Our previous studies have indicated that nitric oxide takes part in the basal regulation of vascular tone in skeletal muscle. The purpose of this study was to investigate whether nitric oxide has a role in the active hyperaemic response of a working muscle in a resting subject. Haemodynamic effects of nitric oxide synthase (NOS) inhibition (L-NAME, 10 mg/kg/30 min iv. infusion) were determined simultaneously in the resting m. quadriceps femoris and in the working (breathing) m. rectus abdominis in anaesthetised rats ( 86Rb accumulation technique). L-NAME increased blood pressure and total peripheral resistance (TPR) while it decreased cardiac output. Blood flow (BF) decreased and vascular resistance (VR) increased both in resting (BF: 8.91±1.97®5.92±2.59 ml/min/100 g, p<0.05; VR: 106±29.9®212±113 R, p<0.01) and working (BF: 17.0±4.78®6.93±2.15 ml/min/100g, p<0.001; VR: 57.0±18.5®160±56.7 R, p<0.01) muscle following NOS inhibition, but the percentile change of BF was higher in the working muscle (59%) than in the resting one (34%, p0.001). There was a positive correlation between the cardiac output and the blood flow of the resting muscle with or without L-NAME administration, but blood flow of the working muscle failed to have any correlation with the cardiac output in control animals. However, L-NAME administration decreased both the cardiac output and the blood flow and similarly to the resting muscle a positive correlation was found. In conclusion, the haemodynamic effects of NOS inhibition are higher in working muscle than in the resting one: the nitric oxide may have important role in vasodilatation during muscle activity. _a
Våg, J., Hably, Cs., Csabai, Zs., Tost, H., Bartha, J., Fazekas, Á.: Blood flow of the submandibular gland in sodium-depleted and loaded rats: effect of nitric oxide synthase inhibition. Res Exp Med 198, 101-108 (1998).
'Blood flow of the submandibular gland in sodium-depleted and loaded rats: effect of nitric oxide synthase inhibition.' () 198Res Exp Med: 101-108.
Blood flow of the submandibular gland in sodium-depleted and loaded rats: effect of nitric oxide synthase inhibition.Res Exp Med198101108)| false
Skinner, M.R., Marshall, J.M.: Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia. J Physiol Lond 495(Pt2), 553-560 (1996).
'Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia.' () 495J Physiol Lond: 553-560.
Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia.J Physiol Lond495553560)| false
Co-editor(s): Koller, Ákos; Lénárd, László; Szénási, Gábor
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