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  • 1 Semmelweis University Human Physiology Department, Medical School Budapest Hungary
  • | 2 Semmelweis University Human Physiology Department Medical School Tűzoltó u. 37-47 H-1094 Budapest Hungary
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In the first part of this series of papers (Székely and Pataki, 102) the pathogenesis of asthma was approached as a pathological antigen-antibody complex induced vago-vagal axon reflex. In the next part (103) the contribution of individual hormonal predisposition, the environmental and the most frequent allergizing factors have been reviewed. In the first section of this last (third) part of the review the genetic factors contributing to the asthma are surveyed. In this field a great progress has been made during the last decade, a lot of genes have been pinpointed which contribute to the heredity of the disease. In the second section of this last paper on the etiology of asthma an attempt is made to summarize the previously reviewed data and some new ones. Actually a new hypothesis is proposed that beyond the multitude of genetic, environmental and hormonal factors the underlying biochemical mechanism is simple: the disequilibrium of two functionally opposing second messenger systems in the airways: the Ca i++ liberating PLC-PKC cascade and the Ca i++ level reducing cAMP mediated one with preponderance of the former.

  • Al-Bazzaz FJ, Gailey C: Ion transport by sheep distal airways in miniature chamber. Am. J. Physiol. Lung Cell Mol. Physiol. 281, L1028–L1034 (2001)

    Gailey C. , 'Ion transport by sheep distal airways in miniature chamber ' (2001 ) 281 Am. J. Physiol. Lung Cell Mol. Physiol. : L1028 -L1034.

    • Search Google Scholar
  • Alvin K, Weitzberg E, Lundberg JM: Increased amount of nitric oxide in exhaled air of asthmatics. Eur. Respir. J., 6, 1368–1370 (1993)

    Lundberg J.M. , 'Increased amount of nitric oxide in exhaled air of asthmatics ' (1993 ) 6 Eur. Respir. J. : 1368 -1370.

    • Search Google Scholar
  • Arriba-Mendez S, Sanz C, Isidoro-Garcia M, Davild I, Laffond E, Horeno E, Avila C, Lorente F: 927T>C polymorphism of the cysteinyl-leukotrine type-1 receptor (CYSLTR1) gene in children with asthma and atopic dermatitis. Pediatr. Allergy Immunol. 17, 323–328 (2006)

    Lorente F. , '927T>C polymorphism of the cysteinyl-leukotrine type-1 receptor (CYSLTR1) gene in children with asthma and atopic dermatitis ' (2006 ) 17 Pediatr. Allergy Immunol. : 323 -328.

    • Search Google Scholar
  • Ballard ST, Trout L, Garrison J, Inglis SK: Ionic mechanism of forskolin-induced liquid secretion by porcine bronchi. Am. J. Physiol. Lung Cell Mol. Physiol. 290, L97–L104 (2006)

    Inglis S.K. , 'Ionic mechanism of forskolin-induced liquid secretion by porcine bronchi ' (2006 ) 290 Am. J. Physiol. Lung Cell Mol. Physiol. : L97 -L104.

    • Search Google Scholar
  • Batra J, Pratap Singh T, Mabalirajan U, Sinha A, Prasad G, Ghos B: Association of inducible nitric oxide synthase with asthma severity, total serum immunoglobulin E and blood eosinophil levels. Thorax 62, 16–22 (2007)

    Ghos B. , 'Association of inducible nitric oxide synthase with asthma severity, total serum immunoglobulin E and blood eosinophil levels ' (2007 ) 62 Thorax : 16 -22.

    • Search Google Scholar
  • Batra J, Rajpoot R, Ahluwalia J, Devarapu SK, Sharma SK, Dinda AK, Ghosh B: A hexanucleotide repeat upstream of eotaxin gene promoter is associated with asthma, serum total IgE and plasma eotaxin levels. J. Med. Genet. 44, 397–403 (2007)

    Ghosh B. , 'A hexanucleotide repeat upstream of eotaxin gene promoter is associated with asthma, serum total IgE and plasma eotaxin levels ' (2007 ) 44 J. Med. Genet. : 397 -403.

    • Search Google Scholar
  • Billington CK, Joseph SK, Swan C, Scott MG, Jobson TM, Hall IP: Modulation of airway smooth muscle proliferation by type 3 phosphodiesterase inhibition. Am. J. Physiol. 276, L412–L419 (1999)

    Hall I.P. , 'Modulation of airway smooth muscle proliferation by type 3 phosphodiesterase inhibition ' (1999 ) 276 Am. J. Physiol. : L412 -L419.

    • Search Google Scholar
  • Blumenthal M, Marcus-Bagely D, Awdeh Z, Johnson B, Yunis EJ, Alper CA: HLA-DR2, [HLA-B7, SC31, DR2] and [HLA-B8, SC01, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy. J. Immunol. 148, 411–416 (1992)

    Alper C.A. , 'HLA-DR2, [HLA-B7, SC31, DR2] and [HLA-B8, SC01, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy ' (1992 ) 148 J. Immunol. : 411 -416.

    • Search Google Scholar
  • Boknik P, Fockenbrock M, Herzig S, Knapp J, Linck B, Lüss H, Müller FU, Müller T, Schmitz W, Schröder F, Neumann J: Protein phosphatase activity is increased in a rat model of long-term betaadrenergic stimulation. Naunyn-Schmiedeberg’s Arch. Pharmacol. 362, 222–231 (2000)

    Neumann J. , 'Protein phosphatase activity is increased in a rat model of long-term betaadrenergic stimulation ' (2000 ) 362 Naunyn-Schmiedeberg’s Arch. Pharmacol. : 222 -231.

    • Search Google Scholar
  • Boldogh I, Bacsi A, Choudhury BK, Dharajiya N, Alam R, Hazra KT, Mitra S, Goldblum RM, Bur B: ROS generated by pollen NADPH oxidase provide signal that augments antigen-induced allergic airway inflammation. J. Clin. Invest. 115, 2169–2179 (2005)

    Bur B. , 'ROS generated by pollen NADPH oxidase provide signal that augments antigen-induced allergic airway inflammation ' (2005 ) 115 J. Clin. Invest. : 2169 -2179.

    • Search Google Scholar
  • Brasch-Andersen C, Christiansen L, Tan Q, Haagerup A, Vestbo J, Kruse TA: Possible gene dosage effect of gluthatione-S-transferases on atopic asthma: using real time PCR for quantification of GSTM1 and GSTT1 gene copy numbers. Hum. Mutat. 24, 208–214 (2004)

    Kruse T.A. , 'Possible gene dosage effect of gluthatione-S-transferases on atopic asthma: using real time PCR for quantification of GSTM1 and GSTT1 gene copy numbers ' (2004 ) 24 Hum. Mutat. : 208 -214.

    • Search Google Scholar
  • Bredenbröcker D, Dyarmand D, Meingast U, Fehman HC, Staats P, Von Wichert P, Wagner U: Effects of nitric oxide/cGMP system compared with the cAMP system on airway mucus secretion in the rat. Eur. J. Pharmacol. 411, 319–325 (2001)

    Wagner U. , 'Effects of nitric oxide/cGMP system compared with the cAMP system on airway mucus secretion in the rat ' (2001 ) 411 Eur. J. Pharmacol. : 319 -325.

    • Search Google Scholar
  • Brown RA, Spina D, Page CP: Adenosine receptors and asthma. Br. J. Pharmacol. 153Suppl. 1, S446–S456 (2008)

    Page C.P. , 'Adenosine receptors and asthma ' (2008 ) 153 Br. J. Pharmacol. : S446 -S456.

