Vegetables are the major source of dietary nitrate, with wide variations in nitrate content. The presence of nitrate in vegetables is often associated with harmful effects on human health, i.e. with toxic effects of methaemoglobinaemia and the possibility of causing an endogenous formation of carcinogenic N-nitroso compounds. However, it is also associated with beneficial health effects, since nitrate represent an important alternative pathway to bioactive NO and its important physiological roles in vascular and immune function. In this review the concentrations of nitrate in different vegetables from different countries are given. Furthermore, the reasons for the different contents of nitrate in vegetables, the daily intakes and comparisons to the acceptable daily intake (ADI) values, legislation, metabolism and toxicology of nitrate are described as well as harmful and beneficial effects of nitrate on human health.
AFSSA (2007): Estimation du niveau d’exposition aux nitrates et aux nitrites de la population française. Réponse à la demande d’appui scientifique et technique de la DGCCRF réf. 2007-SA-0070 du 8/01/2007.
Appel, L.J., Moore, T.J., Obarzanek, E., Vollmer, W. et al. (1997): A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N. Engl. J Med., 336, 1117–1124.
Vollmer W. , 'A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group ' (1997 ) 336 N. Engl. J Med. : 1117 -1124.
Bazano, L.A., Li, T.Y., Joshipura, K.J. & Hu, F.B. (2008): Intake of fruit, vegetables, and fruit juices and risk of diabetes in women. Diabetes Care, 31, 1311–1317.
Hu F.B. , 'Intake of fruit, vegetables, and fruit juices and risk of diabetes in women ' (2008 ) 31 Diabetes Care : 1311 -1317.
Blom-Zandstra, M. (1989): Nitrate accumulation in vegetables and its relationship to quality. Ann. Appl. Biol., 115, 553–561.
Blom-Zandstra M. , 'Nitrate accumulation in vegetables and its relationship to quality ' (1989 ) 115 Ann. Appl. Biol. : 553 -561.
Bos, P.M.J., Van den Brandt, P.A., Wedel, M. & Ockhuizen, T. (1988): The reproducibility of the conversion of nitrate to nitrite in human saliva after a nitrate load. Fd Chem. Toxicol., 26, 93–97.
Ockhuizen T. , 'The reproducibility of the conversion of nitrate to nitrite in human saliva after a nitrate load ' (1988 ) 26 Fd Chem. Toxicol. : 93 -97.
Bottex, B., Dorne, J. L. C.M., Carlander, D., Benford, D., Przyrembel, H., Heppner, C., Kleiner, J. & Cockburn, A. (2008): Risk-benefit health assessment of food — Food fortification and nitrate in vegetables. Trends Fd Sci. Technol., 19, S113–S119.
Cockburn A. , 'Risk-benefit health assessment of food — Food fortification and nitrate in vegetables ' (2008 ) 19 Trends Fd Sci. Technol. : S113 -S119.
Bourn, D. & Prescott, J. (2002): A comparison of the nutritional value, sensory qualities, and food safety of organically and conventionally produced foods. Crit. Rev. Fd Sci. Nutr., 42, 1–34.
Prescott J. , 'A comparison of the nutritional value, sensory qualities, and food safety of organically and conventionally produced foods ' (2002 ) 42 Crit. Rev. Fd Sci. Nutr. : 1 -34.
Buiatti, E., Palli, D., Decarli, A., Amadori, D., Avellini, C., Bianchi, S., Bonaguri, C., Cipriani, F., Cocco, P. & Giacosa, A. (1990): A case-control study of gastric cancer and diet in Italy. II. Association with nutrients. Int. J. Cancer, 45, 896–901.
Giacosa A. , 'A case-control study of gastric cancer and diet in Italy. II. Association with nutrients ' (1990 ) 45 Int. J. Cancer : 896 -901.
Chung, S.Y., Kim, J.S., Kim, M., Hong, M.K., Lee, J.O., Kim, C.M. & Song, I.S. (2003): Survey of nitrate and nitrite contents of vegetables grown in Korea. Fd Addit. Contam., 20, 621–628.
Song I.S. , 'Survey of nitrate and nitrite contents of vegetables grown in Korea ' (2003 ) 20 Fd Addit. Contam. : 621 -628.
Chung, J.C., Chou, S.S. & Hwang, D.F. (2004): Changes in nitrate and nitrite content of four vegetables during storage at refrigerated and ambient temperatures. Fd Addit. Contam., 21, 317–322.
