View More View Less
  • 1 University of Szeged Institute of Surgical Research P.O. Box 464 H-6701 Szeged Hungary
  • 2 University of Szeged Department of Cardiac Surgery Szeged Hungary
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $752.00

The aim of this study was to outline the consequences of a hypertonic saline-dextran-40 (HSD) infusion-induced peripheral flow stimulus on the ventricular function in closed-chest, pentobarbital-anesthetized dogs. We hypothesized that HSD-induced elevation in endothelin-1 (ET-1) and nitric oxide (NO) release can have a role in myocardial contractile responses; and that cardiac mast cells (MC) degranulation may be involved in this process. The consequences of disodium cromoglycate (a MC stabilizer) or ETR-p1/fl peptide (an endothelin-A receptor antagonist) treatment were evaluated. A 4 ml/kg iv HSD40 infusion significantly increased cardiac index and myocardial contractility, and resulted in a decreased peripheral resistance. The postinfusion period was characterized by significant plasma NO and ET-1 elevations, these hemodynamic and biochemical changes being accompanied by a decreased myocardial ET-1 content, NO synthase activity and enhanced myocardial MC degranulation. Disodium cromoglycate treatment inhibited the HSD40-induced elevations in myocardial contractility and MC degranulation, and similar hemodynamic changes were noted after treatment with ETR-p1/fl peptide, together with a normalized myocardial myocardial ET-1 content, NO synthesis and a significant reduction in MC degranulation. These results indicate that peripheral NO and ET-1 release modulates the cardiac contractility through myocardial ET-A receptor activation and MC degranulation.

  • Baranyi L, Campbell W, Oshima K, Fujimoto S, Boros M, Okada H: The antisense homology box: A new motif within proteins that encodes biologically active peptides. Nature Med. 1, 894–901 (1995)

    Okada H. , 'The antisense homology box: A new motif within proteins that encodes biologically active peptides ' (1995 ) 1 Nature Med. : 894 -901.

    • Search Google Scholar
  • Baranyi L, Campbell W, Ohshima K, Fujimoto S, Boros M, Kaszaki J, Okada H: Antisense homology box derived peptides represent a new class of endothelin receptor inhibitors. Peptides 19, 211–223 (1998)

    Okada H. , 'Antisense homology box derived peptides represent a new class of endothelin receptor inhibitors ' (1998 ) 19 Peptides : 211 -223.

    • Search Google Scholar
  • Beyer ME, Slezak G, Hoffmeister HM: Significance of endothelin B receptors for myocardial contractility and myocardial energy metabolism. J. Pharmacol. Exp. Ther. 278, 1228–1234 (1996)

    Hoffmeister H.M. , 'Significance of endothelin B receptors for myocardial contractility and myocardial energy metabolism ' (1996 ) 278 J. Pharmacol. Exp. Ther. : 1228 -1234.

    • Search Google Scholar
  • Bidri M, Feger F, Varadaradjalou S, Ben Hamouda N, Guillosson JJ, Arock M: Mast cells as a source and target for nitric oxide. Int. Immunopharmacol. 1, 1543–1558 (2001)

    Arock M. , 'Mast cells as a source and target for nitric oxide ' (2001 ) 1 Int. Immunopharmacol. : 1543 -1558.

    • Search Google Scholar
  • Boldt J, Knothe C, Zickmann B, Hammermann H, Stertmann WA, Hempelmann G: Volume loading with hypertonic saline solution: endocrinologic and circulatory responses. J. Cardiothorac. Vasc. Anesth. 8, 317–323 (1994)

    Hempelmann G. , 'Volume loading with hypertonic saline solution: endocrinologic and circulatory responses ' (1994 ) 8 J. Cardiothorac. Vasc. Anesth. : 317 -323.

    • Search Google Scholar
  • Borbely A, Toth A, Edes I, Virag L, Papp JG, Varro A, Paulus WJ, van der Velden J, Stienen GJ, Papp Z: Peroxynitrite-induced alpha-actinin nitration and contractile alterations in isolated human myocardial cells. Cardiovasc. Res. 67, 225–233 (2005)

    Papp Z. , 'Peroxynitrite-induced alpha-actinin nitration and contractile alterations in isolated human myocardial cells ' (2005 ) 67 Cardiovasc. Res. : 225 -233.

    • Search Google Scholar
  • Boros M, Szalay L, Kaszaki J: Endothelin-1 induces mucosal mast cell degranulation and tissue injury via ET-A receptors. Clin. Sci. 103, 31S–34S (2002)

    Kaszaki J. , 'Endothelin-1 induces mucosal mast cell degranulation and tissue injury via ET-A receptors ' (2002 ) 103 Clin. Sci. : 31S -34S.

