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  • 1 Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi-75270, Pakistan
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Growing research on beans suggest that they are good for health, as they reduce the risk and/or help in the management of chronic diseases. Beans are valuable parts of several dietary recommendations. Saponins, α-galactosides, phytates, and lectins are currently drawing attention because of their diverse properties, both adverse and beneficial. The aim was to determine the hepatotoxic effect of dry red kidney beans, i.e. Phaseolus vulgaris, on rabbits at 4 g kg–1, 6 g kg–1, and 8 g kg–1 dosing for the period of 30 days. The histopathological examination revealed inflammation of hepatocyte at all three doses along with congestion. The biochemical testing of liver enzymes revealed elevated alanine transaminase (ALT), aspartate transaminase (AST) and gamma-glutamyl transferase (γ-GT). The dose-dependent increase in liver enzymes indicates the hepatotoxic effect of dry red kidney beans, and various studies have demonstrated that lectins are the toxic components responsible for inflammation of body organs.

  • Chokshi, D. (2007): Subchronic oral toxicity of a standardized white kidney bean (Phaseolus vulgaris) extract in rats. Food Chem. Toxicol., 45(1), 3240.

    • Search Google Scholar
    • Export Citation
  • Cirnatu, D., Jompan, A., Sin, A.I. & Zugravu, C.A. (2011): Multiple organ histopathological changes in broiler chickens fed on genetically modified organism. Rom. J. Morphol. Embryo., 52(1), 475480.

    • Search Google Scholar
    • Export Citation
  • De Moya, C.C., Grant, G., Frühbeck, G., Urdaneta, E., García, M., Marzo, F. & Santidrián, S. (2003): Local (gut) and systemic metabolism of rats is altered by consumption of raw bean (Phaseolus vulgaris L. var. athropurpurea). Brit. J. Nutr., 89(03), 311318.

    • Search Google Scholar
    • Export Citation
  • Garcia-Lopez, J.S. (1984): Binding of minerals by cooked pinto beans (Phaseolus vulgaris) fiber, influence of fiber on iron absorption by normal and anemic rat intestinal segments. Doctoral dissertation, University of Wisconsin, Madison.

    • Search Google Scholar
    • Export Citation
  • George-Gay, B. & Parker, K. (2003): Understanding the complete blood count with differential. J. Perianesth. Nurs., 18(2), 96117.

  • Giannini, E.G., Testa, R. & Savarino, V. (2005): Liver enzyme alteration: A guide for clinicians. Can. Med. Assoc. J., 172(3), 367379.

    • Search Google Scholar
    • Export Citation
  • Gupta, R.K., Gupta, K., Sharma, A., Das, M., Ansari, I.A. & Dwivedi, P.D. (2016): Health risks and benefits of chickpea (Cicer arietinum) consumption. J. Agr. Food Chem., 65(1), 622.

    • Search Google Scholar
    • Export Citation
  • Hall, P. & Cash, J. (2012): What is the real function of the liver ‘function’ tests. Ulster. Med. J., 81(1), 3036.

  • Hamid, R. & Masood, A. (2009): Dietary lectins as disease causing toxicants. Pakistan J. Nutr., 8(3), 293303.

  • Ikegwuonu, F.I. & Bassir, O. (1976): Alterations in function, enzyme activities, and histopathology of the liver of the rat after administration of phytohemagglutinins (lectins). Toxicol. Appl. Pharm., 37(2), 211216.

    • Search Google Scholar
    • Export Citation
  • Jeon, S., Han, S., Lee, J., Hong, T. & Yim, D.S. (2012): The safety and pharmacokinetics of cyanidin-3-glucoside after 2-week administration of black bean seed coat extract in healthy subjects. Korean J. Physiol. Pha., 16(4), 249253.

    • Search Google Scholar
    • Export Citation
  • Jones, A.L. (2011): Phaseolus bean. Post-harvest operation. Food and Agriculture Organization of the United Nations. 24 pages.

  • Kumar, S., Verma, A.K., Das, M., Jain, S.K. & Dwivedi, P.D. (2013): Clinical complications of kidney bean (Phaseolus vulgaris L.) consumption. Nutrition, 29(6), 821827.

