View More View Less
  • 1 Semmelweis University Faculty of Dentistry, Clinic of Prosthetic Dentistry Budapest Hungary
  • 2 Semmelweis University Faculty of Medicine, Institute of Medical Chemistry Molecular Biology and Pathobiochemistry Budapest Hungary
  • 3 Semmelweis University Faculty of Dentistry, Clinic of Pediatric Dentistry and Orthodontics Budapest Hungary
  • 4 Semmelweis University Clinic of Prosthetic Dentistry, Faculty of Dentistry H-1088 Budapest Szentkirályi utca 47 Hungary
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $752.00

Spondyloarthropathies consist of chronic inflammatory disorders genetically linked with each other through HLA-B27 molecules, and are connected with the destruction of periarticular bone and also with systemic bone loss in many cases. Expected molecular mechanisms behind these conditions overlap the functions of Hsp70s, a group of major molecular chaperones and cytokines. Hsp70s may control disease progression via inhibition of unfolded HLA-B27 protein accumulation and alteration of ER stress signaling. Further, Hsp70s may improve disease related malfunction of antigen presentation, and may induce nitric oxide (NO) release from macrophages which probably protective against spondyloarthropathies as well. Considering premised possible influence of Hsp70s on core mechanisms of spondyloarthropathies it may be expected that, increased expression of Hsp70s advantageously retards disease progress, or may lead to remission. On the other hand Hsp70s as danger signals induce the secretion of proinflammatory cytokines playing major role in the progression of spondyloarthropathy induced bone loss. Consequently, the effect of Hsp70s on the progression of spondyloarthropathic bone loss is “Janus-faced” in some respect: increase of Hsp70s’ level is likely advantageous regarding to the core of disorder; but it may facilitate existing bone resorption processes.

  • Aït-Aïssa S, Porcher JM, Arrigo AP, Lambré C: Activation of the Hsp70 promoter by environmental inorganic and organic chemicals: relationships with cytotoxicity and liophilicity. Toxicology 145, 147–157 (2000)

    Lambré C. , 'Activation of the Hsp70 promoter by environmental inorganic and organic chemicals: relationships with cytotoxicity and liophilicity ' (2000 ) 145 Toxicology : 147 -157.

    • Search Google Scholar
  • Allen RL, Bowness P, McMichael AJ: The role of HLA-B27 in spondyloarthritis. Immunogenetics 50, 220–227 (1999)

    McMichael A.J. , 'The role of HLA-B27 in spondyloarthritis ' (1999 ) 50 Immunogenetics : 220 -227.

    • Search Google Scholar
  • Allen RL, Raine T, Haude A, Trowsdaale J, Wilson MJ: Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures. J. Immunol. 167, 5543–5547 (2001)

    Wilson M.J. , 'Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures ' (2001 ) 167 J. Immunol. : 5543 -5547.

    • Search Google Scholar
  • Asea A: Stress proteins and initiation of immune response: Chaperokine activity of Hsp72. Exerc. Immunol. Rev. 11, 34–35 (2005)

    Asea A. , 'Stress proteins and initiation of immune response: Chaperokine activity of Hsp72 ' (2005 ) 11 Exerc. Immunol. Rev. : 34 -35.

    • Search Google Scholar
  • Asea A, Kraeft S, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, Koo GC, Calderwood SK: Hsp70 stimulates cytokine production through a CD14 dependent pathway, demonstrating its dual role as a chaperone and cytokine. Nat. Med. 6, 435–442 (2000)

    Calderwood S.K. , 'Hsp70 stimulates cytokine production through a CD14 dependent pathway, demonstrating its dual role as a chaperone and cytokine ' (2000 ) 6 Nat. Med. : 435 -442.

    • Search Google Scholar
  • Barker D, Nohl FS, Postlethwaite KR, Smith DG: Case report of multiple implant failure in a patient with ankylosing spondylitis. Eur. J. Prosthodont. Restor. Dent. 16, 20–23 (2008)

    Smith D.G. , 'Case report of multiple implant failure in a patient with ankylosing spondylitis ' (2008 ) 16 Eur. J. Prosthodont. Restor. Dent. : 20 -23.

    • Search Google Scholar
  • Boyle LH, Gaston JSH: Breaking the rules: the unconventional recognition of HLA-B27 by CD4+T lymphocytes as an insight into the pathogenesis of the spondyloarthropathies. Rheumatol. 41, 1280–1285 (2003)

    Gaston J.S.H. , 'Breaking the rules: the unconventional recognition of HLA-B27 by CD4+T lymphocytes as an insight into the pathogenesis of the spondyloarthropathies ' (2003 ) 41 Rheumatol : 1280 -1285.