Hwang D.F. , 'Changes in nitrate and nitrite content of four vegetables during storage at refrigerated and ambient temperatures ' (2004 ) 21 Fd Addit. Contam. : 317 -322.
Commission Regulation (EU) No 1258/2011. (2011): Amending Regulation (EC) No 1881/2006 as regards maximum levels for nitrates in foodstuffs. Official Journal of the European Union, 320, 15–17. [cited 2012 April 5]. Available from: http://eurlex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2011:320:0015:0017:EN:PDF
'Amending Regulation (EC) No 1881/2006 as regards maximum levels for nitrates in foodstuffs ' (2011 ) 320 Official Journal of the European Union : 15 -17.
Du, S.T., Zhang, Y.S. & Lin, X.Y. (2007): Accumulation of nitrate in vegetables and its possible implications to human health. Agric. Sci. China, 6, 1246–1255.
Lin X.Y. , 'Accumulation of nitrate in vegetables and its possible implications to human health ' (2007 ) 6 Agric. Sci. China : 1246 -1255.
Duncan, C., Dougall, H., Johnston, P., Green, S., Brogan, R., Leifert, C., Smith, L., Golden, M. & Benjamin, N. (1995): Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate. Nat. Med., 1, 546–551.
Benjamin N. , 'Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate ' (1995 ) 1 Nat. Med. : 546 -551.
Duncan, C., Li, H., Dykhuizen, R., Frazer, R., Johnston, P. & MacKnight, G. (1997): Protection against oral and gastrointestinal diseases: Importance of dietary nitrate intake, oral nitrate reduction and enterosalivary nitrate circulation. Comp. Biochem. Physiol., 118 A, 939–948.
MacKnight G. , 'Protection against oral and gastrointestinal diseases: Importance of dietary nitrate intake, oral nitrate reduction and enterosalivary nitrate circulation ' (1997 ) 118A Comp. Biochem. Physiol. : 939 -948.
EC (1992): Opinion on nitrate and nitrite. Reports of the Scientific Committee for Food (SCF) 26th Series:21–28. [cited 2011 Mar 15]. Available from: http://ec.europa.eu/food/fs/sc/scf/reports/scf_reports_26.pdf
'Opinion on nitrate and nitrite ' (1992 ) 26thSeries Reports of the Scientific Committee for Food (SCF) : 21 -28.
EC (1997): Opinion on nitrate and nitrite. Reports of the Scientific Committee for Food (SCF) No 197 38th Series:1–33. [cited 2011 Mar 15]. Available from: http://ec.europa.eu/food/fs/sc/scf/reports/scf_reports_38.pdf
EFSA (2008): Nitrate in vegetables. Scientific opinion of the panel on contaminants in the food chain. EFSA Journal, 689, 1e79, [cited 2011 Feb 10]. Available from: http://www.efsa.europa.eu/EFSA/Scientific_Opinion/contam_ej_689_nitrate_en.pdf
'Nitrate in vegetables. Scientific opinion of the panel on contaminants in the food chain ' (2008 ) 689 EFSA Journal : 1e79 -.
EPA (United States Environmental Protection Agency) (2008): Drinking Water Contaminants. [cited 2011 Feb 11]. Available from: http://water.epa.gov/drink/contaminants/index.cfm#Inorganic
Fan, A.M. & Steinbers, V.E. (1996): Health implications of nitrate and nitrite in drinking water: An update on methemoglobinemia occurrence and reproductive and developmental toxicity. Regul. Toxicol. Pharmacol., 213, 35–43.
Steinbers V.E. , 'Health implications of nitrate and nitrite in drinking water: An update on methemoglobinemia occurrence and reproductive and developmental toxicity ' (1996 ) 213 Regul. Toxicol. Pharmacol. : 35 -43.
FAO/WHO (1962): Evaluation of the toxicity of a number of antimicrobials and antioxidants, Sixth report of the joint FAO/WHO Expert Committee on Food Additives. World Health Organization technical report Series nr., 228, 69–75.
'Evaluation of the toxicity of a number of antimicrobials and antioxidants, Sixth report of the joint FAO/WHO Expert Committee on Food Additives ' (1962 ) 228 World Health Organization technical report Series nr. : 69 -75.
FAO/WHO (2003): Nitrate (and potential endogenous formation of N-nitroso compounds). WHO Food Additive series 50. Geneva: World Health Organisation. [cited 2011 Mar 15]. Available from: http://www.inchem.org/documents/jecfa/jecmono/v50je06.htm
'', in Nitrate (and potential endogenous formation of N-nitroso compounds) , (2003 ) -.
