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  • 1 Medical University Prof. Dr. Paraskev Stoyanov Department of Preclinical and Clinical Pharmacology and Toxicology 9002 Varna 55 M. Drinov Str. Bulgaria
  • 2 Bulgarian Academy of Sciences Department of Behavior Neurobiology, Institute of Neurobiology 1113 Sofia 23 Acad. G. Bonchev str. Bulgaria
  • 3 SU “Sv. Kl.Ohridsky” Faculty of Pre-School and Primary School Education Sofia 69A Shipchenski prohod Bulgaria
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The main bioactive substances in Aronia melanocarpa fruit juice (AMFJ) are polyphenols (flavonoids, procyanidins, and phenolic acids). A great number of polyphenols are able to traverse the blood-brain barrier. In recent years more attention is drawn to the ability of these substances to influence central nervous system functions. The aim of the present study was to investigate the effects of AMFJ on exploratory behaviour and locomotor activity in male Wistar rats. AMFJ was administered orally for 7, 14, 21, and 30 days at three increasing doses (2.5, 5, and 10 ml kg−1). The changes in exploratory behaviour and locomotor activity were recorded in an Opto Varimex apparatus. It was found that the low doses of AMFJ (2.5 and 5 ml kg−1) for all treatment periods did not significantly affect exploratory behaviour and locomotor activity of rats compared to the saline-treated controls. AMFJ at the highest dose of 10 ml kg−1 had no significant effect on exploration and locomotion for the treatment periods of 7 and 14 days, while for the periods of 21 and 30 days it significantly decreased the number of horizontal and vertical movements, which might be the result of a sedative effect. At all the doses and testing periods, AMFJ did not disturb the progressive decrease in motor behaviour, suggesting habituation.

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