    • Search Google Scholar
  • Boyle LH, Goodall JC, Opat SS, Gaston JSH: The recognition of HLA-B27 by human CD4+ T lymphocytes. J. Immunol. 167, 2619–2624 (2001)

    Gaston J.S.H. , 'The recognition of HLA-B27 by human CD4+ T lymphocytes ' (2001 ) 167 J. Immunol. : 2619 -2624.

    • Search Google Scholar
  • Breban M, Hammer RE, Richardson JA, Taurog JD: Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment. J. Exp. Med. 178, 1607–1616 (1993)

    Taurog J.D. , 'Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment ' (1993 ) 178 J. Exp. Med. : 1607 -1616.

    • Search Google Scholar
  • Breban M, May E: Treatment of SpA-like disease in HLA-B27 transgenic animals. Clin. Exp. Rheum. 20, S50–S51 (2002)

    May E. , 'Treatment of SpA-like disease in HLA-B27 transgenic animals ' (2002 ) 20 Clin. Exp. Rheum. : S50 -S51.

    • Search Google Scholar
  • Breban M, Said-Nahal R, Hugot JP, Micelli-Richard C: Familial and genetic aspects of spondyloarthropathy. Rheum. Dis. Clin. North. Am. 29, 575–594 (2003)

    Micelli-Richard C. , 'Familial and genetic aspects of spondyloarthropathy ' (2003 ) 29 Rheum. Dis. Clin. North. Am. : 575 -594.

    • Search Google Scholar
  • Calderwood SK: Extracellular heat shock proteins in cell signaling. FEBS Letters 581, 3689–3694 (2007)

    Calderwood S.K. , 'Extracellular heat shock proteins in cell signaling ' (2007 ) 581 FEBS Letters : 3689 -3694.

    • Search Google Scholar
  • Campisi J, Fleshner M: The role of extracellular Hsp72 in acute stress-induced potentiation of innate immunity in physically active rats. J. Appl. Physiol. 94, 43–52 (2003)

    Fleshner M. , 'The role of extracellular Hsp72 in acute stress-induced potentiation of innate immunity in physically active rats ' (2003 ) 94 J. Appl. Physiol. : 43 -52.

    • Search Google Scholar
  • Csermely, P: Proteins, RNA-s and chaperones in enzyme evolution: a folding perspective. Trends Biochem. Sci. 22, 147–149 (1997)

    Csermely P. , 'Proteins, RNA-s and chaperones in enzyme evolution: a folding perspective ' (1997 ) 22 Trends Biochem. Sci. : 147 -149.

    • Search Google Scholar
  • Csermely, P: Chaperone-percolator model: a possible molecular mechanism of Anfinsen-cage-type chaperones. BioEssay 21, 959–965 (1999)

    Csermely P. , 'Chaperone-percolator model: a possible molecular mechanism of Anfinsen-cage-type chaperones ' (1999 ) 21 BioEssay : 959 -965.

    • Search Google Scholar
  • Dangoria NS, DeLay ML, Kingsbury DJ, Mear JP, Uchanska-Ziegler B, Ziegler A, Colbert RA: HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endosplasmic reticulum. J. Biol. Chem. 227, 23459–23468 (2002)

    Colbert R.A. , 'HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endosplasmic reticulum ' (2002 ) 227 J. Biol. Chem. : 23459 -23468.

    • Search Google Scholar
  • Daugaard M, Rohde M, Jäättelä M: The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions. FEBS Letters 581, 3702–3710 (2007)

    Jäättelä M. , 'The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions ' (2007 ) 581 FEBS Letters : 3702 -3710.

    • Search Google Scholar
  • Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmaann M, Scheinecker C, van der Heide D, Landewe R, Lacey D, Richards WG, Schett G: Dickkopf-1 is a master regulator of joint remodeling. Nat. Med. 13, 156–163 (2007)

    Schett G. , 'Dickkopf-1 is a master regulator of joint remodeling ' (2007 ) 13 Nat. Med. : 156 -163.

