Author: Janos Varga MD, PhD
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  • National Koranyi Institute for TB and Pulmonology, Budapest, Hungary
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Expiratory flow limitation can develop in parallel with the progression of COPD, and as a consequence, dynamic hyperinflation and lung mechanical abnormalities can develop. Dynamic hyperinflation can cause increased breathlessness and reduction in exercise tolerance. Achievement of critical inspiratory reserve volume is one of the main factors in exercise intolerance. Obesity has specific lung mechanical effects. There is also a difference concerning gender and dyspnoea. Increased nerve activity is characteristic in hyperinflation. Bronchodilator therapy, lung volume reduction surgery, endurance training at submaximal intensity, and heliox or oxygen breathing can decrease the degree of dynamic hyperinflation.

  • 1.

    Almeida P, Rodrigues F: Exercise training modalities and strategies to improve exercise performance in patients with respiratory disease. Rev. Port. Pneumol. 20(1), 3641 (2014)

    • Search Google Scholar
    • Export Citation
  • 2.

    Baraldo, Turato G, Saetta M: Pathophysiology of the small airways in chronic obstructive pulmonary disease. Respiration 84(2), 8997 (2012)

    • Search Google Scholar
    • Export Citation
  • 3.

    Beeh KM, Singh D, Di Scala L, Drollmann A: Once-daily NVA237 improves exercise tolerance from the first dose in patients with COPD: the GLOW3 trial. Int. J. Chron. Obstruct. Pulmon. Dis. 7, 503513 (2012)

    • Search Google Scholar
    • Export Citation
  • 4.

    Beeh KM, Wagner F, Khindri S, Drollmann AF: Effect of indacaterol on dynamic lung hyperinflation and breathlessness in hyperinflated patients with COPD. COPD 8(5), 340345 (2011)

    • Search Google Scholar
    • Export Citation
  • 5.

    Binazzi B, Lanini B, Gigliotti F, Scano G: Breathing pattern and chest wall kinematics during phonation in chronic obstructive pulmonary disease patients. Respiration 86(6), 462471 (2013)

    • Search Google Scholar
    • Export Citation
  • 6.

    Casaburi R, Porszasz J: Reduction of hyperinflation by pharmacologic and other interventions. Proc. Am. Thorac. Soc. 3(2), 185189 (2006)

    • Search Google Scholar
    • Export Citation
  • 7.

    Cooper CB: The connection between chronic obstructive pulmonary disease symptoms and hyperinflation and its impact on exercise and function. Am. J. Med. 119 (10 Suppl 1), 2131 (2006)

    • Search Google Scholar
    • Export Citation
  • 8.

    Gosselink R: Breathing techniques in patients with chronic obstructive pulmonary disease COPD). Chron. Respir. Dis. 1(3), 163172 (2004)

    • Search Google Scholar
    • Export Citation
  • 9.

    Guenette JA, Jensen D, Webb KA, Ofir D, Raghavan N, O’Donnell DE: Sex differences in exertional dypnea in patients with mild COPD: physiological mechanisms. Respir. Physiol. Neurobiol. 177(3), 218227 (2011)

    • Search Google Scholar
    • Export Citation
  • 10.

    Guenette JA, Webb KA, O’Donnell DE: Does dynamic hyperinflation contribute to dyspnoea during exercise in patients with COPD? Eur. Respir. J. 40(2), 322329 (2012)

    • Search Google Scholar
    • Export Citation
  • 11.

    Guenette JA, Jensen D, O’Donnell DE: Respiratory function and the obesity paradox. Curr. Opin. Clin. Nutr. Metab. Care 13(6), 618624 (2010)

    • Search Google Scholar
    • Export Citation
  • 12.

    Harms CA: Does gender affect on pulmonary function and exercise capacity? Respir. Physiol. Neurobiol. 151(2–3), 124131 (2006)

  • 13.

    Hsieh MJ, Lan CC, Chen NH, Huang CC, Wu YK, Cho HY, Tsai YH: Effects of high-intensity exercise training in a pulmonary rehabilitation programme for patients with chronic obstructive pulmonary disease. Respirology 12(3), 381388 (2007)

    • Search Google Scholar
    • Export Citation
  • 14.

    Kilbride E, McLoughlin P, Gallagher CG, Harty HR: Do gender differences exist in the ventilatory response to progressive exercise in males and females of average fitness? Eur. J. Appl. Physiol. 6, 595602 (2003)

    • Search Google Scholar
    • Export Citation
  • 15.

