Authors:
Naoki Harikai Mukogawa Women’s University School of Pharmacy and Pharmaceutical Sciences 11-68 Koshien Kyuban-cho Nishinomiya, Hyogo 663-8179 Japan

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M. Yamada Mukogawa Women’s University School of Pharmacy and Pharmaceutical Sciences 11-68 Koshien Kyuban-cho Nishinomiya, Hyogo 663-8179 Japan

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To understand the molecular mechanism of hyperglucocorticoidism in obese Zucker rats, this study investigated glucocorticoid synthesis-related factors and their transcription factors in the adrenals. glucocorticoid synthesis-related factors and their transcription factors in the adrenals. The serum corticosterone level after foot shock stress was higher in obese Zucker rats than in lean Zucker rats. after foot shock stress was higher in obese Zucker rats than in lean Zucker rats. In the adrenals from obese Zucker rats, the mRNA and protein levels of steroidogenic acute regulatory protein were higher than those from lean Zucker rats. rats. However, the mRNA level of steroidogenic factor-1(SF-1), an important transcription factor for these glucocorticoid synthesis-related factors, did not differ between lean and obese Zucker rats. glucocorticoid synthesis-related factors, did not differ between lean and obese Zucker rats. Focusing on leptin signal transduction, Akt phosphorylation, which was known to inhibit glucocorticoid secretion, decreased in the adrenals from obese Zucker rats. from obese Zucker rats. We found that the stress-induced glucocorticoid secretion and the glucocorticoid synthesisrelated factors in the adrenals were increased in obese Zucker rats. factors in the adrenals were increased in obese Zucker rats. The decrease of Akt phosphorylation in the adrenals might induce these increases in obese Zucker rats.adrenals might induce these increases in obese Zucker rats.

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Senior editors

Editor(s)-in-Chief: Rosivall, László

Honorary Editor(s)-in-Chief): Monos, Emil

Managing Editor(s): Bartha, Jenő; Berhidi, Anna

Co-editor(s): Koller, Ákos; Lénárd, László; Szénási, Gábor

Assistant Editor(s): G. Dörnyei (Budapest), Zs. Miklós (Budapest), Gy. Nádasy (Budapest)

Hungarian Editorial Board

    1. Benedek, György (Szeged)
    1. Benyó, Zoltán (Budapest)
    1. Boros, Mihály (Szeged)
    1. Chernoch, László (Debrecen)
    1. Détári, László (Budapest)
    1. Hamar, János (Budapest)
    1. Hantos, Zoltán (Szeged)
    1. Hunyady, László (Budapest)
    1. Imre, Sándor (Debrecen)
    1. Jancsó, Gábor (Szeged)
    1. Karádi, Zoltán (Pécs)
    1. Kovács, László (Debrecen)
    1. Palkovits, Miklós (Budapest)
    1. Papp, Gyula (Szeged)
    1. Pavlik, Gábor (Budapest)
    1. Spät, András (Budapest)
    1. Szabó, Gyula (Szeged)
    1. Szelényi, Zoltán (Pécs)
    1. Szolcsányi, János (Pécs)
    1. Szollár, Lajos (Budapest)
    1. Szücs, Géza (Debrecen)
    1. Telegdy, Gyula (Szeged)
    1. Toldi, József (Szeged)
    1. Tósaki, Árpád (Debrecen)

International Editorial Board

    1. R. Bauer (Jena)
    1. W. Benjelloun (Rabat)
    1. A. W. Cowley Jr. (Milwaukee)
    1. D. Djuric (Belgrade)
    1. C. Fry (London)
    1. S. Greenwald (London)
    1. O. Hänninen (Kuopio)
    1. H. G. Hinghofer-Szalkay (Graz)
    1. Th. Kenner (Graz)
    1. Gy. Kunos (Richmond)
    1. M. Mahmoudian (Tehran)
    1. T. Mano (Seki, Gifu)
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    1. O. Petersen (Liverpool)
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    1. A. Romanovsky (Phoenix)
    1. G. M. Rubanyi (Richmond)
    1. T. Sakata (Oita)
    1. A. Siddiqui (Karachi)
    1. Cs. Szabo (Beverly)
    1. E. Vicaut (Paris)
    1. N. Westerhof (Amsterdam)
    1. L. F. Zhang (Xi'an)

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Acta Physiologica Hungarica
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Phone/Fax: +36-1-2100-100
E-mail: aph@semmelweis-univ.hu

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Acta Physiologica Hungarica
Language English
Size  
Year of
Foundation
1950
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0231-424X (Print)
ISSN 1588-2683 (Online)

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