    • Search Google Scholar
  • Fábián TK, Gáspár J, Fejérdy L, Kaán B, Bálint M, Csermely P, Fejérdy P: Hsp70 is present in human saliva. Med. Sci. Monit. 9, BR62–BR65 (2003)

    Fejérdy P. , 'Hsp70 is present in human saliva ' (2003 ) 9 Med. Sci. Monit. : BR62 -BR65.

  • Fábián TK, Tóth Zs, Fejérdy L, Kaán B, Csermely P, Fejérdy P: Photo-acoustic stimulation increases the amount of 70 kDa heat shock protein (Hsp70) in human whole saliva. A pilot study. Int. J. Psychophysiol. 52, 211–216 (2004)

    Fejérdy P. , 'Photo-acoustic stimulation increases the amount of 70 kDa heat shock protein (Hsp70) in human whole saliva. A pilot study ' (2004 ) 52 Int. J. Psychophysiol. : 211 -216.

    • Search Google Scholar
  • Fábián TK, Fejérdy P, Nguyen MT, Sőti Cs, Csermely P: Potential immunological functions of salivary Hsp70 in mucosal and periodontal defense mechanisms. Arch. Immunol. Ther. Exp. 55, 91–98 (2007)

    Csermely P. , 'Potential immunological functions of salivary Hsp70 in mucosal and periodontal defense mechanisms ' (2007 ) 55 Arch. Immunol. Ther. Exp. : 91 -98.

    • Search Google Scholar
  • Falgarone G, Blanchard HS, Riot B, Simonet M, Breban M: The cytotoxic T cell-mediated response against Yersenia pseudotuberculosis in HLA-B27 transgenic rat. Infect. Immun. 67, 3773–3779 (1999)

    Breban M. , 'The cytotoxic T cell-mediated response against Yersenia pseudotuberculosis in HLA-B27 transgenic rat ' (1999 ) 67 Infect. Immun. : 3773 -3779.

    • Search Google Scholar
  • Falgarone G, Blanchard HS, Virecoulon F, Simonet M, Breban M: Coordinate involvement of invasin and Yop proteins in a Yersinia pseudotuberculosis-specific class I-restricted cytotoxic T cell-mediated response. J. Immunol. 162, 2875–2883 (1999)

    Breban M. , 'Coordinate involvement of invasin and Yop proteins in a Yersinia pseudotuberculosis-specific class I-restricted cytotoxic T cell-mediated response ' (1999 ) 162 J. Immunol. : 2875 -2883.

    • Search Google Scholar
  • Fejérdy L, Tóth Zs, Kaán B, Fábián TK, Csermely P, Fejérdy P: Lokális hő- és mechanikai stress (masszázs) stimuláció hatása az emberi kevert nyál molekuláris chaperon (Hsp70) koncentrációjára. Előzetes vizsgálatok. In Hungarian (The effect of heat stimulation and mechanical stress (massage) of salivary glands on the secretoric parameters of salivary Hsp70. A pilot study) Fogorv. Szle. 97, 204–210 (2004)

    Fejérdy P. , 'Lokális hő- és mechanikai stress (masszázs) stimuláció hatása az emberi kevert nyál molekuláris chaperon (Hsp70) koncentrációjára. Előzetes vizsgálatok ' (2004 ) 97 Hungarian (The effect of heat stimulation and mechanical stress (massage) of salivary glands on the secretoric parameters of salivary Hsp70. A pilot study) Fogorv. Szle. : 204 -210.

    • Search Google Scholar
  • Grasso S, Scifo C, Cardile V, Gulino R, Renis M: Adaptive response to the stress induced by hyperthermia or hydrogen peroxide in human fibroblasts. Exp. Biol. Med. 228, 491–498 (2003)

    Renis M. , 'Adaptive response to the stress induced by hyperthermia or hydrogen peroxide in human fibroblasts ' (2003 ) 228 Exp. Biol. Med. : 491 -498.

    • Search Google Scholar
  • Gough AK, Lilley J, Eyre S, Holder RL, Emery P: Generalized bone loss in patients with early rheumatoid arthritis. Lancet 344, 23–27 (1994)

    Emery P. , 'Generalized bone loss in patients with early rheumatoid arthritis ' (1994 ) 344 Lancet : 23 -27.

    • Search Google Scholar
  • Hacquard-Bouder C, Falgarone G, Bosquet A, Smaoui F, Monnet D, Ittah M, Breban M: Defective costimulatory function is a striking feature of antigen-presenting cells in an HLA-B27-transgenic rat model of spondyloarthropathy. Arthritis. Rheum. 50, 1624–1635 (2004)

    Breban M. , 'Defective costimulatory function is a striking feature of antigen-presenting cells in an HLA-B27-transgenic rat model of spondyloarthropathy ' (2004 ) 50 Arthritis. Rheum. : 1624 -1635.

