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  • 1 University of Belgrade Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine PO Box 38 11129 Belgrade Serbia
  • | 2 University of Belgrade Institute of Medical Physiology “Richard Burian”, Faculty of Medicine Belgrade Serbia
  • | 3 University of Belgrade Institute of Pathology, Faculty of Medicine Belgrade Serbia
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The present study was undertaken in order to examine transduction mechanism involved in the single application of 100 μM homocysteine (Hcy) on isolated rat femoral artery (RFA) rings equilibrated on the basal tone; to establish if a single application of 100 μM Hcy alters contractile effect of phenylephrine (Phe), or oppositely the relaxant effect of acetylcholine (ACh) or bradykinin (BK) after 60-min-long incubation of 100 μM Hcy; and finally to identify morphological changes on the vascular wall after a 24-h-long incubation of 100 μM Hcy. Hcy produced contractile response of intact RFA, which was increased after endothelial denudation, while decreased by urapidil (an α1 receptor blocker), nifedipine (a voltage-gated L-type Ca++ channel blocker) or indomethacin (a cyclooxygenase inhibitor). The initial RFA contraction evoked by Phe was further increased by the single addition of Hcy, which was not the case when ouabain (an inhibitor of Na+/K+-ATPase) was preincubated. After 60-min-long incubation of Hcy relaxant actions of ACh and BK were unaltered, equieffective and equipotent. A 24-h-long incubation of RFA rings with Hcy produced an impairment of vascular endothelium, expressed as a minor or more pronounced interruption of endothelial cells.

  • Abraham JM, Cho L: The homocysteine hypothesis: still relevant to the prevention and treatment of cardiovascular disease? Cleve. Clin. J. Med. 77, 911–918 (2010)

    Cho L. , 'The homocysteine hypothesis: still relevant to the prevention and treatment of cardiovascular disease? ' (2010 ) 77 Cleve. Clin. J. Med. : 911 -918.

    • Search Google Scholar
  • Cacciapuoti F: Hyper-homocysteinemia: a novel risk factor or a powerful marker for cardiovascular diseases? Pathogenetic and therapeutical uncertainties. J. Thromb. Thrombolysis 32, 82–88 (2011)

    Cacciapuoti F. , 'Hyper-homocysteinemia: a novel risk factor or a powerful marker for cardiovascular diseases? Pathogenetic and therapeutical uncertainties ' (2011 ) 32 J. Thromb. Thrombolysis : 82 -88.

    • Search Google Scholar
  • Can C, Erol A, Olukman M, Cinar MG, Ulker S: Vascular endothelial dysfunction in cyclosporine-treated rat aortas is not associated with serum total homocysteine levels. Transplant. Proc. 40, 3702–3706 (2008)

    Ulker S. , 'Vascular endothelial dysfunction in cyclosporine-treated rat aortas is not associated with serum total homocysteine levels ' (2008 ) 40 Transplant. Proc. : 3702 -3706.

    • Search Google Scholar
  • Chen C, Conklin BS, Ren Z, Zhong DS: Homocysteine decreases endothelium-dependent vasorelaxation in porcine arteries. J. Surg. Res. 102, 22–30 (2002)

    Zhong D.S. , 'Homocysteine decreases endothelium-dependent vasorelaxation in porcine arteries ' (2002 ) 102 J. Surg. Res. : 22 -30.

    • Search Google Scholar
  • Davel AP, Ceravolo GS, Wenceslau CF, Carvalho MH, Brum PC, Rossoni LV: Increased vascular contractility and oxidative stress in β2-adrenoceptor knockout mice: the role of NADPH oxidase. J. Vasc. Res. 49, 342–352 (2012)

    Rossoni L.V. , 'Increased vascular contractility and oxidative stress in β2-adrenoceptor knockout mice: the role of NADPH oxidase ' (2012 ) 49 J. Vasc. Res. : 342 -352.

    • Search Google Scholar
  • de Andrade CR, Tirapelli CR, Haddad R, Eberlin MN, Ramalho LN, Iyomasa MM, Uyemura SA, de Oliveira AM: Hyperhomocysteinemia induced by feeding rats diets rich in DL-homocysteine thiolactone promotes alterations on carotid reactivity independent of arterial structure. Vascul. Pharmacol. 51, 291–298 (2009)

    de Oliveira A.M. , 'Hyperhomocysteinemia induced by feeding rats diets rich in DL-homocysteine thiolactone promotes alterations on carotid reactivity independent of arterial structure ' (2009 ) 51 Vascul. Pharmacol. : 291 -298.

