High calorie intake and high weight gain is one of the worldwide health problems particularly in industrial and developed countries. The subjected individuals are at high risk for developing various disorders such as diabetes and particularly cardiovascular problems. It has been well established that life style modification plays an important role in reducing these problems, particularly weight reduction and caloric restriction (CR) as a non-pharmacological approach. This study sought to examine the possible effect of caloric restriction on nitric oxide production, ACE activity and blood pressure regulation in rat. Two groups of rats were selected as the control (C) and the CR group and a with standard and an every other day diet, respectively, for 4 weeks. At the end of study in the CR group systolic blood pressure was significantly decreased compared to controls. The serum NO
was significantly increased compared to the C group. The serum ACE activity was lower in the CR group. Therefore, it may be concluded that CR could reduce blood pressure by elevating NO production and lowering ACE activity.
Gibbs WW: Gaining on fat. Sci. Am. 27, 88–94 (1996)
Gibbs W.W., 'Gaining on fat' (1996) 27Sci. Am.: 88-94.
Gibbs W.W.Gaining on fatSci. Am.1996278894)| false
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Laragh J.H., '', in Hypertention: pathophysiology, diagnosis and management, (1995) -.
Laragh J.H.Hypertention: pathophysiology, diagnosis and management1995)| false
Sharifi AM, Akbarloo N, Heshmatian B, Ziai A: Alteration of local ACE activity and vascular responsiveness during development of 2K1C renovascular hypertention. Pharmacological Research 47, 201–209 (2003)
Ziai A., 'Alteration of local ACE activity and vascular responsiveness during development of 2K1C renovascular hypertention' (2003) 47Pharmacological Research: 201-209.
Ziai A.Alteration of local ACE activity and vascular responsiveness during development of 2K1C renovascular hypertentionPharmacological Research200347201209)| false
Dzau VJ, Pratt RE (1986): Renin angiotensin system: biology, pathophysiology and pharmacology. In: The heart and cardiovascular system, eds Fozzard H, Haber M et al., Raven Press, New York, pp. 1631–1661.
Pratt R.E., '', in The heart and cardiovascular system, (1986) -.
Pratt R.E.The heart and cardiovascular system1986)| false
Nakata K, Nishimura K, Takada T, Ikusa T, Yamaguchi H, Iso T: Effect of an angiotensin-converting enzyme (ACE) inhibitor, SA446, on tissue activity in normotensive, spontaneously hypertensive and renal hypertensive rats. J. Cardiovasc. Pharmacol. 9, 305–310 (1987)
Iso T., 'Effect of an angiotensin-converting enzyme (ACE) inhibitor, SA446, on tissue activity in normotensive, spontaneously hypertensive and renal hypertensive rats' (1987) 9J. Cardiovasc. Pharmacol.: 305-310.
Iso T.Effect of an angiotensin-converting enzyme (ACE) inhibitor, SA446, on tissue activity in normotensive, spontaneously hypertensive and renal hypertensive ratsJ. Cardiovasc. Pharmacol.19879305310)| false
Reisin E, Abel R, Modan M, Silverberg DS, Eliahus HE, Modan B: Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients. New Eng. J. Med. 298, 1–6 (1978)
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Modan B.Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patientsNew Eng. J. Med.197829816)| false
Co-editor(s): Koller, Ákos; Lénárd, László; Szénási, Gábor
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