    • Search Google Scholar
  • Hacquard-Bouder C, Ittah M, Breban M: Animal models of HLA-B27-associated diseases: new outcomes. Joint. Bone. Spine. 73, 132–138 (2006)

    Breban M. , 'Animal models of HLA-B27-associated diseases: new outcomes ' (2006 ) 73 Joint. Bone. Spine. : 132 -138.

    • Search Google Scholar
  • Herman S, Krönke G, Schett G: Molecular mechanisms of inflammatory bone damage: emerging targets for therapy. Trends. Mol. Med. 14, 245–253 (2008)

    Schett G. , 'Molecular mechanisms of inflammatory bone damage: emerging targets for therapy ' (2008 ) 14 Trends. Mol. Med. : 245 -253.

    • Search Google Scholar
  • Jardetzky TS, Lane WS, Robinson RA, Madden DR, Wiley DC: Identification of self peptides bound to purified HLA-B27. Nature 353, 326–329 (1991)

    Wiley D.C. , 'Identification of self peptides bound to purified HLA-B27 ' (1991 ) 353 Nature : 326 -329.

    • Search Google Scholar
  • Johnson KL, Kamel MA: The Wnt signaling pathway and bone metabolism. Curr. Opin. Rheumatol. 19, 376–382 (2007)

    Kamel M.A. , 'The Wnt signaling pathway and bone metabolism ' (2007 ) 19 Curr. Opin. Rheumatol. : 376 -382.

    • Search Google Scholar
  • Kaneki H, Guo R, Chen D, Yao Z, Schwarz EM, Zhang YE, Boyce BF, Xing L: Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. J. Biol. Chem. 281, 4326–4333 (2006)

    Xing L. , 'Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts ' (2006 ) 281 J. Biol. Chem. : 4326 -4333.

    • Search Google Scholar
  • Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Olivera-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM: OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397, 315–323 (1999)

    Penninger J.M. , 'OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis ' (1999 ) 397 Nature : 315 -323.

    • Search Google Scholar
  • Kotake S, Udagawa N, Takahashi N, Matsuzaki K, Itoh K, Ishiyama S, Saito S, Inoue K, Kamatani N, Gillespie MT, Martin TJ, Suda T: IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J. Clin. Invest. 103, 1345–1352 (1999)

    Suda T. , 'IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis ' (1999 ) 103 J. Clin. Invest. : 1345 -1352.

    • Search Google Scholar
  • Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully, S, Hsu H, Sullivan J, Hawkins, N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ: Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93, 165–176 (1998)

    Boyle W.J. , 'Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation ' (1998 ) 93 Cell : 165 -176.

    • Search Google Scholar
  • Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP, Teitelbaum SL: TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J. Clin. Invest. 106, 1481–1488 (2000)

    Teitelbaum S.L. , 'TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand ' (2000 ) 106 J. Clin. Invest. : 1481 -1488.

    • Search Google Scholar
  • Luo X, Zuo X, Zhang B, Song L, Wei X, Zhou Y, Xiao X: Release of heat shock protein 70 and the effects of extracellular heat shock protein 70 on the production of IL-10 in fibroblast-like synoviocytes. Cell Stress Chaperones 13, 365–373 (2008)

    Xiao X. , 'Release of heat shock protein 70 and the effects of extracellular heat shock protein 70 on the production of IL-10 in fibroblast-like synoviocytes ' (2008 ) 13 Cell Stress Chaperones : 365 -373.

    • Search Google Scholar
  • Madden DR, Gorga JC, Strominger JL, Wiley DC: The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation. Nature 353, 321–325 (1991)

    Wiley D.C. , 'The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation ' (1991 ) 353 Nature : 321 -325.

    • Search Google Scholar
  • May E, Dorris ML, Satumtira N, Igbal I, Rehman MI, Lightfoot E, Taurog JD: CD8 alpha beta T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats. J. Immunol. 170, 1099–1105 (2003)

    Taurog J.D. , 'CD8 alpha beta T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats ' (2003 ) 170 J. Immunol. : 1099 -1105.