Gangolli, S.D., Van den Brandt, P.A., Feron, V.J., Janzowsky, C., Koeman, J.H., Speijers, G.J.A., Spiegelhalder, B., Walker, R. & Wishnok, J.S. (1994): Assessment of nitrate, nitrite and N-nitroso compounds. Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. Section, 292, 1–38.
Wishnok J.S. , 'Assessment of nitrate, nitrite and N-nitroso compounds ' (1994 ) 292 Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. Section : 1 -38.
Gent, M.P.N. (2002): Growth and composition of salad greens as affected by organic compared to nitrate fertilizer and by environment in high tunnels. J. Pl. Nutr., 25, 981–998.
Gent M.P.N. , 'Growth and composition of salad greens as affected by organic compared to nitrate fertilizer and by environment in high tunnels ' (2002 ) 25 J. Pl. Nutr. : 981 -998.
Gento, P.D. (1994): Contenido de nitratos en vegetales cultivados de la provincia de Valencia. Alimentaria, 249, 49–51.
Gento P.D. , 'Contenido de nitratos en vegetales cultivados de la provincia de Valencia ' (1994 ) 249 Alimentaria : 49 -51.
Gladwin, M.T., Schechter, A.N., Kim-Shapiro, D.B., Patel, R.P., Hogg, N., Shiva, S., Cannon, II R.O., Kelm, M., Wink, D.A., Espey, M.G., Oldfield, E.H., Pluta, R.M., Freeman, B.A., Lancaster Jr., J.R., Feelisch, M. & Lundberg, J. (2005): The emerging biology of the nitrite anion. Nature Chem. Biol., 1, 308–314.
Lundberg J. , 'The emerging biology of the nitrite anion ' (2005 ) 1 Nature Chem. Biol. : 308 -314.
Guadagnin, S.G., Rath, S. & Reyes, F.G.R. (2005): Evaluation of the nitrate content in leaf vegetables produced through different agricultural systems. Fd Addit. Contam., 22, 1203–1208.
Reyes F.G.R. , 'Evaluation of the nitrate content in leaf vegetables produced through different agricultural systems ' (2005 ) 22 Fd Addit. Contam. : 1203 -1208.
Hageman, R.H. & Flesher, D. (1960): Nitrate reductase activity in corn seedlings as affected by light and nitrate content of nutrient media. Pl. Physiol., 35, 700–708.
Flesher D. , 'Nitrate reductase activity in corn seedlings as affected by light and nitrate content of nutrient media ' (1960 ) 35 Pl. Physiol. : 700 -708.
Hernández-Ramírez, R.U., Galván-Portillo, M.V., Ward, M.H., Agudo, A., González, C.A., Oñate-Ocaña, L.F., Herrera-Goepfert, R., Palma-Coca, O. & López-Carrillo, L. (2009): Dietary intake of polyphenols, nitrate and nitrite and gastric cancer risk in Mexico City. Int. J. Cancer, 125, 1424–1430.
López-Carrillo L. , 'Dietary intake of polyphenols, nitrate and nitrite and gastric cancer risk in Mexico City ' (2009 ) 125 Int. J. Cancer : 1424 -1430.
Hord, N.G., Tang, Y. & Bryan, N.S. (2009): Food sources of nitrates and nitrites: The physiologic context for potential health benefits. Am. J. Clin. Nutr., 90, 1–10.
Bryan N.S. , 'Food sources of nitrates and nitrites: The physiologic context for potential health benefits ' (2009 ) 90 Am. J. Clin. Nutr. : 1 -10.
Hsu, J., Arcot, J. & Lee, N.A. (2009): Analytical methods: Nitrate and nitrite quantification from cured meat and vegetables and their estimated dietary intake in Australians. Fd Chem., 115, 334–339.
Lee N.A. , 'Analytical methods: Nitrate and nitrite quantification from cured meat and vegetables and their estimated dietary intake in Australians ' (2009 ) 115 Fd Chem. : 334 -339.
Ja, K.H., Lee, S.S., Choi, B.Y. & Kim, M.K. (2007): Nitrate intake relative to antioxidant vitamin intake affects gastric cancer risk: A case-control study in Korea. Nutr. Cancer, 59, 185–191.