    • Search Google Scholar
  • Casadei B, Sears CE: Nitric-oxide-mediated regulation of cardiac contractility and stretch responses. Prog. Biophys. Mol. Biol. 82, 67–80 (2003)

    Sears C.E. , 'Nitric-oxide-mediated regulation of cardiac contractility and stretch responses ' (2003 ) 82 Prog. Biophys. Mol. Biol. : 67 -80.

    • Search Google Scholar
  • Chancey AL, Brower GL, Janicki JS: Cardiac mast cell mediated activation of gelatinase and alteration of ventricular diastolic function. Am. J. Physiol. 282, H2152–H2158 (2002)

    Janicki J.S. , 'Cardiac mast cell mediated activation of gelatinase and alteration of ventricular diastolic function ' (2002 ) 282 Am. J. Physiol. : H2152 -H2158.

    • Search Google Scholar
  • Davies PF, Robotewskyj A, Griem ML, Dull RO, Polacek DC: Hemodynamic forces and vascular cell communication in arteries. Arch. Pathol. Lab. Med. 116, 1301–1306 (1992)

    Polacek D.C. , 'Hemodynamic forces and vascular cell communication in arteries ' (1992 ) 116 Arch. Pathol. Lab. Med. : 1301 -1306.

    • Search Google Scholar
  • Dvorak AM: Mast cell degranulation in human hearts. N. Engl. J. Med. 315, 969 (1986)

    Dvorak A.M. , 'Mast cell degranulation in human hearts ' (1986 ) 315 N. Engl. J. Med. : 969 -.

    • Search Google Scholar
  • Ehrenreich H, Burd PR, Rottem M, Hultner L, Hylton JB, Garfield M, Coligan JE, Metcalfe DD, Fauci AS: Endothelins belong to the assortment of mast cell-derived and mast cell-bound cytokines. New Biol. 4, 147–156 (1992)

    Fauci A.S. , 'Endothelins belong to the assortment of mast cell-derived and mast cell-bound cytokines ' (1992 ) 4 New Biol. : 147 -156.

    • Search Google Scholar
  • Feigl EO: Coronary physiology. Physiol. Rev. 63, 1–205 (1983)

    Feigl E.O. , 'Coronary physiology ' (1983 ) 63 Physiol. Rev. : 1 -205.

  • Filipiak KJ, Tarchalska-Krynska B, Opolski G, Rdzanek A, Kochman J, Kosior DA, Czlonkowski A: Tryptase levels in patients after acute coronary syndromes: the potential new marker of an unstable plaque? Clin. Cardiol. 26, 366–372 (2003)

    Czlonkowski A. , 'Tryptase levels in patients after acute coronary syndromes: the potential new marker of an unstable plaque? ' (2003 ) 26 Clin. Cardiol. : 366 -372.

    • Search Google Scholar
  • Fissthaler B, Dimmeler S, Hermann C, Bussek R, Fleming I: Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress. Acta Physiol. Scand. 168, 81–88 (2000)

    Fleming I. , 'Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress ' (2000 ) 168 Acta Physiol. Scand. : 81 -88.

    • Search Google Scholar
  • Gaboury JP, Johnston B, Niu X-F, Kubes P: Mechanism underlying acute mast cell-induced leukocyte rolling and adhesion in vivo. J. Immunol. 154, 804–813 (1995)

    Kubes P. , 'Mechanism underlying acute mast cell-induced leukocyte rolling and adhesion in vivo ' (1995 ) 154 J. Immunol. : 804 -813.

    • Search Google Scholar
  • Galli SJ: New concepts about the mast cell. New Engl. J. Med. 328, 257–265 (1993)

    Galli S.J. , 'New concepts about the mast cell ' (1993 ) 328 New Engl. J. Med. : 257 -265.

  • Goldfarb RD: Cardiac mechanical performance in circulatory shock: A critical review of methods and results. Circ. Shock 9, 633–653 (1982)

    Goldfarb R.D. , 'Cardiac mechanical performance in circulatory shock: A critical review of methods and results ' (1982 ) 9 Circ. Shock : 633 -653.

    • Search Google Scholar
  • Gregg DE: Effect of coronary perfusion pressure or coronary flow on oxygen usage of the myocardium. Circ. Res. 13, 497–500 (1963)

    Gregg D.E. , 'Effect of coronary perfusion pressure or coronary flow on oxygen usage of the myocardium ' (1963 ) 13 Circ. Res. : 497 -500.

