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M. Then Institute of Pharmacognosy, Semmelweis University H-1085 Budapest, Üllői út 26. Hungary

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K. Szentmihályi Institute of Material and Environmental Chemistry, Chemical Research Center, Hungarian Academy of Sciences H-1025 Budapest, Pusztaszeri út 59-67. Hungary

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A. Gere Pharmacological and Drug Safety Research, Richter Gedeon Ltd. H-1103 Budapest, Gyömrői út 19-21. Hungary

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Sz. Jasztrab Institute of Pharmacognosy, Semmelweis University H-1085 Budapest, Üllői út 26. Hungary

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É. Szőke Institute of Pharmacognosy, Semmelweis University H-1085 Budapest, Üllői út 26. Hungary

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In vitro investigations for the antioxidant and free radical scavenging activity of Myrtilli folium-, Phaseoli fructus sine seminibus- and a drug mixture (Equiseti herba, Myrtilli folium, Phaseoli fructus sine seminibus, Urticae folium) extracts showed antioxidant (LPO inhibitory and chain-breaking antioxidant) activity and free radical (superoxide anion and hydroxyl radical) scavenging effect. The extracts inhibited lipid peroxidation induced enzymatically by adding NADPH and non-enzymatically by adding Fe2+ in brain microsomes and in brain homogenates, respectively. The extracts reduced the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), which showed chain-breaking antioxidant activity. The extracts scavenged superoxide radicals (O2-·) by inhibiting the reduction of nitro blue tetrazolium evoked by phenazine methosulphate. In addition, the extracts inhibited Fenton-reagent (Fe2+ and H2O2) induced deoxyribose degradation, therefore, it was concluded that the extracts have hydroxyl radical (OH·) scavenging property.

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    'Diabetes mellitus, hypertension, and cardiovascular disease: which role for oxidative stress. ' () 44 Metab. clin. Exp. : 363 -368 .

    • Search Google Scholar
  • Glasl, H. (1985): Photometrische Normierung von Flavonoid-O und C-Glycosiden. Fresenius Z. anal. Chem., 321, 325-330.

    'Photometrische Normierung von Flavonoid-O und C-Glycosiden. ' () 321 Fresenius Z. anal. Chem. : 325 -330 .

    • Search Google Scholar
  • Hagymási, K., Blázovics, A., Lugasi, A., Kristo, S. T., Fehér, J. & Kéry, Á. (2000): In vitro antioxidant evaluation of Dandelio (Taraxacum offidnale Web.) water extracts. Acta Alimentaria, 29, 1-7.

    'In vitro antioxidant evaluation of Dandelio (Taraxacum offidnale Web.) water extracts. ' () 29 Acta Alimentaria : 1 -7 .

    • Search Google Scholar
  • Jovanovic, S. V., Steenken, S., Tosic, M., Marjanovic, B. & Simic, M. G. (1994): Flavonoids as antioxidants. J. Am. Chem. Soc, 116, 4846-4851.

    'Flavonoids as antioxidants. ' () 116 J. Am. Chem. Soc : 4846 -4851 .

  • Lapenna, D., Mezzetti, A., De Gioia, S. & Ciofani, G. (1992): Heparin: does it act as an antioxidant in vivo? Biochem. Pharmac, 44, 188-191.

    'Heparin: does it act as an antioxidant in vivo? ' () 44 Biochem. Pharmac : 188 -191 .

    • Search Google Scholar
  • Lowry, O. H., Rosebourgh, N. J., Farr, A. L. & Randall, R. J. (1951): Protein measurement with Folin reagent. J. biol. Chem., 193, 265-275.

    'Protein measurement with Folin reagent. ' () 193 J. biol. Chem. : 265 -275 .

  • Morel, I., Lescoat, G., Cogrel, P., Sergent, O., Pasdeloup, N., Brissot, P., Cillard, P. & Cillard, J. (1993): Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures. Biochem. Pharmac., 45, 13-19.

    'Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures. ' () 45 Biochem. Pharmac. : 13 -19 .

    • Search Google Scholar
  • Pascual, C., Gonzalez, R., Armesto, J. & Muriel, P. (1993): Effect of silymarin and silybinin on oxygen radicals. Drug. Dev. Res., 29, 73-77.

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  • Braughler, J. M., Duncan, L. A. & Chase, R. L. (1986): The involvement of iron in lipid peroxidation. Importance of ferric to ferrous ratios in initiation. J biol. Chem., 261, 10282-10289.

    'The involvement of iron in lipid peroxidation. Importance of ferric to ferrous ratios in initiation. ' () 261 J biol. Chem. : 10282 -10289 .

    • Search Google Scholar
  • Catella-Lawson, F. & FitzGerald, G. (1996): Oxidative stress and platelet activation in diabetes mellitus. Diabetes Res. clin. Pract, 30, S13-S18.

    'Oxidative stress and platelet activation in diabetes mellitus. ' () 30 Diabetes Res. clin. Pract : S13 -S18 .

    • Search Google Scholar
  • Bertuglia, S., Malandrino, S. & Colantuoni, A. (1995): Effects of the natural flavonoid delphinidin on diabetic microangiopathy. Arzneim.-Forsch., 45, 481-485.

    'Effects of the natural flavonoid delphinidin on diabetic microangiopathy. ' () 45 Arzneim.-Forsch. : 481 -485 .