  • Bucková D, Hollá LI, Znojil V, Vasků A: Polymorphisms of the CD14 gene and atopic phenotypes in Czech patients with IgE-mediated allergy. J. Hum. Genet. 51, 977–983 (2006)

    Vasků A. , 'Polymorphisms of the CD14 gene and atopic phenotypes in Czech patients with IgE-mediated allergy ' (2006 ) 51 J. Hum. Genet. : 977 -983.

    • Search Google Scholar
  • Burges JK: Connective tissue growth factor: a role in airway remodelling in asthma? Clin. Exp. Pharmacol. Physiol. 32, 988–994 (2005)

    Burges J.K. , 'Connective tissue growth factor: a role in airway remodelling in asthma? ' (2005 ) 32 Clin. Exp. Pharmacol. Physiol. : 988 -994.

    • Search Google Scholar
  • Candiano G, Bruschi M, Pedemonte N, Caci E, Liberatori S., Bini L, Pellegrini C, Vigano M, O’Connor BJ, Lee TH, Galietta LJ, Zegarra-Moran O: Gelsolin secretion in interleukin-4-treated bronchial epithelia and in asthmatic airways. Am. J. Respir. Crit. Care Med. 172, 1090–1096 (2005)

    Zegarra-Moran O. , 'Gelsolin secretion in interleukin-4-treated bronchial epithelia and in asthmatic airways ' (2005 ) 172 Am. J. Respir. Crit. Care Med. : 1090 -1096.

    • Search Google Scholar
  • Carlin S, Poronnik P, Cook DI, Carpenter L, Biden TJ, Johnson PR, Black JL: An antisense protein kinase C-zeta inhibits proliferation of human airway smooth muscle cells. Am. J. Respir. Cell. Mol. Biol. 23, 555–559 (2000)

    Black J.L. , 'An antisense protein kinase C-zeta inhibits proliferation of human airway smooth muscle cells ' (2000 ) 23 Am. J. Respir. Cell. Mol. Biol. : 555 -559.

    • Search Google Scholar
  • Chiang CH, Tang YC, Lin MW, Chung MY: Association between the IL-4 promoter polymorphisms and asthma or severity of hyperresponsiveness in Taiwanese. Respirology 12, 42–48 (2007)

    Chung M.Y. , 'Association between the IL-4 promoter polymorphisms and asthma or severity of hyperresponsiveness in Taiwanese ' (2007 ) 12 Respirology : 42 -48.

    • Search Google Scholar
  • Child F, Lenney W, Clayton S, Davies S, Jones PW, Alldersea JE, Strange RC, Fryer The association of maternal but not paternal genetic variation in GSTP1 with asthma phenotypes in children. Respir. Med. 97, 1247–1256 (2003)

    Fryer A.A. , 'The association of maternal but not paternal genetic variation in GSTP1 with asthma phenotypes in children ' (2003 ) 97 Respir. Med. : 1247 -1256.

    • Search Google Scholar
  • Chinet TC, Gabriel SE, Penland CM, Sato M, Stutts MJ, Boucher RC, Van Scott MR: CFTR-like chloride channels in non-ciliated bronchiolar epithelial (Clara) cells. Biochem. Biophys. Res. Commun. 230, 470–475 (1997)

    Scott M.R. , 'CFTR-like chloride channels in non-ciliated bronchiolar epithelial (Clara) cells ' (1997 ) 230 Biochem. Biophys. Res. Commun. : 470 -475.

    • Search Google Scholar
  • Cho SH, Ryu CH, Oh CK: Plasminogen activator inhibitor-1 in the pathogenesis of asthma. Exp. Biol. Med. (Maywood) 229, 138–146 (2004)

    Oh C.K. , 'Plasminogen activator inhibitor-1 in the pathogenesis of asthma ' (2004 ) 229 Exp. Biol. Med. (Maywood) : 138 -146.

    • Search Google Scholar
  • Contopoulos-Ioannnidis DG, Kouri IN, Ioannidis JP: Genetic predisposition to asthma and atopy. Respiration 74, 8–12 (2007)

    Ioannidis J.P. , 'Genetic predisposition to asthma and atopy ' (2007 ) 74 Respiration : 8 -12.

    • Search Google Scholar
  • Contopoulos-Ioannnidis DG, Manoli EN, Ioannidis JP: Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes. J. Allergy Clin. Immunol. 115, 963–972 (2005)

    Ioannidis J.P. , 'Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes ' (2005 ) 115 J. Allergy Clin. Immunol. : 963 -972.

    • Search Google Scholar
  • Conway JD, Bartolotta T, Abdullah LH, Davis CW: Regulation of mucin secretion from human bronchial epithelial cells grown in murine hosted xenografts. Am. J. Physiol. Lung Cell Mol. Physiol. 284, L945–L954 (2003)

    Davis C.W. , 'Regulation of mucin secretion from human bronchial epithelial cells grown in murine hosted xenografts ' (2003 ) 284 Am. J. Physiol. Lung Cell Mol. Physiol. : L945 -L954.

    • Search Google Scholar
  • Dent G, White SR, Tenor H, Bodtke K, Schudt C, Leff AR, Magnussen H, Rabe KF: Cyclic nucleotide phosphodiesterase in human bronchial epithelial cells: characterization of isoenzymes and functional effects of PDE inhibitors. Pulm. Pharmacol. Ther. 11, 47–56 (1998)

    Rabe K.F. , 'Cyclic nucleotide phosphodiesterase in human bronchial epithelial cells: characterization of isoenzymes and functional effects of PDE inhibitors ' (1998 ) 11 Pulm. Pharmacol. Ther. : 47 -56.

    • Search Google Scholar
  • Devor DC, Schultz BD: Ibuprofen inhibits cystic fibrosis transmembrane conductance regulator mediated Cl-secretion. J. Clin. Invest. 102, 679–687 (1998)

    Schultz B.D. , 'Ibuprofen inhibits cystic fibrosis transmembrane conductance regulator mediated Cl-secretion ' (1998 ) 102 J. Clin. Invest. : 679 -687.

    • Search Google Scholar
  • Ding KH, Hussain S, Akhtar RA, Isales CM, Abdel-Latif A: Inhibition of muscarinic-stimulated polyphosphoinositide hydrolysis and Ca2+ mobilization in cat iris sphincter smooth muscle cells by cAMP-elevating agents. Cell Signal. 9, 411–421 (1997)

    Abdel-Latif A. , 'Inhibition of muscarinic-stimulated polyphosphoinositide hydrolysis and Ca2+ mobilization in cat iris sphincter smooth muscle cells by cAMP-elevating agents ' (1997 ) 9 Cell Signal. : 411 -421.

    • Search Google Scholar
  • Duffy DL, Martin NG, Battistutta D, Hopper JL, Matthews JD: Genetics of asthma and hay fever in Australian twins. An. Rev. Respir. Dis. 142, 1351–1356 (1990)

    Matthews J.D. , 'Genetics of asthma and hay fever in Australian twins ' (1990 ) 142 An. Rev. Respir. Dis. : 1351 -1356.

    • Search Google Scholar
  • Fryer AD, Jacoby DB: Muscarinic receptors and control of airway smooth muscle. Am. J. Respir. Crit. Care Med. 158, S154–S160 (1998)

    Jacoby D.B. , 'Muscarinic receptors and control of airway smooth muscle ' (1998 ) 158 Am. J. Respir. Crit. Care Med. : S154 -S160.

