View More View Less
  • 1 Semmelweis University Faculty of Medicine Budapest Hungary
  • | 2 Semmelweis University 2nd Department of Internal Medicine Budapest Hungary
  • | 3 Hungarian Academy of Sciences Molecular Medicine Research Unit Budapest Hungary
  • | 4 Semmelweis University 2nd Department of Internal Medicine Szentkirályi u. 46 H-1088 Budapest Hungary
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $752.00

Gut-associated lymphoid tissue (GALT) is supposed to play an integral role in the organization of colonic repair mechanisms. Majority of the GALT is composed of isolated and aggregated lymphoid follicles distributed throughout the intestines. These lymphoid follicles, including Peyer’s patches of the small, and isolated lymphoid follicles (ILFs) of both the small and large intestines, are composed of a specialised follicle associated epithelium overlying a subepithelial dome containing numerous dendritic cells, macrophages, T and B cells. Within inflammatory conditions the number, the diameter and the density of ILFs are increasing. Follicles are involved not just in immune surveillance, but their presence is also indispensable for normal colonic mucosal regeneration. Regarding mucosal repair the relation of ILFs to bone marrow derived stem cells, follicular dendritic cells, subepithelial myofibroblasts and crypt formations, and the putative organizer role of ILFs have not been clarified yet.

  • Andoh A, Bamba S, Fujiyama Y, Brittan M, Wright NA: Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response. J. Gastroenterol. 40, 1089–1099 (2005)

    Wright N.A. , 'Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response ' (2005 ) 40 J. Gastroenterol. : 1089 -1099.

    • Search Google Scholar
  • Azzali G: Structure, lymphatic vascularization and lymphocyte migration in mucosa-associated lymphoid tissue. Immunol. Rev. 195, 178–189 (2003)

    Azzali G. , 'Structure, lymphatic vascularization and lymphocyte migration in mucosa-associated lymphoid tissue ' (2003 ) 195 Immunol. Rev. : 178 -189.

    • Search Google Scholar
  • Baird AW, Cuthbert AW: Neuronal involvement in type 1 hypersensitivity reactions in gut epithelia. Br. J. Pharmacol. 92, 647–655 (1987)

    Cuthbert A.W. , 'Neuronal involvement in type 1 hypersensitivity reactions in gut epithelia ' (1987 ) 92 Br. J. Pharmacol. : 647 -655.

    • Search Google Scholar
  • Beg Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. Trends. Immunol. 23, 509–512 (2002)

    Beg A.A. , 'Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses ' (2002 ) 23 Trends. Immunol. : 509 -512.

    • Search Google Scholar
  • Cavender DE, Haskard DO, Joseph B, Ziff M: Interleukin 1 increases the binding of human B and T lymphocytes to endothelial cell monolayers. J. Immunol. 136, 203–207 (1986)

    Ziff M. , 'Interleukin 1 increases the binding of human B and T lymphocytes to endothelial cell monolayers ' (1986 ) 136 J. Immunol. : 203 -207.

    • Search Google Scholar
  • Cesta MF: Normal structure, function, and histology of mucosa-associated lymphoid tissue. Toxicologic Pathology 34, 599–608 (2006)

    Cesta M.F. , 'Normal structure, function, and histology of mucosa-associated lymphoid tissue ' (2006 ) 34 Toxicologic Pathology : 599 -608.

    • Search Google Scholar
  • Chamberlain G, Fox J, Ashton B, Middleton J: Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25, 2739–2749 (2007)

    Middleton J. , 'Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing ' (2007 ) 25 Stem Cells : 2739 -2749.

    • Search Google Scholar
  • Chiocchetti R, Mazzuoli G, Albanese V, Mazzoni M, Clavenzani P, Lalatta-Costerbosa G, Lucchi ML, Di Guardo G, Marruchella G, Furness JB: Anatomical evidence for ileal Peyer’s patches innervation by enteric nervous system: a potential route for prion neuroinvasion? Cell Tissue Res. 332, 185–194 (2008)

    Furness J.B. , 'Anatomical evidence for ileal Peyer’s patches innervation by enteric nervous system: a potential route for prion neuroinvasion? ' (2008 ) 332 Cell Tissue Res : 185 -194.

