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  • 1 Food Toxicological National Reference Laboratory National Food Chain Safety Office, Food and Feed Safety Directorate 1095 Budapest Mester utca 81 Hungary
  • | 2 Budapest University of Technology and Economics Department of Inorganic and Analytical Chemistry, Faculty of Chemical and Biotechnology 1111 Budapest Szt. Gellert tér 4 Hungary
  • | 3 Texas A&M University Department of Environmental and Occupational Health, School of Rural Public Health 1266 TAMU College Station TXT 77843-1266 USA
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A new liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed to confirm chloramphenicol (CAP) residues in foods of animal origin and in urine samples, which were earlier found positive under the screening analysis, performed by competitive enzyme-linked immunoassay (ELISA) technique. The developed LC-MS/MS method was applied to four non-compliant samples from 2008 to 2012; giving concentrations of CAP residues from 1.18 to 3.68 μg kg−1. All samples, qualified positive by ELISA, were confirmed with the LC-MS/MS technique and found to be non-compliant. The effectiveness of the confirmatory method was proven by participating in a successful proficiency test in year 2010. Both LC-MS/MS and ELISA methods were validated according to the European Union 2002/657/EC decision. The decision limit of the confirmatory method was determined as 0.02 μg kg−1 for CAP in each validated matrix, while the detection capability of the screening test was 0.15 μg kg−1.

  • Allen, E.H. (1985): Review of chromatographic methods for chloramphenicol residues in milk, eggs, and tissues from foodproducing animals. J. Assoc. Anal. Chem., 68, 990–999.

    Allen E.H. , 'Review of chromatographic methods for chloramphenicol residues in milk, eggs, and tissues from foodproducing animals ' (1985 ) 68 J. Assoc. Anal. Chem. : 990 -999.

    • Search Google Scholar
  • Aresta, A., Bianchi, D., Calvano, C.D. & Zambonin, C.G. (2010): Solid phase microextraction-liquid chromatography (SPME-LC) determination of chloramphenicol in urine and environmental water samples. J. Pharm. Biomed. Anal., 53, 440–444.

    Zambonin C.G. , 'Solid phase microextraction-liquid chromatography (SPME-LC) determination of chloramphenicol in urine and environmental water samples ' (2010 ) 53 J. Pharm. Biomed. Anal. : 440 -444.

    • Search Google Scholar
  • Barganska, Z., Slebioda, M. & Namiesnik, J. (2011): Determination of antibiotic residues in honey. TrAC-Trend Anal. Chem., 30, 1035–1041.

    Namiesnik J. , 'Determination of antibiotic residues in honey ' (2011 ) 30 TrAC-Trend Anal. Chem. : 1035 -1041.

    • Search Google Scholar
  • Berendsen, B.J.A., Essers, M.L., Stolker, A.A.M. & Nielen, M.W.F. (2011): Quantitative trace analysis of eight chloramphenicol isomers in urine by chiral liquid chromatography coupled to tandem mass spectrometry. J. Chromatogr. A., 1218, 7331–7340.

    Nielen M.W.F. , 'Quantitative trace analysis of eight chloramphenicol isomers in urine by chiral liquid chromatography coupled to tandem mass spectrometry ' (2011 ) 1218 J. Chromatogr. A : 7331 -7340.

    • Search Google Scholar
  • Berendsen, B.J.A., Stolker, A.A.M. & Nielen, M.W.F. (2013): Selectivity in the sample preparation for the analysis of drug residues in products of animal origin using LC-MS. TrAC-Trend Anal. Chem, 43, 229–239.

    Nielen M.W.F. , 'Selectivity in the sample preparation for the analysis of drug residues in products of animal origin using LC-MS ' (2013 ) 43 TrAC-Trend Anal. Chem : 229 -239.

    • Search Google Scholar
  • Bogusz, M.J., Hassan, H., Al-Enazi, E., Ibrahim, Z. & Al-Tufail, M. (2004): Rapid determination of chloramphenicol and its glucuronide in food products by liquid chromatography-electrospray negative ionization tandem mass spectrometry. J. Chromatogr. B, 807, 343–356.

    Al-Tufail M. , 'Rapid determination of chloramphenicol and its glucuronide in food products by liquid chromatography-electrospray negative ionization tandem mass spectrometry ' (2004 ) 807 J. Chromatogr. B : 343 -356.

    • Search Google Scholar
  • Bononi, M. & Tateo, F. (2008): Liquid chromatography/tandem mass spectrometry analysis of chloramphenicol in propolis extracts available on the Italian market. J. Fd Compos. Anal., 21, 84–89.