    • Search Google Scholar
  • Fukui Y, Hizawa N, Takahashi D, Maeda Y, Jinushi E, Konno S, Nishimura M: Association between non-specific airway hyperresponsiveness and Arg16Gly beta2-adrenergic receptor gene polymorphism in asymptomatic healthy Japanese subjects. Chest 130, 449–454 (2006)

    Nishimura M. , 'Association between non-specific airway hyperresponsiveness and Arg16Gly beta2-adrenergic receptor gene polymorphism in asymptomatic healthy Japanese subjects ' (2006 ) 130 Chest : 449 -454.

    • Search Google Scholar
  • Gao PS, Heller NM, Walker W, Chen CH, Moller M, Plunkett B, Roberts MH, Schleimer RP, Hopkin JM, Huang SK: Variation of dinucleotide repeat sequence in the first exon of the STAT6 gene is associated with atopic asthma and differentially regulates the promoter activity in vitro. J. Med. Genet. 41, 535–539 (2004)

    Huang S.K. , 'Variation of dinucleotide repeat sequence in the first exon of the STAT6 gene is associated with atopic asthma and differentially regulates the promoter activity in vitro ' (2004 ) 41 J. Med. Genet. : 535 -539.

    • Search Google Scholar
  • Gao PS, Kawada H, Kasamatsu T, Mao XQ, Roberts MH, Miyamoto Y, Yoshimura M, Saitoh Y, Yasue H, Nakao K, Adra CN, Kun JF, Morooka S, Inoko H, Ho LP, Shirakawa T, Hopkin JM: Variants of NOS1, NOS2 and NOS3 genes in asthmatics. Biochem. Biophys. Res. Commun. 267, 761–763 (2000)

    Hopkin J.M. , 'Variants of NOS1, NOS2 and NOS3 genes in asthmatics ' (2000 ) 267 Biochem. Biophys. Res. Commun. : 761 -763.

    • Search Google Scholar
  • Gao J, Lin Y, Qiu C, Liu Y, Ma Y, Gan J: Relationship between HLAA-DQA1, — DQB1 genes polymorphism and susceptibility to bronchial asthma among Northern Hans (in Chinese). Zhonghua Yi Xue Za Zhi 2002, 379–383 (2002)

  • Gao J, Shan G, Sun B, Thompson PJ, Gao X: Association between polymorphism of tumour necrosis factor alpha-308 gene promoter and asthma: a meta-analysis. Thorax 61, 466–471 (2006)

    Gao X. , 'Association between polymorphism of tumour necrosis factor alpha-308 gene promoter and asthma: a meta-analysis ' (2006 ) 61 Thorax : 466 -471.

    • Search Google Scholar
  • Gervaziev YV, Kaznacheev VA, Gervazieva VB: Allelic polymorphism in the interleukin-4 promoter regions and their association with bronchial asthma among the Russsian population. Int. Arch. Allergy Immunol. 141, 257–264 (2006)

    Gervazieva V.B. , 'Allelic polymorphism in the interleukin-4 promoter regions and their association with bronchial asthma among the Russsian population ' (2006 ) 141 Int. Arch. Allergy Immunol. : 257 -264.

    • Search Google Scholar
  • Gosens R, Zaagsma J, Grootte Bromhhaar M, Nelemans A, Meurs H: Acetylcholine: a novel regulator of airway smooth muscle remodelling? Eur. J. Pharmacol. 500, 193–201 (2004)

    Meurs H. , 'Acetylcholine: a novel regulator of airway smooth muscle remodelling? ' (2004 ) 500 Eur. J. Pharmacol. : 193 -201.

    • Search Google Scholar
  • Gilliland FD, Y-F Li, Saxon A, Diaz-Sanchez D: Effect of gluthation-S-transferaze M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study. Lancet 363, 119–124 (2004)

    Diaz-Sanchez D. , 'Effect of gluthation-S-transferaze M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study ' (2004 ) 363 Lancet : 119 -124.

    • Search Google Scholar
  • Ha KS, Exton JH: Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts. J. Cell. Biol. 123, 1789–1796 (1993)

    Exton J.H. , 'Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts ' (1993 ) 123 J. Cell. Biol. : 1789 -1796.

    • Search Google Scholar
  • Hakonarson H, Grunstein MM: Regulation of second messengers associated with airway smooth muscle contraction and relaxation. Am. J. Respir. Crit. Care Med. 158, S115–S122 (1998)

    Grunstein M.M. , 'Regulation of second messengers associated with airway smooth muscle contraction and relaxation ' (1998 ) 158 Am. J. Respir. Crit. Care Med. : S115 -S122.

    • Search Google Scholar
  • Hamid Q, Springall DR, Riveros-Moreno V, Chanez P, Howarth P, Redington A, Bousquet J, Godard P, Holgate S, Polak JM: Induction of nitric oxide synthase in asthma. Lancet 342, 1510–1513 (1993)

    Polak J.M. , 'Induction of nitric oxide synthase in asthma ' (1993 ) 342 Lancet : 1510 -1513.

  • Heinzmann A, Jerkic SP, Ganter K, Kurz T, Blattmann S, Schuchmann L, Gerhold K, Berner R, Deichmann KA: Association study of the IL13 variant Arg10Gln in atopic and juvenile idiopathic arthritis. J. Allergy Clin. Immunol. 112, 735–739 (2003)

    Deichmann K.A. , 'Association study of the IL13 variant Arg10Gln in atopic and juvenile idiopathic arthritis ' (2003 ) 112 J. Allergy Clin. Immunol. : 735 -739.

    • Search Google Scholar
  • Higa S, Hirano T, Mayumi M, Hiraoka M, Ohshima Y, Nambu M, Yamaguchi E, Hizawa N, Kondo N, Matsui E, Katada Y, Miyatake A, Kawase I, Tanaka T: Association between interleukin-18 gene polymorphism 105A/C and asthma. Clin. Exp. Allergy 33, 1097–1102 (2003)

    Tanaka T. , 'Association between interleukin-18 gene polymorphism 105A/C and asthma ' (2003 ) 33 Clin. Exp. Allergy : 1097 -1102.

    • Search Google Scholar
  • Hirst SJ, Walker TR, Chilvers R: Phenotypic diversity and molecular mechanisms of airway smooth muscle proliferation in asthma. Eur. Respir. J. 16, 159–177 (2000)

    Chilvers R. , 'Phenotypic diversity and molecular mechanisms of airway smooth muscle proliferation in asthma ' (2000 ) 16 Eur. Respir. J. : 159 -177.

    • Search Google Scholar
  • Hizawa N, Maeda Y, Konno S, Fukui Y, Takahashi D, Nishimura M: Genetic polymorphism at FCER1B and PAI-1 and asthma susceptibility. Clin. Exp. Allergy 36, 872–876 (2006)

    Nishimura M. , 'Genetic polymorphism at FCER1B and PAI-1 and asthma susceptibility ' (2006 ) 36 Clin. Exp. Allergy : 872 -876.

    • Search Google Scholar
  • Hogaboam CM, Carpenter KJ, Schuh JM, Proudfoot AA, Bridger G, Buckland KF: The therapeutic potential in targeting CCR5 and CXCR4 receptors in infectious and allergic pulmonary disease. Pharmacol. Ther. 107, 314–328 (2005)

    Buckland K.F. , 'The therapeutic potential in targeting CCR5 and CXCR4 receptors in infectious and allergic pulmonary disease ' (2005 ) 107 Pharmacol. Ther. : 314 -328.