    • Search Google Scholar
  • Czinner, E., Hagymási, K., Blázovics, A., Kéry, Á., Szöke, É. & Lemberkovics, É. (2001): The in vitro effect of Helichrysi flos on microsomal lipid peroxidation. J. Ethnopharmac, 77, 31-35.

    'The in vitro effect of Helichrysi flos on microsomal lipid peroxidation. ' () 77 J. Ethnopharmac : 31 -35 .

    • Search Google Scholar
  • DAB (1999): Deutsches Arzneibuch Ed. 10, Deutscher Apotheker Verlag, Stuttgart.

  • Duke, J. A. (2000): CRC Handbook of medicinal herbs. CRC Press, Inc., Boca Raton, Florida, pp. 1-677.

    1 677

  • Ernst, E. (1997): Plants with hypoglycemic activity in humans. Phytomedicine, 4, 73-78.

    'Plants with hypoglycemic activity in humans. ' () 4 Phytomedicine : 73 -78 .

  • European Pharmacopoeia (2002): Thin layer chromatography. Ed. 4. 2.2.27. Strasbourg, Council of Europe.

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Senior editors

Editor(s)-in-Chief: András Salgó, Budapest University of Technology and Economics, Budapest, Hungary

Co-ordinating Editor(s) Marianna Tóth-Markus, Budapest, Hungary

Co-editor(s): A. Halász, Budapest, Hungary

       Editorial Board

  • László Abrankó, Hungarian University of Agriculture and Life Sciences, Budapest, Hungary
  • Tamás Antal, University of Nyíregyháza, Nyíregyháza, Hungary
  • Diána Bánáti, University of Szeged, Szeged, Hungary
  • József Baranyi, Institute of Food Research, Norwich, UK
  • Ildikó Bata-Vidács, Eszterházy Károly Catholic University, Eger, Hungary
  • Ferenc Békés, FBFD PTY LTD, Sydney, NSW Australia
  • György Biró, Budapest, Hungary
  • Anna Blázovics, Semmelweis University, Budapest, Hungary
  • Francesco Capozzi, University of Bologna, Bologna, Italy
  • Marina Carcea, Research Centre for Food and Nutrition, Council for Agricultural Research and Economics Rome, Italy
  • Zsuzsanna Cserhalmi, Budapest, Hungary
  • Marco Dalla Rosa, University of Bologna, Bologna, Italy
  • István Dalmadi, Hungarian University of Agriculture and Life Sciences, Budapest, Hungary
  • Katarina Demnerova, University of Chemistry and Technology, Prague, Czech Republic
  • Mária Dobozi King, Texas A&M University, Texas, USA
  • Muying Du, Southwest University in Chongqing, Chongqing, China
  • Sedef Nehir El, Ege University, Izmir, Turkey
  • Søren Balling Engelsen, University of Copenhagen, Copenhagen, Denmark
  • Éva Gelencsér, Budapest, Hungary
  • Vicente Manuel Gómez-López, Universidad Católica San Antonio de Murcia, Murcia, Spain
  • Jovica Hardi, University of Osijek, Osijek, Croatia
  • Hongju He, Henan Institute of Science and Technology, Xinxiang, China
  • Károly Héberger, Research Centre for Natural Sciences, ELKH, Budapest, Hungary
  • Nebojsa Ilić, University of Novi Sad, Novi Sad, Serbia
  • Dietrich Knorr, Technische Universität Berlin, Berlin, Germany
  • Hamit Köksel, Hacettepe University, Ankara, Turkey
  • Katia Liburdi, Tuscia University, Viterbo, Italy
  • Meinolf Lindhauer, Max Rubner Institute, Detmold, Germany
  • Min-Tze Liong, Universiti Sains Malaysia, Penang, Malaysia
  • Marena Manley, Stellenbosch University, Stellenbosch, South Africa
  • Miklós Mézes, Hungarian University of Agriculture and Life Sciences, Gödöllő, Hungary
  • Áron Németh, Budapest University of Technology and Economics, Budapest, Hungary
  • Perry Ng, Michigan State University,  Michigan, USA
  • Quang Duc Nguyen, Hungarian University of Agriculture and Life Sciences, Budapest, Hungary
  • Laura Nyström, ETH Zürich, Switzerland
  • Lola Perez, University of Cordoba, Cordoba, Spain
  • Vieno Piironen, University of Helsinki, Finland
  • Alessandra Pino, University of Catania, Catania, Italy
  • Mojmir Rychtera, University of Chemistry and Technology, Prague, Czech Republic
  • Katharina Scherf, Technical University, Munich, Germany
  • Regine Schönlechner, University of Natural Resources and Life Sciences, Vienna, Austria
  • Arun Kumar Sharma, Department of Atomic Energy, Delhi, India
  • András Szarka, Budapest University of Technology and Economics, Budapest, Hungary
  • Mária Szeitzné Szabó, Budapest, Hungary
  • Sándor Tömösközi, Budapest University of Technology and Economics, Budapest, Hungary
  • László Varga, Széchenyi István University, Mosonmagyaróvár, Hungary
  • Rimantas Venskutonis, Kaunas University of Technology, Kaunas, Lithuania
  • Barbara Wróblewska, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences Olsztyn, Poland

 

Acta Alimentaria
E-mail: Acta.Alimentaria@uni-mate.hu

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Acta Alimentaria
Language English
Size B5
Year of
Foundation
1972
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia    
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
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Publisher
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ISSN 0139-3006 (Print)
ISSN 1588-2535 (Online)

 

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