    • Search Google Scholar
  • Ni M, Lee AS: ER chaperones in mammalian development and human diseases. FEBS Letters 581, 3641–3651 (2007)

    Lee A.S. , 'ER chaperones in mammalian development and human diseases ' (2007 ) 581 FEBS Letters : 3641 -3651.

    • Search Google Scholar
  • Nössner E, Parham P: Species — specific differences in chaperone interaction of human mouse major histocompatibility complex class I molecules. J. Exp. Med. 181, 327–337 (1995)

    Parham P. , 'Species — specific differences in chaperone interaction of human mouse major histocompatibility complex class I molecules ' (1995 ) 181 J. Exp. Med. : 327 -337.

    • Search Google Scholar
  • Panjwani NN, Popova L, Srivastava PK: Heat shock proteins gp96 and hsp70 activate the release of nitric oxide by APCs. J. Immunol. 168, 2997–3003 (2002)

    Srivastava P.K. , 'Heat shock proteins gp96 and hsp70 activate the release of nitric oxide by APCs ' (2002 ) 168 J. Immunol. : 2997 -3003.

    • Search Google Scholar
  • Rea, IM; McNerlan, S; Pockley, AG: Serum heat shock protein and anti-heat shock protein antibody levels in aging. Exp. Gerontol. 36, 341–352 (2001)

    Pockley A.G. , 'Serum heat shock protein and anti-heat shock protein antibody levels in aging ' (2001 ) 36 Exp. Gerontol. : 341 -352.

    • Search Google Scholar
  • Redlich K, Hayer S, Ricci R, David JP, Tohidast-Akrad M, Kollias G, Steiner G, Smolen JS, Wagner EF, Schett G: Osteoclasts are essential for TNF-alpha-mediated joint destruction. J. Clin. Invest. 110, 1419–1427 (2002)

    Schett G. , 'Osteoclasts are essential for TNF-alpha-mediated joint destruction ' (2002 ) 110 J. Clin. Invest. : 1419 -1427.

    • Search Google Scholar
  • Reháková Z, Capková J, Stepanková R, Sinkora J, Louzecká A, Ivanyi P, Weinreich S: Germ-free mice do not develop ankylosing enthesopathy, a spontaneous joint disease. Hum. Immunol. 61, 555–558 (2000)

    Weinreich S. , 'Germ-free mice do not develop ankylosing enthesopathy, a spontaneous joint disease ' (2000 ) 61 Hum. Immunol. : 555 -558.

    • Search Google Scholar
  • Reveille JD, Ball EJ, Khan MA: HLA-B27 and genetic predisposing factors in spondyloarthropathies. Curr. Opin. Rheumatol. 13, 265–272 (2001)

    Khan M.A. , 'HLA-B27 and genetic predisposing factors in spondyloarthropathies ' (2001 ) 13 Curr. Opin. Rheumatol. : 265 -272.

    • Search Google Scholar
  • Said-Nahal R, Miceli-Richard C, Berthelot J-M, Duché A, Dernis-Labous E, Le Blévec G, Saraux A, Perdriger A, Guis S, Claudepierre P, Sibilia J, Amor B, Dougados M, Breban M: The familiar form of spondyloarthropathy: a clinical study of 115 multiplex families. Arthritis Rheum. 43, 1356–1365 (2000)

    Breban M. , 'The familiar form of spondyloarthropathy: a clinical study of 115 multiplex families ' (2000 ) 43 Arthritis Rheum. : 1356 -1365.

    • Search Google Scholar
  • Said-Nahal R, Miceli-Richard C, D’Agostino MA, Dernis-Labous E, Berthelot J-M, Duché A, Le Blévec G, Saraux A, Perdriger A, Guis S, Amor B, Dougados, M, Breban M, Groupe Francais d’Etude Génétique des Spondylarthropathies: Phenotypic diversity is not determined by independent genetic factors in familial spondylarthropathy. Arthritis Rheum. 45, 478–484 (2001)

    Breban M. , 'Phenotypic diversity is not determined by independent genetic factors in familial spondylarthropathy ' (2001 ) 45 Arthritis Rheum : 478 -484.

    • Search Google Scholar
  • Suzuki T, Segami N, Nishimura M, Hattori H, Nojima T: Analysis of 70Kd heat shock protein expression in patients with internal derangement of the temporomandibular joint. Int. J. Oral. Maxillofac. Surg. 29, 301–304 (2000)

    Nojima T. , 'Analysis of 70Kd heat shock protein expression in patients with internal derangement of the temporomandibular joint ' (2000 ) 29 Int. J. Oral. Maxillofac. Surg. : 301 -304.