    • Search Google Scholar
  • Holberg CJ, Morgan WJ, Wrigth AL, Martinez FD: Differences in familial segregation of FEV 1 between asthmatic and non-asthmatic families. Role of a maternal component. Am. J. Respir. Crit. Care Med. 158, 162–169 (1998)

    Martinez F.D. , 'Differences in familial segregation of FEV1 between asthmatic and non-asthmatic families. Role of a maternal component ' (1998 ) 158 Am. J. Respir. Crit. Care Med. : 162 -169.

    • Search Google Scholar
  • Holla LI, Jurajda M, Pohunek P, Znojil V: Haplotype analysis of the endothelial nitric oxide synthase gene in asthma. Hum. Immunol. 69, 306–313 (2008)

    Znojil V. , 'Haplotype analysis of the endothelial nitric oxide synthase gene in asthma ' (2008 ) 69 Hum. Immunol. : 306 -313.

    • Search Google Scholar
  • Holla LI, Stejskalova A, Znojil V, Vasku A: Association of the promoter polymorphisms within the NOS3 gene and allergic diseases. Int. Arch. Allergy Immunol. 141, 103–109 (2006)

    Vasku A. , 'Association of the promoter polymorphisms within the NOS3 gene and allergic diseases ' (2006 ) 141 Int. Arch. Allergy Immunol. : 103 -109.

    • Search Google Scholar
  • Hoshino M, Morita S, Iwashita H, Sagiya Y, Nagai T, Nakanishi A, Ashida Y, Nishimura O, Fujisawa Y, Fujino M: Increased expression of the human Ca 2+ -activated Cl cannel 1 (CaCC1 gene) in the asthmatic airway. Am. J. Crit. Care Med. 165, 1132–1136 (2002)

    Fujino M. , 'Increased expression of the human Ca2+-activated Cl− cannel 1 (CaCC1 gene) in the asthmatic airway ' (2002 ) 165 Am. J. Crit. Care Med. : 1132 -1136.

    • Search Google Scholar
  • Hui J, Plamer LJ, James AL, Musk AW, Beilby JP: AluyMICB dimorphism within the class I region of the major histocompatibility complex is associated with asthma and airflow obstruction in the Busselton population. Clin. Exp. Allergy 36, 728–734 (2006)

    Beilby J.P. , 'AluyMICB dimorphism within the class I region of the major histocompatibility complex is associated with asthma and airflow obstruction in the Busselton population ' (2006 ) 36 Clin. Exp. Allergy : 728 -734.

    • Search Google Scholar
  • Hussain AN, Kumar V: Asthma. In: Robbin and Cotron Pathologic Basis of disease. Eds: Kumar V, Abbas AA, Fausto N. Elsevier-Sanders. 1999. pp. 723–727

  • Ibe BO, Portugal AM, Raj JU: Levalbuterol inhibits human airway smooth muscle cell proliferation: therapeutic implications in the management of asthma. Int. J. Allergy Immunol. 139, 225–236 (2006)

    Raj J.U. , 'Levalbuterol inhibits human airway smooth muscle cell proliferation: therapeutic implications in the management of asthma ' (2006 ) 139 Int. J. Allergy Immunol. : 225 -236.

    • Search Google Scholar
  • Isidoro-García M, Dávila I, Moreno E, Laffond E, Lorente F, Gonzáles-Sarmineto R: IL4RA gene polymorphism (Q576R) is associated with higher total IgE levels in Spanish patients with family history of atopy. Med. Clin. 124, 211–212 (2005)

    Gonzáles-Sarmineto R. , 'IL4RA gene polymorphism (Q576R) is associated with higher total IgE levels in Spanish patients with family history of atopy ' (2005 ) 124 Med. Clin. : 211 -212.

    • Search Google Scholar
  • Isidoro-García M, Dávila I, Moreno E, Lorente F, Gonzáles-Sarmineto R: Analysis of the leukotriene C4 synthase A-444C promoter polymorphism in a Spanish population. J. Allergy Clin. Immunol. 115, 206–207 (2005)

    Gonzáles-Sarmineto R. , 'Analysis of the leukotriene C4 synthase A-444C promoter polymorphism in a Spanish population ' (2005 ) 115 J. Allergy Clin. Immunol. : 206 -207.

    • Search Google Scholar
  • Jacoby BD, Gleich GJ, Fryer AD: Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor. J. Clin. Invest. 91, 1314–1318 (1993)

    Fryer A.D. , 'Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor ' (1993 ) 91 J. Clin. Invest. : 1314 -1318.

    • Search Google Scholar
  • Kaliner M, Shelhamer JH, Borson B, Nadel J, Patow C, Marom Z: Human respiratory mucus. Ann. Rev. Respir. Dis. 134, 612–621 (1986)

    Marom Z. , 'Human respiratory mucus ' (1986 ) 134 Ann. Rev. Respir. Dis. : 612 -621.

  • Kamada F, Suzuki Y, Shao C, Tamari M, Hasegawa K, Hirota T, Shimizu M, Takahashi N, Mao XQ, Doi S, Fujivara H, Miyatake A, Fujita K, Chiba Y, Aoki Y, Kure S, Tamura G, Shirakawa T, Matsubara Y: Association of hCLCA1 gene with childhood and adult asthma. Genes Immunol. 5, 540–547 (2004)

    Matsubara Y. , 'Association of hCLCA1 gene with childhood and adult asthma ' (2004 ) 5 Genes Immunol. : 540 -547.

    • Search Google Scholar
  • Kawagishi Y, Mita H, Taniguchi M, Maruyama M, Oosaki R, Higashi N, Kashii T, Kobayashi M, Akiyama K: Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma. J. Allergy Clin. Immunol. 109, 936–942 (2002)

    Akiyama K. , 'Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma ' (2002 ) 109 J. Allergy Clin. Immunol. : 936 -942.

    • Search Google Scholar
  • Kedda MA, Shi J, Duffy D, Phelps S, Yang I, O’Hara K, Fong K, Thompson PJ: Characterization of two polymorphisms in the leukotriene C4 synthase gene in an Australian population of subjects with mild, moderate and severe asthma. J. Allergy Clin. Immunol. 113, 889–895 (2004)

    Thompson P.J. , 'Characterization of two polymorphisms in the leukotriene C4 synthase gene in an Australian population of subjects with mild, moderate and severe asthma ' (2004 ) 113 J. Allergy Clin. Immunol. : 889 -895.

    • Search Google Scholar
  • Keskin O, Birben E, Sackesen C, Soyer OU, Alyamac E, Karaaslan C, Tokol N, Ercan H, Kalayci O: The effect of CD14-c159T genotypes on the cytokine response to endotoxin by peripheral blood mononuclear cells from asthmatic children. Ann. Allergy Asthma Immunol. 97, 321–328 (2006)

    Kalayci O. , 'The effect of CD14-c159T genotypes on the cytokine response to endotoxin by peripheral blood mononuclear cells from asthmatic children ' (2006 ) 97 Ann. Allergy Asthma Immunol. : 321 -328.

    • Search Google Scholar
  • Khoo SK, Zhang G, Backer V, Porsbjerg C, Nepper-Christensen S, Creegan R, Baynam G, de Klerk N, Rossi GA, Hagel I, Di Prisco MC, Lynch N, Britton J, Hall I, Musk AW, Goldblatt J, Le Souëf PN, Greenlandic Population Study Group: Association of a novel IL4RA polymorphism, Ala57/Thr in Greenlander Inuit. Allergy Clin. Immunol. 118, 627–634 (2006)

    Souëf P.N. , 'Association of a novel IL4RA polymorphism, Ala57/Thr in Greenlander Inuit ' (2006 ) 118 Allergy Clin. Immunol. : 627 -634.