Kim M.K. , 'Nitrate intake relative to antioxidant vitamin intake affects gastric cancer risk: A case-control study in Korea ' (2007 ) 59 Nutr. Cancer : 185 -191.
Jalali, M. (2008): Nitrate concentrations in some vegetables and soils in Hamadan, western Iran. Archs Agron. Soil Sci., 54, 569–583.
Jalali M. , 'Nitrate concentrations in some vegetables and soils in Hamadan, western Iran ' (2008 ) 54 Archs Agron. Soil Sci. : 569 -583.
Johnson, C.J. & Kross, B.C. (1990): Continuing importance of nitrate contamination of groundwater and wells in rural areas. Am. J. Indust. Med., 18, 449–456.
Kross B.C. , 'Continuing importance of nitrate contamination of groundwater and wells in rural areas ' (1990 ) 18 Am. J. Indust. Med. : 449 -456.
Joossens, J.V., Hill, M.J., Elliott, P., Stamler, R., Stamler, J. & Lesafre, E., Dyer, A., Nichols, R., Kesteloot, H. and on behalf of European Cancer Prevention (ECP) and the Intersalt Cooperative Research Group (1996): Dietary salt, nitrate and stomach cancer mortality in 24 countries. Int. J. Epidemiol., 25, 494–504.
Kesteloot H. , 'Dietary salt, nitrate and stomach cancer mortality in 24 countries ' (1996 ) 25 Int. J. Epidemiol. : 494 -504.
Joshipura, K.J., Ascherio, A., Manson, J.E., Stampfer, M.J., Rimm, E.B., Hennekens, C.H. & Speizer, F. (1999): Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA, 282, 1233–1239.
Speizer F. , 'Fruit and vegetable intake in relation to risk of ischemic stroke ' (1999 ) 282 JAMA : 1233 -1239.
Joshipura, K.J., Hu, F.B., Manson, J.E., Stampfer, M.J., Rimm, E.B., Speizer, F.E., Colditz, G., Ascherio, A., Rosner, B., Spiegelman, D. & Willett, W.C. (2001): The effect of fruit and vegetable intake on risk for coronary heart disease. Anln Int. Med., 134, 1106–1114.
Willett W.C. , 'The effect of fruit and vegetable intake on risk for coronary heart disease ' (2001 ) 134 Anln Int. Med. : 1106 -1114.
Katan, M.B. (2009): Nitrate in foods: Harmful or healthy? Am. J. Clin. Nutr., 90, 11–12.
Katan M.B. , 'Nitrate in foods: Harmful or healthy? ' (2009 ) 90 Am. J. Clin. Nutr. : 11 -12.
Knobelock, L., Salna, B., Hogan, A., Postle, J. & Anderson, H. (2000): Blue babies and nitrate-contaminated well water. Environ. Health Perspect., 108, 675–678.
Anderson H. , 'Blue babies and nitrate-contaminated well water ' (2000 ) 108 Environ. Health Perspect. : 675 -678.
Larsen, F.J., Weitzberger, E., Lundberg, J.O. & Ekblom, B. (2007): Effects of dietary nitrate on oxygen cost during exercise. Acta Physiol. (Oxf), 191, 59–66.
Ekblom B. , 'Effects of dietary nitrate on oxygen cost during exercise ' (2007 ) 191 Acta Physiol. (Oxf) : 59 -66.
L’Hirondel, J.L. (2001): Nitrate and man. Toxic, harmless or beneficial? CABI Publishing, Wallingford, United Kingdom, pp. 56–70.
L’Hirondel J.L. , '', in Nitrate and man. Toxic, harmless or beneficial? , (2001 ) -.
Lundberg, J.O., Weitzberg, E., Lundberg, J.M. & Alving, K. (1994): Intragastric nitric oxide production in humans: Measurements in expelled air. Gut, 35, 1543–1546.
Alving K. , 'Intragastric nitric oxide production in humans: Measurements in expelled air ' (1994 ) 35 Gut : 1543 -1546.
Lundberg, J.O., Weitzberg, E., Cole, J.A. & Benjamin, N. (2004): Nitrate, bacteria and human health. Nat. Rev. Microbiol., 2, 593–602.
Benjamin N. , 'Nitrate, bacteria and human health ' (2004 ) 2 Nat. Rev. Microbiol. : 593 -602.
Lundberg, J.O., Weitzberg, E. & Gladwin, M.T. (2008): The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat. Rev. Drug Discov., 7, 156–167.
