Acta Alimentaria
Volume/Issue:
Volume 29: Issue 4
THE EFFECT OF FAT RICH DIET AND ALCOHOL ON ION CONCENTRATION IN BILE FLUID IN RATS
Authors: K. Szentmihályi 1 , A. Blázovics 2 , I. Kocsis 2 , Edit Fehér 3 , B. Lakatos 4 , and Péter Vinkler 5
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  • 1 Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences H-1025 Budapest, Pusztaszeri út 59-67. Hungary
  • 2 a II. Department of Surgery, Semmelweis University Please ask the editor of the journal.
  • 3 a II. Department of Surgery, Semmelweis University Please ask the editor of the journal.
  • 4 University of Veterinary Sciences Please ask the editor of the journal.
  • 5 Central Research Chemical Institute of HAS Budapest-114
DOI:
https://doi.org/10.1556/aalim.29.2000.4.6
Page Count:
359–366
Publication Date:
01 Oct 2000
Online Publication Date:
22 Jul 2005
Article Category:
Research Article
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The metabolic alteration of fatty liver causes significant changes in the composition of bile fluid secreted by epithelial liver cells. These processes include both organic molecular and inorganic ion content changes in bile juice as well. In this work ion concentration differences of bile fluid in experimental hyperlipidemic rats compared to normal ones were monitored. Fatty liver in young male Wistar albino rats was induced by 2% cholesterol, 20% sunflower oil and 0.5% cholic acid added to the normal food and 3% alcoholic water was administered to rats for 9 days. The development of hyperlipidemy was detected by measuring serum parameters and fatty liver was proved by morphological investigations. The ion concentrations of bile fluid samples were determined by ICP-OES (inductively coupled plasma optical emission spectrometry). The bile fluid samples were digested with a mixture of HNO3 and H2 O2 . The results show that the concentration of calcium and phosphorus in bile juice increased significantly in hyperlipidemic rats compared to the control. Significant concentration changes have also been detected for chromium and manganese. The changes in metal ion metabolism also point to the damage of liver cells owing to metal complex evacuation.

  • Lieber, C. S. (1997): Ethanol metabolism, cirrhosis and alcoholism. Clin. Chem. Acta, 257, 59-84.

    'Ethanol metabolism, cirrhosis and alcoholism. ' () 257 Clin. Chem. Acta : 59 -84.

  • Bogin, E., Avidar, Y. & Merom, M. (1986): Biochemical changes in liver and blood during liver attering in rats. J. clin. Chem. clin. Biochem., 24, b2.626.

    'Biochemical changes in liver and blood during liver attering in rats ' () 24 J. clin. Chem. clin. Biochem. : b2.626.

    • Search Google Scholar

  • Chetty, K. N., Conway, R., Harris, K. C, Dorsey, W. C, Hill, D., Chetty, S., Yerrapragada, R. & Jain, S. (1999): Dietary supplementation with oil influences iron concentrations in rats. Nutr. Res., 19, 1665-1670.

    'Dietary supplementation with oil influences iron concentrations in rats. ' () 19 Nutr. Res. : 1665 -1670.

    • Search Google Scholar

  • Cohen, I. (1990): Magnesium and liver cirrhosis. Metal Ions Biol., 26, 271-284.

    'Magnesium and liver cirrhosis. ' () 26 Metal Ions Biol. : 271 -284.

  • Bendich, A. (1990): antioxidant micronutrients and immune responses. Ann. N. Y. Acad. Sci., 587, 169-180.

    'antioxidant micronutrients and immune responses. ' () 587 Ann. N. Y. Acad. Sci. : 169 -180.

    • Search Google Scholar

  • Blázovics, A., Fehér, E. & Fehér, J. (1992): Free radical reactions in experimental hyperlipidemia in pathomechanism of fatty liver, -in: Csomós, G. & Fehér, J. (eds). Free radical and liver. Spinger-Verlag, Berlin, pp. 96-126.

    Free radical and liver , () 96 -126.

  • Blázovics, A., Örsi, F., Kemény, T., Fehér, E., Barta, I. & Fehér, J. (1997): Lipids and lipid peroxidation in liver, bile and gallbladder. Progress in Hepato Pharmacology, 2, 103-116.

    'Lipids and lipid peroxidation in liver, bile and gallbladder. ' () 2 Progress in Hepato Pharmacology : 103 -116.

    • Search Google Scholar

  • FlinkE. B., Shane, S. R., Scobbo, R. R., Blehschmidt, N. G. & Mcdowell, P. (1979): Relationship of free fatty acids and magnesium in ethanol with drawal in dogs. Metabol., 28, 858-864.

    'Relationship of free fatty acids and magnesium in ethanol with drawal in dogs. ' () 28 Metabol. : 858 -864.

    • Search Google Scholar

  • Freeman, B. & Crapo J. D. (1982): Biology of disease, free radicals and tissue injury. Lab. Invest., 47, 412-426.

    'Biology of disease, free radicals and tissue injury. ' () 47 Lab. Invest. : 412 -426.

  • Gleeson, D., Murphy, G. M. & Dowling, R. H. (1994): Changes in serum calcium levels influence biliary calcium levels in humans. Gastroenterology, 107, 1812-1818.

    'Changes in serum calcium levels influence biliary calcium levels in humans. ' () 107 Gastroenterology : 1812 -1818.

    • Search Google Scholar

  • Lieber, C. S. (1991): Hepatic, metabolic and toxic effects of ethanol: Update alcoholism. Clin. Exp. Res., 15, 573-592.

    'Hepatic, metabolic and toxic effects of ethanol: Update alcoholism. ' () 15 Clin. Exp. Res. : 573 -592.

    • Search Google Scholar

  • Orlando, R., Tonose, G., De Fino, M. & Cangiano, F. (1987): Changes in serum zinc levels during cronic liver disease. Minerva Med., 78, 1759-1763.

    'Changes in serum zinc levels during cronic liver disease. ' () 78 Minerva Med. : 1759 -1763.

    • Search Google Scholar

  • Strange, R. C. (1984): Hepatic bile flow. Physiol. Rev., 64, 1055-1102.

    'Hepatic bile flow. ' () 64 Physiol. Rev. : 1055 -1102.

  • Yagasaki, K. (1998): Dietary control of abnormal lipid metabolism secondary to hypothyroidism, cancer and inflammatory disease. Recent Res. Dev. Lipids Res., 2, 21-28.

    'Dietary control of abnormal lipid metabolism secondary to hypothyroidism, cancer and inflammatory disease. ' () 2 Recent Res. Dev. Lipids Res. : 21 -28.

    • Search Google Scholar
Cover Acta Alimentaria
Acta Alimentaria
Print ISSN:
0139-3006
Online ISSN:
1588-2535

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