    • Search Google Scholar
    • Export Citation
  • Kyznietsova, M.Y., Makieieva, O.M., Lavrovska, D.O., Tymoshenko, M.O., Sheverova, D.P., Halenova, T.I., Mycholayovych, O. & Savchuk, L.I.O. (2015): Effect of aqueous extract from Phaseolus vulgaris pods on lipid peroxidation and antioxidant enzymes activity in the liver and kidney of diabetic rats. J. Appl. Pharm. Sci. (JAPS), 5(5), 16.

    • Search Google Scholar
    • Export Citation
  • Liang, Y. (2014): Effect of regular dietary consumption of beans or peas on body weight, body composition, and blood pressure in men and women with mild hypercholesterolemia. Doctoral dissertation, University of Alberta

    • Search Google Scholar
    • Export Citation
  • Lichtenstein, A.H., Appel, L.J., Brands, M., Carnethon, M., Daniels, S., Franch, H.A., Franklin, B., Krisetherton, P., Harris, W.S., Howard, B. & Karanja, N. (2006): Diet and lifestyle recommendations revision, 2006. A scientific statement from the American Heart Association nutrition committee. Circulation, 114(1), 8296.

    • Search Google Scholar
    • Export Citation
  • Marzo, F., Alonso, R., Urdaneta, E., Arricibita, F.J. & Ibanez, F. (2002): Nutritional quality of extruded kidney bean (Phaseolus vulgaris L. var. Pinto) and its effects on growth and skeletal muscle nitrogen fractions in rats. J. Anim. Sci., 80(4), 875879.

    • Search Google Scholar
    • Export Citation
  • Mcginnis, L. & Suszkiw, J. (2006): Breeding better beans. Agric. Res., 54(6), 12.

  • Mitchell, M. & Jr, T.N. (2008): Manual of exotic pet practice. Elsevier Health Sciences. pp. 127143.

  • Miyake, K., Tanaka, T. & Mcneil, P.L. (2007): Lectin-based food poisoning: A new mechanism of protein toxicity. PLoS ONE, 2(8), e687.

  • Natarajan, S.S., Pastor-Corrales, M.A., Khan, F.H. & Garrett, W.M. (2013): Proteomic analysis of common bean (Phaseolus vulgaris L.) by two-dimensional gel electrophoresis and mass spectrometry. J. Basic Appl. Sci., 9, 424.

    • Search Google Scholar
    • Export Citation
  • Paredes, C., Becerra, V. & Tay, U. (2009): Inorganic nutritional composition of common bean (Phaseolus vulgaris L.) genotypes race Chile. Chil. J. Agr. Res., 69(4), 486495.

    • Search Google Scholar
    • Export Citation
  • Pereira, L.L.S., Pereira, C.A., Vicente DesousaDESOUSA, R., Dos Santos, C.D., Ferreira Demoraes, C. & Satiro, L.C. (2012): White bean flour (Phaseolus vulgaris): Therapeutic and toxicological research in Wistar rats. J. Appl. Pharm. Sci., 2(3), 1.

    • Search Google Scholar
    • Export Citation
  • Reyes-Moreno, C., Paredes-LóPez, O. & Gonzalez, E. (1993): Hard-to-cook phenomenon in common beans –A review. Crit. Rev. Food Sci. Nutr., 33(3), 227286.

    • Search Google Scholar
    • Export Citation
  • Shah, A.K., Brundage, R.C., Gratwohl, A. & Sawchuk, R.J. (1992): Pharmacokinetic model for subcutaneous absorption of cyclosporine in the rabbit during chronic treatment. J. Pharm. Sci., 81(6), 491495.

    • Search Google Scholar
    • Export Citation
  • Smith, C.P. & Taylor, V. (1995): The behaviour of rabbits: Implications for their laboratory management. -in: Standards in laboratory animal management. Proceedings (2) of UFAW Symposium, Potters Bar, Herts, UK, pp. 127143.

    • Search Google Scholar
    • Export Citation
  • Soetan, K. O. (2008): Pharmacological and other beneficial effects of antinutritional factors in plants –A review. Afr. J. Biotechnol., 7(25), 4713-4721.

    • Search Google Scholar
    • Export Citation
  • Vasconcelos, I.M. & Oliveira, J.T.A. (2004): Antinutritional properties of plant lectins. Toxicon., 44(4), 385403.

  • Winham, D., Webb, D. & Barr, A. (2008): Beans and good health. Nutr. Today, 43(5), 201209.

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