Authors:
H.A. Malek Clinical Pharmacology Department, Mansoura University, Faculty of Medicine, Mansoura, Egypt

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A. Shalaby Clinical Pharmacology Department, Mansoura University, Faculty of Medicine, Mansoura, Egypt

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A β3 adrenoceptor agonist plays an important regulatory role in stimulation of thermogenesis and lipolysis and it appears to have anti-ulcer and spasmolytic effects. So the present aim was to examine the effect of BRL 37344 (a selective B3 adrenoceptor agonist) on reflux esophagitis.

Methods

Forty-eight rats were divided into twelve sham-operated rats and thirty-six rats with induced reflux esophagitis (RE), which were divided into either RE alone or pretreated with BRL 37344 and/or omeprazole with or without indomethacin. RE was induced in rats, then gastric acid output, pH, plasma nitric oxide (NO), esophageal PGE2, malondialdehyde (MDA) and reduced glutathione (GSH) were measured and the esophageal injury was assessed by macroscopic damage score.

Results

Pretreatment with BRL significantly increased plasma NO, GSH, decreased acid output, esophageal MDA and esophageal injury in comparison to pretreatment. In addition, there was a no significant increase in esophageal PGE2.

Conclusion

It can be concluded that BRL 37344 has an anti-oxidant protective effect in rats with RE.

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Senior editors

Editor(s)-in-Chief: Rosivall, László

Honorary Editor(s)-in-Chief): Monos, Emil

Managing Editor(s): Bartha, Jenő; Berhidi, Anna

Co-editor(s): Koller, Ákos; Lénárd, László; Szénási, Gábor

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Acta Physiologica Hungarica
Language English
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1950
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