Gladwin M.T. , 'The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics ' (2008 ) 7 Nat. Rev. Drug Discov. : 156 -167.
Magee, P.N. & Barnes, J.M. (1954): Some toxic properties of dimethylnitrosamine. Br. J. Ind. Med., 11, 167–174.
Barnes J.M. , 'Some toxic properties of dimethylnitrosamine ' (1954 ) 11 Br. J. Ind. Med. : 167 -174.
Malmauret, L., Parent-Massin, D., Hardy, J.L. & Verger, P. (2002): Contaminants in organic and conventional foodstuffs in France. Fd Addit. Contam., 19, 524–532.
Verger P. , 'Contaminants in organic and conventional foodstuffs in France ' (2002 ) 19 Fd Addit. Contam. : 524 -532.
Martin, S. & Restani, P. (2003): Determination of nitrates by a novel ion chromatographic method: Occurrence in leafy vegetables (organic and conventional) and exposure assessment for Italian consumers. Fd Addit. Contam., 20, 787–792.
Restani P. , 'Determination of nitrates by a novel ion chromatographic method: Occurrence in leafy vegetables (organic and conventional) and exposure assessment for Italian consumers ' (2003 ) 20 Fd Addit. Contam. : 787 -792.
Mayne, S.T., Risch, H.A., Dubrow, R., Chow, W.H., Gammon, M.D., Vaughan, T.L., Farrow, D.C., Schoenberg, J.B., Stanford, J.L., Ahsan, H., West, A.B., Rotterdam, H., Blot, W.J. & Fraumeni, J.F., Jr. (2001): Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol. Biomarkers Prev., 10, 1055–1062.
Fraumeni J.F. , 'Nutrient intake and risk of subtypes of esophageal and gastric cancer ' (2001 ) 10 Cancer Epidemiol. Biomarkers Prev. : 1055 -1062.
McKnight G., Smith, L.M., Drummond, R.S., Duncan, C.W., Goldem, M.N.H. & Benjamin, N. (1997): The chemical synthesis of nitric oxide in the stomach from dietary nitrate in man. Gut., 40, 211–214.
Benjamin N. , 'The chemical synthesis of nitric oxide in the stomach from dietary nitrate in man ' (1997 ) 40 Gut. : 211 -214.
McKnight, G.M., Duncan, C.W., Leifert, C. & Golden, M.H. (1999): Dietary nitrate in man: Friend or foe? Br. J. Nutr., 81, 349–358.
Golden M.H. , 'Dietary nitrate in man: Friend or foe? ' (1999 ) 81 Br. J. Nutr. : 349 -358.
Most, M.M. (2004): Estimated phytochemical content of the dietary approaches to stop hypertension (DASH) diet is higher than in the Control Study Diet. J. Am. Diet. Assoc., 104, 1725–1727.
Most M.M. , 'Estimated phytochemical content of the dietary approaches to stop hypertension (DASH) diet is higher than in the Control Study Diet ' (2004 ) 104 J. Am. Diet. Assoc. : 1725 -1727.
Mozolewski, W. & Smoczynski, S. (2004): Effect of culinary processes on the content of nitrates and nitrites in potatoes. Pak. J. Nutr., 3, 357–361.
Smoczynski S. , 'Effect of culinary processes on the content of nitrates and nitrites in potatoes ' (2004 ) 3 Pak. J. Nutr. : 357 -361.
Mueller, B.A., Newton, K., Holly, E.A. & Preson-Martin, S. (2001): Residential water source and the risk of childhood brain tumors. Environ. Health Perspect., 109, 551–556.
Preson-Martin S. , 'Residential water source and the risk of childhood brain tumors ' (2001 ) 109 Environ. Health Perspect. : 551 -556.
Müller, RL., Hagel, H.J., Grein, G., Ruppin, H. & Domsehke, W. (1984): Dynamik der endogenen bakteriellen Nitrit Bildung im Magen. I. Mittelung: Verlaufsbeobachtung am Menschen unter natürlichen Bedingungen. Zbl. Bakt. Hyg. I Abt. Orig. B, 179, 381–396.
Domsehke W. , 'Dynamik der endogenen bakteriellen Nitrit Bildung im Magen. I. Mittelung: Verlaufsbeobachtung am Menschen unter natürlichen Bedingungen ' (1984 ) 179 Zbl. Bakt. Hyg. I Abt. Orig. B : 381 -396.
Pate, J.S. (1980): Transport and partitioning of nitrogenous solutes. Annu. Rev. Pl. Physiol., 31, 313–340.
