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J. Simon
J. Simon
Department of Anesthesiology and Intensive Care, University of Szeged, Szeged, Hungary
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T. Farkas
T. Farkas
Department of Anesthesiology and Intensive Care, University of Szeged, Szeged, Hungary
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Z. Gingl
Z. Gingl
Department of Technical Informatics, University of Szeged, Szeged, Hungary
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A. Csillik
A. Csillik
Department of Anesthesiology and Intensive Care, University of Szeged, Szeged, Hungary
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A. Korsós
A. Korsós
Department of Anesthesiology and Intensive Care, University of Szeged, Szeged, Hungary
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L. Rudas
L. Rudas
Department of Anesthesiology and Intensive Care, University of Szeged, Szeged, Hungary
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É. Zöllei
É. Zöllei
Department of Anesthesiology and Intensive Care, University of Szeged, Szeged, Hungary
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Acute, severe hypovolemia is a medical emergency. Traditional vital sign parameters allow no optimal triage. High predictive power of finger plethysmography-based stroke volume (SV) and pulse pressure (PP) was recently suggested. To assess the performance of the PP and SV parameters, lower body negative pressure of −40 mmHg, than −60 mmHg — corresponding to moderate and severe central hypovolemia — was applied in 22 healthy males (age 35 ± 7 years). Slow breathing induced fluctuations in the above indices, characterized by stroke volume variability (SVV), and pulse pressure variability (PPV), were assessed. Responses in heart rate (HR) and shock index (SI) were also studied. Discriminative capacity of these parameters was characterized by the area under the ROC (receiver operating characteristic) curves (AUC).
Results
In comparison of baseline to severe central hypovolemia SV, PP, HR and SI showed good discriminating capacity (AUC 99%, 88%, 87% and 93%, respectively). The discriminating capacity of SVV and PPV was poor (77% and 70%, respectively). In comparison of moderate and severe hypovolemia, the discriminating capacity of the studied parameters was uniformly limited.
Conclusions
Plethysmography-based SV and PP parameters can be used to detect acute severe volume loss. Sensitive parameters discriminating moderate and severe central hypovolemia are still lacking.
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