View More View Less
  • 1 Mukogawa Women’s University School of Pharmacy and Pharmaceutical Sciences 11-68 Koshien Kyuban-cho Nishinomiya, Hyogo 663-8179 Japan
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $752.00

To understand the molecular mechanism of hyperglucocorticoidism in obese Zucker rats, this study investigated glucocorticoid synthesis-related factors and their transcription factors in the adrenals. glucocorticoid synthesis-related factors and their transcription factors in the adrenals. The serum corticosterone level after foot shock stress was higher in obese Zucker rats than in lean Zucker rats. after foot shock stress was higher in obese Zucker rats than in lean Zucker rats. In the adrenals from obese Zucker rats, the mRNA and protein levels of steroidogenic acute regulatory protein were higher than those from lean Zucker rats. rats. However, the mRNA level of steroidogenic factor-1(SF-1), an important transcription factor for these glucocorticoid synthesis-related factors, did not differ between lean and obese Zucker rats. glucocorticoid synthesis-related factors, did not differ between lean and obese Zucker rats. Focusing on leptin signal transduction, Akt phosphorylation, which was known to inhibit glucocorticoid secretion, decreased in the adrenals from obese Zucker rats. from obese Zucker rats. We found that the stress-induced glucocorticoid secretion and the glucocorticoid synthesisrelated factors in the adrenals were increased in obese Zucker rats. factors in the adrenals were increased in obese Zucker rats. The decrease of Akt phosphorylation in the adrenals might induce these increases in obese Zucker rats.adrenals might induce these increases in obese Zucker rats.

  • Chua SC Jr, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, Leibel RL: Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271(5251), 994–996 (1996)

    Leibel R.L. , 'Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor ' (1996 ) 271 Science : 994 -996.

    • Search Google Scholar
  • Livingstone DE, Jones GC, Smith K, Jamieson PM, Andrew R, Kenyon CJ, Walker BR: Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology 141(2), 560–563 (2000)

    Walker B.R. , 'Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats ' (2000 ) 141 Endocrinology : 560 -563.

    • Search Google Scholar
  • Walker CD, Scribner KA, Stern JS, Dallman MF: Obese Zucker (fa/fa) rats exhibit normal target sensitivity to corticosterone and increased drive to adrenocorticotropin during the diurnal trough. Endocrinology 131(6), 2629–2637 (1992)

    Dallman M.F. , 'Obese Zucker (fa/fa) rats exhibit normal target sensitivity to corticosterone and increased drive to adrenocorticotropin during the diurnal trough ' (1992 ) 131 Endocrinology : 2629 -2637.

    • Search Google Scholar
  • Yukimura Y, Bray GA, Wolfsen AR: Some effects of adrenalectomy in the fatty rat. Endocrinology 103(5), 1924–1928 (1978)

    Wolfsen A.R. , 'Some effects of adrenalectomy in the fatty rat ' (1978 ) 103 Endocrinology : 1924 -1928.

    • Search Google Scholar
  • Langley SC, York DA: Effects of antiglucocorticoid RU 486 on development of obesity in obese fa/fa Zucker rats. Am. J. Physiol. 259(3 Pt 2), R539–544 (1990)

    York D.A. , 'Effects of antiglucocorticoid RU 486 on development of obesity in obese fa/fa Zucker rats ' (1990 ) 259 Am. J. Physiol : R539 -544.

    • Search Google Scholar
  • White BD, Davenport WD, Porter JR: Responsiveness of isolated adrenocortical cells from lean and obese Zucker rats to ACTH. Am. J. Physiol. 255(3 Pt 1), E229–235 (1988)

    Porter J.R. , 'Responsiveness of isolated adrenocortical cells from lean and obese Zucker rats to ACTH ' (1988 ) 255 Am. J. Physiol : E229 -235.

    • Search Google Scholar
  • Kallen CB, Arakane F, Christenson LK, Watari H, Devoto L, Strauss JF 3rd: Unveiling the mechanism of action and regulation of the steroidogenic acute regulatory protein. Mol. Cell. Endocrinol. 145(1–2), 39–45 (1998)

    Strauss J.F. , 'Unveiling the mechanism of action and regulation of the steroidogenic acute regulatory protein ' (1998 ) 145 Mol. Cell. Endocrinol : 39 -45.

