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  • 1 Universiti Sains Malaysia School of Industrial Technology 11800 Penang Malaysia
  • | 2 Universiti Sains Malaysia School of Pharmaceutical Sciences 11800 Penang Malaysia
  • | 3 Universiti Sains Malaysia Doping Control Centre 11800 Penang Malaysia
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Lactobacilli and bifidobacteria are most commonly encountered in the dairy industries, either existing naturally in milk or inoculated as starters in fermented dairy products. Recent research suggests that fermented dairy products are a cocktail of bioactive ingredients. The objective of our study was to evaluate the bioactivity of cell wall fractions of Lactobacillus and Bifidobacterium grown in reconstituted skimmed milk, and the possibility of intra- and extracellular extracts of these bacteria for applications in foods and beyond. Intracellular and extracellular extracts of Lactobacillus and Bifidobacterium showed inhibitory activities against food and dermal pathogens. All strains were able to produce inhibitors, such as organic acids, antimicrobial peptides, diacetyl, and hydrogen peroxide. Most strains showed higher production of extracellular than intracellular inhibitors (P<0.05). Meanwhile, all strains were able to produce hyaluronic acid, lipoteichoic acid, peptidoglycan, neutral sphingomyelinase and acid sphingomyelinase at concentrations applicable for cosmeceutical application. Findings from our study demonstrated that inhibitors and bioactives from lactobacilli and bifidobacteria have the potential to be developed into formulations for food and non-food applications.

  • Barre, O., Mourlane, F. & Solioz, M. (2007): Copper induction of lactate oxidase on Lactococcus lactis: a novel metal stress response. J. Bacteriol., 189, 5947–5954.

    Solioz M. , 'Copper induction of lactate oxidase on Lactococcus lactis: a novel metal stress response ' (2007 ) 189 J. Bacteriol : 5947 -5954.

    • Search Google Scholar
  • Berardesca, E., Distante, F., Vigonoli, G.P. & Oresajo, C. (1997): Alpha hydroxyl acids modulate stratum corneum barrier function. Br. J. Dermatol., 137, 934–938.

    Oresajo C. , 'Alpha hydroxyl acids modulate stratum corneum barrier function ' (1997 ) 137 Br. J. Dermatol : 934 -938.

    • Search Google Scholar
  • Brown, M.B. & Jones, S.A. (2005): Hyaluronic acid: a unique topical vehicle for the localized delivery of drug to the skin. J. Eur. Acad. Dermatol. Venereol., 19, 308–321.

    Jones S.A. , 'Hyaluronic acid: a unique topical vehicle for the localized delivery of drug to the skin ' (2005 ) 19 J. Eur. Acad. Dermatol. Venereol : 308 -321.

    • Search Google Scholar
  • Debabov, D.V., Micheal, Y. & Neuhaus, F.C. (2000): Biosynthesis of lipoteichoic acid in Lactobacillus rhamnosus: role of DltD in D-alanylation. J. Bacteriol., 182, 2855–2864.

    Neuhaus F.C. , 'Biosynthesis of lipoteichoic acid in Lactobacillus rhamnosus: role of DltD in D-alanylation ' (2000 ) 182 J. Bacteriol : 2855 -2864.

    • Search Google Scholar
  • di Marzio, L., Russo, F.P. & Amicosante, G. (2001): Apoptotic effects of selected strains of lactic acid bacteria on a human T leukemia cell line are associated with bacterial arginine deiminase and/or sphingomyelinase activities. Nutr. Cancer, 40, 185–196.

    Amicosante G. , 'Apoptotic effects of selected strains of lactic acid bacteria on a human T leukemia cell line are associated with bacterial arginine deiminase and/or sphingomyelinase activities ' (2001 ) 40 Nutr. Cancer : 185 -196.

