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  • 1 Semmelweis University and Department Geriatrics, National Institute of Psychiatry & Neurology Institute of Human Physiology and Clinical Experimental Research Budapest Hungary
  • 2 Semmelweis University and Department Geriatrics, National Institute of Psychiatry & Neurology 2nd Department of Obstetrics and Gynecology Budapest Hungary
  • 3 Semmelweis University and Department Geriatrics, National Institute of Psychiatry & Neurology 2nd Department of Internal Medicine — Department Section of Geriatrics, Faculty of Medicine Budapest Hungary
  • 4 Faculty of Medicine, Semmelweis University 2nd Department of Obstetrics and Gynecology Üllői út 78/A H-1082 Budapest Hungary
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Hypertension causes small vessel remodeling, vasomotor alterations. We investigated diameter, tone and mechanics of intramural small coronaries of female rats that received chronic angiotensin treatment to induce hypertension.Angiotensin II infusion (AII, 100 ng/bwkg/min, sc.) was used to establish hypertension in 10 female rats. Other 10 rats served as controls. Following 4 weeks of treatment, side branches of the left anterior descendant coronary (diameter∼200 μm) were isolated, cannulated and pressure-diameter curves were registered between 2–90 mmHg. Changes in vessel diameter were measured in Krebs solution, in the presence of thromboxane A2 receptor agonist (U46619, 10−6M), bradykinin (BK, 10−6M), and finally at complete relaxation (in Ca2+-free solution).Chronic AII treatment raised the mean arterial pressure (130±5 mmHg vs. 96±2 mmHg, average ±SEM) significantly. Wall thickness of the AII group was significantly greater (40.2±4.2 μm vs. 31.4±2.7 μm at 50 mmHg in Ca2+-free solution), but cross-section of the vessel wall did not differ. Tangentional wall stress and elastic modulus decreased significantly in hypertensive animals. Constrictions in the presence of U46619 were greater in the AII group (24.4± 5.6% vs. 14.5±3.3% at 50 mmHg).In hypertension, intramural small coronaries showed inward eutrophic remodeling, as a morphological adaptation following AII treatment enhanced thromboxane A2 — induced tone.

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