    • Search Google Scholar
  • Rice DA, Kirkman MS, Aitken LD, Mouw AR, Schimmer BP, Parker KL: Analysis of the promoter region of the gene encoding mouse cholesterol side-chain cleavage enzyme. J. Biol. Chem. 265(20), 11713–11720 (1990)

    Parker K.L. , 'Analysis of the promoter region of the gene encoding mouse cholesterol side-chain cleavage enzyme ' (1990 ) 265 J. Biol. Chem : 11713 -11720.

    • Search Google Scholar
  • Caron KM, Ikeda Y, Soo SC, Stocco DM, Parker KL, Clark BJ: Characterization of the promoter region of the mouse gene encoding the steroidogenic acute regulatory protein. Mol. Endocrinol. 11(2), 138–147 (1997)

    Clark B.J. , 'Characterization of the promoter region of the mouse gene encoding the steroidogenic acute regulatory protein ' (1997 ) 11 Mol. Endocrinol : 138 -147.

    • Search Google Scholar
  • Cammas FM, Pullinger GD, Barker S, Clark AJ: The mouse adrenocorticotropin receptor gene: cloning and characterization of its promoter and evidence for a role for the orphan nuclear receptor steroidogenic factor 1. Mol. Endocrinol. 11(7), 867–876 (1997)

    Clark A.J. , 'The mouse adrenocorticotropin receptor gene: cloning and characterization of its promoter and evidence for a role for the orphan nuclear receptor steroidogenic factor 1 ' (1997 ) 11 Mol. Endocrinol : 867 -876.

    • Search Google Scholar
  • Wang XL, Bassett M, Zhang Y, Yin S, Clyne C, White PC, Rainey W.E: Transcriptional regulation of human 11beta-hydroxylase (hCYP11B1). Endocrinology 141(10), 3587–3594 (2000)

    Rainey W.E. , 'Transcriptional regulation of human 11beta-hydroxylase (hCYP11B1 ' (2000 ) 141 Endocrinology : 3587 -3594.

    • Search Google Scholar
  • Lalli E, Melner MH, Stocco DM, Sassone-Corsi P: DAX-1 blocks steroid production at multiple levels. Endocrinology 139(10), 4237–4243 (1998)

    Sassone-Corsi P. , 'DAX-1 blocks steroid production at multiple levels ' (1998 ) 139 Endocrinology : 4237 -4243.

    • Search Google Scholar
  • Zwermann O, Beuschlein F, Lalli E, Klink A, Sassone-Corsi P, Reincke M: Clinical and molecular evidence for DAX-1 inhibition of steroidogenic factor-1-dependent ACTH receptor gene expression. Eur. J. Endocrinol. 152(5), 769–776 (2005)

    Reincke M. , 'Clinical and molecular evidence for DAX-1 inhibition of steroidogenic factor-1-dependent ACTH receptor gene expression ' (2005 ) 152 Eur. J. Endocrinol : 769 -776.

    • Search Google Scholar
  • Zazopoulos E, Lalli E, Stocco DM, Sassone-Corsi P: DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis. Nature 390(6657), 311–315 (1997)

    Sassone-Corsi P. , 'DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis ' (1997 ) 390 Nature : 311 -315.

    • Search Google Scholar
  • Harikai N: Characteristic induction of steroidogenic factor-1 (SF-1) and DAX-1 and enhanced expression of glucocorticoid synthesis-related genes in adrenals from spontaneously hypertensive rats. Gen. Physiol. Biophys. 17(2), 110–115 (2012)

    Harikai N. , 'Characteristic induction of steroidogenic factor-1 (SF-1) and DAX-1 and enhanced expression of glucocorticoid synthesis-related genes in adrenals from spontaneously hypertensive rats ' (2012 ) 17 Gen. Physiol. Biophys : 110 -115.

    • Search Google Scholar
  • Hsu HT, Chang YC, Chiu YN, Liu CL, Chang KJ, Guo IC: Leptin interferes with adrenocorticotropin/3′,5′-cyclic adenosine monophosphate (cAMP) signaling, possibly through a Janus kinase 2-phosphatidylinositol 3-kinase/Akt-phosphodiesterase 3-cAMP pathway, to down-regulate cholesterol side-chain cleavage cytochrome P450 enzyme in human adrenocortical NCI-H295 cell line. J. Clin. Endocrinol. Metab. 91(7), 2761–2769 (2006)

    Guo I.C. , 'Leptin interferes with adrenocorticotropin/3′,5′-cyclic adenosine monophosphate (cAMP) signaling, possibly through a Janus kinase 2-phosphatidylinositol 3-kinase/Akt-phosphodiesterase 3-cAMP pathway, to down-regulate cholesterol side-chain cleavage cytochrome P450 enzyme in human adrenocortical NCI-H295 cell line ' (2006 ) 91 J. Clin. Endocrinol. Metab : 2761 -2769.

