The main bioactive substances in Aronia melanocarpa fruit juice (AMFJ) are polyphenols (flavonoids, procyanidins, and phenolic acids). A great number of polyphenols are able to traverse the blood-brain barrier. In recent years more attention is drawn to the ability of these substances to influence central nervous system functions. The aim of the present study was to investigate the effects of AMFJ on exploratory behaviour and locomotor activity in male Wistar rats. AMFJ was administered orally for 7, 14, 21, and 30 days at three increasing doses (2.5, 5, and 10 ml kg−1). The changes in exploratory behaviour and locomotor activity were recorded in an Opto Varimex apparatus. It was found that the low doses of AMFJ (2.5 and 5 ml kg−1) for all treatment periods did not significantly affect exploratory behaviour and locomotor activity of rats compared to the saline-treated controls. AMFJ at the highest dose of 10 ml kg−1 had no significant effect on exploration and locomotion for the treatment periods of 7 and 14 days, while for the periods of 21 and 30 days it significantly decreased the number of horizontal and vertical movements, which might be the result of a sedative effect. At all the doses and testing periods, AMFJ did not disturb the progressive decrease in motor behaviour, suggesting habituation.
-
Andres-Lacueva, C., Shukitt-Hale, B., Galli, R.L., Jauregui, O., Lamuela-Raventos, R.M. & Joseph, J.A. (2005): Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr. Neurosci., 8, 111–120.
Joseph J.A. , 'Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory ' (2005 ) 8 Nutr. Neurosci. : 111 -120.
-
Daenen, E.W.P.M., Van der Heyden, J.A., Kruse, C.G., Wolterink, G. & Van Ree, J.M. (2001): Adaptation and habituation to an open field and responses to various stressful events in animals with neonatal lesions in the amygdala or ventral hippocampus. Brain Res., 918, 153–165.
Ree J.M. , 'Adaptation and habituation to an open field and responses to various stressful events in animals with neonatal lesions in the amygdala or ventral hippocampus ' (2001 ) 918 Brain Res. : 153 -165.
-
de Carvalho, R.S., Duarte, F.S. & de Lima, T.C. (2011): Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice. Behavl Brain Res., 221, 75–82.
Lima T.C. , 'Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice ' (2011 ) 221 Behavl Brain Res. : 75 -82.
-
Denev, P.N., Kratchanov, C.G., Ciz, M., Lojek, A. & Kratchanova, M.G. (2012): Bioavailability and antioxidant activity of black chokeberry (Aronia melanocarpa) polyphenols: in vitro and in vivo evidences and possible mechanisms of action. A review. Comp. Rev. Fd Sci. Fd Safety, 11, 471–489.
Kratchanova M.G. , 'Bioavailability and antioxidant activity of black chokeberry (Aronia melanocarpa) polyphenols: in vitro and in vivo evidences and possible mechanisms of action. A review ' (2012 ) 11 Comp. Rev. Fd Sci. Fd Safety : 471 -489.
-
EEC (1986): Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes.
'', in Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes , (1986 ) -.
-
Fernandez, S.P., Nguyen, M., Yow, T.T., Chu, C., Johnston, G.A., Hanrahan, J.R. & Chebib, M. (2009): The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochem. Res., 34, 1867–1875.
Chebib M. , 'The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice ' (2009 ) 34 Neurochem. Res. : 1867 -1875.
-
Gould, T.D., Dao, T.D. & Kavacsics, C.E. (2009): The open field test. -in: Gould, T.D. (Ed.): Mood and anxiety related phenotypes in mice. Humana Press, pp. 1–2.
Kavacsics C.E. , '', in Mood and anxiety related phenotypes in mice , (2009 ) -.
-
Giusti, M.M., Rodrigues-Saona, L.E. & Wrolstad, R.E. (1999): Spectral characteristics, molar absorptivity and color of pelargonidin derivatives. J. Agric. Fd Chem., 47, 4631–4637.