    Lahaije AJ, van Helvoort HA, Dekhuijzen PN, Vercoulen JH, Heijdra YF: Resting and ADL-induced dynamic hyperinflation explain physical inactivity in COPD better than FEV1. Respir. Med. 107(6), 834840 (2013)

    • Search Google Scholar
    • Export Citation
  • 16.

    Lammi MR, Ciccolella D, Marchetti N, Kohler M, Criner GJ: Increased oxygen pulse after lung volume reduction surgery is associated with educed dynamic hyperinflation. Eur. Respir. J. 40(4), 837843 (2012)

    • Search Google Scholar
    • Export Citation
  • 17.

    Laveneziana P, Valli G, Onorati P, Paoletti P, Ferrazza AM, Palange P: Effect of heliox on heart rate kinetics and dynamic hyperinflation during high-intensity exercise in COPD. Eur. J. Appl. Physiol. 111(2), 225234 (2012)

    • Search Google Scholar
    • Export Citation
  • 18.

    Laveneziana P, Guenette JA, Webb KA, O’Donnell DE: New physiological insights into dyspnea and exercise intolerance in chronic obstructive pulmonary disease patients. Expert. Rev. Respir. Med. 6(6), 651662 (2012)

    • Search Google Scholar
    • Export Citation
  • 19.

    Louvaris Z, Zakynthinos S, Aliverti A, Habazettl H, Vasilopoulou M, Andrianopoulos V, Wagner H, Wagner P, Vogiatzis I: Heliox increases quadriceps muscle oxygen delivery during exercise in COPD patients with and without dynamic hyperinflation. J. Appl. Physiol. 113(7), 10121023 (2012)

    • Search Google Scholar
    • Export Citation
  • 20.

    Maltais F, Celli B, Casaburi R, Porszasz J, Jarreta D, Seoane B, Caracta C: Aclimidium bromide improves exercise endurance and lung hyperinflation in patients with moderate to severe COPD. Respir. Med. 105(4), 580587 (2011)

    • Search Google Scholar
    • Export Citation
  • 21.

    Martin C, Frija J, Burgel PR: Dysfunctional lung anatomy and small airways degeneration in COPD. Int. J. Chron. Obstruct. Pulmon. Dis. 8, 713 (2013)

    • Search Google Scholar
    • Export Citation
  • 22.

    Ma S, Hecht A, Varga J, Rambod M, Morford S, Goto S, Casaburi R, Porszasz J: Breath-by-breath quantification of progressive airflow limitation during exercise in COPD: a new method. Respir. Med. 104(3), 389396 (2010)

    • Search Google Scholar
    • Export Citation
  • 23.

    McCloskey DI (1981): Corollary discharges: motor commands and perception. In: Handbook of Physiology, Section 1 the Nervous System, Volume I Cellular Biology of Neurons, Part 2, eds Brookhart JM, Mountcastle VB, Bethesda, American Physiology Society, pp. 14151417

    • Search Google Scholar
    • Export Citation
  • 24.

    Nissel O: The respiratory work and pressure during exercise, and their relation to dyspnea. Acta Med. Scan. 166(2), 113119 (1960)

  • 25.

    O’Connell JM, Campbell AH: Respiratory mechanics in airways obstruction associated with inspiratory dyspnea. Thorax 31(6), 669677 (1976)

    • Search Google Scholar
    • Export Citation
  • 26.

    O’Donnell DE, Hamilton AL, Webb KA: Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD. J. Appl. Physiol. 101(4), 10251035 (2006)

    • Search Google Scholar
    • Export Citation
  • 27.

    O’Donnell DE, Voduc N, Fitzpatrick M, Webb KA: Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease. Eur. Respir. J. 24(1), 8694 (2004)

    • Search Google Scholar
    • Export Citation
  • 28.

    O’Donnell DE, Webb KA: Exertional breathlessness in patients with chronic airflow limitation. The role of lung hyperinflation. Am. Rev. Respir. Dis. 148(5), 13511357 (1993)

    • Search Google Scholar
    • Export Citation
  • 29.

    O’Donnell DE, Webb KA: The major limitation to exercise performance in COPD is dynamic hyperinflation. J. Appl. Physiol. 105(2), 753755 (2008)

    • Search Google Scholar
    • Export Citation
  • 30.

    Oliveira MF, Rodrigues MK, Treptow E, Cunha TM, Ferreira EMV, Neder JA: Effects of oxygen supplementation on cerebral oxygenation during exercise in chronic obstructive pulmonary disease patients not entitled to long-term oxygen therapy. Clin. Physiol. Funct. Imaging 32(1), 5258 (2012)

    • Search Google Scholar
    • Export Citation
  • 31.

