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  • 1 University of Szeged Department of Microbiology, Faculty of Sciences H-6701 Szeged P.O. Box 533 Hungary
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Cells of the astaxanthin-producing yeast Xanthophyllomyces dendrorhous were subjected to successive 60 Co and UV irradiation. Colonies exhibiting increased pigmentation were recovered from different non-selective plates. Mutant strains were subcultured to ensure their genetic homogeneity and their pigment production was characterized. Analysis of the metabolic patterns of 7 pigment-overproducing mutants (derived from 3 wild-type parental isolates) revealed different patterns of carotenoid production: the greatest increase in astaxanthin production (6.7-fold) was found for X. dendrorhous strain ATCC 24229/S119 (274 μ g g −1 dry weight). Mutant strains with increased total carotenoid content, but without significant change in astaxanthin production, were also isolated.

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