Wrolstad R.E. , 'Spectral characteristics, molar absorptivity and color of pelargonidin derivatives ' (1999 ) 47 J. Agric. Fd Chem. : 4631 -4637.
-
Hertog, M.G.L., Hollman, P.C.H. & Vanema, D.P. (1992): Optimization of a quantitative HPLC determination of potentially anticarcinogenic flavonoids in vegetables and fruits. J. Agric. Fd Chem., 40, 1591–1598.
Vanema D.P. , 'Optimization of a quantitative HPLC determination of potentially anticarcinogenic flavonoids in vegetables and fruits ' (1992 ) 40 J. Agric. Fd Chem. : 1591 -1598.
-
Jäger, A.K. & Saaby, L. (2011): Flavonoids and the CNS. Molecules, 16, 1471–1485.
Saaby L. , 'Flavonoids and the CNS ' (2011 ) 16 Molecules : 1471 -1485.
-
Janle, E.M., Lila, M.A., Grannan, M., Wood, L., Higgins, A., Yousef, G.G., Rogers, R.B., Kim, H., Jackson, G.S., Ho, L. & Weaver, C.M. (2010): Pharmacokinetics and tissue distribution of 14C-Labeled grape polyphenols in the periphery and the central nervous system following oral administration. J. Med. Fd, 13, 926–933.
Weaver C.M. , 'Pharmacokinetics and tissue distribution of 14C-Labeled grape polyphenols in the periphery and the central nervous system following oral administration ' (2010 ) 13 J. Med. Fd : 926 -933.
-
Jiang, J.G., Huang, X.J., Chen, J. & Lin, Q.S. (2007): Comparison of the sedative and hypnotic effects of flavonoids, saponins, and polysaccharides extracted from Semen Ziziphus jujube. Nat. Prod. Res., 21, 310–320.
Lin Q.S. , 'Comparison of the sedative and hypnotic effects of flavonoids, saponins, and polysaccharides extracted from Semen Ziziphus jujube ' (2007 ) 21 Nat. Prod. Res. : 310 -320.
-
Köhler, C. & Lorens, S.A. (1978): Open field activity and avoidance behaviour following serotonin depletion: a comparison of the effects of parachlorophenylalanine and electrolytic midbrain raphe lesions. Pharmacol. Biochem. Behav., 8, 223–233.
Lorens S.A. , 'Open field activity and avoidance behaviour following serotonin depletion: a comparison of the effects of parachlorophenylalanine and electrolytic midbrain raphe lesions ' (1978 ) 8 Pharmacol. Biochem. Behav. : 223 -233.
-
Lynn, D.A. & Brown, G.R. (2009): The ontogeny of exploratory behavior in male and female adolescent rats (Rattus norvegicus). Developmental Psychobiol., 51, 513–520.
Brown G.R. , 'The ontogeny of exploratory behavior in male and female adolescent rats (Rattus norvegicus) ' (2009 ) 51 Developmental Psychobiol. : 513 -520.
-
Martínez, M.C., Fernandez, S.P., Loscalzo, L.M., Wasowski, C., Paladini, A.C., Marder, M., Medina, J.H. & Viola, H. (2009): Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice. Pharmacol. Biochem. Behav., 92, 291–296.
Viola H. , 'Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice ' (2009 ) 92 Pharmacol. Biochem. Behav. : 291 -296.
-
Prut, L. & Belzung, C. (2003): The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur. J. Pharmacol., 463, 3–33.
Belzung C. , 'The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review ' (2003 ) 463 Eur. J. Pharmacol. : 3 -33.
-
Rangel-Ordonez, L., Noldner, M., Schubert-Zsilavecz, M. & Wurglics, M. (2010): Plasma levels and distribution of flavonoids in rat brain after single and repeated doses of standardized Ginkgo biloba Extract EGb 761. Planta Med., 76, 1683–1690.
Wurglics M. , 'Plasma levels and distribution of flavonoids in rat brain after single and repeated doses of standardized Ginkgo biloba Extract EGb 761 ' (2010 ) 76 Planta Med. : 1683 -1690.