    Ora J, Laveneziana P, Wadell K, Preston M, Webb KA, O’Donnell DE: Effect of obesity on respiratory mechanics during rest and exercise in COPD. J. Appl. Physiol. 111(1), 1019 (2011)

    • Search Google Scholar
    • Export Citation
  • 32.

    Petrovic M, Reiter M, Zipko H, Pohl W, Wanke T: Effects of inspiratory muscle training on dynamic hyperinflation in patients with COPD. Int. J. Chron. Obstruct. Pulmon. Dis. 7, 797805 (2012)

    • Search Google Scholar
    • Export Citation
  • 33.

    Porszasz J, Emtner M, Goto S, Somfay A, Whipp BJ, Casaburi R: Exercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPD. Chest 128(4), 20252034 (2005)

    • Search Google Scholar
    • Export Citation
  • 34.

    Puente-Mastu L, Stringer WW: Hyperinflation and its management in COPD. Int. J. Chron. Obstruct. Pulmon. Dis. 1(4), 381400 (2006)

  • 35.

    Richter MJ, Voswinkel R, Tiede H, Seeger W, Schulz R, Ghofrani HA, Reichenberger F: [Dynamic hyperinflation in pulmonary arterial hypertension: “hyperinflator” and “non-hyperinflator”]. Pneumologie 67(5), 280287 (2012)

    • Search Google Scholar
    • Export Citation
  • 36.

    Sheel AW, Romer LM: Ventilation and respiratory mechanics. Compr. Physiol. 2, 10931142 (2012)

  • 37.

    Similowski T, Derenne JP: Inspiratory muscle testing in stable COPD patients. Eur. Respir. J. 7(10), 18711876 (1994)

  • 38.

    Somfay A, Porszasz J, Lee SM, Casaburi R: Dose-response effect of oxygen on hyperinflation and exercise endurance in nonhypoxaemic COPD patients. Eur. Respir. J. 18(1), 7784 (2001)

    • Search Google Scholar
    • Export Citation
  • 39.

    Somfay A, Porszasz J, Lee SM, Casaburi R: Effect of hyperoxia on gas exchange and lactate kinetics following exercise onset in nonhypoxemic COPD patients. Chest 121(2), 393400 (2002)

    • Search Google Scholar
    • Export Citation
  • 40.

    Sorli J, Grassino A, Lorange G, Milic-Emili J: Control of breathing in patients with chronic obstructive lung disease. Clin. Sci. Mol. Med. 54(3), 295304 (1978)

    • Search Google Scholar
    • Export Citation
  • 41.

    Spurzem JR, Rennard SI: Pathogenesis of COPD. Semin. Respir. Crit. Care Med. 26(2), 142153 (2005)

  • 42.

    Tantucci C: Expiratory flow limitation definition, mechanisms, methods, and significance. Pulm. Med. 2013, 749860 (2013)

  • 43.

    Uldry C, Janssens JP, de Muralt B, Fitting JW: Sniff nasal inspiratory pressure in patients with chronic obstructive pulmonary disease. Eur. Respir. J. 10(6), 12921296 (1997)

    • Search Google Scholar
    • Export Citation
  • 44.

    Varga J, Shuyi M, Hecht A, Hsia D, Casaburi R, Porszasz J: Detection of dynamic airway compression during exercise in COPD by breath by breath analysis of spontaneous flow-volume lLoops. ERS Supplement: 204s:P1224 (2006)

    • Search Google Scholar
    • Export Citation
  • 45.

    West: (2005): Respiratory physiology: the essentials. MD: Lippincott Williams & Wilkins, Hagerstown, pp. 5160

  • 46.

    Wilkens H, Weingard B, Lo Mauro A, Schena E, Pedotti A, Sybrecht GW, Aliveri A: Breathing pattern and chest wall volumes during exercise in patients with cystic fibrosis, pulmonary fibrosis and COPD before and after lung transplantation. Thorax 65(9), 808814 (2010)

    • Search Google Scholar
    • Export Citation
  • 47.

    Zafar MA, Tsuang W, Lach L, Eschenbacher W, Panos RJ: Dynamic hyperinflation correlates with exertional oxygen desaturation in patients with chronic obstructive pulmonary disease. Lung 191(2), 177182 (2013)

    • Search Google Scholar
    • Export Citation
  • 48.

    Yan S: Sensation of inspiratory difficulty during inspiratory threshold and hyperinflationary loadings. Effect of inspiratory muscle strength. Am. J. Respir. Crit. Care Med. 160(5 Pt 1), 15441549 (1999)

    • Search Google Scholar
    • Export Citation

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