View More View Less
  • 1 University of Pécs, School of Medicine 1st Department of Medicine Rákóczi út 2 H-7623 Pécs Hungary
  • | 2 University of Pécs, School of Medicine Department of Pharmacology and Pharmacotherapy Pécs Hungary
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $752.00

Capsaicin is a well-known component of red pepper. Recent studies have shown that capsaicin could prevent gastric ulcer provoked by various NSAID-s like acetylsalicylic acid (ASA). Primary objective of this human clinical phase I trial was to investigate whether two different doses of capsaicin co-administered with ASA could alter the inhibitory effect of ASA on platelet aggregation. 15 healthy male subjects were involved in the study and treated orally with 400 μg capsaicin, 800 μg capsaicin, 500 mg ASA, 400 μg capsaicin+500 mg ASA and 800 μg capsaicin+500 mg ASA. Blood was drawn before and 1, 2, 6 and 24 hours after the drug administration. After that epinephrine induced platelet aggregation was measured by optical aggregometry. Between treatments, volunteers had a 6-day wash-out period. Our results showed that capsaicin had no effect on platelet aggregation, while as expected, ASA monotherapy resulted in a significant and clinically effective platelet aggregation inhibition (p ≤ 0.001). The combined ASA-capsaicin therapies reached equivalent effectiveness in platelet aggregation inhibition as ASA monotherapy. Our investigation proved that capsaicin did not influence the inhibitory effect of ASA on platelet aggregation, thus the capsaicin-ASA treatment would combine the antiplatelet effect of ASA with the possible gastroprotection of capsaicin.

  • Adams MJ, Ahuja KD, Geraghty DP: Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation. Thromb. Res. 124, 721–723 (2009)

    Geraghty D.P. , 'Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation ' (2009 ) 124 Thromb. Res. : 721 -723.

    • Search Google Scholar
  • Al Othman ZA, Ahmed YB, Habila MA, Ghafar Determination of capsaicin and dihydrocapsaicin in Capsicum fruit samples using high performance liquid chromatography. Molecules 16, 8919–8929 (2011)

    Ghafar A.A. , 'Determination of capsaicin and dihydrocapsaicin in Capsicum fruit samples using high performance liquid chromatography ' (2011 ) 16 Molecules : 8919 -8929.

    • Search Google Scholar
  • Antithrombotic Trialists’ (ATT) Collaboration: Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomized trials. Lancet 373, 1849–1860 (2009)

    'Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomized trials ' (2009 ) 373 Lancet : 1849 -1860.

    • Search Google Scholar
  • Baylie RL, Brayden JE: TRPV channels and vascular function. Acta Physiol. (Oxf.) 203, 99–116 (2011)

    Brayden J.E. , 'TRPV channels and vascular function ' (2011 ) 203 Acta Physiol. (Oxf.) : 99 -116.

    • Search Google Scholar
  • Bayliss, W: On the local reactions of the arterial wall to changes of internal pressure. J. Physiol. 28, 220–231 (1902)

    Bayliss W. , 'On the local reactions of the arterial wall to changes of internal pressure ' (1902 ) 28 J. Physiol. : 220 -231.

    • Search Google Scholar
  • Born GV: Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 194, 927–929 (1962)

    Born G.V. , 'Aggregation of blood platelets by adenosine diphosphate and its reversal ' (1962 ) 194 Nature : 927 -929.

    • Search Google Scholar
  • Buck SH, Burks TF: The neuropharmacology of capsaicin: review of some recent observations. Pharmacol. Rev. 38, 179–226 (1986)

    Burks T.F. , 'The neuropharmacology of capsaicin: review of some recent observations ' (1986 ) 38 Pharmacol. Rev. : 179 -226.

    • Search Google Scholar
  • Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D: The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816–824 (1997)

    Julius D. , 'The capsaicin receptor: a heat-activated ion channel in the pain pathway ' (1997 ) 389 Nature : 816 -824.

    • Search Google Scholar
  • Damman P, Woudstra P, Kuijt WJ, de Winter RJ, James SK: P2Y12 platelet inhibition in clinical practice. J. Thromb. Thrombolysis 33, 143–153 (2011)

    James S.K. , 'P2Y12 platelet inhibition in clinical practice ' (2011 ) 33 J. Thromb. Thrombolysis : 143 -153.