    • Search Google Scholar
  • Chugh AR, Zuba-Surma EK, Dawn B: Bone marrow-derived mesenchymal stems cells and cardiac repair. Minerva Cardioangiol. 57, 185–202 (2009)

    Dawn B. , 'Bone marrow-derived mesenchymal stems cells and cardiac repair ' (2009 ) 57 Minerva Cardioangiol. : 185 -202.

    • Search Google Scholar
  • Freemont AJ, Ford WL: Functional and morphological changes in post-capillary venules in relation to lymphocytic infiltration into BCG-induced granulomata in rat skin. J. Pathol. 147, 1–12 (1985)

    Ford W.L. , 'Functional and morphological changes in post-capillary venules in relation to lymphocytic infiltration into BCG-induced granulomata in rat skin ' (1985 ) 147 J. Pathol. : 1 -12.

    • Search Google Scholar
  • Gormley PD, Powell-Richards AO, Azuara-Blanco A, Donoso LA, Dua HS: Lymphocyte subsets in conjunctival mucosa-associated lymphoid-tissue after exposure to retinal-S-antigen. Int. Ophthalmol. 22, 77–80 (1998)

    Dua H.S. , 'Lymphocyte subsets in conjunctival mucosa-associated lymphoid-tissue after exposure to retinal-S-antigen ' (1998 ) 22 Int. Ophthalmol. : 77 -80.

    • Search Google Scholar
  • Guo L, Kuroda N, Nakayama H, Miyazaki E, Hayashi Y, Toi M, Hiroi M, Enzan H: Cytokeratin-positive subserosal myofibroblasts in gastroduodenal ulcer; another type of myofibroblasts. Histol. Histopathol. 21, 697–704 (2006)

    Enzan H. , 'Cytokeratin-positive subserosal myofibroblasts in gastroduodenal ulcer; another type of myofibroblasts ' (2006 ) 21 Histol. Histopathol. : 697 -704.

    • Search Google Scholar
  • Hamauzu T, Kuroda N, Guo L, Miyazaki E, Hayashi Y, Toi M, Hiroi M, Enzan H: CAM5.2-positive subserosal myofibroblasts in appendicitis. Med. Mol. Morphol. 39, 209–213 (2006)

    Enzan H. , 'CAM5.2-positive subserosal myofibroblasts in appendicitis ' (2006 ) 39 Med. Mol. Morphol. : 209 -213.

    • Search Google Scholar
  • Hirose J, Kawashima H, Yoshie O, Tashiro K, Miyasaka M: Versican interacts with chemokines and modulates cellular responses. J. Biol. Chem. 276, 5228–5234 (2001)

    Miyasaka M. , 'Versican interacts with chemokines and modulates cellular responses ' (2001 ) 276 J. Biol. Chem. : 5228 -5234.

    • Search Google Scholar
  • Humphrey JH, Grennan D, Sundaram V: The origin of follicular dendritic cells in the mouse and the mechanism of trapping of immune complexes on them. Eur. J. Immunol. 14, 859–864 (1994)

    Sundaram V. , 'The origin of follicular dendritic cells in the mouse and the mechanism of trapping of immune complexes on them ' (1994 ) 14 Eur. J. Immunol. : 859 -864.

    • Search Google Scholar
  • Jakubzick C, Bogunovic M, Bonito AJ, Kuan EL, Merad M, Randolph GJ: Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes. J. Exp. Med. 205, 2839–2850 (2008)

    Randolph G.J. , 'Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes ' (2008 ) 205 J. Exp. Med. : 2839 -2850.

    • Search Google Scholar
  • Joyce NC, Haire MF, Palade GE: Morphologic and biochemical evidence for a contractile cell network within the rat intestinal mucosa. Gastroenterology 92, 68–81 (1987)

    Palade G.E. , 'Morphologic and biochemical evidence for a contractile cell network within the rat intestinal mucosa ' (1987 ) 92 Gastroenterology : 68 -81.

    • Search Google Scholar
  • Kapasi ZF, Qin D, Kerr WG, Kosco-Vilbois MH, Shultz LD, Tew JG, Szakal AK: Follicular dendritic cell (FDC) precursors in primary lymphoid tissues. J. Immunol. 160, 1078–1084 (1998)

    Szakal A.K. , 'Follicular dendritic cell (FDC) precursors in primary lymphoid tissues ' (1998 ) 160 J. Immunol. : 1078 -1084.