    • Search Google Scholar
  • Janicki JS, Brower GL, Gardner JD, Forman MF, Stewart JA Jr, Murray DB, Chancey AL: Cardiac mast cell regulation of matrix metalloproteinase-related ventricular remodeling in chronic pressure or volume overload. Cardiovasc. Res. 69, 657–665 (2006)

    Chancey A.L. , 'Cardiac mast cell regulation of matrix metalloproteinase-related ventricular remodeling in chronic pressure or volume overload ' (2006 ) 69 Cardiovasc. Res. : 657 -665.

    • Search Google Scholar
  • Kaszaki J, Wolfard A, Bari F, Boros M, Parratt JR, Nagy S: Effect of nitric oxide synthase inhibition on myocardial contractility in anesthetized normal and endotoxemic dogs. Shock 6, 279–285 (1996)

    Nagy S. , 'Effect of nitric oxide synthase inhibition on myocardial contractility in anesthetized normal and endotoxemic dogs ' (1996 ) 6 Shock : 279 -285.

    • Search Google Scholar
  • Kennedy RH, Hauer-Jensen M, Joseph J: Cardiac function in hearts isolated from a rat model deficient in mast cells. Am. J. Physiol. 288, H632–H637 (2005)

    Joseph J. , 'Cardiac function in hearts isolated from a rat model deficient in mast cells ' (2005 ) 288 Am. J. Physiol. : H632 -H637.

    • Search Google Scholar
  • Klinker JF, Seifert R: Morphine and muscle relaxants are receptor-independent G-protein activators and cromolyn is an inhibitor of stimulated G-protein activity. Inflamm. Res. 46, 46–50 (1997)

    Seifert R. , 'Morphine and muscle relaxants are receptor-independent G-protein activators and cromolyn is an inhibitor of stimulated G-protein activity ' (1997 ) 46 Inflamm. Res. : 46 -50.

    • Search Google Scholar
  • Konrad D, Oldner A, Wanecek M, Rudehill A, Weitzberg E, Biber B, Johansson G, Haggmark S, Haney M: Positive inotropic and negative lusitropic effects of endothelin receptor agonism in vivo. Am. J. Physiol. 289, H1702–H1709 (2005)

    Haney M. , 'Positive inotropic and negative lusitropic effects of endothelin receptor agonism in vivo ' (2005 ) 289 Am. J. Physiol. : H1702 -H1709.

    • Search Google Scholar
  • Kuchan MJ, Frangos JA: Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells. Am. J. Physiol. 264, H150–H156 (1993)

    Frangos J.A. , 'Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells ' (1993 ) 264 Am. J. Physiol. : H150 -H156.

    • Search Google Scholar
  • Kuebler WM, Abels C, Schuerer L, Goetz AE: Measurement of neutrophil content in brain and lung tissue by a modified myeloperoxidase assay. Int. J. Microcirc. Clin. Exp. 16, 89–97 (1996)

    Goetz A.E. , 'Measurement of neutrophil content in brain and lung tissue by a modified myeloperoxidase assay ' (1996 ) 16 Int. J. Microcirc. Clin. Exp. : 89 -97.

    • Search Google Scholar
  • Massion PB, Feron O, Dessy C, Balligand JL: Nitric oxide and cardiac function: ten years after, and continuing. Circ. Res. 93, 388–398 (2003)

    Balligand J.L. , 'Nitric oxide and cardiac function: ten years after, and continuing ' (2003 ) 93 Circ. Res. : 388 -398.

    • Search Google Scholar
  • Maurer M, Wedemeyer J, Metz M, Piliponsky AM, Weller K, Chatterjea D, Clouthier DE, Yanagisawa MM, Tsai M, Galli SJ: Mast cells promote homeostasis by limiting endothelin-1 induced toxicity. Nature 432, 512–516 (2004)

    Galli S.J. , 'Mast cells promote homeostasis by limiting endothelin-1 induced toxicity ' (2004 ) 432 Nature : 512 -516.

    • Search Google Scholar
  • Moshage H, Kok B, Huizenga JR, Jansen PL: Nitrite and nitrate determinations in plasma: a critical evaluation. Clin. Chem. 41, 892–896 (1995)

    Jansen P.L. , 'Nitrite and nitrate determinations in plasma: a critical evaluation ' (1995 ) 41 Clin. Chem. : 892 -896.

    • Search Google Scholar
  • Murray DB, Gardner JD, Brower GL, Janichi JS: Endothelin-1 mediates cardiac mast cell degranulation, matrix metalloproteinase activation and myocardial remodeling in rats. Am. J. Physiol. 287, H2405–H2409 (2004)

    Janichi J.S. , 'Endothelin-1 mediates cardiac mast cell degranulation, matrix metalloproteinase activation and myocardial remodeling in rats ' (2004 ) 287 Am. J. Physiol. : H2405 -H2409.