    • Search Google Scholar
  • Shimizu K, Amagaya S, Ogihara Y: Analysis of corticosterone in the serum of mice and rats using highperformance liquid chromatography. J. Chromatogr. 272(1), 170–175 (1983)

    Ogihara Y. , 'Analysis of corticosterone in the serum of mice and rats using highperformance liquid chromatography ' (1983 ) 272 J. Chromatogr : 170 -175.

    • Search Google Scholar
  • Caron KM, Soo SC, Wetsel WC, Stocco DM, Clark BJ, Parker KL: Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc. Natl. Acad. Sci. USA. 94(21), 11540–11545 (1997)

    Parker K.L. , 'Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia ' (1997 ) 94 Proc. Natl. Acad. Sci. USA : 11540 -11545.

    • Search Google Scholar
  • Hu MC, Hsu NC, El Hadj NB, Pai CI, Chu HP, Wang CK, Chung BC: Steroid defi ciency syndromes in mice with targeted disruption of Cyp11a1. Mol. Endocrinol. 16(8), 1943–1950 (2002)

    Chung B.C. , 'Steroid defi ciency syndromes in mice with targeted disruption of Cyp11a1 ' (2002 ) 16 Mol. Endocrinol : 1943 -1950.

    • Search Google Scholar
  • Mullins LJ, Peter A, Wrobel N, McNeilly JR, McNeilly AS, Al-Dujaili EA, Brownstein DG, Mullins JJ, Kenyon CJ: Cyp11b1 null mouse, a model of congenital adrenal hyperplasia. J. Biol. Chem. 284(6), 3925–3934 (2009)

    Kenyon C.J. , 'Cyp11b1 null mouse, a model of congenital adrenal hyperplasia ' (2009 ) 284 J. Biol. Chem : 3925 -3934.

    • Search Google Scholar
  • Hoivik EA, Lewis AE, Aumo L, Bakke M: Molecular aspects of steroidogenic factor 1 (SF-1). Mol. Cell. Endocrinol. 315(1–2), 27–39 (2010)

    Bakke M. , 'Molecular aspects of steroidogenic factor 1 (SF-1) ' (2010 ) 315 Mol. Cell. Endocrinol : 27 -39.

    • Search Google Scholar
  • Tena-Sempere M, Pinilla L, Gonzalez LC, Casanueva FF, Dieguez C, Aguilar E: Homologous and heterologous down-regulation of leptin receptor messenger ribonucleic acid in rat adrenal gland. J. Endocrinol. 167(3), 479–486 (2000)

    Aguilar E. , 'Homologous and heterologous down-regulation of leptin receptor messenger ribonucleic acid in rat adrenal gland ' (2000 ) 167 J. Endocrinol : 479 -486.

    • Search Google Scholar
  • Pralong FP, Roduit R, Waeber G, Castillo E, Mosimann F, Thorens B, Gaillard RC: Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland. Endocrinology 139(10), 4264–4268 (1998)

    Gaillard R.C. , 'Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland ' (1998 ) 139 Endocrinology : 4264 -4268.

    • Search Google Scholar
  • Cherradi N, Capponi AM, Gaillard RC, Pralong FP: Decreased expression of steroidogenic acute regulatory protein: a novel mechanism participating in the leptin-induced inhibition of glucocorticoid biosynthesis. Endocrinology 142(8), 3302–3308 (2001)

    Pralong F.P. , 'Decreased expression of steroidogenic acute regulatory protein: a novel mechanism participating in the leptin-induced inhibition of glucocorticoid biosynthesis ' (2001 ) 142 Endocrinology : 3302 -3308.

    • Search Google Scholar
  • Kruse M, Bornstein SR, Uhlmann K, Paeth G, Scherbaum WA: Leptin down-regulates the steroid producing system in the adrenal. Endocr. Res. 24(3–4), 587–590 (1998)

    Scherbaum W.A. , 'Leptin down-regulates the steroid producing system in the adrenal ' (1998 ) 24 Endocr. Res : 587 -590.