    • Search Google Scholar
  • Kim YS, Park HJ, Hong MH, Kang PM, Morgan JP, Jeong MH, Cho JG, Park JC, Ahn Y: TNF-alpha enhances engraftment of mesenchymal stem cells into infarcted myocardium. Front. Biosci. 14, 2845–2856 (2009)

    Ahn Y. , 'TNF-alpha enhances engraftment of mesenchymal stem cells into infarcted myocardium ' (2009 ) 14 Front. Biosci. : 2845 -2856.

    • Search Google Scholar
  • Kraehenbuhl J-P, Neutra MN: Molecular and cellular basis of immune protection of mucosal surfaces. Physiol. Rev. 72, 853–879 (1992)

    Neutra M.N. , 'Molecular and cellular basis of immune protection of mucosal surfaces ' (1992 ) 72 Physiol. Rev. : 853 -879.

    • Search Google Scholar
  • Kvietys PR, Sandig M: Neutrophil diapedesis: paracellular or transcellular? News Physiol. Sci. 16, 15–19 (2001)

    Sandig M. , 'Neutrophil diapedesis: paracellular or transcellular? ' (2001 ) 16 News Physiol. Sci. : 15 -19.

    • Search Google Scholar
  • Le Visage C, Dunham B, Flint P, Leong KW: Coculture of mesenchymal stem cells and respiratory epithelial cells to engineer a human composite respiratory mucosa. Tissue Eng. 10, 1426–1435 (2004)

    Leong K.W. , 'Coculture of mesenchymal stem cells and respiratory epithelial cells to engineer a human composite respiratory mucosa ' (2004 ) 10 Tissue Eng. : 1426 -1435.

    • Search Google Scholar
  • Li M, Carpio D, Zheng Y, Bruzzo P, Singh V, Ouaaz F, Medzhitov RM, Beg An essential role of the NFkappa B/toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. J. Immunol. 166, 7128–7135 (2001)

    Beg A.A. , 'An essential role of the NFkappa B/toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells ' (2001 ) 166 J. Immunol. : 7128 -7135.

    • Search Google Scholar
  • Lindhout E, Koopman G, Pals ST, de Groot C: Triple check for antigen specificity of B cells during germinal centre reactions. Immunol. Today 18, 573–577 (1997)

    Groot C. , 'Triple check for antigen specificity of B cells during germinal centre reactions ' (1997 ) 18 Immunol. Today : 573 -577.

    • Search Google Scholar
  • Liu N, Chen R, Du H, Wang J, Zhang Y, Wen J: Expression of IL-10 and TNF-alpha in rats with cerebral infarction after transplantation with mesenchymal stem cells. Cell. Mol. Immunol. 6, 207–213 (2009)

    Wen J. , 'Expression of IL-10 and TNF-alpha in rats with cerebral infarction after transplantation with mesenchymal stem cells ' (2009 ) 6 Cell. Mol. Immunol. : 207 -213.

    • Search Google Scholar
  • Liu ZJ, Zhuge Y, Velazquez OC: Trafficking and differentiation of mesenchymal stem cells. J. Cell. Biochem. 106, 984–991 (2009)

    Velazquez O.C. , 'Trafficking and differentiation of mesenchymal stem cells ' (2009 ) 106 J. Cell. Biochem. : 984 -991.

    • Search Google Scholar
  • Lorenz RG, Chaplin DD, McDonald KG, McDonough JS, Newberry RD: Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin beta receptor, and TNF receptor I function. J. Immunol. 170, 5475–5482 (2003)

    Newberry R.D. , 'Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin beta receptor, and TNF receptor I function ' (2003 ) 170 J. Immunol. : 5475 -5482.

    • Search Google Scholar
  • Majors A, Austin R, de la Motte C, Pyeritz RE, Hascall VC, Kessler SP, Sen G, Strong SA: Endoplasmic reticulum stress induces hyaluronan deposition and leukocyte adhesion. J. Biol. Chem. 278, 47223–47231 (2003)

    Strong S.A. , 'Endoplasmic reticulum stress induces hyaluronan deposition and leukocyte adhesion ' (2003 ) 278 J. Biol. Chem. : 47223 -47231.

    • Search Google Scholar
  • Matsumoto T, Okamoto R, Yajima T, Mori T, Okamoto S, Ikeda Y, Mukai M, Yamazaki M, Oshima S, Tsuchiya K, Nakamura T, Kanai T, Okano H, Inazawa J, Hibi T, Watanabe M: Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine. Gastroenterology 128, 1851–1867 (2005)

    Watanabe M. , 'Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine ' (2005 ) 128 Gastroenterology : 1851 -1867.