    Tateo F. , 'Liquid chromatography/tandem mass spectrometry analysis of chloramphenicol in propolis extracts available on the Italian market ' (2008 ) 21 J. Fd Compos. Anal. : 84 -89.

    • Search Google Scholar
  • Chen, X.B., Wu, Y.L. & Yang, T. (2011): Simultaneous determination of clenbuterol, chloramphenicol and diethylstilbestrol in bovine milk by isotope dilution ultraperformance liquid chromatography-tandem mass spectrometry. J. Chromatogr. B., 879, 799–803.

    Yang T. , 'Simultaneous determination of clenbuterol, chloramphenicol and diethylstilbestrol in bovine milk by isotope dilution ultraperformance liquid chromatography-tandem mass spectrometry ' (2011 ) 879 J. Chromatogr. B. : 799 -803.

    • Search Google Scholar
  • EC (2002): Commission Decision 2002/657/EC., Off. J. EU Comm., L221/8.

    '', in Off. J. EU Comm. , (2002 ) -.

  • EC (2003): Commission Decision 2003/181/EC., Off. J. EU Comm., L71/17.

    '', in Off. J. EU Comm. , (2003 ) -.

  • CRLs (2010): Guidelines for the validation of screening methods for residues of veterinary medicines (Initial validation and transfer). Community Reference Laboratories 20/1/2010. http://ec.europa.eu/food/food/chemicalsafety/residues/Guideline_Validation_Screening_en.pdf

    '', in Guidelines for the validation of screening methods for residues of veterinary medicines (Initial validation and transfer) , (2010 ) -.

  • Fernandez-Torres, R., Bello Lopez, M.A., Olias Consentino, M., Callejon Mochon, M. & Ramos Payan, M. (2011): Enzymatic-microwave assisted extraction and high-performance liquid chromatography-mass spectrometry for the determination of selected veterinary antibiotics in fish and mussel samples. J. Pharm. Biomed. Anal., 54, 1146–1156.

    Ramos Payan M. , 'Enzymatic-microwave assisted extraction and high-performance liquid chromatography-mass spectrometry for the determination of selected veterinary antibiotics in fish and mussel samples ' (2011 ) 54 J. Pharm. Biomed. Anal. : 1146 -1156.

    • Search Google Scholar
  • Impens, S., Reybroeck, W., Vercammen, J., Courtheyn, D., Ooghe, S., Wasch, K.D., Smedts, W. & De Brabander, H. (2003): Screening and confirmation of chloramphenicol in shrimp tissue using ELISA in combination with GC-MS2 and LC-MS2. Anal. Chim. Acta, 483, 153–163.

    Brabander H. , 'Screening and confirmation of chloramphenicol in shrimp tissue using ELISA in combination with GC-MS2 and LC-MS2 ' (2003 ) 483 Anal. Chim. Acta : 153 -163.

    • Search Google Scholar
  • Kolosova, A.Y., Samsonova, J.V. & Egorov, A.M. (2000): Competitive ELISA of chloramphenicol: Influence of immunoreagent structure and application of the method for the inspection of food of animal origin. Fd Agric. Immun., 12, 115–125.

    Egorov A.M. , 'Competitive ELISA of chloramphenicol: Influence of immunoreagent structure and application of the method for the inspection of food of animal origin ' (2000 ) 12 Fd Agric. Immun. : 115 -125.

    • Search Google Scholar
  • Lopez, M.I., Pettis, J.S., Smith, I.B. & Chu, P.S. (2008): Multiclass determination and confirmation of antibiotic residues in honey using LC-MS/MS. J. Agric. Fd Chem., 56, 1553–1559.

    Chu P.S. , 'Multiclass determination and confirmation of antibiotic residues in honey using LC-MS/MS ' (2008 ) 56 J. Agric. Fd Chem. : 1553 -1559.

    • Search Google Scholar
  • Park, I.S., Kim, D.K. & Kim, N. (2004): Responses of chloramphenicol immunosensor to analyte types. J. Microbiol. Biotech., 14, 1157–1162.

    Kim N. , 'Responses of chloramphenicol immunosensor to analyte types ' (2004 ) 14 J. Microbiol. Biotech. : 1157 -1162.

    • Search Google Scholar
  • Park, I.S. & Kim, N. (2006): Development of a chemiluminescent immunosensor for chloramphenicol. Anal. Chim. Acta, 578, 19–24.