Pate J.S. , 'Transport and partitioning of nitrogenous solutes ' (1980 ) 31 Annu. Rev. Pl. Physiol. : 313 -340.
Pennington, J.A.T. (1998): Dietary exposure models for nitrates and nitrites. Fd Control., 9, 385–395.
Pennington J.A.T. , 'Dietary exposure models for nitrates and nitrites ' (1998 ) 9 Fd Control. : 385 -395.
Pe’Res-Llamas, F., Navarro, I., Mari’n, J.F., Madrid, J.A. & Zamora, S. (1996): Estudio comparativo sobre la calida nutritiva de alimentos procedentes de la agricultura ecologica y convencional. Alimentaria, 274, 39–44.
Zamora S. , 'Estudio comparativo sobre la calida nutritiva de alimentos procedentes de la agricultura ecologica y convencional ' (1996 ) 274 Alimentaria : 39 -44.
Powlson, D.S., Addiscott, T.M., Benjamin, N., Cassman, K.G. & de Kok, T.M. (2008): When does nitrate become a risk for humans? J. Environ. Qual., 37, 291–295.
Kok T.M. , 'When does nitrate become a risk for humans? ' (2008 ) 37 J. Environ. Qual. : 291 -295.
Ralt, D. (2009): Does NO metabolism play a role in the effects of vegetables in health? Nitric oxide formation via the reduction of nitrites and nitrates. Med. Hypotheses, 73, 794–796.
Ralt D. , 'Does NO metabolism play a role in the effects of vegetables in health? Nitric oxide formation via the reduction of nitrites and nitrates ' (2009 ) 73 Med. Hypotheses : 794 -796.
Ruddell, W.S., Bone, E.S., Hill, M.J., Blendis, L.M. & Walters, C.L. (1976): Gastric-juice nitrite. A risk factor for cancer in the hypochlorhydric stomach? The Lancet, 2, 1037–1039.
Walters C.L. , 'Gastric-juice nitrite. A risk factor for cancer in the hypochlorhydric stomach? ' (1976 ) 2 The Lancet : 1037 -1039.
Sacks, F.M., Svetkey, L.P., Vollmer, W.M., Appel, L.J., Bray, G.A., Harsha, D., Obarzanek, E., Conlin, P.R., Miller, E.R.3rd, Simons-Morton, D.G., Karanja, N., Lin, P.H. & Dash-Sodium Collaborative Research Group (2001): Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. N. Engl. J. Med., 344, 3–10.
Lin P.H. , 'Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet ' (2001 ) 344 N. Engl. J. Med. : 3 -10.
Santamaria, P. (2001): Ways of reducing rocket salad nitrate content. Acta Hortic., 548, 529–537.
Santamaria P. , 'Ways of reducing rocket salad nitrate content ' (2001 ) 548 Acta Hortic. : 529 -537.
Santamaria, P. (2006): Nitrate in vegetables: Toxicity, content, intake and EC regulation. J. Sci. Fd Agric., 86, 10–17.
Santamaria P. , 'Nitrate in vegetables: Toxicity, content, intake and EC regulation ' (2006 ) 86 J. Sci. Fd Agric. : 10 -17.
Santamaria, P., Elia, A., Serio, F. & Todaro, E. (1999): A survey of nitrate and oxalate content in retail fresh vegetables. J. Sci. Fd Agric., 79, 1882–1888.
Todaro E. , 'A survey of nitrate and oxalate content in retail fresh vegetables ' (1999 ) 79 J. Sci. Fd Agric. : 1882 -1888.
Schuster, B.E. & Lee, K. (1987): Nitrate and nitrite methods of analysis and levels in raw carrots, processed carrots and in selected vegetables and grain products. J. Fd Sci., 52, 1632–1636.
Lee K. , 'Nitrate and nitrite methods of analysis and levels in raw carrots, processed carrots and in selected vegetables and grain products ' (1987 ) 52 J. Fd Sci. : 1632 -1636.
Sobko, T., Marcus, C., Govoni, M. & Kamiya, S. (2010): Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers. Nitric Oxide, 22, 136–140.
Kamiya S. , 'Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers ' (2010 ) 22 Nitric Oxide : 136 -140.
Speijers, G.J.A. (1996): Nitrate, -in: Toxicological evaluation of certain food additives and contaminants in food. Ed. World Health Organization, Geneva, Fd Additives Series, 35, 325–360.