    • Search Google Scholar
  • Ohnishi M, Wada A, Tsutamoto T, Fujii M, Matsumoto T, Yamamoto T, Takayama T, Wang X, Kinoshita M: Endothelin stimulates an endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, in experimental heart failure. Clin. Sci. 103 S48, 241S–244S (2002)

    Kinoshita M. , 'Endothelin stimulates an endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, in experimental heart failure ' (2002 ) 103 Clin. Sci. : S48 -.

    • Search Google Scholar
  • Ovadia B, Bekker JM, Fitzgerald RK, Kon A, Thelitz S, Johengen MJ, Hendricks-Munoz K, Gerrets R, Black SM, Fineman J: Nitric oxide-endothelin-1 interaction after acute ductal constriction in fetal lambs. Am. J. Physiol. 282, H862–H871 (2002)

    Fineman J. , 'Nitric oxide-endothelin-1 interaction after acute ductal constriction in fetal lambs ' (2002 ) 282 Am. J. Physiol. : H862 -H871.

    • Search Google Scholar
  • Patella V, de Crescenzo G, Ciccarelli A, Marinó I, Adt M, Marone G: Human heart mast cells: A definitive case of mast cell heterogenity. Int. Arch. Allergy Immunol. 106, 386–393 (1995)

    Marone G. , 'Human heart mast cells: A definitive case of mast cell heterogenity ' (1995 ) 106 Int. Arch. Allergy Immunol. : 386 -393.

    • Search Google Scholar
  • Salvemini D, Masini E, Pistelli A, Mannaioni PF, Vane J: Nitric oxide: a regulatory mediator of mast cell reactivity. J. Cardiovasc. Pharmacol. 17, S258–S264 (1991)

    Vane J. , 'Nitric oxide: a regulatory mediator of mast cell reactivity ' (1991 ) 17 J. Cardiovasc. Pharmacol. : S258 -S264.

    • Search Google Scholar
  • Sheehy AM, Burson MA, Black SM: Nitric oxide exposure inhibits endothelial NOS activity but not gene expression: a role for superoxide. Am. J. Physiol. 274, L833–L841 (1998)

    Black S.M. , 'Nitric oxide exposure inhibits endothelial NOS activity but not gene expression: a role for superoxide ' (1998 ) 274 Am. J. Physiol. : L833 -L841.

    • Search Google Scholar
  • Silver RB, Reid AC, Mackins CJ, Askwith T, Schaefer U, Herzlinger D, Levi R: Mast cells: A unique source of rennin. Proc. Natl. Acad. Sci. 101, 13607–13612 (2004)

    Levi R. , 'Mast cells: A unique source of rennin ' (2004 ) 101 Proc. Natl. Acad. Sci. : 13607 -13612.

    • Search Google Scholar
  • Spataro AC, Bosmann HB: Mechanism of action of disodium cromoglycate-mast cell calcium ion influx after a histamine-releasing stimulus. Bichem. Pharmacol. 25, 505–510 (1976)

    Bosmann H.B. , 'Mechanism of action of disodium cromoglycate-mast cell calcium ion influx after a histamine-releasing stimulus ' (1976 ) 25 Bichem. Pharmacol. : 505 -510.

    • Search Google Scholar
  • Szabó C, Mitchell JA, Thiemermann C, Vane JR: Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br. J. Pharmacol. 108, 786–792 (1993)

    Vane J.R. , 'Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock ' (1993 ) 108 Br. J. Pharmacol. : 786 -792.

    • Search Google Scholar
  • Theoharides TC: The mast cell: a neuroimmunoendocrine master player. Int. J. Tissue React. 18, 1–21 (1996)

    Theoharides T.C. , 'The mast cell: a neuroimmunoendocrine master player ' (1996 ) 18 Int. J. Tissue React. : 1 -21.

    • Search Google Scholar
  • van Wamel AJ, Ruwhof C, van der Valk-Kokshoom LE, Schrier PI, van der Laarse A: The role of angiotensin II, endothelin-1 and transforming growth factor-beta as autocrine/paracrine mediators of stretch-induced cardiomyocyte hypertrophy. Mol. Cell. Biochem. 218, 113–124 (2001)

    Laarse A. , 'The role of angiotensin II, endothelin-1 and transforming growth factor-beta as autocrine/paracrine mediators of stretch-induced cardiomyocyte hypertrophy ' (2001 ) 218 Mol. Cell. Biochem. : 113 -124.