    • Search Google Scholar
  • Debreceni A, Abdel-Salam OM, Figler M, Juricskay I, Szolcsányi J, Mózsik G: Capsaicin increases gastric emptying rate in healthy human subjects measured by 13C-labeled octanoic acid breath test. J. Physiol. Paris 93, 455–460 (1999)

    Mózsik G. , 'Capsaicin increases gastric emptying rate in healthy human subjects measured by 13C-labeled octanoic acid breath test ' (1999 ) 93 J. Physiol. Paris : 455 -460.

    • Search Google Scholar
  • Declaration of Helsinki (1964) as revised in Tokyo (1975), Venice (1983), Hong Kong (1989), Somerset West, RSA (1996), and Edinbourgh, Scotland (2000) with the Note of Clarification on Paragraph 29, Washington (2002)

  • Donnerer J, Amann R, Schuligoi R, Lembeck F: Absorption and metabolism of capsaicinoids following intragastric administration in rats. Naunyn Schmiedebergs Arch. Pharmacol. 342, 357–361 (1990)

    Lembeck F. , 'Absorption and metabolism of capsaicinoids following intragastric administration in rats ' (1990 ) 342 Naunyn Schmiedebergs Arch. Pharmacol. : 357 -361.

    • Search Google Scholar
  • ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur. Heart. J. 33, 2569–2619 (2012)

  • de Gaetano G, Crescente M, Cerletti C: Current concepts about inhibition of platelet aggregation. Platelets 19, 565–570 (2008)

    Cerletti C. , 'Current concepts about inhibition of platelet aggregation ' (2008 ) 19 Platelets : 565 -570.

    • Search Google Scholar
  • García Rodríguez LA, Hernández-Díaz S, de Abajo FJ: Association between aspirin and upper gastrointestinal complications: Systematic review of epidemiologic studies. Br. J. Clin. Pharmacol. 52, 563–571 (2001)

    de Abajo F.J. , 'Association between aspirin and upper gastrointestinal complications: Systematic review of epidemiologic studies ' (2001 ) 52 Br. J. Clin. Pharmacol. : 563 -571.

    • Search Google Scholar
  • García Rodríguez LA, Jick H: Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs. Lancet 343, 769–772 (1994)

    Jick H. , 'Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs ' (1994 ) 343 Lancet : 769 -772.

    • Search Google Scholar
  • Harper AG, Brownlow SL, Sage SO: A role for TRPV1 in agonist-evoked activation of human platelets. J. Thromb. Haemost. 7, 330–338 (2009)

    Sage S.O. , 'A role for TRPV1 in agonist-evoked activation of human platelets ' (2009 ) 7 J. Thromb. Haemost. : 330 -338.

    • Search Google Scholar
  • Hayden M, Pignone M, Phillips C, Mulrow C: Aspirin for the primary prevention of cardiovascular events: A summary of the evidence for the U.S. preventive services task force. Ann. Intern. Med. 136, 161–172 (2002)

    Mulrow C. , 'Aspirin for the primary prevention of cardiovascular events: A summary of the evidence for the U.S. preventive services task force ' (2002 ) 136 Ann. Intern. Med. : 161 -172.

    • Search Google Scholar
  • Hernández-Díaz S, García Rodríguez LA: Incidence of serious upper gastrointestinal bleeding/perforation in the general population: Review of epidemiologic studies. J. Clin. Epidemiol. 55, 157–163 (2002)

    García Rodríguez L.A. , 'Incidence of serious upper gastrointestinal bleeding/perforation in the general population: Review of epidemiologic studies ' (2002 ) 55 J. Clin. Epidemiol. : 157 -163.

    • Search Google Scholar
  • Hogaboam CM, Wallace JL: Inhibition of platelet aggregation by capsaicin. An effect unrelated to actions on sensory afferent neurons. Eur. J. Pharmacol. 202, 129–131 (1991)

    Wallace J.L. , 'Inhibition of platelet aggregation by capsaicin. An effect unrelated to actions on sensory afferent neurons ' (1991 ) 202 Eur. J. Pharmacol. : 129 -131.

    • Search Google Scholar
  • Holzer P: Tachykinins as targets of gastroenterological pharmacotherapy. Drug News Perspect. 11, 394–401 (1998)

    Holzer P. , 'Tachykinins as targets of gastroenterological pharmacotherapy ' (1998 ) 11 Drug News Perspect. : 394 -401.

    • Search Google Scholar
  • Holzer P, Pabst MA: Visceral afferent neurons: Role in gastric mucosal protection. News Physiol. Sci. 14, 201–206 (1999)

    Pabst M.A. , 'Visceral afferent neurons: Role in gastric mucosal protection ' (1999 ) 14 News Physiol. Sci. : 201 -206.

