View More View Less
  • a School of Public Health and Zoonoses, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141004, India
  • b Department of Entomology, Punjab Agricultural University, Ludhiana, 141004, India
  • c CSK HP Agricultural University, Palampur, 176062, India
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $878.00

Indiscriminate use of antibiotics in apicultural practices may lead to contamination of otherwise healthy and naturally produced honey. Contamination not only affects honey quality but also pose significant health risks to consumers. In this context, one hundred raw honey samples from India were analysed for presence of antibiotic residues. For determination of oxytetracycline and erythromycin, high performance liquid chromatography and for chloramphenicol, enzyme immunoassay based validated procedures were used. Oxytetracycline and erythromycin with concentrations above maximum tolerance limits were detected in 24% and 2% samples, respectively. None of the samples contained chloramphenicol residues. Although, total dietary intake of detected antibiotics through honey was found to be <1% of their acceptable daily intake values, the presence of antibiotics in honey is an alarming health concern for people following customary honey feeding. The outcomes underline the need of inter-sectoral approaches to create awareness among beekeepers regarding health risks associated with residues of antibiotics in honey and merits of approved apicultural practices. Therefore, to meet global food safety requirements, continual residue monitoring schemes along with enlightenment of beekeepers on scientific beehive management and risks associated with incautious apicultural practices are of vital importance.

  • Bhattacharya, B.K. & Sen, S.K. (2006): Antibiotics buisness: A glimpse. Indian J. Biotechnol., 5, 471-476.

  • EC (2002): European Commission regulation of 2002/657/E: Implementing council directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. O.J. Eur. Comm., 2002, L 221/8-L 221/36.

    • Search Google Scholar
    • Export Citation
  • FSSAI (Food Safety and Standard Authority of India) (2014): Food Safety and Standards (contaminants, toxins and residues) Amendment Regulations, 2014. Regulation No. 2.3.2. Gazette of India, Extraordinary, Part III, Section 4 vide ADVT.III/4/Exty./191/F/2104.

    • Search Google Scholar
  • Gunes, N., Cibik, R., Gunes, M.E. & Aydin, L. (2008): Erythromycin residue in honey from the Southern Marmara region of Turkey. Food Addit. Contam. A., 25, 1313-1317.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • ICH (2005): Harmonised tripartite guideline validation of analytical procedures: Text and methodology; Q2 (R1). International Conference on Harmonisation.

    • Search Google Scholar
  • Johnson, S., Jadon, N., Mathur, H.B. & Agarwal, H.C. (2010): Antibiotic residues in honey . http://www.scribd. com/doc/38591126/7/Review-of-Literature. (Last accessed January 8, 2018).

    • Search Google Scholar
    • Export Citation
  • Kumar A., Gill, J.P.S., Bedi, J.S. & Kumar, A. (2018): Pesticide residues in Indian raw honeys, an indicator of environmental pollution. Environ. Sci. Pollut. R., 25, 34005-34016.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Kumar, A., Gill, J.P.S., Bedi, J.S. & Chhuneja, P.K. (2019): Health risks associated with antibiotics and pesticides in honey: knowledge, attitude and practices of beekeepers in India. Indian J. Vet. Public Health, 16(1), 1-9.

    • Search Google Scholar
    • Export Citation
  • Lumpkin, M.M. (2007): Safety of Chinese imports: Oversight and analysis of the federal response. Testimony before the senate committee on commerce, science, and transportation. 2007. Available at https://www.uschamber. com/china-policy-resources. (Last accessed: 18 March 2019).

    • Search Google Scholar
    • Export Citation
  • Mahmoudi, R., Moosavy, M., Norian, R., Kazemi, S., Nadari, M.R.A. & Mardani, K. (2014): Detection of oxytetracycline residues in honey samples using ELISA and HPLC methods. Pharm. Sci., 19, 145-150.

    • Search Google Scholar
    • Export Citation
  • Mahmoudi, R. & Pakbin, B. (2015): An overview of the hazards and management strategies for antibiotic residue in honey. Int. J. Food Saf. Nutr. Publ. Health, 6, 1-9.

    • Search Google Scholar
    • Export Citation
  • Pagliuca, G., Gazzotti, T., Serra, G. & Sabatini, A.G. (2002): A scientific note on the determination of oxytetracycline residues in honey by high-performance liquid chromatography with UV detection. Apidologie, 33, 583-584.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Rao, C.R.M., Kumar, L.C.A. & Sekharan, C.B. (2015): Quantitative analysis of oxytetracycline residues in honey by high performance liquid chromatography. Int. Res. J. Biol. Sci., 4, 59-65.

    • Search Google Scholar
    • Export Citation
  • Reybroeck, W. (2018): Residues of antibiotics and chemotherapeutics in honey. J. Apicult. Res., 57, 97-112.

  • Solomon, R., Santhi, V.S. & Jayaraj, V. (2006): Prevalence of antibiotics in nectar and honey in South Tamilnadu, India. Integrative Biosciences, 10, 163-167.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Venable, R., Haynes, C. & Cook, J.M. (2014): Reported prevalence and quantitative LC-MS methods for the analysis of veterinary drug residues in honey: a review. Food Addit. Contam. A., 31, 621-640.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Wang, J. (2004): Determination of five macrolide antibiotic residues in honey by LC-ESI-MS and LC-ESI-MS/MS. J. Agr. Food Chem., 52(2), 171-181.

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jun 2020 0 0 0
Jul 2020 0 0 0
Aug 2020 25 0 0
Sep 2020 40 9 7
Oct 2020 47 2 2
Nov 2020 41 5 4
Dec 2020 6 1 1