neuroendocrinology : 75 -81.

    • Search Google Scholar
  • Siever LJ: Neurobiology of aggression and violence. Am. J. Psychiatry 165, 429–442 (2008)

    Siever LJ , 'Neurobiology of aggression and violence ' (2008 ) 165 Am. J. Psychiatry : 429 -442.

    • Search Google Scholar
  • Sitthisomwong P, Weiner S, Levin L, Reisman S, Siegel A: The effect of a cholecystokinin agonist on masseter muscle activity in the cat. J. Dent. Res. 79, 1823–1828 (2000)

    Siegel A , 'The effect of a cholecystokinin agonist on masseter muscle activity in the cat ' (2000 ) 79 J. Dent. Res. : 1823 -1828.

    • Search Google Scholar
  • Strott CA: Sulfonation and molecular action. Endocr. Rev. 23, 703–732 (2002)

    Strott CA , 'Sulfonation and molecular action ' (2002 ) 23 Endocr. Rev. : 703 -732.

  • Studler JM, Reibaud M, Herve D, Blanc G, Glowinski J, Tassin JP: Opposite effects of sulfated cholecystokinin on DA-sensitive adenylate cyclase in two areas of the rat nucleus accumbens. Eur. J. Pharmacol. 126, 125–128 (1986)

    Tassin JP , 'Opposite effects of sulfated cholecystokinin on DA-sensitive adenylate cyclase in two areas of the rat nucleus accumbens ' (1986 ) 126 Eur. J. Pharmacol. : 125 -128.

    • Search Google Scholar
  • Swerdlow NR, van der Kooy D, Koob GF, Wenger JR: Cholecystokinin produces conditioned place-aversions, not place-preferences, in food-deprived rats: evidence against involvement in satiety. Life Sci. 32, 2087–2093 (1983)

    Wenger JR , 'Cholecystokinin produces conditioned place-aversions, not place-preferences, in food-deprived rats: evidence against involvement in satiety ' (1983 ) 32 Life Sci. : 2087 -2093.

    • Search Google Scholar
  • Vaccarino FJ, Rankin J: Nucleus accumbens cholecystokinin (CCK) can either attenuate or potentiate amphetamine-induced locomotor activity: evidence for rostral-caudal differences in accumbens CCK function. Behav. Neurosci. 103, 831–836 (1989)

    Rankin J , 'Nucleus accumbens cholecystokinin (CCK) can either attenuate or potentiate amphetamine-induced locomotor activity: evidence for rostral-caudal differences in accumbens CCK function ' (1989 ) 103 Behav. Neurosci. : 831 -836.

    • Search Google Scholar
  • Van Kampen J, Frydryszak H, Stoessl AJ: Behavioural evidence for cholecystokinin-dopamine D1 receptor interactions in the rat. Eur. J. Pharmacol. 298, 7–15 (1996)

    Stoessl AJ , 'Behavioural evidence for cholecystokinin-dopamine D1 receptor interactions in the rat ' (1996 ) 298 Eur. J. Pharmacol. : 7 -15.

    • Search Google Scholar
  • van Megen HJ, Westenberg HG, den Boer JA, Kahn RS: Cholecystokinin in anxiety. Eur. Neuropsychopharmacol. 6, 263–280 (1996)

    Kahn RS , 'Cholecystokinin in anxiety ' (1996 ) 6 Eur. Neuropsychopharmacol. : 263 -280.

  • van Megen HJ, Westenberg HG, Den Boer JA, Kahn RS: The panic-inducing properties of the cholecystokinin tetrapeptide CCK4 in patients with panic disorder. Eur. Neuropsychopharmacol. 6, 187–194 (1996)

    Kahn RS , 'The panic-inducing properties of the cholecystokinin tetrapeptide CCK4 in patients with panic disorder ' (1996 ) 6 Eur. Neuropsychopharmacol. : 187 -194.