    • Search Google Scholar
  • Warner TD: Relationships between the endothelin and nitric oxide pathways. Clin. Exp. Pharmacol. Physiol. 26, 247–252 (1999)

    Warner T.D. , 'Relationships between the endothelin and nitric oxide pathways ' (1999 ) 26 Clin. Exp. Pharmacol. Physiol. : 247 -252.

    • Search Google Scholar
  • Wypij DM, Nichols JS, Novak PJ, Stacy DL, Berman J, Wiseman JS: Role of mast cell chymase in the extracellular processing of big-endothelin-1 to endothelin-1 in the perfused rat lung. Biochem. Pharmacol. 43, 845–853 (1992)

    Wiseman J.S. , 'Role of mast cell chymase in the extracellular processing of big-endothelin-1 to endothelin-1 in the perfused rat lung ' (1992 ) 43 Biochem. Pharmacol. : 845 -853.

    • Search Google Scholar

The author instruction is available in PDF.

Please, download the file from HERE

  • Impact Factor (2016): 0.571
  • 5-year Impact Factor (2016): 0.675
  • Physiology (Medical) Quartile score (2016): Q4
  • SJR Indicator (2016): 0.276
  • H-Index (2016): H-Index (2016): 23

Language: English

Founded in 1950
Publication: One volume of four issues annually
Publication Programme: 2016: Vol. 103
Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • EMBASE/Excerpta Medica
  • Global Health
  • Index Copernicus
  • Index Medicus
  • Medline
  • Referativnyi Zhurnal
  • Science Citation Index Expanded
  • SCOPUS

 

Subscribers can access the electronic version of every printed article.

Senior editors

Editor(s)-in-Chief: Rosivall, László

Honorary Editor(s)-in-Chief): Monos, Emil

Managing Editor(s): Bartha, Jenő; Berhidi, Anna

Co-editor(s): Koller, Ákos; Lénárd, László; Szénási, Gábor

Assistant Editor(s): G. Dörnyei (Budapest), Zs. Miklós (Budapest), Gy. Nádasy (Budapest)

Hungarian Editorial Board

      Benedek, György (Szeged)
      Benyó, Zoltán (Budapest)
      Boros, Mihály (Szeged)
      Chernoch, László (Debrecen)
      Détári, László (Budapest)
      Hamar, János (Budapest)
      Hantos, Zoltán (Szeged)
      Hunyady, László (Budapest)
      Imre, Sándor (Debrecen)
      Jancsó, Gábor (Szeged)
      Karádi, Zoltán (Pécs)
      Kovács, László (Debrecen)
      Palkovits, Miklós (Budapest)
      Papp, Gyula (Szeged)
      Pavlik, Gábor (Budapest)
      Spät, András (Budapest)
      Szabó, Gyula (Szeged)
      Szelényi, Zoltán (Pécs)
      Szolcsányi, János (Pécs)
      Szollár, Lajos (Budapest)
      Szücs, Géza (Debrecen)
      Telegdy, Gyula (Szeged)
      Toldi, József (Szeged)
      Tósaki, Árpád (Debrecen)

International Editorial Board

      R. Bauer (Jena)
      W. Benjelloun (Rabat)
      A. W. Cowley Jr. (Milwaukee)
      D. Djuric (Belgrade)
      C. Fry (London)
      S. Greenwald (London)
      O. Hänninen (Kuopio)
      H. G. Hinghofer-Szalkay (Graz)
      Th. Kenner (Graz)
      Gy. Kunos (Richmond)
      M. Mahmoudian (Tehran)
      T. Mano (Seki, Gifu)
      G. Navar (New Orleans)
      H. Nishino (Nagoya)
      O. Petersen (Liverpool)
      U. Pohl (Münich)
      R. S. Reneman (Maastricht)
      A. Romanovsky (Phoenix)
      G. M. Rubanyi (Richmond)
      T. Sakata (Oita)
      A. Siddiqui (Karachi)
      Cs. Szabo (Beverly)
      E. Vicaut (Paris)
      N. Westerhof (Amsterdam)
      L. F. Zhang (Xi'an)

Editorial Office:
Akadémiai Kiadó Zrt.
Prielle Kornélia u. 21–35, H-1117 Budapest, Hungary

Editorial Correspondence:
Acta Physiologica Hungarica
Semmelweis University, Faculty of Medicine Institute of Pathophysiology
Nagyvárad tér 4, H-1089 Budapest, Hungary
Phone/Fax: +36-1-2100-100
E-mail: aph@semmelweis-univ.hu