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  • 1 Department of Physiology, Trinity College Dublin, Ireland and Department of Leukocyte Biology Imperial College School of Medicine, London, UK
  • 2 Department of Physiology, Trinity College Dublin, Ireland and Department of Leukocyte Biology Imperial College School of Medicine, London, UK
  • 3 Department of Physiology Dublin 2, Trinity College, Ireland
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The attenuation of baroreflex gain associated with hereditary hypertension couldinvolve abnormal signalling by nitric oxide or substance P. Baroreflex gain was measured in age-matched male genetically hypertensive (GH) and normotensive (N) anaesthetised rats from heart rate changes in response to i.v. phenylephrine or sodium nitroprusside. In subgroups of these animals, nitric oxide synthesis was inhibited using NG-nitro-L-arginine methyl ester (L-NAME, 30 mg.

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