    • Search Google Scholar
  • Jancsó N, Jancsó-Gábor A, Szolcsányi J: Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br. J. Pharmacol. 31, 138–151 (1967)

    Szolcsányi J. , 'Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin ' (1967 ) 31 Br. J. Pharmacol. : 138 -151.

    • Search Google Scholar
  • Jancsó N, Jancsó-Gábor A, Szolcsányi J: The role of sensory nerves endings in the neurogen inflammation induced in human skin and in the eye and paw of the rat. Br. J. Pharmacol. 33, 32–41 (1968)

    Szolcsányi J. , 'The role of sensory nerves endings in the neurogen inflammation induced in human skin and in the eye and paw of the rat ' (1968 ) 33 Br. J. Pharmacol. : 32 -41.

    • Search Google Scholar
  • Jancsó-Gábor A, Szolcsányi J, Jancsó N: Irreversible impairment of the irregulation induced by capsaicin and similar pungent substances in rat and guinea-pigs. J. Physiol. 206, 495–507 (1970)

    Jancsó N. , 'Irreversible impairment of the irregulation induced by capsaicin and similar pungent substances in rat and guinea-pigs ' (1970 ) 206 J. Physiol. : 495 -507.

    • Search Google Scholar
  • Kawada T, Suzuki T, Takahashi M, Iwai K: Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats. Toxicol. Appl. Pharmacol. 72, 449–456 (1984)

    Iwai K. , 'Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats ' (1984 ) 72 Toxicol. Appl. Pharmacol. : 449 -456.

    • Search Google Scholar
  • Koltai K, Feher G, Kenyeres P, Lenart I, Alexy T, Horvath B, Marton Z, Kesmarky G, Toth K: Relation of platelet aggregation and fibrinogen levels to advancing age in aspirin- and thienopyridine-treated patients. Clin. Hemorheol. Microcirc. 40, 295–302 (2008)

    Toth K. , 'Relation of platelet aggregation and fibrinogen levels to advancing age in aspirin- and thienopyridine-treated patients ' (2008 ) 40 Clin. Hemorheol. Microcirc. : 295 -302.

    • Search Google Scholar
  • Lanas A, Ferrández A: Treatment and prevention of aspirin induced gastroduodenal ulcers and gastrointestinal bleeding. Expert. Opin. Drug. Saf. 1, 245–252 (2002)

    Ferrández A. , 'Treatment and prevention of aspirin induced gastroduodenal ulcers and gastrointestinal bleeding ' (2002 ) 1 Expert. Opin. Drug. Saf. : 245 -252.

    • Search Google Scholar
  • Makara GB, Csalay L, Frenkl R, Somfai Z, Szepesházi K: Effect of capsaicin on the experimental ulcer in the rat. Acta Med. Sci. Hung. 21, 213–216 (1965)

    Szepesházi K. , 'Effect of capsaicin on the experimental ulcer in the rat ' (1965 ) 21 Acta Med. Sci. Hung. : 213 -216.

    • Search Google Scholar
  • Mózsik Gy, Dömötör A, Abdel-Salam OM: Molecular pharmacological approach to drug actions on the afferent and efferent fibres of the vagal nerve involved in gastric mucosal protection in rats. Inflammopharmacology 14, 243–249 (2006)

    Abdel-Salam O.M. , 'Molecular pharmacological approach to drug actions on the afferent and efferent fibres of the vagal nerve involved in gastric mucosal protection in rats ' (2006 ) 14 Inflammopharmacology : 243 -249.

    • Search Google Scholar
  • Mózsik Gy, Vincze A, Szolcsányi J: Four response stages of capsaicin-sensitive primary afferent neurons to capsaicin and its analog: gastric acid secretion, gastric mucosal damage and protection. J. Gastroenterol. Hepatol. 16, 1093–1097 (2001)

    Szolcsányi J. , 'Four response stages of capsaicin-sensitive primary afferent neurons to capsaicin and its analog: gastric acid secretion, gastric mucosal damage and protection ' (2001 ) 16 J. Gastroenterol. Hepatol. : 1093 -1097.

    • Search Google Scholar
  • Mózsik Gy, Debreceni A, Abdel-Salam OM, Szabó I, Figler M, Ludány A, Juricskay I, Szolcsányi J: Small doses capsaicin given intragastrically inhibit gastric secretion in healthy human subjects. J. Physiol. Paris. 93, 433–436 (1999)

    Szolcsányi J. , 'Small doses capsaicin given intragastrically inhibit gastric secretion in healthy human subjects ' (1999 ) 93 J. Physiol. Paris : 433 -436.

