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  • 1 University of Pécs Department of Public Health and Preventive Medicine, Faculty of Medicine H-7624 Pécs Szigeti út 12 Hungary
  • 2 International CoD™ Cancer Information Centre Foundation H-9155 Lébény P.O. Box 9 Hungary
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Several plant-originated natural compounds were shown to exhibit chemopreventive effect in carcinogenesis. In our studies, we have investigated CoD™ extract, a complex plant extract made from several tropical plants with possible cancer preventive effect in animal experiments. c-myc, p53 and Ha-ras gene expressions were investigated 24, 48 and 72 h after CoD™ extract and dimethylbenz(a)-anthracene (DMBA) treatment in CBA/Ca(H-2 K ) mice. CoD™ extract administered together with DMBA diminished c-myc, p53 and Ha-ras gene expressions both in the 24 and 48 h experiments, but not in the 72 h experiments. Further in vivo and human studies are needed to clarify the possible role of CoD™ extract in the prevention of tumour formation after carcinogenic exposures.

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