-
Rudolph, U. & Möhler, H. (2006): GABA-based therapeutic approaches: GABAA receptor subtype functions. Curr. Opin. Pharmacol., 6, 18–23.
Möhler H. , 'GABA-based therapeutic approaches: GABAA receptor subtype functions ' (2006 ) 6 Curr. Opin. Pharmacol. : 18 -23.
-
Singleton, V.L. & Rossi, J.A. (1965): Colorimetry of total phenolics with phosphomolybdic phosphotungstic acid reagents. Am. J. Enol. Viticult., 16, 144–158.
Rossi J.A. , 'Colorimetry of total phenolics with phosphomolybdic phosphotungstic acid reagents ' (1965 ) 16 Am. J. Enol. Viticult. : 144 -158.
-
Thiel, C.M., Müller, C.P., Huston, J.P. & Schwarting, R.J.K. (1999): High versus low reactivity to a novel environment: behavioural pharmacology and neurochemical assessments. Neuroscience, 93, 243–251.
Schwarting R.J.K. , 'High versus low reactivity to a novel environment: behavioural pharmacology and neurochemical assessments ' (1999 ) 93 Neuroscience : 243 -251.
-
Valcheva-Kuzmanova, S. & Zhelyazkova-Savova, M. (2009): Anxiolytic-like effect of Aronia melanocarpa fruit juice in rats. Methods Findings Expl. Clin. Pharmacol., 31, 651–654.
Zhelyazkova-Savova M. , 'Anxiolytic-like effect of Aronia melanocarpa fruit juice in rats. Methods Findings ' (2009 ) 31 Expl. Clin. Pharmacol. : 651 -654.
-
Vissiennona, C., Nieber, K., Kelber, O. & Butterweck, V. (2011): Route of administration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin — are they prodrugs? J. Nutr. Biochem., 23, 733–740.
Butterweck V. , 'Route of administration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin — are they prodrugs? ' (2011 ) 23 J. Nutr. Biochem. : 733 -740.
-
Williams, C.M., El Mohsen, M.A., Vauzour, D., Rendeiro, C., Butler, L.T., Ellis, J.A., Whiteman, M. & Spencer, J.P. (2008): Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radical Biol. Med., 45, 295–305.
Spencer J.P. , 'Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels ' (2008 ) 45 Free Radical Biol. Med. : 295 -305.
-
Willis, L.M., Shukitt-Hale, B. & Joseph, J.A. (2009): Recent advances in berry supplementation and age-related cognitive decline (Note). Curr. Opin. Clin. Nutr. Metab. Care, 12, 91–94.
Joseph J.A. , 'Recent advances in berry supplementation and age-related cognitive decline (Note) ' (2009 ) 12 Curr. Opin. Clin. Nutr. Metab. Care : 91 -94.
-
Zhishen, J., Mengcheng, T. & Jianming, W. (1999): The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Fd Chem., 64, 555–559.
Jianming W. , 'The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals ' (1999 ) 64 Fd Chem. : 555 -559.
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Oct 2020 | 2 | 0 | 0 |
| Nov 2020 | 5 | 15 | 3 |
| Dec 2020 | 3 | 0 | 0 |
| Jan 2021 | 2 | 0 | 0 |
| Feb 2021 | 0 | 0 | 0 |
| Mar 2021 | 3 | 0 | 0 |
| Apr 2021 | 0 | 0 | 0 |
Oxidation in foods and beverages and antioxidant applications. Vols 1 & 2
E.A. Decker, R.J. Elias and D.J. McClements (Eds) Woodhead Publishing Ltd., Oxford, Cambridge, Philadelphia, New Delhi 2010, ISBN 978-1-84569-648-1; ISBN 978-84569-983-3, 408 and 528 pages.
Copyright Akadémiai Kiadó
AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.
Copyright Akadémiai Kiadó AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.
Powered by PubFactory