In vitro testing of antiviral, antibacterial, antifungal effects and cytotoxicity of selected Turkish Phlomis species

B. Özcelik; I. Orhan; M. Kartal; B. Konuklugil

doi:10.1556/aalim.39.2010.2.2

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Acta Alimentaria

Volume/Issue:: Volume 39: Issue 2

In vitro testing of antiviral, antibacterial, antifungal effects and cytotoxicity of selected Turkish Phlomis species

Authors:

B. Özcelik

B. Özcelik Gazi University Department of Pharmaceutical Microbiology, Faculty of Pharmacy 06330 Ankara Turkey

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I. Orhan

I. Orhan Gazi University Department of Pharmacognosy, Faculty of Pharmacy 06330 Ankara Turkey

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M. Kartal

M. Kartal Ankara University Department of Pharmacognosy, Faculty of Pharmacy 06110 Ankara Turkey

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B. Konuklugil

B. Konuklugil Ankara University Department of Pharmacognosy, Faculty of Pharmacy 06110 Ankara Turkey

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Pages:: 119–125

Online Publication Date:: 12 Jun 2010

Publication Date:: 01 Jun 2010

Article Category:: Journal Article

DOI:: https://doi.org/10.1556/aalim.39.2010.2.2

Keywords:: Lamiaceae; antiviral; antimicrobial; cytotoxicity

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The objective of this study was to examine antibacterial, antifungal and antiviral properties of selected Phlomis species (Lamiaceae) growing in Turkey. The petroleum ether and methanol extracts of the seven species, namely P. armeniaca Willd., P. bourgaei Boiss., P. leucophracta P.H. Davis & Hub.-Mor., P. lunariifolia Sibth. & Sm., P. lycia D. Don, P. pungens Willd. var. pungens , and P. pungens var. hirta Velen. were tested against Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Bacillus subtilis , and Enterococcus faecalis for their antibacterial activity using ampicillin and oflaxocin as references. Antifungal activity of the same extracts was determined against Candida albicans using microdilution method with ketocanazole as reference. Both DNA virus Herpes simplex type-1 (HSV-1) and RNA virus Parainfluenza (PI-3) were employed for antiviral assessment of the Phlomis extracts using Madin-Darby Bovine Kidney and Vero cell lines in which acyclovir for HSV-1 and oseltamivir for PI-3 were employed as reference drugs. Although both the petroleum ether and methanol extracts seemed to exert similar antibacterial activity, the methanolic extracts were observed to be more active against S. aureus and E. faecalis . On the other hand, methanolic extract of P. pungens var. pungens possessed notable antiviral activity against both type of viruses.

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Acta Alimentaria

Print ISSN:: 0139-3006

Online ISSN:: 1588-2535

Editorial Board

László Abrankó, Hungarian University of Agriculture and Life Sciences, Budapest, Hungary
Tamás Antal, University of Nyíregyháza, Nyíregyháza, Hungary
Diána Bánáti, University of Szeged, Szeged, Hungary
József Baranyi, Institute of Food Research, Norwich, UK
Ildikó Bata-Vidács, Eszterházy Károly Catholic University, Eger, Hungary
Ferenc Békés, FBFD PTY LTD, Sydney, NSW Australia
György Biró, Budapest, Hungary
Anna Blázovics, Semmelweis University, Budapest, Hungary
Francesco Capozzi, University of Bologna, Bologna, Italy
Marina Carcea, Research Centre for Food and Nutrition, Council for Agricultural Research and Economics Rome, Italy
Zsuzsanna Cserhalmi, Budapest, Hungary
Marco Dalla Rosa, University of Bologna, Bologna, Italy
István Dalmadi, Hungarian University of Agriculture and Life Sciences, Budapest, Hungary
Katarina Demnerova, University of Chemistry and Technology, Prague, Czech Republic
Mária Dobozi King, Texas A&M University, Texas, USA
Muying Du, Southwest University in Chongqing, Chongqing, China
Sedef Nehir El, Ege University, Izmir, Turkey
Søren Balling Engelsen, University of Copenhagen, Copenhagen, Denmark
Éva Gelencsér, Budapest, Hungary
Vicente Manuel Gómez-López, Universidad Católica San Antonio de Murcia, Murcia, Spain
Jovica Hardi, University of Osijek, Osijek, Croatia
Hongju He, Henan Institute of Science and Technology, Xinxiang, China
Károly Héberger, Research Centre for Natural Sciences, ELKH, Budapest, Hungary
Nebojsa Ilić, University of Novi Sad, Novi Sad, Serbia
Dietrich Knorr, Technische Universität Berlin, Berlin, Germany
Hamit Köksel, Hacettepe University, Ankara, Turkey
Katia Liburdi, Tuscia University, Viterbo, Italy
Meinolf Lindhauer, Max Rubner Institute, Detmold, Germany
Min-Tze Liong, Universiti Sains Malaysia, Penang, Malaysia
Marena Manley, Stellenbosch University, Stellenbosch, South Africa
Miklós Mézes, Hungarian University of Agriculture and Life Sciences, Gödöllő, Hungary
Áron Németh, Budapest University of Technology and Economics, Budapest, Hungary
Perry Ng, Michigan State University, Michigan, USA
Quang Duc Nguyen, Hungarian University of Agriculture and Life Sciences, Budapest, Hungary
Laura Nyström, ETH Zürich, Switzerland
Lola Perez, University of Cordoba, Cordoba, Spain
Vieno Piironen, University of Helsinki, Finland
Alessandra Pino, University of Catania, Catania, Italy
Mojmir Rychtera, University of Chemistry and Technology, Prague, Czech Republic
Katharina Scherf, Technical University, Munich, Germany
Regine Schönlechner, University of Natural Resources and Life Sciences, Vienna, Austria
Arun Kumar Sharma, Department of Atomic Energy, Delhi, India
András Szarka, Budapest University of Technology and Economics, Budapest, Hungary
Mária Szeitzné Szabó, Budapest, Hungary
Sándor Tömösközi, Budapest University of Technology and Economics, Budapest, Hungary
László Varga, Széchenyi István University, Mosonmagyaróvár, Hungary
Rimantas Venskutonis, Kaunas University of Technology, Kaunas, Lithuania
Barbara Wróblewska, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences Olsztyn, Poland

Acta Alimentaria
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Acta Alimentaria
Language	English
Size	B5
Year of Foundation	1972
Volumes per Year	1
Issues per Year	4
Founder	Magyar Tudományos Akadémia
Founder's Address	H-1051 Budapest, Hungary, Széchenyi István tér 9.
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ISSN	0139-3006 (Print)
ISSN	1588-2535 (Online)