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  • 1 UBA Cátedra de Fisiopatología Junín 956, 6th floor 1113 Buenos Aires República Argentina
  • 2 UBA Departamento de Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica Junín 956, 6th floor 1113 Buenos Aires República Argentina
  • 3 USAL Facultad de Medicina Tucumán 1845 Buenos Aires
  • 4 CONICET República Argentina
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The hypothesis of the present study was that diabetes mellitus might affect brain metabolism. Streptozotocin (STZ)-induced diabetic rats, treated with vanadyl sulphate (V) and sodium tungstate (T) were employed to observe the aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatine kinase (CK) activities in brain homogenates. Significant increases in AST, ALT and CK activities were found in diabetic brain homogenates against controls, suggesting increments of transamination in brain and/or increases in cell membrane permeability to these enzymes. The increase in brain CK possibly expresses alterations in energy production. The decrease in CK activity caused by V and T treatment in diabetic rats suggests that both agents tend to normalize energy consumption. It is also possible that V and T-induced hypoglycemic effects cause metabolic alterations in brain.

  • Barberas A, Rodríguez-Gil JE, Guinovart J: Insulin-like actions of tungstate in diabetic rats: Normalization of hepatic glucose metabolism. J. Biol. Chem. 269, 20047–20053 (1994)

    Guinovart J. , 'Insulin-like actions of tungstate in diabetic rats: Normalization of hepatic glucose metabolism ' (1994 ) 269 J. Biol. Chem. : 20047 -20053.

    • Search Google Scholar
  • Barberas A, Fernández-Alvarez J, Truc A, Gomis R, Guinovart JJ: Efects of tungstate on neonatally streptozotocin-induced diabetic rats. Mechanism leading to normalization of glycemia. Diabetologia 40, 143–149 (1997)

    Guinovart J.J. , 'Efects of tungstate on neonatally streptozotocin-induced diabetic rats. Mechanism leading to normalization of glycemia ' (1997 ) 40 Diabetologia : 143 -149.

    • Search Google Scholar
  • Brechard SM, Pottier AM, Henguin JC: Long term improvement of glucose homeostasis by vanadate in obese hyperinsulinemic fa/fa rats. Endocrinology 125, 2510–2516 (1989)

    Henguin J.C. , 'Long term improvement of glucose homeostasis by vanadate in obese hyperinsulinemic fa/fa rats ' (1989 ) 125 Endocrinology : 2510 -2516.

    • Search Google Scholar
  • Heyliger CE, Tahillant AG, McNeill JH: Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats. Science 272, 1474–1477 (1985)

    McNeill J.H. , 'Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats ' (1985 ) 272 Science : 1474 -1477.

    • Search Google Scholar
  • Lemberg A, Eyzayaga FX, Vatta M, Domímguez A, Romay S, Bianciotti LG, Sansó G, Fernández B: Prehepatic portal hypertension in rats modifies norepinephrine metabolism in the hypothalamus medulla oblongata and portal vein. Digestive Diseases and Sciences 38, 1259–1262 (1993)

    Fernández B. , 'Prehepatic portal hypertension in rats modifies norepinephrine metabolism in the hypothalamus medulla oblongata and portal vein ' (1993 ) 38 Digestive Diseases and Sciences : 1259 -1262.

    • Search Google Scholar
  • Lemberg A, Perazzo J, Romay S, Eyzayaga FX, Vatta M, Rodríguez Fermepn MR, Bianciotti LG, Monserrat L, Fernández B: Norepinephrine uptake is enhanced in discrete telencephalic and diencephalic areas and nuclei in prehepatic portal hypertensive rats. Brain Research Bulletin 45, 133–156 (1998)

    Fernández B. , 'Norepinephrine uptake is enhanced in discrete telencephalic and diencephalic areas and nuclei in prehepatic portal hypertensive rats ' (1998 ) 45 Brain Research Bulletin : 133 -156.

    • Search Google Scholar
  • Lowry OH, Rosenbrangh NJ, Far AL, Randall RJ: Protein measurement with Folin phenol reagent. J. Biol. Chem. 193, 265–275 (1951)

    Randall R.J. , 'Protein measurement with Folin phenol reagent ' (1951 ) 193 J. Biol. Chem. : 265 -275.

    • Search Google Scholar
  • Netopilova M, Haugvicova R, Kubova H, Drsata G, Mares P: Influence of convulsants on rat brain activity of alanine aminotransferase and aspartate aminotransferase. Neurochem. Res. 26, 1265–1270 (2001)

    Mares P. , 'Influence of convulsants on rat brain activity of alanine aminotransferase and aspartate aminotransferase ' (2001 ) 26 Neurochem. Res. : 1265 -1270.

    • Search Google Scholar
  • Scorticati C, Prestifilippo JP, Eyzayaga FX, Castro JC, Romay S, Fernández MA, Lemberg A, Perazzo JC: Hyperammonemia, brain edema and blood-brain barier alterations in prehepatic portal hypertensive rats and paracetamol intoxication. World Journal of Gastroenterology 10, 1321–1324 (2004)

    Perazzo J.C. , 'Hyperammonemia, brain edema and blood-brain barier alterations in prehepatic portal hypertensive rats and paracetamol intoxication ' (2004 ) 10 World Journal of Gastroenterology : 1321 -1324.

    • Search Google Scholar
  • Wolf PL: Evaluation und utilization of a kinetic enzyme direct measuring photometer. J. Clin. Pathol. 28, 587–591 (1975)

    Wolf P.L. , 'Evaluation und utilization of a kinetic enzyme direct measuring photometer ' (1975 ) 28 J. Clin. Pathol. : 587 -591.

    • Search Google Scholar
  • Yuen VG, Vera E, Battel ML, Li WM, McNeill JH: Acute and chronic oral administration of bis (maltolate) oxovanadium (IV) in Zucker diabetic fatty (ZDT) rats. Diabetes Res. Clin. Pract. 43, 9–19 (1999)

    McNeill J.H. , 'Acute and chronic oral administration of bis (maltolate) oxovanadium (IV) in Zucker diabetic fatty (ZDT) rats ' (1999 ) 43 Diabetes Res. Clin. Pract. : 9 -19.

    • Search Google Scholar

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Editor(s)-in-Chief: Rosivall, László

Honorary Editor(s)-in-Chief): Monos, Emil

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