    • Search Google Scholar
  • Tatakis DN, Guglielmoni P: HLA-B27 transgenic rats are susceptible to accelerated alveolar bone loss. J. Periodontol. 71, 1395–1400 (2000)

    Guglielmoni P. , 'HLA-B27 transgenic rats are susceptible to accelerated alveolar bone loss ' (2000 ) 71 J. Periodontol. : 1395 -1400.

    • Search Google Scholar
  • Taurog JD, Richardson JA, Croft JT, Simmons WA, Zhou M, Fernandez-Sueiro JL, Balish E, Hammer RE: The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J. Exp. Med. 180, 2359–2364 (1994)

    Hammer R.E. , 'The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats ' (1994 ) 180 J. Exp. Med. : 2359 -2364.

    • Search Google Scholar
  • Taurog JD, Maika S, Satumtira N, Dorris ML, McLean IL, Yanagisawa H, Sayad A, Stagg AJ, Fox GM, Lé O’Brien A, Rehman M, Zhou M, Weiner AL, Splawski JB, Richardson JA, Hammer RE: Inflammatory disease in HLA-B27 transgenic rats. Immunol. Rev. 169, 209–223 (1999)

    Hammer R.E. , 'Inflammatory disease in HLA-B27 transgenic rats ' (1999 ) 169 Immunol. Rev. : 209 -223.

    • Search Google Scholar
  • Tobian AA, Canaday DH, Harding CV: Bacterial heat shock proteins enhance class II MHC antigen processing and presentation of chaperoned peptides to CD4+ T cells. J. Immunol. 173, 5130–5137 (2004)

    Harding C.V. , 'Bacterial heat shock proteins enhance class II MHC antigen processing and presentation of chaperoned peptides to CD4+ T cells ' (2004 ) 173 J. Immunol. : 5130 -5137.

    • Search Google Scholar
  • Tran TM, Satumtira N, Dorris ML, May E, Wang A, Furuta E, Taurog JD: HLA-B27 in transgenic rats forms disulfide-linked heavy chain oligomers and multimers that bind to the chaperone BiP. J. Immunol. 172, 5110–5119 (2004)

    Taurog J.D. , 'HLA-B27 in transgenic rats forms disulfide-linked heavy chain oligomers and multimers that bind to the chaperone BiP ' (2004 ) 172 J. Immunol. : 5110 -5119.

    • Search Google Scholar
  • Warner TF, Madsen J, Starling J, Wagner RD, Taurog JD, Balish E: Human HLA-B27 gene enhances susceptibility of rats to oral infection by Listeria monocytogenes. Am. J. Pathol. 149, 1737–1743 (1996)

    Balish E. , 'Human HLA-B27 gene enhances susceptibility of rats to oral infection by Listeria monocytogenes ' (1996 ) 149 Am. J. Pathol. : 1737 -1743.

    • Search Google Scholar
  • Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL: IL-1 mediates TNF-induced osteoclastogenesis. J. Clin. Invest. 115, 282–290 (2005)

    Teitelbaum S.L. , 'IL-1 mediates TNF-induced osteoclastogenesis ' (2005 ) 115 J. Clin. Invest. : 282 -290.

    • Search Google Scholar
  • Wong PK, Quinn JM, Sims NA, van Nieuwenhuijze A, Campbell IK, Wicks IP: Interleukin-6 modulates production of T-lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis. Arthritis Rheum. 54, 158–168 (2006)

    Wicks I.P. , 'Interleukin-6 modulates production of T-lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis ' (2006 ) 54 Arthritis Rheum : 158 -168.

    • Search Google Scholar
  • Wright BH, Corton JM, El-Nahas AM, Wood RF, Pokley AG: Elevated levels of circulating heat shock protein 70 (Hsp70) in peripheral and renal vascular disease. Heart Vessels 15, 18–22 (2000)

    Pokley A.G. , 'Elevated levels of circulating heat shock protein 70 (Hsp70) in peripheral and renal vascular disease ' (2000 ) 15 Heart Vessels : 18 -22.

    • Search Google Scholar

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Sep 2020 7 0 0
Oct 2020 9 0 0
Nov 2020 9 11 4
Dec 2020 4 0 0
Jan 2021 12 0 0
Feb 2021 7 0 0
Mar 2021 5 0 0