    • Search Google Scholar
  • McGhee JR, Mestecky J, Dertzbaugh MT, Eldridge JH, Hirasawa M, Kiyono H: The mucosal immune system: from fundamental concepts to vaccine development. Vaccine 10, 75–88 (1992)

    Kiyono H. , 'The mucosal immune system: from fundamental concepts to vaccine development ' (1992 ) 10 Vaccine : 75 -88.

    • Search Google Scholar
  • Moghaddami M, Cummins A, Mayrhofer G: Lymphocyte-filled villi: comparison with other lymphoid aggregations in the mucosa of the human small intestine. Gastroenterology 115, 1414–1425 (1998)

    Mayrhofer G. , 'Lymphocyte-filled villi: comparison with other lymphoid aggregations in the mucosa of the human small intestine ' (1998 ) 115 Gastroenterology : 1414 -1425.

    • Search Google Scholar
  • Muñoz-Fernández R, Blanco FJ, Frecha C, Martín F, Kimatrai M, Abadía-Molina AC, García-Pacheco JM, Olivares EG: Follicular dendritic cells are related to bone marrow stromal cell progenitors and to myofibroblasts. J. Immunol. 177, 280–289 (2006)

    Olivares E.G. , 'Follicular dendritic cells are related to bone marrow stromal cell progenitors and to myofibroblasts ' (2006 ) 177 J. Immunol. : 280 -289.

    • Search Google Scholar
  • Nascimbeni R, Di Fabio F, Di Betta E, Mariani P, Fisogni S, Villanacci V: Morphology of colorectal lymphoid aggregates in cancer, diverticular and inflammatory bowel diseases. Mod. Pathol. 18, 681–685 (2005)

    Villanacci V. , 'Morphology of colorectal lymphoid aggregates in cancer, diverticular and inflammatory bowel diseases ' (2005 ) 18 Mod. Pathol. : 681 -685.

    • Search Google Scholar
  • Neutra MR, Frey A, Kraehenbuhl JP: Epithelial M cells: gateways for mucosal infection and immunization. Cell 86, 345–348 (1996)

    Kraehenbuhl J.P. , 'Epithelial M cells: gateways for mucosal infection and immunization ' (1996 ) 86 Cell : 345 -348.

    • Search Google Scholar
  • Neutra MR, Mantis NJ, Kraehenbuhl JP: Collaboration of epithelial cells with organized mucosal lymphoid tissues. Nat. Immunol. 2, 1004–1009 (2001)

    Kraehenbuhl J.P. , 'Collaboration of epithelial cells with organized mucosal lymphoid tissues ' (2001 ) 2 Nat. Immunol. : 1004 -1009.

    • Search Google Scholar
  • Niedergang F, Kraehenbuhl JP: Much ado about M cells. Trends Cell. Biol. 10, 137–141 (2000)

    Kraehenbuhl J.P. , 'Much ado about M cells ' (2000 ) 10 Trends Cell. Biol. : 137 -141.

  • O’Brien LM, Fitzpatrick E, Baird AW, Campion DP: Eosinophil-nerve interactions and neuronal plasticity in rat gut associated lymphoid tissue (GALT) in response to enteric parasitism. J. Neuroimmunol. 197, 1–9 (2008)

    Campion D.P. , 'Eosinophil-nerve interactions and neuronal plasticity in rat gut associated lymphoid tissue (GALT) in response to enteric parasitism ' (2008 ) 197 J. Neuroimmunol. : 1 -9.

    • Search Google Scholar
  • O’Malley KE, Sloan T, Joyce P, Baird AW: Type I hypersensitivity reactions in intestinal mucosae from rats infected with Fasciola hepatica. Parasite Immunol. 15, 449–453 (1993)

    Baird A.W. , 'Type I hypersensitivity reactions in intestinal mucosae from rats infected with Fasciola hepatica ' (1993 ) 15 Parasite Immunol. : 449 -453.