    • Search Google Scholar
  • Korzycka-Zaborowska B, Hopkin JM, Górski P: Genetic variants of FcɛRIβ and IL-4 and atopy in a Polish population. Allergol. Immunopathol. 32, 53–58 (2004)

    Górski P. , 'Genetic variants of FcɛRIβ and IL-4 and atopy in a Polish population ' (2004 ) 32 Allergol. Immunopathol. : 53 -58.

    • Search Google Scholar
  • Krymskaya VP, Penn RB, Orsini MJ, Scott PH, Plevin RJ, Walker TR, Eszterhas AJ, Amrani Y, Chilvers ER, Panattieri RA Jr: Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation. Am. J. Physiol. 277, L65–L78 (1999)

    Panattieri R.A. , 'Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation ' (1999 ) 277 Am. J. Physiol. : L65 -L78.

    • Search Google Scholar
  • Kumar V, Abbas Asthma. In: Robbin and Cotron Pathologic Basis of Disease. Eds: Kumar V, Abbas AA and Fausto N, Elsevier-Sanders, 1999, pp. 723–727

  • Laprise C, Boulet LP, Morisette J, Winstall E, Raymond V: Evidence for association between atopy, airway hyperresponsiveness and the β subunit Glu237/Gly variant of high affinity immunoglobulin E in French-Canadian population. Immunogenetics 51, 695–702 (2000)

    Raymond V. , 'Evidence for association between atopy, airway hyperresponsiveness and the β subunit Glu237/Gly variant of high affinity immunoglobulin E in French-Canadian population ' (2000 ) 51 Immunogenetics : 695 -702.

    • Search Google Scholar
  • Lara-Marquez ML, Yunis JJ, Layrisse Z, Ortega F, Carvallo-Gil E, Montagnani S, Makhatadze NJ, Pocino M, Granja C, Yunis E: Immunogenetics of atopic asthma: association of DRBI*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the Venezuelan population. Clin. Exp. Allergy 29, 60–71 (1999)

    Yunis E. , 'Immunogenetics of atopic asthma: association of DRBI*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the Venezuelan population ' (1999 ) 29 Clin. Exp. Allergy : 60 -71.

    • Search Google Scholar
  • Lee SG, Kim BS, Kim JH, Lee SY, Choi SO, Shim JY, Hong TJ, Hong SJ: Gene-gene interaction between interleukin-4 and interleukin-4 alpha in Korean children with asthma. Clin. Exp. Allergy 34, 1202–1208 (2004)

    Hong S.J. , 'Gene-gene interaction between interleukin-4 and interleukin-4 alpha in Korean children with asthma ' (2004 ) 34 Clin. Exp. Allergy : 1202 -1208.

    • Search Google Scholar
  • Le Souëf PN: Variations in genetic influences on the development of asthma throughout childhood, adolescence and early adult life. Curr. Opin. Allergy Clin. Immunol. 6, 317–322 (2006)

    Souëf P.N. , 'Variations in genetic influences on the development of asthma throughout childhood, adolescence and early adult life ' (2006 ) 6 Curr. Opin. Allergy Clin. Immunol. : 317 -322.

    • Search Google Scholar
  • Liedtke CM, Cole T, Ikebe M: Differential activation of PKC-delta and-zeta by alpha 1-adrenergic stimulation in human airway epithelial cells. Am. J. Physiol. 273, C937–C943 (1997)

    Ikebe M. , 'Differential activation of PKC-delta and-zeta by alpha 1-adrenergic stimulation in human airway epithelial cells ' (1997 ) 273 Am. J. Physiol. : C937 -C943.

    • Search Google Scholar
  • Lee CC, Huang HY, Chiang BL: Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness. Mol. Ther. 16, 60–65 (2008)

    Chiang B.L. , 'Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness ' (2008 ) 16 Mol. Ther. : 60 -65.

    • Search Google Scholar
  • Lee, SG, Kim BS, Kim JH, Lee SY, Choi SO, Shim JY, Hong TJ, Hong SJ: Gene-gene interaction between interleukin-4 and interleukin-4 receptor alpha in Korean children with asthma. Clin. Exp. Allergy 34, 1202–1208 (2004)

    Hong S.J. , 'Gene-gene interaction between interleukin-4 and interleukin-4 receptor alpha in Korean children with asthma ' (2004 ) 34 Clin. Exp. Allergy : 1202 -1208.

    • Search Google Scholar
  • Li Y, Wu B, Xiong H, Zhu C, Zhang L: Polymorphisms of STAT-6, STAT-4 and IFN-gamma genes and the risk of asthma in Chinese population. Respir. Med. 101, 1977–1981 (2007)

    Zhang L. , 'Polymorphisms of STAT-6, STAT-4 and IFN-gamma genes and the risk of asthma in Chinese population ' (2007 ) 101 Respir. Med. : 1977 -1981.

    • Search Google Scholar
  • Liu M, Large WA, Albert AP: Stimulation of beta-adrenoceptors inhibits store-operated channel currents via a cAMP dependent protein kinase mechanism in rabbit portal vein myocytes. J. Physiol. (London) 562, 395–406 (2005)

    Albert A.P. , 'Stimulation of beta-adrenoceptors inhibits store-operated channel currents via a cAMP dependent protein kinase mechanism in rabbit portal vein myocytes ' (2005 ) 562 J. Physiol. (London) : 395 -406.

    • Search Google Scholar
  • Liu X, Xu Y., Zhang Z: Changes in delayed rectifier K + channel function and its regulation by protein kinase C pathway in bronchial myocytes from asthmatic rats. Chin. Med. J. (Engl.) 116, 1799–1803 (2003)

    Zhang Z. , 'Changes in delayed rectifier K+ channel function and its regulation by protein kinase C pathway in bronchial myocytes from asthmatic rats ' (2003 ) 116 Chin. Med. J. (Engl.) : 1799 -1803.

    • Search Google Scholar
  • Luo B, Prescott SM, Topham MK: Diacylglycerol kinase zeta regulates phosphatidylinositol-4-phosphate-5-kinase Iα by a novel mechanism. Cell Signal. 16, 891–897 (2004)

    Topham M.K. , 'Diacylglycerol kinase zeta regulates phosphatidylinositol-4-phosphate-5-kinase Iα by a novel mechanism ' (2004 ) 16 Cell Signal. : 891 -897.

    • Search Google Scholar
  • Maeda Y, Hizawa N, Jinushi E, Honda A, Takahshi D, Fukui Y, Konno S, Shimizu T, Shimizu H, Yamaguchi E, Nishimura M: Polymorphisms in the muscarinic receptor 1 gene confer susceptibility to asthma in Japanese subjects. Am. J. Respir. Crit. Care Med. 174, 1119–1124 (2006)

    Nishimura M. , 'Polymorphisms in the muscarinic receptor 1 gene confer susceptibility to asthma in Japanese subjects ' (2006 ) 174 Am. J. Respir. Crit. Care Med. : 1119 -1124.

    • Search Google Scholar
  • Mak JC, Barnes PJ: Muscarinic receptor subtypes in human and guinea pig lung. Eur. J. Pharmacol. 164, 223–230 (1989)

    Barnes P.J. , 'Muscarinic receptor subtypes in human and guinea pig lung ' (1989 ) 164 Eur. J. Pharmacol. : 223 -230.

