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  • 1 Laboratory of Circulation Pavlov Institute of Physiology 199034 St. Petersburg, Nab. Makarova 6, Russia
  • 2 Laboratory of Circulation, Pavlov Institute of Physiology 199034 St. Petersburg, Nab. Makarova 6, Russia
  • 3 Laboratory of Circulation, Pavlov Institute of Physiology 199034 St. Petersburg, Nab. Makarova 6, Russia
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The effect of melatonin on neurogenic reactivity of the juvenile rat tail artery segment was studied. The electrical field stimulation-evoked contraction of the segment decreased in the course of the experiment. Melatonin (0.1 µM) applied at different time points of the experiment produced an increase in the contraction, which directly correlated with a spontaneous decrease in the electrical field stimulation-evoked response. The increase in the potentiating effect of melatonin in the course of the experiment was not due to sensitization of the segment to this substance. Noradrenaline-evoked contraction of the vessel segment was not changed by melatonin. The data indicate that melatonin restores the diminished neurogenic reactivity of the juvenile rat tail artery probably by potentiation of the contractile response of the vessel, but this effect is hardly due to a change in sensitivity of the postjunctional membrane to noradrenaline.

  • Geary GG, Duckles SP, Krause DN: Effect of melatonin in the rat tail artery: role of K+ channels and endothelial factors. Br. J. Pharmacol. 123, 1533-1540 (1998)

    'Effect of melatonin in the rat tail artery: role of K+ channels and endothelial factors ' () 123 Br. J. Pharmacol. : 1533 -1540.

    • Search Google Scholar
  • Geary GG, Krause DN, Duckles SP: Melatonin directly constricts rat cerebral arteries through modulation of potassium channels. Am. J. Physiol. 273, H1530-H1536 (1997)

    'Melatonin directly constricts rat cerebral arteries through modulation of potassium channels ' () 273 Am. J. Physiol. : H1530 -H1536.

    • Search Google Scholar
  • Krause DN, Barrios VE, Duckles SP: Melatonin receptors mediate potentiation of contractile responses to adrenergic nerve stimulation in rat caudal artery. Eur. J. Pharmacol. 276, 207-213 (1995)

    'Melatonin receptors mediate potentiation of contractile responses to adrenergic nerve stimulation in rat caudal artery ' () 276 Eur. J. Pharmacol. : 207 -213.

    • Search Google Scholar
  • Krause DN, Dubocovich ML: Melatonin receptors. Annu. Rev. Pharmacol. Toxicol. 31, 549-568 (1991)

    'Melatonin receptors ' () 31 Annu. Rev. Pharmacol. Toxicol. : 549 -568.

  • Ting KN, Dunn WR, Da vies DJ, Sugden D, Delagrange P, Guardiola-Lemaitre B, Scalbert E, Wilson VG: Studies on the vasoconstrictor action of melatonin and putative melatonin receptor ligands in the tail artery of juvenile Wistar rats. Br. J. Pharmacol. 122, 1299-1306 (1997)

    'Studies on the vasoconstrictor action of melatonin and putative melatonin receptor ligands in the tail artery of juvenile Wistar rats ' () 122 Br. J. Pharmacol. : 1299 -1306.

    • Search Google Scholar
  • Vandeputte C, Giummelly P, Atkinson J, Delagrange P, Scalbert E, Capdeville-Atkinson C: Melatonin potentiates NE-induced vasoconstriction without augmenting cytosolic calcium concentration. Am. J. Physiol. 280, H420-H425 (2001)

    'Melatonin potentiates NE-induced vasoconstriction without augmenting cytosolic calcium concentration ' () 280 Am. J. Physiol. : H420 -H425.

    • Search Google Scholar
  • Dvoretsky DP, Yartsev VN, Karachentseva OV, Granstrem MP: Changes in reactivity of rat arteries subjected to dynamic stretch. Acta Physiol. Scand. 169, 13-20 (2000)

    'Changes in reactivity of rat arteries subjected to dynamic stretch ' () 169 Acta Physiol. Scand. : 13 -20.

    • Search Google Scholar
  • Evans BK, Mason R, Wilson VG: Evidence for direct vasoconstrictor activity of melatonin in “pressurized” segments of isolated caudal artery from juvenile rats. Naunyn Schmiedebergs Arch. Pharmacol. 346, 362-365 (1992)

    'Evidence for direct vasoconstrictor activity of melatonin in “pressurized” segments of isolated caudal artery from juvenile rats ' () 346 Naunyn Schmiedebergs Arch. Pharmacol. : 362 -365.

    • Search Google Scholar
  • Viswanathan M, Laitinen JT, Saavedra JM: Expression of melatonin receptors in arteries involved in thermoregulation. Proc. Natl. Acad. Sci. USA. 87, 6200-6203 (1990)

    'Expression of melatonin receptors in arteries involved in thermoregulation ' () 87 Proc. Natl. Acad. Sci. USA. : 6200 -6203.