    • Search Google Scholar
  • Mózsik Gy, Dömötör A, Past T, Vas V, Perjési P, Kuzma M, (2009): Capsaicinoids: from the plant cultivation to the production of the human medical drug. Akadémiai Kiadó, Budapest

    Kuzma M. , '', in Capsaicinoids: from the plant cultivation to the production of the human medical drug , (2009 ) -.

  • Mózsik Gy, Rácz I, Szolcsányi J: Gastroprotection induced by capsaicin in healthy human subjects. World J. Gastroenterol. 11, 5180–5184 (2005)

    Szolcsányi J. , 'Gastroprotection induced by capsaicin in healthy human subjects ' (2005 ) 11 World J. Gastroenterol. : 5180 -5184.

    • Search Google Scholar
  • Mózsik Gy: Capsaicin is new orally applicable gastroprotective and new therapeutic drug alone or in combinations in human healthy subjects and patients. Prog Drug Res 68, 209–258 (2014)

    Mózsik G. , 'Capsaicin is new orally applicable gastroprotective and new therapeutic drug alone or in combinations in human healthy subjects and patients ' (2014 ) 68 Prog Drug Res : 209 -258.

    • Search Google Scholar
  • Okajima K, Harada N: Regulation of inflammatory responses by sensory neurons: molecular mechanism(s) and possible therapeutic applications. Curr. Med. Chem. 13, 2241–2251 (2006)

    Harada N. , 'Regulation of inflammatory responses by sensory neurons: molecular mechanism(s) and possible therapeutic applications ' (2006 ) 13 Curr. Med. Chem. : 2241 -2251.

    • Search Google Scholar
  • Patrono C, Coller B, Dalen JE, FitzGerald GA, Fuster V, Gent M, Hirsh J, Roth G: Platelet-active drugs: the relationships among dose, effectiveness, and side effects. Chest 119, 39–63 (2001)

    Roth G. , 'Platelet-active drugs: the relationships among dose, effectiveness, and side effects ' (2001 ) 119 Chest : 39 -63.

    • Search Google Scholar
  • Pintér E, Helyes Z, Szolcsányi J: Inhibitory effect of somatostatin on inflammation and nociception. Pharmacol. Ther. 112, 440–456 (2006)

    Szolcsányi J. , 'Inhibitory effect of somatostatin on inflammation and nociception ' (2006 ) 112 Pharmacol. Ther. : 440 -456.

    • Search Google Scholar
  • Sanmuganathan P, Ghahramani P, Jackson PR, Wallis EJ, Ramsay LE: Aspirin for primary prevention of coronary heart disease: safety and absolute benefit related to coronary risk derived from meta-analysis of randomised trials. Heart 85, 265–271 (2001)

    Ramsay L.E. , 'Aspirin for primary prevention of coronary heart disease: safety and absolute benefit related to coronary risk derived from meta-analysis of randomised trials ' (2001 ) 85 Heart : 265 -271.

    • Search Google Scholar
  • Sarlos P: Capsaicin prevents the indomethacin-induced gastric mucosal damage in human healthy subject. Gastroenterology 124 Suppl 1, A–511 (2003)

    Sarlos P. , 'Capsaicin prevents the indomethacin-induced gastric mucosal damage in human healthy subject ' (2003 ) 124 Gastroenterology : A -511.

    • Search Google Scholar
  • Seshasai SR, Wijesuriya S, Sivakumaran R, Nethercott S, Erqou S, Sattar N, Ray KK: Effect of aspirin on vascular and nonvascular outcomes: meta-analysis of randomized controlled trials. Arch. Intern. Med. 172, 209–216 (2012)

    Ray K.K. , 'Effect of aspirin on vascular and nonvascular outcomes: meta-analysis of randomized controlled trials ' (2012 ) 172 Arch. Intern. Med. : 209 -216.

    • Search Google Scholar
  • Smith SC Jr, Allen J, Blair SN, Bonow RO, Brass LM, Fonarow GC, Grundy SM, Hiratzka L, Jones D, Krumholz HM, Mosca L, Pasternak RC, Pearson T, Pfeffer MA, Taubert KA: AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute. Circ. 113, 2363–2372 (2006)

    Taubert K.A. , 'AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute ' (2006 ) 113 Circ. : 2363 -2372.