    • Search Google Scholar
  • Vasar E, Peuranen E, Harro J, Lang A, Oreland L, Männistö PT: Social isolation of rats increases the density of cholecystokinin receptors in the frontal cortex and abolishes the anti-exploratory effect of caerulein. Naunyn Schmiedebergs Arch. Pharmacol. 348, 96–101 (1993)

    Männistö PT , 'Social isolation of rats increases the density of cholecystokinin receptors in the frontal cortex and abolishes the anti-exploratory effect of caerulein ' (1993 ) 348 Naunyn Schmiedebergs Arch. Pharmacol. : 96 -101.

    • Search Google Scholar
  • Vasar E, Soosaar A, Harro J, Lang A: Changes at cholecystokinin receptors induced by long-term treatment with diazepam and haloperidol. Eur. Neuropsychopharmacol. 2, 447–454 (1992)

    Lang A , 'Changes at cholecystokinin receptors induced by long-term treatment with diazepam and haloperidol ' (1992 ) 2 Eur. Neuropsychopharmacol. : 447 -454.

    • Search Google Scholar
  • Vasar EE, Maimets MO, Allikmets LKh: Role of serotonin 2 receptors in regulating aggressive behavior. Zh. Vyssh. Nerv. Deiat. Im. I P Pavlova 34, 283–289 (1984)

    Allikmets L , 'Role of serotonin 2 receptors in regulating aggressive behavior ' (1984 ) 34 Zh. Vyssh. Nerv. Deiat. Im. I P Pavlova : 283 -289.

    • Search Google Scholar
  • Wang H, Zhu YZ, Wong PT, Farook JM, Teo AL, Lee LK, Moochhala S: cDNA microarray analysis of gene expression in anxious PVG and SD rats after cat-freezing test. Exp. Brain Res. 149, 413–421 (2003)

    Moochhala S , 'cDNA microarray analysis of gene expression in anxious PVG and SD rats after cat-freezing test ' (2003 ) 149 Exp. Brain Res. : 413 -421.

    • Search Google Scholar
  • Wiertelak EP, Maier SF, Watkins LR: Cholecystokinin antianalgesia: safety cues abolish morphine analgesia. Science 256, 830–833 (1992)

    Watkins LR , 'Cholecystokinin antianalgesia: safety cues abolish morphine analgesia ' (1992 ) 256 Science : 830 -833.

    • Search Google Scholar
  • Wunderlich GR, DeSousa NJ, Vaccarino FJ: Cholecystokinin modulates both the development and the expression of behavioral sensitization to amphetamine in the rat. Psychopharmacology (Berl.) 151, 283–290 (2000)

    Vaccarino FJ , 'Cholecystokinin modulates both the development and the expression of behavioral sensitization to amphetamine in the rat ' (2000 ) 151 Psychopharmacology (Berl.) : 283 -290.

    • Search Google Scholar
  • You ZB, Tzschentke TM, Brodin E, Wise RA: Electrical stimulation of the prefrontal cortex increases cholecystokinin, glutamate, and dopamine release in the nucleus accumbens: an in vivo microdialysis study in freely moving rats. J. Neurosci. 18, 6492–6500 (1998)

    Wise RA , 'Electrical stimulation of the prefrontal cortex increases cholecystokinin, glutamate, and dopamine release in the nucleus accumbens: an in vivo microdialysis study in freely moving rats ' (1998 ) 18 J. Neurosci. : 6492 -6500.

    • Search Google Scholar
  • Zetler G, Baumann GH: The cholecystokinin-like peptide, ceruletide, reduces isolation-induced aggression in mice. Neuropharmacology 25, 831–832 (1986)

    Baumann GH , 'The cholecystokinin-like peptide, ceruletide, reduces isolation-induced aggression in mice ' (1986 ) 25 Neuropharmacology : 831 -832.

    • Search Google Scholar
  • Zwanzger P, Domschke K, Bradwejn J: Neuronal network of panic disorder: the role of the neuropeptide cholecystokinin. Depress. Anxiety 29, 762–774 (2012)

    Bradwejn J , 'Neuronal network of panic disorder: the role of the neuropeptide cholecystokinin ' (2012 ) 29 Depress. Anxiety : 762 -774.

    • Search Google Scholar

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