    • Search Google Scholar
  • Gokay S, Ciçek D, Müderrisoglu H: Hyperhomocysteinemia in a young woman presenting with acute myocardial infarction: Case report. Interv. Med. Appl. Sci. 5, 39–42 (2013)

    Müderrisoglu H. , 'Hyperhomocysteinemia in a young woman presenting with acute myocardial infarction: Case report ' (2013 ) 5 Interv. Med. Appl. Sci. : 39 -42.

    • Search Google Scholar
  • Hedayati N, Annambhotla S, Jiang J, Wang X, Chai H, Lin PH, Yao Q, Chen C: Growth hormone-releasing peptide ghrelin inhibits homocysteine-induced endothelial dysfunction in porcine coronary arteries and human endothelial cells. J. Vasc. Surg. 49, 199–207 (2009)

    Chen C. , 'Growth hormone-releasing peptide ghrelin inhibits homocysteine-induced endothelial dysfunction in porcine coronary arteries and human endothelial cells ' (2009 ) 49 J. Vasc. Surg. : 199 -207.

    • Search Google Scholar
  • Hucks D, Thuraisingham RC, Raftery MJ, Yaqoob MM: Homocysteine induced impairment of nitric oxide-dependent vasorelaxation is reversible by the superoxide dismutase mimetic TEMPOL. Nephrol. Dial. Transplant. 19, 1999–2005 (2004)

    Yaqoob M.M. , 'Homocysteine induced impairment of nitric oxide-dependent vasorelaxation is reversible by the superoxide dismutase mimetic TEMPOL ' (2004 ) 19 Nephrol. Dial. Transplant. : 1999 -2005.

    • Search Google Scholar
  • Kanagy NL, Mecca TE, Webb RC: Arachidonate metabolites and serotonin contraction of femoral arteries from DOCA-salt hypertensive rats. Blood Press. 5, 113–120 (1996)

    Webb R.C. , 'Arachidonate metabolites and serotonin contraction of femoral arteries from DOCA-salt hypertensive rats ' (1996 ) 5 Blood Press : 113 -120.

    • Search Google Scholar
  • Locsey L, Szegedi J, Dán A, Görögh S, Tóths E: Homocysteine and cystatin C level changes in haemodialysed patients and connection with cerebro- and cardiovascular complications. Acta Physiol. Hung. 88, 293–299 (2001)

    Tóths E. , 'Homocysteine and cystatin C level changes in haemodialysed patients and connection with cerebro- and cardiovascular complications ' (2001 ) 88 Acta Physiol. Hung. : 293 -299.

    • Search Google Scholar
  • Matté C, Durigon E, Stefanello FM, Cipriani F, Wajner M, Wyse AT: Folic acid pretreatment prevents the reduction of Na(+),K(+)-ATPase and butyrylcholinesterase activities in rats subjected to acute hyperhomocysteinemia. Int. J. Dev. Neurosci. 24, 3–8 (2006)

    Wyse A.T. , 'Folic acid pretreatment prevents the reduction of Na(+),K(+)-ATPase and butyrylcholinesterase activities in rats subjected to acute hyperhomocysteinemia ' (2006 ) 24 Int. J. Dev. Neurosci. : 3 -8.

    • Search Google Scholar
  • Miao CY, Villeneuve N, Brunel-Jacquemin C, Petit C, Guillaumin JP, Gransagne D, Briant C, Vilaine JP, Vanhoutte PM: Chronic mild hyperhomocysteinemia induces aortic endothelial dysfunction but does not elevate arterial pressure in rats. J. Vasc. Res. 42, 148–156 (2005)

    Vanhoutte P.M. , 'Chronic mild hyperhomocysteinemia induces aortic endothelial dysfunction but does not elevate arterial pressure in rats ' (2005 ) 42 J. Vasc. Res. : 148 -156.

