Acta Physiologica Hungarica
Volume/Issue:
Volume 94: Issue 1-2
Renin-angiotensin system affects endothelial morphology and permeability of renal afferent arteriole
Authors: L. Rosivall, J. Peti-Peterdi, Zs. Rázga 4 , A. Fintha 2 , Cs. Bodor 1 , and S. MirzaHosseini
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  • 1 Hungarian Academy of Sciences and Semmelweis University Nephrology Research Group Hungary
  • 2 Semmelweis University Institute of Pathophysiology, Faculty of Medicine Nagyvárad tér 4 H-1089 Budapest Hungary
  • 3 University of Southern California Department of Physiology and Biophysics, Keck School of Medicine Los Angeles USA
  • 4 University of Szeged Department of Pathology, Faculty of Medicine Hungary
  • 5 Avicenna International College Budapest Hungary
DOI:
https://doi.org/10.1556/aphysiol.94.2007.1-2.3
Page Count:
7–17
Publication Date:
01 Mar 2007
Online Publication Date:
26 Feb 2007
Article Category:
Research Article

Article Info

Page Count:
7–17
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The afferent arteriole (AA) is an important regulatory site of renal function and blood pressure. We have demonstrated endothelial fenestration and high permeability in the vicinity of renin granulated epithelioid cells in the juxtaglomerular portion of the afferent arteriole in different mammals. The permeability of fenestrated endothelium of afferent arteriole may be important in connection to various physiologic and pathophysiologic processes. We have assumed that the permeable fenestration may serve as a communication channel between the intravascular circulation and a pathway for renin secretion. Utilising the multiphoton image technique we were able to visualise the endothelial fenestration and renin granules of the in vitro microperfused AA and in vivo AA. We demonstrated that ferritin-positive, i.e., permeable portion of the afferent arteriole, under control conditions is on average 45 μm, which is about one-third to half of the total length of the afferent arteriole. The length of this portion is not constant and can change by physiologic and pharmacologic manipulation of renin formation. The permeability of the afferent arteriole is not changing only parallel with the pharmacologically stimulated renin secretion as already demonstrated in adult rats, but also with the change of renin appearance in afferent arteriole within the very first few days of life after birth. Independently from the age there is a significant correlation between the renin-positive and permeable portion of the AA. Further studies are necessary to clarify the physiological significance of afferent arteriolar permeability and its changes in the postnatal development of the kidney, as well as in correlation with activity of renin- angiotensin system.

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Cover Acta Physiologica Hungarica
Acta Physiologica Hungarica
Print ISSN:
0231-424X
Online ISSN:
1588-2683
Keywords:
endothelium; juxtaglomerular apparatus pathology; permeability; age; renin; angiotensin system

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