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  • 1 S.V. Anichkov Department of Neuropharmacology; Institute of Experimental Medicine of the Russian Academy of Medical Sciences 197376 St. Petersburg, Pavlov Street 12, Russia
  • 2 Neurophysiology Research Group of the Hungarian Academy of Sciences at Institute of Physiology Pécs University Medical School, Pécs, Hungary
  • 3 Neurophysiology Research Group of the Hungarian Academy of Sciences at Institute of Physiology Pécs University Medical School, Pécs, Hungary
  • 4 Institute of Experimental Medicine of the Russian Academy of Medical Sciences St. Petersburg, Russia
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The influence of chronic administration of 5??1? receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and 5-??1? receptor antagonist NAN-190 (0.1 mg/kg, i.p.) injected for 14 days alone or in combination with 17õ-estradiol (0.5 õg i.m./rat/day) was studied on passive avoidance performance (PAR) and on behavior in the open field test in adult intact and ovariectomized (OVX) female rats. Administration of 5-??1? receptor antagonist NAN-190 alone significantly improved PAR (p<0.05) in intact females with proestrus and estrus and in OVX females. Administration of 5-??1? receptor agonist 8-OH-DPAT alone or in combination with 17Ã-estradiol significantly (p<0.05) improved PAR in OVX rats and failed to normalize PAR in intact rats with proestrus and estrus. Results of the work specify the involvement of 5-??1? receptors in the mechanisms of passive avoidance learning in OVX female rats.

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