    Kim N. , 'Development of a chemiluminescent immunosensor for chloramphenicol ' (2006 ) 578 Anal. Chim. Acta : 19 -24.

    • Search Google Scholar
  • Rejtharová, M. & Rejthar, L. (2009): Determination of chloramphenicol in urine, feed water, milk and honey samples using molecular imprinted polymer clean-up. J. Chromatogr. A, 1216, 8246–8253.

    Rejthar L. , 'Determination of chloramphenicol in urine, feed water, milk and honey samples using molecular imprinted polymer clean-up ' (2009 ) 1216 J. Chromatogr. A : 8246 -8253.

    • Search Google Scholar
  • Shen, H.Y. & Jiang, H.L. (2005): Screening determination and confirmation of chloramphenicol in seafood, meat and honey using ELISA, HPLC-UVD, GC-ECD, GC-MS-EI-SIM and GCMS-NCI-SIM methods. Anal. Chim. Acta, 535, 33–41.

    Jiang H.L. , 'Screening determination and confirmation of chloramphenicol in seafood, meat and honey using ELISA, HPLC-UVD, GC-ECD, GC-MS-EI-SIM and GCMS-NCI-SIM methods ' (2005 ) 535 Anal. Chim. Acta : 33 -41.

    • Search Google Scholar
  • Shen, J., Zhang, Z., Yao, Y., Shi, W., Liu, Y. & Zhang, S. (2006): A monoclonal antibody-based time-resolved fluoroimmunoassay for chloramphenicol in shrimp and chicken muscle. Anal. Chim. Acta, 575, 262–266.

    Zhang S. , 'A monoclonal antibody-based time-resolved fluoroimmunoassay for chloramphenicol in shrimp and chicken muscle ' (2006 ) 575 Anal. Chim. Acta : 262 -266.

    • Search Google Scholar
  • Siqueira, S.R.R., Donato, J.L., Nucci, G. & Reyes, F.G.R. (2009): A high-throughput method for determining chloramphenicol residues in poultry, egg, shrimp, fish, swine and bovine using LC-ESI-MS/MS. J. Sep. Sci., 32, 4012–4019.

    Reyes F.G.R. , 'A high-throughput method for determining chloramphenicol residues in poultry, egg, shrimp, fish, swine and bovine using LC-ESI-MS/MS ' (2009 ) 32 J. Sep. Sci. : 4012 -4019.

    • Search Google Scholar
  • Tian, H. (2011): Determination of chloramphenicol, enrofloxacin and 29 pesticides residues in bovine milk by liquid chromatography-tandem mass spectrometry. Chemosphere, 83, 349–355.

    Tian H. , 'Determination of chloramphenicol, enrofloxacin and 29 pesticides residues in bovine milk by liquid chromatography-tandem mass spectrometry ' (2011 ) 83 Chemosphere : 349 -355.

    • Search Google Scholar
  • Tölgyesi, Á., Fekete, J., Fekete, S., Sharma, V.K., Békési, K. & Tóth, E. (2012a): Analysis of sub μg/kg lincomycin in honey, muscle, milk, and eggs using fast liquid chromatography-tandem mass spectrometry. J. Chromatogr. Sci., 50, 190–198.

    Tóth E. , 'Analysis of sub μg/kg lincomycin in honey, muscle, milk, and eggs using fast liquid chromatography-tandem mass spectrometry ' (2012 ) 50 J. Chromatogr. Sci. : 190 -198.

    • Search Google Scholar
  • Tölgyesi, Á., Sharma, V.K., Fekete, S., Fekete, J., Simon, A. & Farkas, S. (2012b): Development of a rapid method for the determination and confirmation of nitroimidazoles in six matrices by fast liquid chromatographytandem mass spectrometry. J. Pharm. Biomed. Anal., 64–65, 40–48.

    Farkas S. , 'Development of a rapid method for the determination and confirmation of nitroimidazoles in six matrices by fast liquid chromatographytandem mass spectrometry ' (2012 ) 64–65 J. Pharm. Biomed. Anal. : 40 -48.

    • Search Google Scholar
  • Uhlig, S., Gowik, P. & Radeck, W. (2003): Performance of a matrix-comprehensive in-house validation study by means of an especially designed software. Anal. Chim. Acta, 483, 351–362.

    Radeck W. , 'Performance of a matrix-comprehensive in-house validation study by means of an especially designed software ' (2003 ) 483 Anal. Chim. Acta : 351 -362.