    • Search Google Scholar
  • Slattery J, Warlow CP, Shorrock CJ, Langman MJ: Risks of gastrointestinal bleeding during secondary prevention of vascular events with aspirin-analysis of gastrointestinal bleeding during the UK-TIA trial. Gut. 37, 509–511 (1995)

    Langman M.J. , 'Risks of gastrointestinal bleeding during secondary prevention of vascular events with aspirin-analysis of gastrointestinal bleeding during the UK-TIA trial ' (1995 ) 37 Gut. : 509 -511.

    • Search Google Scholar
  • Sylvester DM, LaHann TR: Effects of capsaicinoids on platelet aggregation. Proc. West. Pharmacol. Soc. 32, 95–100 (1989)

    LaHann T.R. , 'Effects of capsaicinoids on platelet aggregation ' (1989 ) 32 Proc. West. Pharmacol. Soc. : 95 -100.

    • Search Google Scholar
  • Szabó IL, Czimmer J, Szolcsányi J, Mózsik G: Molecular pharmacological approaches to effects of capsaicinoids and of classical antisecretory drugs on gastric basal acid secretion and on indomethacin-induced gastric mucosal damage in human healthy subjects (mini review). Curr. Pharm. Des. 19, 84–89 (2013)

    Mózsik G. , 'Molecular pharmacological approaches to effects of capsaicinoids and of classical antisecretory drugs on gastric basal acid secretion and on indomethacin-induced gastric mucosal damage in human healthy subjects (mini review) ' (2013 ) 19 Curr. Pharm. Des. : 84 -89.

    • Search Google Scholar
  • Szallasi A, Blumberg PM: Vanilloid (capsaicin) receptors and mechanisms. Pharmacol. Rev. 51, 159–212 (1999)

    Blumberg P.M. , 'Vanilloid (capsaicin) receptors and mechanisms ' (1999 ) 51 Pharmacol. Rev. : 159 -212.

    • Search Google Scholar
  • Szolcsányi J, Barthó L (1981): Impaired defence mechanisms to peptic ulcer in the capsaicin desensitized rat. In: Advances in Physiological Sciences. Gastrointestinal Defence Mechanisms, eds Mozsik Gy, Hänninen O, Jávor T, Pergamon Press, Oxford — Akadémiai Kiadó, Budapest, pp. 39–51

    Barthó L. , '', in Advances in Physiological Sciences. Gastrointestinal Defence Mechanisms , (1981 ) -.

  • Szolcsányi J (1984): Capsaicin-sensitive chemoceptive neural system with dual sensory-efferent function. In: Antidromic Vasodilatation and Neurogenic Inflammation, eds Chahl LA, Szolcsányi J, Lembech F, Akadémiai Kiadó, Budapest, pp. 27–56

    Szolcsányi J. , '', in Antidromic Vasodilatation and Neurogenic Inflammation , (1984 ) -.

  • Szolcsányi J (1985): Sensory receptors and the antinociceptive effect of capsaicin. In: Tachykinin Antagonists, eds Hakanson R, Sundler F, Elsevier Publishers, Amsterdam, pp. 45–54

    Szolcsányi J. , '', in Tachykinin Antagonists , (1985 ) -.

  • Szolcsányi J: A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain. J. Physiol. 73, 251–259 (1977)

    Szolcsányi J. , 'A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain ' (1977 ) 73 J. Physiol. : 251 -259.

    • Search Google Scholar
  • Wang JP, Hsu MF, Teng CM: Antiplatelet effect of capsaicin. Thromb. Res. 36, 497–507 (1984)

    Teng C.M. , 'Antiplatelet effect of capsaicin ' (1984 ) 36 Thromb. Res. : 497 -507.

  • Wilson P, D’Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB: Prediction of coronary heart disease using risk factor categories. Circ. 97, 1837–1847 (1998)

    Kannel W.B. , 'Prediction of coronary heart disease using risk factor categories ' (1998 ) 97 Circ. : 1837 -1847.

    • Search Google Scholar
  • Wolfe MM, Lichtenstein DR, Singh G: Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N. Engl. J. Med. 340, 1888–1899 (1999)

    Singh G. , 'Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs ' (1999 ) 340 N. Engl. J. Med. : 1888 -1899.