    • Search Google Scholar
  • Onishi S, Miyata H, Inamoto T, Qi WM, Yamamoto K, Yokoyama T, Warita K, Hoshi N, Kitagawa H: Immunohistochemical study on the delayed progression of epithelial apoptosis in follicle-associated epithelium of rat Peyer’s patch. J. Vet. Med. Sci. 69, 1123–1129 (2007)

    Kitagawa H. , 'Immunohistochemical study on the delayed progression of epithelial apoptosis in follicle-associated epithelium of rat Peyer’s patch ' (2007 ) 69 J. Vet. Med. Sci. : 1123 -1129.

    • Search Google Scholar
  • Perry ME, Mustafa Y, Brown KA: The microvasculature of the human palatine tonsil and its role in the homing of lymphocytes. Adv. Otorhinolaryngol. 47, 11–15 (1992)

    Brown K.A. , 'The microvasculature of the human palatine tonsil and its role in the homing of lymphocytes ' (1992 ) 47 Adv. Otorhinolaryngol. : 11 -15.

    • Search Google Scholar
  • Podolsky DK: Healing the epithelium: solving the problem from two sides. J. Gastroenterol. 32, 122–126 (1997)

    Podolsky D.K. , 'Healing the epithelium: solving the problem from two sides ' (1997 ) 32 J. Gastroenterol. : 122 -126.

    • Search Google Scholar
  • Powell DW, Adegboyega PA, Di Mari JF, Mifflin RC: Epithelial cells and their neighbors I. Role of intestinal myofibroblasts in development, repair, and cancer. Am. J. Physiol. Gastrointest. Liver. Physiol. 289, 2–7 (2005)

    Mifflin R.C. , 'Epithelial cells and their neighbors I. Role of intestinal myofibroblasts in development, repair, and cancer ' (2005 ) 289 Am. J. Physiol. Gastrointest. Liver. Physiol. : 2 -7.

    • Search Google Scholar
  • Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, West AB: Myofibroblasts. II. Intestinal subepithelial myofibroblasts. Am. J. Physiol. 277, C183–C201 (1999)

    West A.B. , 'Myofibroblasts. II. Intestinal subepithelial myofibroblasts ' (1999 ) 277 Am. J. Physiol. : C183 -C201.

    • Search Google Scholar
  • Prindull G, Zipori D: Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm. Blood 103, 2892–2899 (2004)

    Zipori D. , 'Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm ' (2004 ) 103 Blood : 2892 -2899.

    • Search Google Scholar
  • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R: Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118, 229–241 (2004)

    Medzhitov R. , 'Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis ' (2004 ) 118 Cell : 229 -241.

    • Search Google Scholar
  • Renes IB, Verburg M, Bulsing NP, Ferdinandusse S, Büller HA, Dekker J, Einerhand AW: Protection of the Peyer’s patch-associated crypt and villus epithelium against methotrexate-induced damage is based on its distinct regulation of proliferation. J. Pathol. 198, 60–68 (2002)

    Einerhand A.W. , 'Protection of the Peyer’s patch-associated crypt and villus epithelium against methotrexate-induced damage is based on its distinct regulation of proliferation ' (2002 ) 198 J. Pathol. : 60 -68.

    • Search Google Scholar
  • Saxena SK, Thompson JS, Sharp JG: Role of organized intestinal lymphoid aggregates in intestinal regeneration. J. Invest. Surg. 10, 97–103 (1997)

    Sharp J.G. , 'Role of organized intestinal lymphoid aggregates in intestinal regeneration ' (1997 ) 10 J. Invest. Surg. : 97 -103.

    • Search Google Scholar
  • Sheng W, Wang G, La Pierre DP, Wen J, Deng Z, Wong CK, Lee DY, Yang BB: Versican mediates mesenchymal-epithelial transition. Mol. Biol. Cell. 17, 2009–2020 (2006)

    Yang B.B. , 'Versican mediates mesenchymal-epithelial transition ' (2006 ) 17 Mol. Biol. Cell. : 2009 -2020.

    • Search Google Scholar
  • Sipos F, Muzes G, Valcz G, Galamb O, Tóth K, Leiszter K, Krenács T, Tulassay Z, Molnár B: Regeneration associated growth factor receptor and epithelial marker expression in lymphoid aggregates of ulcerative colitis. Scand. J. Gastroenterol. 45, 440–448 (2010)

    Molnár B. , 'Regeneration associated growth factor receptor and epithelial marker expression in lymphoid aggregates of ulcerative colitis ' (2010 ) 45 Scand. J. Gastroenterol. : 440 -448.