    • Search Google Scholar
  • FAO/WHO (2006): Evaluation of health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria: Report of a Joint FAO/WHO Expert Consultation (Online). (Accessed 10 July 2012). Available at: http://www.who.int/foodsafety/publications/fs_management/en/probiotics.pdf

    '', in Evaluation of health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria: Report of a Joint FAO/WHO Expert Consultation (Online). (Accessed 10 July 2012) , (2006 ) -.

  • Frehel, C. & Ryter, A. (1979): Peptidoglycan turnover during growth of a Bacillus megaterium Dap-Lys-mutant. J. Bacteriol., 137, 947–955.

    Ryter A. , 'Peptidoglycan turnover during growth of a Bacillus megaterium Dap-Lys-mutant ' (1979 ) 137 J. Bacteriol : 947 -955.

    • Search Google Scholar
  • Juarez, T.M. & Elena, N.M. (2004): Production of antimicrobial substance in lactic acid bacteria I: determination of hydrogen peroxide. Methods Mol. Biol., 268, 337–346.

    Elena N.M. , 'Production of antimicrobial substance in lactic acid bacteria I: determination of hydrogen peroxide ' (2004 ) 268 Methods Mol. Biol : 337 -346.

    • Search Google Scholar
  • Neuman, M.G., Oruna, L., Coto, G. & Vincent, M. (2010): Hyaluronic acid signals for repair in ethanol-induced apoptosis in skin cells in vitro. Clin. Biochem., 43, 822–826.

    Vincent M. , 'Hyaluronic acid signals for repair in ethanol-induced apoptosis in skin cells in vitro ' (2010 ) 43 Clin. Biochem : 822 -826.

    • Search Google Scholar
  • Oh, S., Kim, S.H., Ko, Y. & Lee, S.H. (2006): Effect of bacteriocin produced by Lactococcus sp. HY 449 on skininflammatory bacteria. Fd Chem. Toxicol., 44, 1184–1190.

    Lee S.H. , 'Effect of bacteriocin produced by Lactococcus sp. HY 449 on skininflammatory bacteria ' (2006 ) 44 Fd Chem. Toxicol : 1184 -1190.

    • Search Google Scholar
  • Omidbakhsh, N.O. (2011):Hydrogen peroxide-based skin disinfectant. US Patent Application. Publication US 2011/0129435 A1.

    Omidbakhsh N.O. , '', in Hydrogen peroxide-based skin disinfectant , (2011 ) -.

  • Pokusaeva, K., Fitzgerald, G.F. & van Sinderen, D. (2011): Carbohydrate metabolism in bifidobacteria. Genes Nutr., 6, 285–306.

    Sinderen D. , 'Carbohydrate metabolism in bifidobacteria ' (2011 ) 6 Genes Nutr : 285 -306.

  • Pollack, J.H., Ntamere, A.S. & Neuhaus, F.C. (1992): D-alanyl-lipoteichoic acid in Lactobacillus casei: secretion of vesicles in response to benzyl penicillin. J. Gen. Microbiol., 138, 849–859.

    Neuhaus F.C. , 'D-alanyl-lipoteichoic acid in Lactobacillus casei: secretion of vesicles in response to benzyl penicillin ' (1992 ) 138 J. Gen. Microbiol : 849 -859.

    • Search Google Scholar
  • Quintas, N.G., Blancato, V., Repizo, G. & Magni, C. (2008): Citrate metabolism and aroma compound production in lactic acid bacteria. -in: Mayo, B., López, P. & Pérez-Martinez, G. (Eds): Molecular aspects of lactic acid bacetria for traditional and new applications. Research Signpost India, pp. 65–88.

    Magni C. , '', in Molecular aspects of lactic acid bacetria for traditional and new applications , (2008 ) -.

  • Ruiz-Gonzalez, V., Cancino-Diaz, C.J., Rodeiguez-Martinez, S.R. & Cancino-Diaz, E.C. (2009): Keratinocytes treated with peptidoglycan from Staphylococcus aureus produce vascular endothelial growth factor, and its expression is amplified by the subsequent production of interleukin-13. Int. J. Dermatol., 48, 846–854.