Speijers G.J.A. , '', in Toxicological evaluation of certain food additives and contaminants in food , (1996 ) -.
Speijers, G.J.A. & Van den Brandt, P.A. (2003): Nitrate (and potential endogenous formation of N-nitroso compounds). [Online]. WHO Fd Additives Series 50. [cited 2011 Mar 20]. Available from: http://www.inchem.org/documents/jecfa/jecmono/v50je06.htm
Spiegelhalder, B., Eisenbrand, G. & Preussmann, R. (1976): Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds. Fd Cosmet. Toxicol., 14, 545–548.
Preussmann R. , 'Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds ' (1976 ) 14 Fd Cosmet. Toxicol. : 545 -548.
Stephany, R.W. & Schuller, P.L. (1978): The intake of nitrate, nitrite and volatile N-nitrosamines and the occurrence of volatile N-nitrosamines in human urine and veal calves. IARC Sci. Publ., 19, 443–460.
Schuller P.L. , 'The intake of nitrate, nitrite and volatile N-nitrosamines and the occurrence of volatile N-nitrosamines in human urine and veal calves ' (1978 ) 19 IARC Sci. Publ. : 443 -460.
Stephany, R.W. & Schuller, P.L. (1980): Daily dietary intakes of nitrate, nitrite and volatile N-nitrosamines in the Netherlands using the duplicate portion sampling technique. Oncology, 37, 203–210.
Schuller P.L. , 'Daily dietary intakes of nitrate, nitrite and volatile N-nitrosamines in the Netherlands using the duplicate portion sampling technique ' (1980 ) 37 Oncology : 203 -210.
Tamme, T., Reinik, M., Roasto, M., Juhkam, K., Tenno, T. & Kiis, A. (2006): Nitrates and nitrites in vegetables and vegetable-based products and their intakes by the Estonian population. Fd Addit. Contam., 23, 355–361.
Kiis A. , 'Nitrates and nitrites in vegetables and vegetable-based products and their intakes by the Estonian population ' (2006 ) 23 Fd Addit. Contam. : 355 -361.
Tannenbaum, S.R., Weisman, M. & Fett, D. (1976): The effect of nitrate intake on nitrite formation in human saliva. Fd Cosmet. Toxicol., 14, 549–552.
Fett D. , 'The effect of nitrate intake on nitrite formation in human saliva ' (1976 ) 14 Fd Cosmet. Toxicol. : 549 -552.
Thomson, B.M., Nokes, C.J. & Cressey, P.J. (2007): Intake and risk assessment of nitrate and nitrite from New Zealand foods and drinking water. Fd Addit. Contam., 24, 113–121.
Cressey P.J. , 'Intake and risk assessment of nitrate and nitrite from New Zealand foods and drinking water ' (2007 ) 24 Fd Addit. Contam. : 113 -121.
Toselli, M., Flore, J.A., Marangoni, B. & Masia, A. (1999): Effects of root-zone temperature on nitrogen accumulation by nonbearing apple trees. J. Hortic. Sci. Biotechnol., 74, 118–124.
Masia A. , 'Effects of root-zone temperature on nitrogen accumulation by nonbearing apple trees ' (1999 ) 74 J. Hortic. Sci. Biotechnol. : 118 -124.
Tsezou, A., Kitsiou-Tzeli, S., Galla, A., Gourgiotis, D., Mitrou, S., Molybdas, P. & Sinaniotis, C. (1996): High nitrate content in drinking water: Cytogenetic effects in exposed children. Arch. Environ. Health, 51, 458–461.
Sinaniotis C. , 'High nitrate content in drinking water: Cytogenetic effects in exposed children ' (1996 ) 51 Arch. Environ. Health : 458 -461.
Tsuji, K.M.S., Morita, Y., Shibata, T., Kaneta, N., Wakabayashi, K., Uchibori-Hase, S., Ide, S., Fujiwara, K., Suzuki, H. & Ito, Y. (1993): Naturally occurring of nitrite and nitrate existing in various raw and processed foods. J. Fd Hyg. Soc. Jpn., 34, 294–302.
Ito Y. , 'Naturally occurring of nitrite and nitrate existing in various raw and processed foods ' (1993 ) 34 J. Fd Hyg. Soc. Jpn. : 294 -302.
Vittozzi, L. (1992): Toxicology of nitrates and nitrites. Fd Addit. Contam., 9, 579–585.
Vittozzi L. , 'Toxicology of nitrates and nitrites ' (1992 ) 9 Fd Addit. Contam. : 579 -585.