    • Search Google Scholar
  • Sipos F, Muzes G, Galamb O, Spisák S, Krenács T, Tóth K, Tulassay Z, Molnár B: The possible role of isolated lymphoid follicles in colonic mucosal repair. Pathol. Onc. Res. 1, 11–18 (2010)

    Molnár B. , 'The possible role of isolated lymphoid follicles in colonic mucosal repair ' (2010 ) 1 Pathol. Onc. Res. : 11 -18.

    • Search Google Scholar
  • Spees JL, Olson SD, Ylostalo J, Lynch PJ, Smith J, Perry A, Peister A, Wang MY, Prockop DJ: Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma. Proc. Natl Acad. Sci. USA 100, 2397–2402 (2003)

    Prockop D.J. , 'Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma ' (2003 ) 100 Proc. Natl Acad. Sci. USA : 2397 -2402.

    • Search Google Scholar
  • Stenson WF: Toll-like receptors and intestinal epithelial repair. Curr. Opin. Gastroenterol. 24, 103–107 (2008)

    Stenson W.F. , 'Toll-like receptors and intestinal epithelial repair ' (2008 ) 24 Curr. Opin. Gastroenterol. : 103 -107.

    • Search Google Scholar
  • Thiery JP: Epithelial-mesenchymal transitions in development and pathologies. Curr. Opin. Cell. Biol. 15, 740–746 (2003)

    Thiery J.P. , 'Epithelial-mesenchymal transitions in development and pathologies ' (2003 ) 15 Curr. Opin. Cell. Biol. : 740 -746.

    • Search Google Scholar
  • Valcz G, Krenacs T, Sipos F, Patai AV, Wichmann B, Leiszter K, Toth K, Balogh Z, Csizmadia A, Hagymasi K, Masszi T, Molnar B, Tulassay Z: Lymphoid aggregates may contribute to the migration and epithelial commitment of bone marrow-derived cells in colonic mucosa. J. Clin. Pathol. 64, 771–775 (2011)

    Tulassay Z. , 'Lymphoid aggregates may contribute to the migration and epithelial commitment of bone marrow-derived cells in colonic mucosa ' (2011 ) 64 J. Clin. Pathol. : 771 -775.

    • Search Google Scholar
  • Valcz G, Krenács T, Sipos F, Wichmann B, Tóth K, Leiszter K, Balogh Z, Csizmadia A, Hagymási K, Muzes G, Masszi T, Molnár B, Tulassay Z: A csontvelői eredetű őssejtek megjelenése az ép vastagbélhámban és a gyulladást követő hámregenerációban [Appearing of bone marrow derived stem cells in healthy and regenerating colonic epithelium]. Orv. Hetil. 40, 1852–1857 (2009)

    Tulassay Z. , 'A csontvelői eredetű őssejtek megjelenése az ép vastagbélhámban és a gyulladást követő hámregenerációban ' (2009 ) 40 Orv. Hetil. : 1852 -1857.

    • Search Google Scholar
  • van Nierop K, de Groot C: Human follicular dendritic cells: function, origin and development. Semin. Immunol. 14, 251–257 (2002)

    Groot C. , 'Human follicular dendritic cells: function, origin and development ' (2002 ) 14 Semin. Immunol. : 251 -257.

    • Search Google Scholar
  • Velázquez P, Wei B, Braun J: Surveillance B lymphocytes and mucosal immunoregulation. Springer. Semin. Immunopathol. 26, 453–462 (2005)

    Braun J. , 'Surveillance B lymphocytes and mucosal immunoregulation ' (2005 ) 26 Springer. Semin. Immunopathol. : 453 -462.

    • Search Google Scholar
  • Vulchanova L, Casey MA, Crabb GW, Kennedy WR, Brown DR: Anatomical evidence for enteric neuroimmune interactions in Peyer’s patches. J. Neuroimmunol. 185, 64–74 (2007)

    Brown D.R. , 'Anatomical evidence for enteric neuroimmune interactions in Peyer’s patches ' (2007 ) 185 J. Neuroimmunol. : 64 -74.

    • Search Google Scholar
  • Wallace JL, Granger DN: The cellular and molecular basis of gastric mucosal defense. FASEB. J. 10, 731–740 (1996)

    Granger D.N. , 'The cellular and molecular basis of gastric mucosal defense ' (1996 ) 10 FASEB. J. : 731 -740.