    • Search Google Scholar
  • Miranda FJ, Alabadí JA, Lloréns S, Ruiz de Apodaca RF, Centeno JM, Alborch E: Diabetes-induced changes in endothelial mechanisms implicated in rabbit carotid arterial response to 5-hydroxytryptamine. Eur. J. Pharmacol. 401, 397–402 (2000)

    Alborch E. , 'Diabetes-induced changes in endothelial mechanisms implicated in rabbit carotid arterial response to 5-hydroxytryptamine ' (2000 ) 401 Eur. J. Pharmacol. : 397 -402.

    • Search Google Scholar
  • Mujumdar VS, Aru GM, Tyagi SC: Induction of oxidative stress by homocyst(e)ine impairs endothelial function. J. Cell Biochem. 82, 491–500 (2001)

    Tyagi S.C. , 'Induction of oxidative stress by homocyst(e)ine impairs endothelial function ' (2001 ) 82 J. Cell Biochem. : 491 -500.

    • Search Google Scholar
  • Okatani Y, Wakatsuki A, Reiter RJ: Protective effect of melatonin against homocysteine-induced vasoconstriction of human umbilical artery. Biochem. Biophys. Res. Commun. 277, 470–475 (2000)

    Reiter R.J. , 'Protective effect of melatonin against homocysteine-induced vasoconstriction of human umbilical artery ' (2000 ) 277 Biochem. Biophys. Res. Commun. : 470 -475.

    • Search Google Scholar
  • Okatani Y, Wakatsuki A, Reiter RJ: Melatonin counteracts potentiation by homocysteine of KCL-induced vasoconstriction in human umbilical artery: relation to calcium influx. Biochem. Biophys. Res. Commun. 280, 940–944 (2001)

    Reiter R.J. , 'Melatonin counteracts potentiation by homocysteine of KCL-induced vasoconstriction in human umbilical artery: relation to calcium influx ' (2001 ) 280 Biochem. Biophys. Res. Commun. : 940 -944.

    • Search Google Scholar
  • Omae T, Nagaoka T, Tanano I, Yoshida A: Homocysteine inhibition of endothelium-dependent nitric oxide-mediated dilation of porcine retinal arterioles via enhanced superoxide production. Invest. Ophthalmol. Vis. Sci. 28, 2288–2295 (2013)

    Yoshida A. , 'Homocysteine inhibition of endothelium-dependent nitric oxide-mediated dilation of porcine retinal arterioles via enhanced superoxide production ' (2013 ) 28 Invest. Ophthalmol. Vis. Sci. : 2288 -2295.

    • Search Google Scholar
  • Qiu LH, Xie XJ, Zhang BQ: Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation. Biol. Pharm. Bull. 33, 641–646 (2010)

    Zhang B.Q. , 'Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation ' (2010 ) 33 Biol. Pharm. Bull. : 641 -646.

    • Search Google Scholar
  • Quéré I, Hillaire-Buys D, Brunschwig C, Chapal J, Janbon C, Blayac JP, Petit P, Loubatières-Mariani MM: Effects of homocysteine on acetylcholine- and adenosine-induced vasodilatation of pancreatic vascular bed in rats. Br. J. Pharmacol. 122, 351–357 (1997)

    Loubatières-Mariani M.M. , 'Effects of homocysteine on acetylcholine- and adenosine-induced vasodilatation of pancreatic vascular bed in rats ' (1997 ) 122 Br. J. Pharmacol. : 351 -357.

    • Search Google Scholar
  • Radenković M (2012): The OECD principles of good laboratory practice and the current bioethics. In: Bioethics and Pharmacology: Ethics in Preclinical and Clinical Drug Development, eds Todorovic Z, Prostran M and Turza K, Transworld Research Network, pp. 43–50

    Radenković M. , '', in Bioethics and Pharmacology: Ethics in Preclinical and Clinical Drug Development , (2012 ) -.

  • Radenković M, Grbović L, Pešić S, Stojić D: Isolated rat inferior mesenteric artery response to adenosine: possible participation of Na+/K+-ATPase and potassium channels. Pharmacol. Rep. 57, 824–832 (2005)

    Stojić D. , 'Isolated rat inferior mesenteric artery response to adenosine: possible participation of Na+/K+-ATPase and potassium channels ' (2005 ) 57 Pharmacol. Rep. : 824 -832.

    • Search Google Scholar
  • Radenković M, Radunović N, Momcilov P, Grbović L: Altered response of human umbilical artery to 5-HT in gestational diabetic pregnancy. Pharmacol. Rep. 61, 520–528 (2009)

    Grbović L. , 'Altered response of human umbilical artery to 5-HT in gestational diabetic pregnancy ' (2009 ) 61 Pharmacol. Rep. : 520 -528.

