Oxidative stress is related to the liver fibrosis, anticipating the hepatic stellate cells’ (HSC) activation. Our aim was to correlate oxidative stress markers with the histological liver alterations in order to identify predictive, noninvasive parameters of fibrosis progression in the evolution of toxic hepatitis.CCl4 in sunflower oil was administered to rats intragastrically, twice a week. After 2, 3, 4 and 8 weeks of treatment, plasma levels of malondialdehyde (MDA), protein carbonyls (PC), hydrogen donor capacity (HD), sulfhydryl groups (SH), and glutathione (GSH) were measured and histological examination of the liver slides was performed. Dynamics of histological disorders was assessed by The Knodell score. Significant elevation of inflammation grade was obtained after the second week of the experiment only (p=0.001), while fibrosis started to become significant (p=0.001) after 1 month of CCl4 administration. Between plasma MDA and liver fibrosis development a good correlation was obtained (r=0.877, p=0.05). Correlation between PC dynamics and liver alterations was marginally significant for inflammation grade (r=0.756, p=0.138). HD evolution revealed a marginally inverse correlation with inflammation grade (r=−0.794, p=0.108). No correlations could be established for other parameters with either inflammation grade or fibrosis stage.Our study shows that MDA elevation offers the best prediction potential for fibrosis, while marginal prediction fiability could be attributed to high levels of plasma PC and low levels of HD.
Dunning D, Hannivoort RA, de Boer JF, Buist-Homan M, Faber KN, Moshage H: Superoxide anions and hydrogen peroxide inhibit proliferation of activated rat stellate cells and induce different modes of cell death. Liver Int. 29(6), 922–932 (2009)
Moshage H., 'Superoxide anions and hydrogen peroxide inhibit proliferation of activated rat stellate cells and induce different modes of cell death' (2009) 29Liver Int: 922-932.
Moshage H.Superoxide anions and hydrogen peroxide inhibit proliferation of activated rat stellate cells and induce different modes of cell deathLiver Int200929922932)| false
Kim KY, Choi I, Kim SS: Progression of hepatic cell activation is associated with the level of oxidative stress rather than cytokines during CCl4-induced fibrogenesis. Mol. Cells. 10(3), 289–300 (2000)
Kim S.S., 'Progression of hepatic cell activation is associated with the level of oxidative stress rather than cytokines during CCl4-induced fibrogenesis' (2000) 10Mol. Cells.: 289-300.
Kim S.S.Progression of hepatic cell activation is associated with the level of oxidative stress rather than cytokines during CCl4-induced fibrogenesisMol. Cells.200010289300)| false
Usha K, Hemalatha P: Hepatoprotective effect of hygrophila spinosa and cassia occidentalis on carbon tetrachloride induced liver damage in experimental rats. Indian J. of Clin. Biochem. 22(2), 132–135 (2007)
Hemalatha P., 'Hepatoprotective effect of hygrophila spinosa and cassia occidentalis on carbon tetrachloride induced liver damage in experimental rats' (2007) 22Indian J. of Clin. Biochem.: 132-135.
Hemalatha P.Hepatoprotective effect of hygrophila spinosa and cassia occidentalis on carbon tetrachloride induced liver damage in experimental ratsIndian J. of Clin. Biochem.200722132135)| false
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