Field studies were undertaken for two consecutive seasons to evaluate the bioefficacy of cyazypyr 10% OD, a new molecule belonging to anthranilic diamide group of insecticides, along with imidacloprid 17.8% SL and fipronil 5% SC as standard checks, against the insect pest complex of tomato vis-à-vis its impact on natural enemies and crop health. The toxicity of cyazypyr 10% OD and four other molecules, each at two doses (diluted in 600l water), against the pupal stage of Trichogramma pretiosum Riley, an important egg parasitoid of Helicoverpa armigera Hubn., was evaluated in the laboratory. Cyazypyr 10% OD @ 90 and 105 g a.i./ha was highly effective in controlling the fruit borer, Helicoverpa armigera Hubn., aphid, Aphis gossypii Glov. and white fly, Bemisia tabaci Gen., and increasing the yield of marketable fruits. This insecticide @ 60-105 g a.i./ha effectively controlled the leaf miner, Liriomyza trifolii Burg. Imidacloprid 17.8% SL @ 22.5 g a.i./ha and fipronil 5% SC @ 60 g a.i./ha were also highly effective in controlling the pests. Considering the bioefficacy and yield, cyazypyr 10% OD @ 90 g a.i./ha may be recommended for effective control of pest complex of tomato. Cyazypyr 10% OD @ 45–105 g a.i./ha did not significantly reduce the field population of natural enemies and was safe to the crop even @ 360 g a.i./ha. In laboratory test, cyazypyr @ 90 and 60 g a.i./ha found to be safe to T. pretiosum Riley pupae, causing only 23.17 and 20.73% mortality, respectively.