    • Search Google Scholar
  • Yibar, A., Cetinkaya, F. & Soyutemiz G.E. (2011): ELISA screening and liquid chromatography-tandem mass spectrometry confirmation of chloramphenicol residues in chicken muscle, and the validation of a confirmatory method by liquid chromatography-tandem mass spectrometry. Poult. Sci., 90, 2619–2626.

    Soyutemiz G.E. , 'ELISA screening and liquid chromatography-tandem mass spectrometry confirmation of chloramphenicol residues in chicken muscle, and the validation of a confirmatory method by liquid chromatography-tandem mass spectrometry ' (2011 ) 90 Poult. Sci. : 2619 -2626.

    • Search Google Scholar

 

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Senior editors

Editor(s)-in-Chief: András Salgó

Co-ordinating Editor(s) Marianna Tóth-Markus

Co-editor(s): A. Halász

       Editorial Board

  • L. Abrankó (Szent István University, Gödöllő, Hungary)
  • D. Bánáti (University of Szeged, Szeged, Hungary)
  • J. Baranyi (Institute of Food Research, Norwich, UK)
  • I. Bata-Vidács (Agro-Environmental Research Institute, National Agricultural Research and Innovation Centre, Budapest, Hungary)
  • J. Beczner (Food Science Research Institute, National Agricultural Research and Innovation Centre, Budapest, Hungary)
  • Gy. Biró (National Institute for Food and Nutrition Science, Budapest, Hungary)
  • A. Blázovics (Semmelweis University, Budapest, Hungary)
  • F. Capozzi (University of Bologna, Bologna, Italy)
  • M. Carcea (Research Centre for Food and Nutrition, Council for Agricultural Research and Economics Rome, Italy)
  • Zs. Cserhalmi (Food Science Research Institute, National Agricultural Research and Innovation Centre, Budapest, Hungary)
  • M. Dalla Rosa (University of Bologna, Bologna, Italy)
  • I. Dalmadi (Szent István University, Budapest, Hungary)
  • K. Demnerova (University of Chemistry and Technology, Prague, Czech Republic)
  • Muying Du (Southwest University in Chongqing, Chongqing, China)
  • S. N. El (Ege University, Izmir, Turkey)
  • S. B. Engelsen (University of Copenhagen, Copenhagen, Denmark)
  • E. Gelencsér (Food Science Research Institute, National Agricultural Research and Innovation Centre, Budapest, Hungary)
  • V. M. Gómez-López (Universidad Católica San Antonio de Murcia, Murcia, Spain)
  • J. Hardi (University of Osijek, Osijek, Croatia)
  • N. Ilić (University of Novi Sad, Novi Sad, Serbia)
  • D. Knorr (Technische Universität Berlin, Berlin, Germany)
  • H. Köksel (Hacettepe University, Ankara, Turkey)
  • K. Liburdi (Tuscia University, Viterbo, Italy)
  • M. Lindhauer (Max Rubner Institute, Detmold, Germany)
  • M.-T. Liong (Universiti Sains Malaysia, Penang, Malaysia)
  • M. Manley (Stellenbosch University, Stellenbosch, South Africa)
  • M. Mézes (Szent István University, Gödöllő, Hungary)
  • Á. Németh (Budapest University of Technology and Economics, Budapest, Hungary)
  • Q. D. Nguyen (Szent István University, Budapest, Hungary)
  • L. Nyström (ETH Zürich, Switzerland)
  • V. Piironen (University of Helsinki, Finland)
  • A. Pino (University of Catania, Catania, Italy)
  • M. Rychtera (University of Chemistry and Technology, Prague, Czech Republic)
  • K. Scherf (Technical University, Munich, Germany)
  • R. Schönlechner (University of Natural Resources and Life Sciences, Vienna, Austria)
  • A. Sharma (Department of Atomic Energy, Delhi, India)
  • A. Szarka (Budapest University of Technology and Economics, Budapest, Hungary)
  • M. Szeitzné Szabó (National Food Chain Safety Office, Budapest, Hungary)
  • L. Varga (University of West Hungary, Mosonmagyaróvár, Hungary)
  • R. Venskutonis (Kaunas University of Technology, Kaunas, Lithuania)
  • B. Wróblewska (Institute of Animal Reproduction and Food Research, Polish Academy of Sciences Olsztyn, Poland)

 

Acta Alimentaria
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Acta Alimentaria
Language English
Size B5
Year of
Foundation
1972
Publication
Programme
2021 Volume 50
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per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia
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Address
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ISSN 0139-3006 (Print)
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