    • Search Google Scholar
  • Radenković M, Stojanović M, Janković R, Topalović M, Stojiljković M: Combined contribution of endothelial relaxing autacoides in the rat femoral artery response to CPCA: an adenosine A2 receptor agonist. Scientific World Journal, 143818 (2012)

    Stojiljković M. , '', in Scientific World Journal , (2012 ) -.

  • Radenković M, Stojanović M, Potpara T, Prostran M: Therapeutic Approach in the Improvement of Endothelial Dysfunction: The Current State of the Art. BioMed Research International, 252158 (2013)

    Prostran M. , '', in BioMed Research International , (2013 ) -.

  • Radenković M, Stojanović M, Topalović M: Contribution of thromboxane A2 in rat common carotid artery response to serotonin. Sci. Pharm. 78, 435–443 (2010)

    Topalović M. , 'Contribution of thromboxane A2 in rat common carotid artery response to serotonin ' (2010 ) 78 Sci. Pharm. : 435 -443.

    • Search Google Scholar
  • Ramaswami G, Chai H, Yao Q, Lin PH, Lumsden AB, Chen C: Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J. Vasc. Surg. 40, 1216–1222 (2004)

    Chen C. , 'Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries ' (2004 ) 40 J. Vasc. Surg. : 1216 -1222.

    • Search Google Scholar
  • Rašić-Marković A, Stanojlović O, Hrnèić D, Krstić D, Colović M, Susić V, Radosavljević T, Djurić D: The activity of erythrocyte and brain Na+/K+ and Mg2+-ATPases in rats subjected to acute homocysteine and homocysteine thiolactone administration. Mol. Cell. Biochem. 327, 39–45 (2009)

    Djurić D. , 'The activity of erythrocyte and brain Na+/K+ and Mg2+-ATPases in rats subjected to acute homocysteine and homocysteine thiolactone administration ' (2009 ) 327 Mol. Cell. Biochem. : 39 -45.

    • Search Google Scholar
  • Seto SW, Lam HY, Lau WS, Au AL, Lam TY, Chim SS, Ngai SM, Chan SW, Leung TY, Yeung JH, Kong SK, Leung GP, Lee SM, Kwan YW: Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery. Eur. J. Pharmacol. 605, 129–137 (2009)

    Kwan Y.W. , 'Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery ' (2009 ) 605 Eur. J. Pharmacol. : 129 -137.

    • Search Google Scholar
  • Spencer TA, Chai H, Fu W, Ramaswami G, Cox MW, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C: Estrogen blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J. Surg. Res. 118, 83–90 (2004)

    Chen C. , 'Estrogen blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries ' (2004 ) 118 J. Surg. Res. : 83 -90.

    • Search Google Scholar
  • Steed MM, Tyagi SC: Mechanisms of cardiovascular remodeling in hyperhomocysteinemia. Antioxid. Redox. Signal. 15, 1927–1943 (2011)

    Tyagi S.C. , 'Mechanisms of cardiovascular remodeling in hyperhomocysteinemia ' (2011 ) 15 Antioxid. Redox. Signal. : 1927 -1943.

    • Search Google Scholar
  • Stojsic ZM, Stevanovic RM, Stojanovic MM, Stanojevic AD, Bacetic DT: Histological features of gastric cardia in adults: an autopsy study. J. Gastrointestin. Liver Dis. 20, 13–18 (2011)

    Bacetic D.T. , 'Histological features of gastric cardia in adults: an autopsy study ' (2011 ) 20 J. Gastrointestin. Liver Dis. : 13 -18.

    • Search Google Scholar
  • Tasatargil A, Sadan G, Golbasi I, Karasu E, Turkay C: Effects of short-term exposure to homocysteine on vascular responsiveness of human internal mammary artery. J. Cardiovasc. Pharmacol. 43, 692–697 (2004)

    Turkay C. , 'Effects of short-term exposure to homocysteine on vascular responsiveness of human internal mammary artery ' (2004 ) 43 J. Cardiovasc. Pharmacol. : 692 -697.