    • Search Google Scholar
  • Mózsik G, Fiegler M, Larincz P, Nagy L, Tárnok F: The role of ATP — adenylate cyclase — cAMP system and its pharmacological regulation in the development of gastric hypersecretion and ulceration. Acta Medica Acad. Sci. Hung. 36, 427–448 (1979)

    Tárnok F. , 'The role of ATP — adenylate cyclase — cAMP system and its pharmacological regulation in the development of gastric hypersecretion and ulceration ' (1979 ) 36 Acta Medica Acad. Sci. Hung. : 427 -448.

    • Search Google Scholar
  • Ordoñez CL, Khashayar R, Wong HH, Ferrando R, Wu R, Hyde DM, Hotchkiss JA, Zhang Y, Novikov A, Dolganov G, Fahy JV: Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am. J. Respir. Care Med. 163, 517–523 (2001)

    Fahy J.V. , 'Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression ' (2001 ) 163 Am. J. Respir. Care Med. : 517 -523.

    • Search Google Scholar
  • Pieper MP, Chaudhary NI, Park JE: Acetylcholine-induced proliferation of fibroblasts and myofibroblasts in vitro is inhibited by tiopropium bromide. Life Sci. 80, 2270–2273 (2007)

    Park J.E. , 'Acetylcholine-induced proliferation of fibroblasts and myofibroblasts in vitro is inhibited by tiopropium bromide ' (2007 ) 80 Life Sci. : 2270 -2273.

    • Search Google Scholar
  • Potaczek DP, Sanak M, Mastalerz L, Setkowicz M, Kaczor M, Nizankowska E, Szczeklik A: The α- chain of high afinity receptor for IgE (FcɛRIα) gene polymorphisms and serum IgE levels. Allergy 61, 1230–1233 (2006)

    Szczeklik A. , 'The α- chain of high afinity receptor for IgE (FcɛRIα) gene polymorphisms and serum IgE levels ' (2006 ) 61 Allergy : 1230 -1233.

    • Search Google Scholar
  • Pykäläinen M, Kinos R, Valkonen S, Rydman P, Kilpeläinen M, Laitinen LA, Karjalainen J, Nieminen M, Hurme M, Kere J, Laitinen T, Lahesmaa R: Association analysis of common variants of STAT6, GATA3 and STAT4 to asthma and high serum IgE phenotypes. J. Allergy Clin. Immunol 115, 80–87 (2005)

    Lahesmaa R. , 'Association analysis of common variants of STAT6, GATA3 and STAT4 to asthma and high serum IgE phenotypes ' (2005 ) 115 J. Allergy Clin. Immunol : 80 -87.

    • Search Google Scholar
  • Raeymaekers L, Eggermont JA, Wuytack F, Casteels R: Effect of cyclic nucleotide dependent protein kinases on endoplasmic reticulum Ca ++ pump of bovine pulmonary artery. Cell Calcium 11, 261–268 (1990)

    Casteels R. , 'Effect of cyclic nucleotide dependent protein kinases on endoplasmic reticulum Ca++ pump of bovine pulmonary artery ' (1990 ) 11 Cell Calcium : 261 -268.

    • Search Google Scholar
  • Rossi AH, Sears PR, Davis CW: Ca 2+ dependency of “Ca 2+ -independent” exocytosis in SPOC1 airway goblet cells. J. Physiol. (London) 559, 555–565 (2004)

    Davis C.W. , 'Ca2+ dependency of “Ca2+-independent” exocytosis in SPOC1 airway goblet cells ' (2004 ) 559 J. Physiol. (London) : 555 -565.

    • Search Google Scholar
  • Roux E, Molimard M, Savineau JP, Marthan R: Muscarinic stimulation of airway smooth muscle cells. Gen. Pharmacol. 31, 349–356 (1998)

    Marthan R. , 'Muscarinic stimulation of airway smooth muscle cells ' (1998 ) 31 Gen. Pharmacol. : 349 -356.

    • Search Google Scholar
  • Sanford AJ, Zhu S, Bai TR, Fitzgerald JM, Paré PD: The role of CC-chemokine receptor-5 delta-32 polymorphism in asthma and in the production of regulated on activation, normal T cells expressed and secreted. Allergy Clin. Immunol. 108, 69–73 (2001)

    Paré P.D. , 'The role of CC-chemokine receptor-5 delta-32 polymorphism in asthma and in the production of regulated on activation, normal T cells expressed and secreted ' (2001 ) 108 Allergy Clin. Immunol. : 69 -73.

    • Search Google Scholar
  • Sant’Ambroglio G, Widdicombe J: Reflexes from the airway rapidly adapting receptors. Respir. Physiol. 125, 33–45 (2001)

    Widdicombe J. , 'Reflexes from the airway rapidly adapting receptors ' (2001 ) 125 Respir. Physiol. : 33 -45.

    • Search Google Scholar
  • Sanz C, Isidoro-García N, Dávila I, Moreno E, Laffond E, Avila C, Lorente F: Promoter gene variants of prostanoid DP receptor (PTGDR) gene in patients with asthma. Allergy 61, 543–548 (2006)

    Lorente F. , 'Promoter gene variants of prostanoid DP receptor (PTGDR) gene in patients with asthma ' (2006 ) 61 Allergy : 543 -548.

    • Search Google Scholar
  • Sanz C, Isidoro-García N, Dávila I, Moreno E, Laffond E, Lorente F: Analysis of 927T > C CYSLTRI and 444A > C LTC4S polymorphism in patients with asthma. Investig. Allergol. Clin. Immunol. 16, 331–337 (2006)

    Lorente F. , 'Analysis of 927T > C CYSLTRI and 444A > C LTC4S polymorphism in patients with asthma ' (2006 ) 16 Investig. Allergol. Clin. Immunol. : 331 -337.

    • Search Google Scholar
  • Sathish V, Leblebici F, Kip SN, Thompson MA, Pabelik CM, Prakash YS, Sieck GC: Regulation of sarcoplasmic reticulum Ca 2+ reuptake in porcine airway smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 294, L787–L796 (2008)

    Sieck G.C. , 'Regulation of sarcoplasmic reticulum Ca2+ reuptake in porcine airway smooth muscle ' (2008 ) 294 Am. J. Physiol. Lung Cell Mol. Physiol. : L787 -L796.

    • Search Google Scholar
  • Schaak S, Mialet-Perez J, Flordellis C, Paris H: Genetic variation of human adrenergic receptors from molecular and functional properties to clinical and pharmacological implications. Curr. Top. Med. Chem. 7, 217–231 (2007)

    Paris H. , 'Genetic variation of human adrenergic receptors from molecular and functional properties to clinical and pharmacological implications ' (2007 ) 7 Curr. Top. Med. Chem. : 217 -231.

    • Search Google Scholar
  • Seah GT, Gao PS, Hopkin JM, Rook GA: Interleukin-4 and its alternatively spliced variant (IL-4δ2) in patients with atopic asthma. Am. J. Respir. Crit. Care Med. 164, 1016–1018 (2001)

    Rook G.A. , 'Interleukin-4 and its alternatively spliced variant (IL-4δ2) in patients with atopic asthma ' (2001 ) 164 Am. J. Respir. Crit. Care Med. : 1016 -1018.

    • Search Google Scholar
  • Shao C, Suzuki Y, Kamada F, Kanno K, Tamari M, Hasegawa K, Aoki Y, Kure S, Yang X, Endo H, Takayanagi R, Nakazawa C, Morikawa T, Miyabayashi S, Chiba Y, Karahashi M, Saito S, Tamura G, Shirakawa T, Matsubara Y: Linkage association of childhood asthma with the chromosome 12 genes. J. Hum. Genet. 49, 115–122 (2004)

    Matsubara Y. , 'Linkage association of childhood asthma with the chromosome 12 genes ' (2004 ) 49 J. Hum. Genet. : 115 -122.