    • Search Google Scholar
  • Harikai N, Shinnou R, Semma M, Tanaka S, Ichikawa A: Expression of adrenoreceptor and melanocortin 2 receptor mRNAs in various tissues from SHR.Cg-Leprcp/NDmcr rats. Clin. Exp. Pharm. Physiol. 34, S20–S22 (2007)

    Ichikawa A. , 'Expression of adrenoreceptor and melanocortin 2 receptor mRNAs in various tissues from SHR.Cg-Leprcp/NDmcr rats ' (2007 ) 34 Clin. Exp. Pharm. Physiol : S20 -S22.

    • Search Google Scholar

The author instruction is available in PDF.

Please, download the file from HERE

Senior editors

Editor(s)-in-Chief: Rosivall, László

Honorary Editor(s)-in-Chief): Monos, Emil

Managing Editor(s): Bartha, Jenő; Berhidi, Anna

Co-editor(s): Koller, Ákos; Lénárd, László; Szénási, Gábor

Assistant Editor(s): G. Dörnyei (Budapest), Zs. Miklós (Budapest), Gy. Nádasy (Budapest)

Hungarian Editorial Board

      Benedek, György (Szeged)
      Benyó, Zoltán (Budapest)
      Boros, Mihály (Szeged)
      Chernoch, László (Debrecen)
      Détári, László (Budapest)
      Hamar, János (Budapest)
      Hantos, Zoltán (Szeged)
      Hunyady, László (Budapest)
      Imre, Sándor (Debrecen)
      Jancsó, Gábor (Szeged)
      Karádi, Zoltán (Pécs)
      Kovács, László (Debrecen)
      Palkovits, Miklós (Budapest)
      Papp, Gyula (Szeged)
      Pavlik, Gábor (Budapest)
      Spät, András (Budapest)
      Szabó, Gyula (Szeged)
      Szelényi, Zoltán (Pécs)
      Szolcsányi, János (Pécs)
      Szollár, Lajos (Budapest)
      Szücs, Géza (Debrecen)
      Telegdy, Gyula (Szeged)
      Toldi, József (Szeged)
      Tósaki, Árpád (Debrecen)

International Editorial Board

      R. Bauer (Jena)
      W. Benjelloun (Rabat)
      A. W. Cowley Jr. (Milwaukee)
      D. Djuric (Belgrade)
      C. Fry (London)
      S. Greenwald (London)
      O. Hänninen (Kuopio)
      H. G. Hinghofer-Szalkay (Graz)
      Th. Kenner (Graz)
      Gy. Kunos (Richmond)
      M. Mahmoudian (Tehran)
      T. Mano (Seki, Gifu)
      G. Navar (New Orleans)
      H. Nishino (Nagoya)
      O. Petersen (Liverpool)
      U. Pohl (Münich)
      R. S. Reneman (Maastricht)
      A. Romanovsky (Phoenix)
      G. M. Rubanyi (Richmond)
      T. Sakata (Oita)
      A. Siddiqui (Karachi)
      Cs. Szabo (Beverly)
      E. Vicaut (Paris)
      N. Westerhof (Amsterdam)
      L. F. Zhang (Xi'an)

Editorial Office:
Akadémiai Kiadó Zrt.
Prielle Kornélia u. 21–35, H-1117 Budapest, Hungary

Editorial Correspondence:
Acta Physiologica Hungarica
Semmelweis University, Faculty of Medicine Institute of Pathophysiology
Nagyvárad tér 4, H-1089 Budapest, Hungary
Phone/Fax: +36-1-2100-100
E-mail: aph@semmelweis-univ.hu

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • EMBASE/Excerpta Medica
  • Global Health
  • Index Copernicus
  • Index Medicus
  • Medline
  • Referativnyi Zhurnal
  • Science Citation Index Expanded
  • SCOPUS

 

Acta Physiologica Hungarica
Language English
Size  
Year of
Foundation
1950
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0231-424X (Print)
ISSN 1588-2683 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Apr 2021 3 0 0
May 2021 2 0 0
Jun 2021 0 0 0
Jul 2021 4 0 0
Aug 2021 18 0 0
Sep 2021 3 0 0
Oct 2021 0 0 0