    • Search Google Scholar
  • Tasatargil A, Sadan G, Karasu E: Homocysteine-induced changes in vascular reactivity of guinea-pig pulmonary arteries: role of the oxidative stress and poly (ADP-ribose) polymerase activation. Pulm. Pharmacol. Ther. 20, 265–272 (2007)

    Karasu E. , 'Homocysteine-induced changes in vascular reactivity of guinea-pig pulmonary arteries: role of the oxidative stress and poly (ADP-ribose) polymerase activation ' (2007 ) 20 Pulm. Pharmacol. Ther. : 265 -272.

    • Search Google Scholar
  • Tyagi SC, Smiley LM, Mujumdar VS, Clonts B, Parker JL: Reduction-oxidation (Redox) and vascular tissue level of homocyst(e)ine in human coronary atherosclerotic lesions and role in extracellular matrix remodeling and vascular tone. Mol. Cell Biochem. 181, 107–116 (1998)

    Parker J.L. , 'Reduction-oxidation (Redox) and vascular tissue level of homocyst(e)ine in human coronary atherosclerotic lesions and role in extracellular matrix remodeling and vascular tone ' (1998 ) 181 Mol. Cell Biochem. : 107 -116.

    • Search Google Scholar
  • Ungvari Z, Koller A: Homocysteine reduces smooth muscle [Ca2+]i and constrictor responses of isolated arterioles. J. Cardiovasc. Pharmacol. 37, 705–712 (2001)

    Koller A. , 'Homocysteine reduces smooth muscle [Ca2+]i and constrictor responses of isolated arterioles ' (2001 ) 37 J. Cardiovasc. Pharmacol. : 705 -712.

    • Search Google Scholar
  • Ungvari Z, Pacher P, Rischák K, Szollár L, Koller A: Dysfunction of nitric oxide mediation in isolated rat arterioles with methionine diet-induced hyperhomocysteinemia. Arterioscler. Thromb. Vasc. Biol. 19, 1899–1904 (1999)

    Koller A. , 'Dysfunction of nitric oxide mediation in isolated rat arterioles with methionine diet-induced hyperhomocysteinemia ' (1999 ) 19 Arterioscler. Thromb. Vasc. Biol. : 1899 -1904.

    • Search Google Scholar
  • Vignini A, Nanetti L, Bacchetti T, Ferretti G, Curatola G, Mazzanti L: Modification induced by homocysteine and low-density lipoprotein on human aortic endothelial cells: an in vitro study. J. Clin. Endocrinol. Metab. 89, 4558–4561 (2004)

    Mazzanti L. , 'Modification induced by homocysteine and low-density lipoprotein on human aortic endothelial cells: an in vitro study ' (2004 ) 89 J. Clin. Endocrinol. Metab. : 4558 -4561.

    • Search Google Scholar
  • Viswanad B, Srinivasan K, Kaul CL, Ramarao P: Effect of tempol on altered angiotensin II and acetylcholine-mediated vascular responses in thoracic aorta isolated from rats with insulin resistance. Pharmacol. Res. 53, 209–215 (2006)

    Ramarao P. , 'Effect of tempol on altered angiotensin II and acetylcholine-mediated vascular responses in thoracic aorta isolated from rats with insulin resistance ' (2006 ) 53 Pharmacol. Res. : 209 -215.

    • Search Google Scholar
  • Yoshino J, Akata T, Shirozu K, Izumi K, Hoka S: Diabetes-associated alterations in volatile anesthetic actions on contractile response to norepinephrine in isolated mesenteric resistance arteries. Anesthesiology 112, 595–606 (2010)

    Hoka S. , 'Diabetes-associated alterations in volatile anesthetic actions on contractile response to norepinephrine in isolated mesenteric resistance arteries ' (2010 ) 112 Anesthesiology : 595 -606.

    • Search Google Scholar
  • Zhang D, Chen Y, Xie X, Liu J, Wang Q, Kong W, Zhu Y: Homocysteine activates vascular smooth muscle cells by DNA demethylation of platelet-derived growth factor in endothelial cells. J. Mol. Cell Cardiol. 53, 487–496 (2012)

    Zhu Y. , 'Homocysteine activates vascular smooth muscle cells by DNA demethylation of platelet-derived growth factor in endothelial cells ' (2012 ) 53 J. Mol. Cell Cardiol. : 487 -496.