Walker, R. (1990): Nitrates, nitrites and N-nitrosocompounds: A review of the occurrence in food and diet and the toxicological implications. Fd Addit. Contam., 7, 717–768.
Walker R. , 'Nitrates, nitrites and N-nitrosocompounds: A review of the occurrence in food and diet and the toxicological implications ' (1990 ) 7 Fd Addit. Contam. : 717 -768.
Webb, A.J., Patel, N., Loukogeorgakis, S., Okorie, M., Aboud, Z., Misra, S., Rashid, R., Miall, P., Deanfield, J., Benjamin, N., MacAllister, R., Hobbs, A.J. & Ahluwalia, A. (2008): Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension, 51, 784–790.
Ahluwalia A. , 'Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite ' (2008 ) 51 Hypertension : 784 -790.
Weightman, R.M., Dyer, C., Buxton, J. & Farrington, D.S. (2006): Effects of light level, time of harvest and position within field on the variability of tissue nitrate concentration in commercial crops of lettuce (Lactuca sativa) and endive (Cichorium endiva). Fd Addit. Contam., 23, 462–469.
Farrington D.S. , 'Effects of light level, time of harvest and position within field on the variability of tissue nitrate concentration in commercial crops of lettuce (Lactuca sativa) and endive (Cichorium endiva) ' (2006 ) 23 Fd Addit. Contam. : 462 -469.
Weyer, P.J., Cerhan, J.R., Kross, B.C., Hallberg, G.R., Kantamneni, J., Breuer, G., Jones, M.P., Zheng, W. & Lynch, C.F. (2001): Municipal drinking water nitrate level and cancer risk in older women: The Iowa women’s health study. Epidemiology, 11, 327–338.
Lynch C.F. , 'Municipal drinking water nitrate level and cancer risk in older women: The Iowa women’s health study ' (2001 ) 11 Epidemiology : 327 -338.
WHO (1995): Evaluation of certain food additives and contaminants. 44th report of the Joint FAO/WHO Expert Committee on Food Additives. Technical Report Series No. 859, Geneva, 29–35.
WHO (2005): Dietary intake of fruit and vegetables and risk of diabetes, mellitus and cardiovascular diseases. Prepared by Bazano, L.C. Background paper for the Joint FAO/WHO workshop on fruit and vegetables for health 1–3 September 2004. Kolbe Japan. [cited 2011 Mar 20]. Available from: http://www.who.int/dietphysicalactivity/publications/f&v_cvd_diabetes.pdf
Woese, K., Lange, D., Boess, C. & Bögl, K.W. (1997): A comparison of organically and conventionally grown foods: Results of a review of the relevant literature. J. Sci. Fd Agric., 74, 281–293.
Bögl K.W. , 'A comparison of organically and conventionally grown foods: Results of a review of the relevant literature ' (1997 ) 74 J. Sci. Fd Agric. : 281 -293.
Ying, L. & Hofseth, L.J. (2007): An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer. Cancer Res., 67, 1407–1410.
Hofseth L.J. , 'An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer ' (2007 ) 67 Cancer Res. : 1407 -1410.
Yordanov, N.D., Novakova, E. & Lubenova, S. (2001): Consecutive estimation of nitrate and nitrite ions in vegetables and fruits by electron paramagnetic resonance spectrometry. Anal. Chim. Acta, 437, 131–138.
Lubenova S. , 'Consecutive estimation of nitrate and nitrite ions in vegetables and fruits by electron paramagnetic resonance spectrometry ' (2001 ) 437 Anal. Chim. Acta : 131 -138.
Yu, C.Y., Du, S.T., Xing, C.H., Lin, X.Y. & Zhang, Y.S. (2006): Effects of CO, concentration on the growth and nutrient uptake of tomato seedlings. J. Zhejiang University (Agriculture & Life Sciences), 32, 307–312.
Zhang Y.S. , 'Effects of CO, concentration on the growth and nutrient uptake of tomato seedlings ' (2006 ) 32 J. Zhejiang University (Agriculture & Life Sciences) : 307 -312.
Zhong, W., Hu, C. & Wang, M. (2002): Nitrate and nitrite in vegetables from north China: content and intake. Fd Addit. Contam., 19, 1125–1129.
Wang M. , 'Nitrate and nitrite in vegetables from north China: content and intake ' (2002 ) 19 Fd Addit. Contam. : 1125 -1129.