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  • 1 Semmelweis University 2nd Department Obstet. Gynecol., Faculty of Medicine Budapest Hungary
  • 2 Semmelweis University Institute of Human Physiology and Clinical Experimental Research, Faculty of Medicine Budapest Hungary
  • 3 Semmelweis University Department of Physiology, Faculty of Medicine Budapest Hungary
  • 4 Semmelweis University 2nd Department of Pathology, Faculty of Medicine Budapest Hungary
  • 5 Bajcsy-Zsilinszky Hospital Department of Cardiology Budapest Hungary
  • 6 Semmelweis University 2nd Department Obstet. Gynecol., Faculty of Medicine Üllői út 78/A H-1083 Budapest Hungary
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To clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on arteriolar biomechanics in a rat model and the possible modulatory role of vitamin D3.Methods and Results The PCOS model was induced in female Wistar rats by ten-weeks DHT treatment. Arteriolar biomechanics was tested in arterioles by pressure arteriography in control as well as DHT- and DHT with vitamin D3-treated animals in contracted and passive conditions. Increased wall stress and distensibility as well as increased vascular lumen were detected after DHT treatment. Concomitant vitamin D3 treatment lowered the mechanical load of the arterioles and restored the vascular diameter.Conclusion The hyperandrogenic state resulted in more rigid, less flexible arteriolar walls with increased vascular lumen compared with controls. DHT treatment caused eutrophic remodelling of gracilis arteriole. These prehypertensive alterations caused by chronic DHT treatment were mostly reversed by concomitant vitamin D3 administration.

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