    • Search Google Scholar
  • Viswanathan M, Laitinen JT, Saavedra JM: Differential expression of melatonin receptors in spontaneously hypertensive rats. Neuroendocrinology 56, 864-870 (1992)

    'Differential expression of melatonin receptors in spontaneously hypertensive rats ' () 56 Neuroendocrinology : 864 -870.

    • Search Google Scholar
  • Viswanathan M, Scalbert E, Delagrange P, Guardiola-Lemaitre B, Saavedra JM: Melatonin receptors mediate contraction of a rat cerebral artery. Neuroreport 8, 3847-3849 (1997)

    'Melatonin receptors mediate contraction of a rat cerebral artery ' () 8 Neuroreport : 3847 -3849.

    • Search Google Scholar
  • Weekley LB: Melatonin-induced relaxation of rat aorta: interaction with adrenergic agonists. J. Pineal. Res. 11, 28-34(1991)

    'Melatonin-induced relaxation of rat aorta: interaction with adrenergic agonists ' () 11 J. Pineal. Res. : 28 -34.

    • Search Google Scholar
  • O'Leary DS, Johnson JM, Taylor WF: Mode of neural control mediating rat tail vasodilation during heating. J. Appl. Physiol. 59, 1533-1538 (1985)

    'Mode of neural control mediating rat tail vasodilation during heating ' () 59 J. Appl. Physiol. : 1533 -1538.

    • Search Google Scholar
  • Satake N, Oe H, Shibata S: Vasorelaxing action of melatonin in rat isolated aorta; possible endothelium dependent relaxation. Gen. Pharmacol. 22, 1127-1133 (1991)

    'Vasorelaxing action of melatonin in rat isolated aorta; possible endothelium dependent relaxation ' () 22 Gen. Pharmacol. : 1127 -1133.

    • Search Google Scholar
  • Ting KN, Blaylock NA, Sugden D, Delagrange P, Scalbert E, Wilson VG: Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br. J. Pharmacol. 127, 987-995 (1999)

    'Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats ' () 127 Br. J. Pharmacol. : 987 -995.

    • Search Google Scholar
  • Wehr TA, Aeschbach D, Duncan WC Jr: Evidence for a biological dawn and dusk in the human circadian timing system. J. Physiol. 535, 937-951 (2001)

    'Evidence for a biological dawn and dusk in the human circadian timing system ' () 535 J. Physiol. : 937 -951.

    • Search Google Scholar
  • Westfall DP, Sedaa K, Bjur RA: Release of endogenous ATP from tail artery. Blood Vessels 24, 125-127 (1987)

    'Release of endogenous ATP from tail artery ' () 24 Blood Vessels : 125 -127.

  • Doolen S, Krause DN, Dubocovich ML, Duckles SP: Melatonin mediates two distinct responses in vascular smooth muscle. Eur. J. Pharmacol. 345, 67-69 (1998)

    'Melatonin mediates two distinct responses in vascular smooth muscle ' () 345 Eur. J. Pharmacol. : 67 -69.

    • Search Google Scholar
  • Young AA, Dawson NJ: Evidence for on-off control of heat dissipation from the tail of the rat. Can. J. Physiol. Pharmacol. 60, 392-398 (1982)

    'Evidence for on-off control of heat dissipation from the tail of the rat ' () 60 Can. J. Physiol. Pharmacol. : 392 -398.

    • Search Google Scholar
  • Dubocovich ML: Melatonin receptors: are there multiple subtypes? Trends Pharmacol. Sci. 16, 50-56 (1995)

    'Melatonin receptors: are there multiple subtypes? Trends Pharmacol ' () 16 Sci. : 50 -56.

    • Search Google Scholar
  • Wright G: Use-dependent decline in rat aorta sensitivity to contraction by potassium Can. J. Physiol. Pharmacol. 69, 921-928 (1991)

    'Use-dependent decline in rat aorta sensitivity to contraction by potassium Can ' () 69 J. Physiol. Pharmacol. : 921 -928.

    • Search Google Scholar
  • Weekley LB: Pharmacologic studies on the mechanism of melatonin-induced vasorelaxation in rat aorta. J. Pineal. Res. 19, 133-138 (1995)

    'Pharmacologic studies on the mechanism of melatonin-induced vasorelaxation in rat aorta ' () 19 J. Pineal. Res. : 133 -138.

    • Search Google Scholar
  • Bao JX: Sympathetic neuromuscular transmission in the rat tail artery: a study based on electrochemical, electrophysiological and mechanical recording. Acta Physiol. Scand. 148, 1-58 (1993)

    'Sympathetic neuromuscular transmission in the rat tail artery: a study based on electrochemical, electrophysiological and mechanical recording ' () 148 Acta Physiol. Scand. : 1 -58.

    • Search Google Scholar
  • Monroe KK, Watts SW: The vascular reactivity of melatonin. Gen. Pharmacol. 30, 31-35 (1998)

    'The vascular reactivity of melatonin ' () 30 Gen. Pharmacol. : 31 -35.

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