    • Search Google Scholar
  • Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, Bugiardini R, Crea F, Cuisset T, Di Mario C, Ferreira JR, Gersh BJ, Gitt AK, Hulot JS, Marx N, Opie LH, Pfisterer M, Prescott E, Ruschitzka F, Sabaté M, Senior R, Taggart DP, van der Wall EE, Vrints CJ, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Knuuti J, Valgimigli M, Bueno H, Claeys MJ, Donner-Banzhoff N, Erol C, Frank H, Funck-Brentano C, Gaemperli O, Gonzalez-Juanatey JR, Hamilos M, Hasdai D, Husted S, James SK, Kervinen K, Kolh P, Kristensen SD, Lancellotti P, Maggioni AP, Piepoli MF, Pries AR, Romeo F, Rydén L, Simoons ML, Sirnes PA, Steg PG, Timmis A, Wijns W, Windecker S, Yildirir A, Zamorano JL: 2013 ESC guidelines on the management of stable coronary artery disease: The Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur. Heart. J. 34, 2949–3003 (2013)

    Zamorano J.L. , '2013 ESC guidelines on the management of stable coronary artery disease: The Task Force on the management of stable coronary artery disease of the European Society of Cardiology ' (2013 ) 34 Eur. Heart. J. : 2949 -3003.

    • Search Google Scholar

The author instruction is available in PDF.

Please, download the file from HERE

Senior editors

Editor(s)-in-Chief: Rosivall, László

Honorary Editor(s)-in-Chief): Monos, Emil

Managing Editor(s): Bartha, Jenő; Berhidi, Anna

Co-editor(s): Koller, Ákos; Lénárd, László; Szénási, Gábor

Assistant Editor(s): G. Dörnyei (Budapest), Zs. Miklós (Budapest), Gy. Nádasy (Budapest)

Hungarian Editorial Board

      Benedek, György (Szeged)
      Benyó, Zoltán (Budapest)
      Boros, Mihály (Szeged)
      Chernoch, László (Debrecen)
      Détári, László (Budapest)
      Hamar, János (Budapest)
      Hantos, Zoltán (Szeged)
      Hunyady, László (Budapest)
      Imre, Sándor (Debrecen)
      Jancsó, Gábor (Szeged)
      Karádi, Zoltán (Pécs)
      Kovács, László (Debrecen)
      Palkovits, Miklós (Budapest)
      Papp, Gyula (Szeged)
      Pavlik, Gábor (Budapest)
      Spät, András (Budapest)
      Szabó, Gyula (Szeged)
      Szelényi, Zoltán (Pécs)
      Szolcsányi, János (Pécs)
      Szollár, Lajos (Budapest)
      Szücs, Géza (Debrecen)
      Telegdy, Gyula (Szeged)
      Toldi, József (Szeged)
      Tósaki, Árpád (Debrecen)

International Editorial Board

      R. Bauer (Jena)
      W. Benjelloun (Rabat)
      A. W. Cowley Jr. (Milwaukee)
      D. Djuric (Belgrade)
      C. Fry (London)
      S. Greenwald (London)
      O. Hänninen (Kuopio)
      H. G. Hinghofer-Szalkay (Graz)
      Th. Kenner (Graz)
      Gy. Kunos (Richmond)
      M. Mahmoudian (Tehran)
      T. Mano (Seki, Gifu)
      G. Navar (New Orleans)
      H. Nishino (Nagoya)
      O. Petersen (Liverpool)
      U. Pohl (Münich)
      R. S. Reneman (Maastricht)
      A. Romanovsky (Phoenix)
      G. M. Rubanyi (Richmond)
      T. Sakata (Oita)
      A. Siddiqui (Karachi)
      Cs. Szabo (Beverly)
      E. Vicaut (Paris)
      N. Westerhof (Amsterdam)
      L. F. Zhang (Xi'an)

Editorial Office:
Akadémiai Kiadó Zrt.
Prielle Kornélia u. 21–35, H-1117 Budapest, Hungary

Editorial Correspondence:
Acta Physiologica Hungarica
Semmelweis University, Faculty of Medicine Institute of Pathophysiology
Nagyvárad tér 4, H-1089 Budapest, Hungary
Phone/Fax: +36-1-2100-100
E-mail: aph@semmelweis-univ.hu

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • EMBASE/Excerpta Medica
  • Global Health
  • Index Copernicus
  • Index Medicus
  • Medline
  • Referativnyi Zhurnal
  • Science Citation Index Expanded
  • SCOPUS

 

Acta Physiologica Hungarica
Language English
Size  
Year of
Foundation
1950
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0231-424X (Print)
ISSN 1588-2683 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
May 2021 4 0 0
Jun 2021 0 1 1
Jul 2021 2 0 0
Aug 2021 2 0 0
Sep 2021 0 0 0
Oct 2021 7 0 0
Nov 2021 0 0 0