    • Search Google Scholar
  • Shimura S: Signal transduction of mucous secretion by bronchial gland cells. Cell Signal. 12, 271–277 (2000)

    Shimura S. , 'Signal transduction of mucous secretion by bronchial gland cells ' (2000 ) 12 Cell Signal. : 271 -277.

    • Search Google Scholar
  • Schmidt D, Dent G, Rabe KF: Selective phosphodiesterase inhibitors for the treatment of bronchial asthma and chronic obstructive pulmonary disease. Clin. Exp. Allergy 29/Suppl. 2, 99–100 (1999)

    Rabe K.F. , 'Selective phosphodiesterase inhibitors for the treatment of bronchial asthma and chronic obstructive pulmonary disease ' (1999 ) 29/ Clin. Exp. Allergy : 99 -100.

    • Search Google Scholar
  • Schmiedl A, Tschernig, T, Brasch F, Pabst R, Bargsten G: Decrease of the surface fraction of surfactant proteins containing Clara cells and type II pneumocytes in a rat asthma model. Exp. Toxicol. Pathol. 56, 265–272 (2005)

    Bargsten G. , 'Decrease of the surface fraction of surfactant proteins containing Clara cells and type II pneumocytes in a rat asthma model ' (2005 ) 56 Exp. Toxicol. Pathol. : 265 -272.

    • Search Google Scholar
  • Schramm CM, Omlor GJ, Quinn LM, Noveral JP: Methylprednisolone and isoproterenol inhibit airway smooth muscle proliferation by separate and additive mechanisms. Life Sci. 59, PL9–PL14 (1996)

    Noveral J.P. , 'Methylprednisolone and isoproterenol inhibit airway smooth muscle proliferation by separate and additive mechanisms ' (1996 ) 59 Life Sci. : PL9 -PL14.

    • Search Google Scholar
  • Silver PJ, DiSalvo J: Adenosine 3′:5′-monophosphate mediated inhibition of myosin light chain phosphorylation in bovine aortic actimyosin. J. Biol. Chem. 254, 9951–9954 (1979)

    DiSalvo J. , 'Adenosine 3′:5′-monophosphate mediated inhibition of myosin light chain phosphorylation in bovine aortic actimyosin ' (1979 ) 254 J. Biol. Chem. : 9951 -9954.

    • Search Google Scholar
  • Skadhauge LR, Christensen K, Kyvik KO, Sigsgaard T: Genetic and environmental influence on asthma: a population-based study of 11,688 Danish twin pairs. Eur. Respir. J. 13, 8–14 (1999)

    Sigsgaard T. , 'Genetic and environmental influence on asthma: a population-based study of 11,688 Danish twin pairs ' (1999 ) 13 Eur. Respir. J. : 8 -14.

    • Search Google Scholar
  • Spiteri MA, Bianco A, Strange RC, Fryer Polymorphisms at the gluthatione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of airway inflammation. Allergy 55Suppl. 61, 15–20 (2000)

    Fryer A.A. , 'Polymorphisms at the gluthatione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of airway inflammation ' (2000 ) 55 Allergy : 15 -20.

    • Search Google Scholar
  • Sun JG, Deng YM, Wu X, Tang HF, Deng JF, Chen JQ, Yang SY, Xie QM: Inhibition of phosphodiesterase activity, airway inflammation and hyperresponsiveness by PDE4 inhibitor and glucocorticoid in a murine model of asthma. Life Sci. 79, 2077–2085 (2006)

    Xie Q.M. , 'Inhibition of phosphodiesterase activity, airway inflammation and hyperresponsiveness by PDE4 inhibitor and glucocorticoid in a murine model of asthma ' (2006 ) 79 Life Sci. : 2077 -2085.

    • Search Google Scholar
  • Székely JI, Pataki Á: Recent findings on the pathogenesis of asthma, a review. Part I. Asthma as a neurohumoral disorder, a pathological vago-vagal axon reflex. Acta Physiol. Hung. 96, 1–17 (2009)

    Pataki , 'Recent findings on the pathogenesis of asthma, a review. Part I. Asthma as a neurohumoral disorder, a pathological vago-vagal axon reflex ' (2009 ) 96 Acta Physiol. Hung. : 1 -17.

    • Search Google Scholar
  • Székely JI, Pataki Á: Recent findings on the pathogenesis of bronchial asthma. Part II. The role of hormonal predisposition, environmental influences and conditioning leading to bronchial asthma. Acta Physiol. Hung. 96, 289–305 (2009)

    Pataki , 'Recent findings on the pathogenesis of bronchial asthma. Part II. The role of hormonal predisposition, environmental influences and conditioning leading to bronchial asthma ' (2009 ) 96 Acta Physiol. Hung. : 289 -305.

    • Search Google Scholar
  • Tachado SD, Akhtar RA, Zhou CJ, Abdel-Latif Effects of isoproterenol and forskolin on carbachol- and fluoroaluminate-induced polyphosphoinositide hydrolysis, inositol trisphosphate production, and contraction in bovine iris sphincter smooth muscle: interaction between cAMP and IP3 second messenger system. Cell Signal. 4, 61–75 (1992)

    Abdel-Latif A.A. , 'Effects of isoproterenol and forskolin on carbachol- and fluoroaluminate-induced polyphosphoinositide hydrolysis, inositol trisphosphate production, and contraction in bovine iris sphincter smooth muscle: interaction between cAMP and IP3 second messenger system ' (1992 ) 4 Cell Signal. : 61 -75.

    • Search Google Scholar
  • Tamer L, Calikoclu M, Aras Ates N, Yildirim H, Karakas S, Atik U: Relationship between N-acetyl transefrase-2 gene polymorphism and risk of bronchial asthma. Tuberk. Toraks 54, 137–143 (2006)

    Atik U. , 'Relationship between N-acetyl transefrase-2 gene polymorphism and risk of bronchial asthma ' (2006 ) 54 Tuberk. Toraks : 137 -143.

    • Search Google Scholar
  • Tamer L, Calikoclu M, Ates NA, Yildirim H, Ercan B, Saritas E, Unlü A, Atik U: Gluthatione-Stransferase gene polymorphisms (GSTT1, SSTM1, GSTP1) as increased risk factors for asthma. Respirology 9, 493–498 (2004)

    Atik U. , 'Gluthatione-Stransferase gene polymorphisms (GSTT1, SSTM1, GSTP1) as increased risk factors for asthma ' (2004 ) 9 Respirology : 493 -498.

    • Search Google Scholar
  • Tang HF, Chen JQ, Xie QM, Zheng XY, Zhu YL, Adcock I, Wang X: The role of PDE4 in pulmonary inflammation and goblet cell hyperplasia in allergic rats. Biochim. Biophys. Acta 1762, 525–532 (2006)

    Wang X. , 'The role of PDE4 in pulmonary inflammation and goblet cell hyperplasia in allergic rats ' (2006 ) 1762 Biochim. Biophys. Acta : 525 -532.

    • Search Google Scholar
  • Temann UA, Prasad B, Gallup MW, Basbaum C, Ho SB, Flavell RA, Rankin JA: A novel role for murine IL-4 in vivo: induction of MUC5AC gene expression and mucin hypersecretion. Am J. Respir. Cell Mol. Biol. 16, 471–478 (1997)

    Rankin J.A. , 'A novel role for murine IL-4 in vivo: induction of MUC5AC gene expression and mucin hypersecretion ' (1997 ) 16 Am J. Respir. Cell Mol. Biol. : 471 -478.

