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  • 1 Pavlov Institute of Physiology Russian Academy of Sciences, St. Petersburg, Russia
  • 2 Almazov Federal Heart, Blood and Endocrinology Centre, St. Petersburg, Russia
  • 3 Institute of Medical Physiology “Richard Burian” Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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Homocysteine thiolactone was demonstrated to inhibit the growth of 10–12-day-old chicken embryo cardiac tissue explants at 7 × 10−9 −1 × 10−3 M concentrations in a dose-dependent manner. The maximal cardiotoxic effect of homocysteine thiolactone was detected at 1 × 10−3 M, which corresponds to severe hyperhomocysteinemia. The results of experiments on culturing of cardiac tissue explants in the medium containing homocysteine thiolactone (1 × 10−3 M) and ouabain at concentrations regulating the signal-transducing (1 × 10−10 M) and pumping (1 × 10−8 M) functions of Na+,K+ -ATPase indicate that the cardiotoxic effect of homocysteine thiolactone is supposed to result from inhibition of the Na+,K+ -ATPase pumping function.

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  • Physiology (Medical) Quartile score (2016): Q4
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