    • Search Google Scholar
  • Wei B, Velazquez P, Turovskaya O, Spricher K, Aranda R, Kronenberg M, Birnbaumer L, Braun J: Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. Proc. Natl Acad. Sci. USA. 102, 2010–2015 (2005)

    Braun J. , 'Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets ' (2005 ) 102 Proc. Natl Acad. Sci. USA. : 2010 -2015.

    • Search Google Scholar
  • Yan Z, Wang JB, Gong S, Huang X: Cell proliferation in the endolymphatic sac in situ after the rat Waldeyer ring equivalent immunostimulation. Laryngoscope 113, 1609–1614 (1993)

    Huang X. , 'Cell proliferation in the endolymphatic sac in situ after the rat Waldeyer ring equivalent immunostimulation ' (1993 ) 113 Laryngoscope : 1609 -1614.

    • Search Google Scholar

The author instruction is available in PDF.

Please, download the file from HERE

Senior editors

Editor(s)-in-Chief: Rosivall, László

Honorary Editor(s)-in-Chief): Monos, Emil

Managing Editor(s): Bartha, Jenő; Berhidi, Anna

Co-editor(s): Koller, Ákos; Lénárd, László; Szénási, Gábor

Assistant Editor(s): G. Dörnyei (Budapest), Zs. Miklós (Budapest), Gy. Nádasy (Budapest)

Hungarian Editorial Board

      Benedek, György (Szeged)
      Benyó, Zoltán (Budapest)
      Boros, Mihály (Szeged)
      Chernoch, László (Debrecen)
      Détári, László (Budapest)
      Hamar, János (Budapest)
      Hantos, Zoltán (Szeged)
      Hunyady, László (Budapest)
      Imre, Sándor (Debrecen)
      Jancsó, Gábor (Szeged)
      Karádi, Zoltán (Pécs)
      Kovács, László (Debrecen)
      Palkovits, Miklós (Budapest)
      Papp, Gyula (Szeged)
      Pavlik, Gábor (Budapest)
      Spät, András (Budapest)
      Szabó, Gyula (Szeged)
      Szelényi, Zoltán (Pécs)
      Szolcsányi, János (Pécs)
      Szollár, Lajos (Budapest)
      Szücs, Géza (Debrecen)
      Telegdy, Gyula (Szeged)
      Toldi, József (Szeged)
      Tósaki, Árpád (Debrecen)

International Editorial Board

      R. Bauer (Jena)
      W. Benjelloun (Rabat)
      A. W. Cowley Jr. (Milwaukee)
      D. Djuric (Belgrade)
      C. Fry (London)
      S. Greenwald (London)
      O. Hänninen (Kuopio)
      H. G. Hinghofer-Szalkay (Graz)
      Th. Kenner (Graz)
      Gy. Kunos (Richmond)
      M. Mahmoudian (Tehran)
      T. Mano (Seki, Gifu)
      G. Navar (New Orleans)
      H. Nishino (Nagoya)
      O. Petersen (Liverpool)
      U. Pohl (Münich)
      R. S. Reneman (Maastricht)
      A. Romanovsky (Phoenix)
      G. M. Rubanyi (Richmond)
      T. Sakata (Oita)
      A. Siddiqui (Karachi)
      Cs. Szabo (Beverly)
      E. Vicaut (Paris)
      N. Westerhof (Amsterdam)
      L. F. Zhang (Xi'an)

Editorial Office:
Akadémiai Kiadó Zrt.
Prielle Kornélia u. 21–35, H-1117 Budapest, Hungary

Editorial Correspondence:
Acta Physiologica Hungarica
Semmelweis University, Faculty of Medicine Institute of Pathophysiology
Nagyvárad tér 4, H-1089 Budapest, Hungary
Phone/Fax: +36-1-2100-100
E-mail: aph@semmelweis-univ.hu

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • EMBASE/Excerpta Medica
  • Global Health
  • Index Copernicus
  • Index Medicus
  • Medline
  • Referativnyi Zhurnal
  • Science Citation Index Expanded
  • SCOPUS

 

Acta Physiologica Hungarica
Language English
Size  
Year of
Foundation
1950
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0231-424X (Print)
ISSN 1588-2683 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Apr 2021 4 1 1
May 2021 5 0 0
Jun 2021 17 0 0
Jul 2021 16 0 0
Aug 2021 13 0 0
Sep 2021 10 0 0
Oct 2021 0 0 0