    • Search Google Scholar
  • Tokunaga T, Kiso T, Namikawa T, Ohtsubo V: cAMP-independent chloride secretion activated by vasoactive intestinal peptide in a monolayer culture of human bronchial epithelial cells. Biol. Pharm. Bull. 22, 745–748 (1999)

    Ohtsubo V. , 'cAMP-independent chloride secretion activated by vasoactive intestinal peptide in a monolayer culture of human bronchial epithelial cells ' (1999 ) 22 Biol. Pharm. Bull. : 745 -748.

    • Search Google Scholar
  • Tomlinson PR, Wilson JW, Stewart AG: Salbutamol inhibits the proliferation of human airway smooth muscle cells grown in culture: relationship to elevated cAMP levels. Biochem. Pharmacol 49, 1809–1819 (1995)

    Stewart A.G. , 'Salbutamol inhibits the proliferation of human airway smooth muscle cells grown in culture: relationship to elevated cAMP levels ' (1995 ) 49 Biochem. Pharmacol : 1809 -1819.

    • Search Google Scholar
  • Van Scott MR, Penland CM, Welch CA, Lazarowski E: Beta-adrenergic regulation of Cl and HCO3 secretion by Clara cells. Am. J. Respir. Cell Mol. Biol. 13, 344–351 (1995)

    Lazarowski E. , 'Beta-adrenergic regulation of Cl− and HCO3− secretion by Clara cells ' (1995 ) 13 Am. J. Respir. Cell Mol. Biol. : 344 -351.

    • Search Google Scholar
  • Wang YX, Fleishmann BK, Kotlikoff MI: M 2 receptor activation of nonselective cation channels in smooth muscle cells: calcium and Gi/Go requirements. Am. J. Physiol. 273, C500–C508 (1997)

    Kotlikoff M.I. , 'M2 receptor activation of nonselective cation channels in smooth muscle cells: calcium and Gi/Go requirements ' (1997 ) 273 Am. J. Physiol. : C500 -C508.

    • Search Google Scholar
  • Wang P, Liu QJ, Liu JS, Li HC, Wei CH, Guo CH, Gong YQ: Lack of association between ADAM33 gene and asthma in a Chinese population. Int. J. Immunogenet. 33, 303–306 (2006)

    Gong Y.Q. , 'Lack of association between ADAM33 gene and asthma in a Chinese population ' (2006 ) 33 Int. J. Immunogenet. : 303 -306.

    • Search Google Scholar
  • Wang K, Wen FQ, Feng YL, Ou XM, Xu D, Yang J, Deng ZP: Increased expression of human calcium activated chloride channel 1 gene is correlated with mucus overproduction in Chinese asthmatic airway. Cell. Biol. Int. 31, 1388–1395 (2007)

    Deng Z.P. , 'Increased expression of human calcium activated chloride channel 1 gene is correlated with mucus overproduction in Chinese asthmatic airway ' (2007 ) 31 Cell. Biol. Int. : 1388 -1395.

    • Search Google Scholar
  • Wellman GC, Santana LF, Bonev AD, Nelson MT: Role of phospholamban in the modulation of atrial Ca2+ sparks and Ca(2+)-activated K(+) channels by cAMP. Am. J. Physiol. Cell Physiol. 281, C1029–1037 (2001)

    Nelson M.T. , 'Role of phospholamban in the modulation of atrial Ca2+ sparks and Ca(2+)-activated K(+) channels by cAMP ' (2001 ) 281 Am. J. Physiol. Cell Physiol. : C1029 -1037.

    • Search Google Scholar
  • Widdicombe JG: Overview of neural pathways in allergy and asthma. Pulm. Pharmacol. Ther. 16, 23–30 (2003)

    Widdicombe J.G. , 'Overview of neural pathways in allergy and asthma ' (2003 ) 16 Pulm. Pharmacol. Ther. : 23 -30.

    • Search Google Scholar
  • Widdicombe JH, Kondo M, Mochizuki H: Regulation of airway mucosal ion transport. Int. J. Allergy Appl. Immunol. 94, 56–61 (1991)

    Mochizuki H. , 'Regulation of airway mucosal ion transport ' (1991 ) 94 Int. J. Allergy Appl. Immunol. : 56 -61.

    • Search Google Scholar
  • Young HS, Jones LR, Stokes DL: Locating phospholamban in co-crystals with Ca(2+)-ATPase by cryoelectron microscopy. Biophys. Res. 81, 884–894 (2001) Fig. 2. Opposite effect on smooth muscle proliferation of the PLC-PKC(zeta) + ERK and cAMP mediated biochemical cascades

    Stokes D.L. , 'Locating phospholamban in co-crystals with Ca(2+)-ATPase by cryoelectron microscopy ' (2001 ) 81 Biophys. Res. : 884 -894.

    • Search Google Scholar

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Senior editors

Editor(s)-in-Chief: Rosivall, László

Honorary Editor(s)-in-Chief): Monos, Emil

Managing Editor(s): Bartha, Jenő; Berhidi, Anna

Co-editor(s): Koller, Ákos; Lénárd, László; Szénási, Gábor

Assistant Editor(s): G. Dörnyei (Budapest), Zs. Miklós (Budapest), Gy. Nádasy (Budapest)

Hungarian Editorial Board

      Benedek, György (Szeged)
      Benyó, Zoltán (Budapest)
      Boros, Mihály (Szeged)
      Chernoch, László (Debrecen)
      Détári, László (Budapest)
      Hamar, János (Budapest)
      Hantos, Zoltán (Szeged)
      Hunyady, László (Budapest)
      Imre, Sándor (Debrecen)
      Jancsó, Gábor (Szeged)
      Karádi, Zoltán (Pécs)
      Kovács, László (Debrecen)
      Palkovits, Miklós (Budapest)
      Papp, Gyula (Szeged)
      Pavlik, Gábor (Budapest)
      Spät, András (Budapest)
      Szabó, Gyula (Szeged)
      Szelényi, Zoltán (Pécs)
      Szolcsányi, János (Pécs)
      Szollár, Lajos (Budapest)
      Szücs, Géza (Debrecen)
      Telegdy, Gyula (Szeged)
      Toldi, József (Szeged)
      Tósaki, Árpád (Debrecen)

International Editorial Board

      R. Bauer (Jena)
      W. Benjelloun (Rabat)
      A. W. Cowley Jr. (Milwaukee)
      D. Djuric (Belgrade)
      C. Fry (London)
      S. Greenwald (London)
      O. Hänninen (Kuopio)
      H. G. Hinghofer-Szalkay (Graz)
      Th. Kenner (Graz)
      Gy. Kunos (Richmond)
      M. Mahmoudian (Tehran)
      T. Mano (Seki, Gifu)
      G. Navar (New Orleans)
      H. Nishino (Nagoya)
      O. Petersen (Liverpool)
      U. Pohl (Münich)
      R. S. Reneman (Maastricht)
      A. Romanovsky (Phoenix)
      G. M. Rubanyi (Richmond)
      T. Sakata (Oita)
      A. Siddiqui (Karachi)
      Cs. Szabo (Beverly)
      E. Vicaut (Paris)
      N. Westerhof (Amsterdam)
      L. F. Zhang (Xi'an)

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Acta Physiologica Hungarica
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Phone/Fax: +36-1-2100-100
E-mail: aph@semmelweis-univ.hu

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Acta Physiologica Hungarica
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