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  • 1 University of Gaziantep, Faculty of Medicine Department of Biochemistry and Clinical Biochemistry Gaziantep Turkey
  • 2 Afyonkarahisar Kocatepe University Department of Physiology, Faculty of Medicine Afyonkarahisar Turkey
  • 3 Ataturk University Bayburt Vocational School Bayburt Turkey
  • 4 Ataturk University Biotechnology Application and Research Center Erzurum Turkey
  • 5 Ataturk University Department of Physiology, Faculty of Medicine Erzurum Turkey
  • 6 Ataturk University College of Physical Education and Sports Erzurum Turkey
  • 7 Ataturk University Department of Anaesthesiology and Reanimation Erzurum Turkey
  • 8 Ataturk University Department of Biochemistry, Faculty of Medicine Erzurum Turkey
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The aim of this study was to investigate whether an 8-week treadmill training attenuates exerciseinduced oxidative stress in rat liver. Male rats were divided into untrained and trained groups. Endurance training consisted of treadmill running at a speed of 2.1 km/h, 1.5 h/day, 5 days a week for 8 weeks. To see the effects of endurance training on acute exhaustive exercise induced oxidative stress, untrained and trained rats were further devided into two groups: animals killed at rest and those killed after acute exhaustive exercise, in which the rats run at 2.1 km/h (10% uphill) until exhaustion. Acute exhaustive exercise increased malondialdehyde level in untrained but not in trained rats. It decreased the activity of glutathione peroxidase and total (enzymatic plus non-enzymatic) superoxide scavenger activity in untrained rats and catalase activity in trained rats. However, it did not affect glutathione S-transferase, glutathione reductase, superoxide dismutase and non-enzymatic superoxide radical scavenger activities in both trained and untrained rats. On the other hand, endurance training decreased glutathione peroxidase and glutathione S-transferase activities. The results suggested that endurance training attenuated exercise-induced oxidative stress in liver, probably by preventing the decreases in glutathione peroxidase and total superoxide scavenger activities during exercise.

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