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  • 1 Semmelweis University Heart Center, Faculty of Medicine Budapest Hungary
  • 2 Semmelweis University Department of Vascular Surgery, Faculty of Medicine Budapest Hungary
  • 3 Eötvös Loránd University of Sciences Department of Physiology and Neurobiology, Institute of Biology Budapest Hungary
  • 4 Semmelweis University Department of Transplantation and Surgery, Faculty of Medicine Budapest Hungary
  • 5 Semmelweis University Department of Pharmacodynamics, Faculty of Pharmacy Budapest Hungary
  • 6 Semmelweis University Department of Pharmacodynamics, Faculty of Pharmacy Nagyvárad tér 4 H-1089 Budapest Hungary
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Foregoing researches made on the N/OFQ system brought up a possible role for this system in cardiovascular regulation. In this study we examined how N/OFQ levels of the blood plasma changed in acute cardiovascular diseases. Three cardiac patient groups were created: enzyme positive acute coronary syndrome (EPACS, n = 10), enzyme negative ACS (ENACS, n = 7) and ischemic heart disease (IHD, n = 11). We compared the patients to healthy control subjects (n = 31). We found significantly lower N/OFQ levels in the EPACS [6.86 (6.21–7.38) pg/ml], ENACS [6.97 (6.87–7.01) pg/ml and IHD groups [7.58 (7.23–8.20) pg/ml] compared to the control group [8.86 (7.27–9.83) pg/ml]. A significant correlation was detected between N/OFQ and white blood cell count (WBC), platelet count (PLT), creatine kinase (CK), glutamate oxaloacetate transaminase (GOT) and cholesterol levels in the EPACS group.Decreased plasma N/OFQ is closely associated with the presence of acute cardiovascular disease, and the severity of symptoms has a significant negative correlation with the N/OFQ levels. We believe that the rate of N/OFQ depression is in association with the level of ischemic stress and the following inflammatory response. Further investigations are needed to clarify the relevance and elucidate the exact effects of the ischemic stress on the N/OFQ system.

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