    Cancino-Diaz E.C. , 'Keratinocytes treated with peptidoglycan from Staphylococcus aureus produce vascular endothelial growth factor, and its expression is amplified by the subsequent production of interleukin-13 ' (2009 ) 48 Int. J. Dermatol : 846 -854.

    • Search Google Scholar
  • Sloss, J.M., Cumberland, N. & Milner, S.M. (1993): Acetic acid used for the elimination ofPseudomonas aeruginosa from burn and soft tissue wounds. J. R. Army Med. Corps, 139, 49–51.

    Milner S.M. , 'Acetic acid used for the elimination ofPseudomonas aeruginosa from burn and soft tissue wounds ' (1993 ) 139 J. R. Army Med. Corps : 49 -51.

    • Search Google Scholar
  • Stanley, J., Laulederkind, F., Bielawska, A. & Raghow, R. (1995): Ceramide induces interleukin 6 gene expression in human fibroblasts. J. Exp. Med., 182, 599–560.

    Raghow R. , 'Ceramide induces interleukin 6 gene expression in human fibroblasts ' (1995 ) 182 J. Exp. Med : 599 -560.

    • Search Google Scholar
  • Survila, A., Kanapeckaite, S., Pileckiene, J. & Budiene, J. (2011): Kinetics of hydrogen evolution on copper electrode involving organic acids as proton donors. Int. J. Electrochem., 2011, 1–9.

    Budiene J. , 'Kinetics of hydrogen evolution on copper electrode involving organic acids as proton donors ' (2011 ) 2011 Int. J. Electrochem : 1 -9.

    • Search Google Scholar
  • Tan, C.L., Ning, S.P. & Boey, P.L. (2011): Detection of bioactive compound from Spilantesacmella (L.) plants and its various in vitro culture products. J. Med., Plant Res., 5, 371–378.

    Boey P.L. , 'Detection of bioactive compound from Spilantesacmella (L.) plants and its various in vitro culture products ' (2011 ) 5 J. Med., Plant Res : 371 -378.

    • Search Google Scholar
  • Tanner, R.S. & James, S.A. (1992): Rapid bactericidal effect of low pH against Pseudomonas aeruginosa. J. Ind. Microbiol. Biotechnol., 10, 229–232.

    James S.A. , 'Rapid bactericidal effect of low pH against Pseudomonas aeruginosa ' (1992 ) 10 J. Ind. Microbiol. Biotechnol : 229 -232.

    • Search Google Scholar
  • Tseng, C.P., Tsau, J.L. & Montville, T.J. (1991): Bioenergetic consequences of catabolic shifts by Lactobacillus plantarumin response to shift in environmental oxygen and pH in chemostat culture. J. Bacteriol., 173, 4411–4416.

    Montville T.J. , 'Bioenergetic consequences of catabolic shifts by Lactobacillus plantarumin response to shift in environmental oxygen and pH in chemostat culture ' (1991 ) 173 J. Bacteriol : 4411 -4416.

    • Search Google Scholar
  • van de Rijn, I. (1983): Streptococcal hyaluronic acid: proposed mechanisms of degradation and loss of synthesis during stationary phase. J. Bacteriol., 156, 1059–1065.

    Rijn I. , 'Streptococcal hyaluronic acid: proposed mechanisms of degradation and loss of synthesis during stationary phase ' (1983 ) 156 J. Bacteriol : 1059 -1065.

    • Search Google Scholar
  • Williams-Champbell, A.M. (1998):Studies on the mode of action of diacetyl and carbon dioxide as inhibitors of meat spoilage bacteria. (Accessed on 18 June 2012). http://digitalcommons.wayne.edu/dissertations/AA19827248

    Williams-Champbell A.M. , '', in Studies on the mode of action of diacetyl and carbon dioxide as inhibitors of meat spoilage bacteria , (1998 ) -.

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