    • Search Google Scholar
  • Zhang B, Qiu L, Fu M, Hu S: Interference in mevalonate pathway ameliorates homocysteine-induced endothelium-dysfunction. Eur. J. Pharmacol. 692, 61–68 (2012)

    Hu S. , 'Interference in mevalonate pathway ameliorates homocysteine-induced endothelium-dysfunction ' (2012 ) 692 Eur. J. Pharmacol. : 61 -68.

    • Search Google Scholar
  • Zhou W, Chai H, Courson A, Lin PH, Lumsden AB, Yao Q, Chen C: Ginkgolide A attenuates homocysteine-induced endothelial dysfunction in porcine coronary arteries. J. Vasc. Surg. 44, 853–862 (2006)

    Chen C. , 'Ginkgolide A attenuates homocysteine-induced endothelial dysfunction in porcine coronary arteries ' (2006 ) 44 J. Vasc. Surg. : 853 -862.

    • Search Google Scholar
  • Živković V, Jakovljević V, Djordjevic D, Vuletić M, Barudzić N, Djurić D: The effects of homocysteine-related compounds on cardiac contractility, coronary flow, and oxidative stress markers in isolated rat heart. Mol. Cell Biochem. 370, 59–67 (2012)

    Djurić D. , 'The effects of homocysteine-related compounds on cardiac contractility, coronary flow, and oxidative stress markers in isolated rat heart ' (2012 ) 370 Mol. Cell Biochem. : 59 -67.

    • Search Google Scholar

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Senior editors

Editor(s)-in-Chief: Rosivall, László

Honorary Editor(s)-in-Chief): Monos, Emil

Managing Editor(s): Bartha, Jenő; Berhidi, Anna

Co-editor(s): Koller, Ákos; Lénárd, László; Szénási, Gábor

Assistant Editor(s): G. Dörnyei (Budapest), Zs. Miklós (Budapest), Gy. Nádasy (Budapest)

Hungarian Editorial Board

    1. Benedek, György (Szeged)
    1. Benyó, Zoltán (Budapest)
    1. Boros, Mihály (Szeged)
    1. Chernoch, László (Debrecen)
    1. Détári, László (Budapest)
    1. Hamar, János (Budapest)
    1. Hantos, Zoltán (Szeged)
    1. Hunyady, László (Budapest)
    1. Imre, Sándor (Debrecen)
    1. Jancsó, Gábor (Szeged)
    1. Karádi, Zoltán (Pécs)
    1. Kovács, László (Debrecen)
    1. Palkovits, Miklós (Budapest)
    1. Papp, Gyula (Szeged)
    1. Pavlik, Gábor (Budapest)
    1. Spät, András (Budapest)
    1. Szabó, Gyula (Szeged)
    1. Szelényi, Zoltán (Pécs)
    1. Szolcsányi, János (Pécs)
    1. Szollár, Lajos (Budapest)
    1. Szücs, Géza (Debrecen)
    1. Telegdy, Gyula (Szeged)
    1. Toldi, József (Szeged)
    1. Tósaki, Árpád (Debrecen)

International Editorial Board

    1. R. Bauer (Jena)
    1. W. Benjelloun (Rabat)
    1. A. W. Cowley Jr. (Milwaukee)
    1. D. Djuric (Belgrade)
    1. C. Fry (London)
    1. S. Greenwald (London)
    1. O. Hänninen (Kuopio)
    1. H. G. Hinghofer-Szalkay (Graz)
    1. Th. Kenner (Graz)
    1. Gy. Kunos (Richmond)
    1. M. Mahmoudian (Tehran)
    1. T. Mano (Seki, Gifu)
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    1. O. Petersen (Liverpool)
    1. U. Pohl (Münich)
    1. R. S. Reneman (Maastricht)
    1. A. Romanovsky (Phoenix)
    1. G. M. Rubanyi (Richmond)
    1. T. Sakata (Oita)
    1. A. Siddiqui (Karachi)
    1. Cs. Szabo (Beverly)
    1. E. Vicaut (Paris)
    1. N. Westerhof (Amsterdam)
    1. L. F. Zhang (Xi'an)

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Acta Physiologica Hungarica
Language English
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1950
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Founder Magyar Tudományos Akadémia
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H-1051 Budapest, Hungary, Széchenyi István tér 9.
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H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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Chief Executive Officer, Akadémiai Kiadó
ISSN 0231-424X (Print)
ISSN 1588-2683 (Online)

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