Acta Alimentaria
Volume/Issue:
Accepted Manuscript / Online First
Extracts of Allium species suppress activation of the NLRP3 and AIM2 inflammasomes and formation of radiation-induced micronuclei
Authors:
Z.J. Tian College of Public Health, Wenzhou Medical University, University Town, Chashan, Wenzhou, Zhejiang, 325035, China

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Y. Bian College of Public Health, Wenzhou Medical University, University Town, Chashan, Wenzhou, Zhejiang, 325035, China

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Y.Q. Liu College of Public Health, Wenzhou Medical University, University Town, Chashan, Wenzhou, Zhejiang, 325035, China

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Y.H. Yin College of Public Health, Wenzhou Medical University, University Town, Chashan, Wenzhou, Zhejiang, 325035, China

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Y. Cao College of Public Health, Wenzhou Medical University, University Town, Chashan, Wenzhou, Zhejiang, 325035, China

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Z.G. Bian College of Public Health, Wenzhou Medical University, University Town, Chashan, Wenzhou, Zhejiang, 325035, China

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Y.M. Li College of Public Health, Wenzhou Medical University, University Town, Chashan, Wenzhou, Zhejiang, 325035, China

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M.J. Lee Department of Laboratory Animal Medicine, College of Veterinary Medicine Kangwon National University, 192-1 Hyoja-dong, Chuncheon-si, Gangwon-do 200-701, Chuncheon, Republic of Korea

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L. Li College of Public Health, Wenzhou Medical University, University Town, Chashan, Wenzhou, Zhejiang, 325035, China

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https://orcid.org/0000-0002-7524-3838
Online Publication Date:
11 Dec 2024
Publication Date:
11 Dec 2024
Article Category:
Research Article
DOI:
https://doi.org/10.1556/066.2024.00172
Keywords:
Allium; inflammasome; NLRP3; AIM2; ionising radiation; micronuclei
Restricted access

Abstract

Allium is a plant genus with high medicinal and dietary value, which encompasses commonly used culinary herbs such as scallion, garlic, and onion. In this study, we investigated whether Allium extracts exert protective effects on radiation-induced chromosomal damage in BALB/c mice. The mice were orally administered 200 mg kg−1 Allium extracts (scallion, garlic, and onion) for 6 weeks and exposed to 2 Gy gamma radiation 1 day after the final feeding. Haematological parameters and the number of micronucleated bone marrow polychromatic erythrocytes (MnPCEs) were evaluated. Additionally, we analysed the effects of Allium extracts on inflammasome activation in lipopolysaccharide-primed murine bone marrow-derived macrophages. The Allium extracts increased the numbers of peripheral white blood cells, lymphocytes, neutrophils, and red blood cells; significantly decreased the number of MnPCEs; and suppressed the maturation of interleukin-1β by blocking activation of the NLRP3 and AIM2 inflammasomes.

In conclusion, Allium extracts protected the hematopoietic function of bone marrow, reduced radiation-induced formation of micronuclei, and suppressed activation of the NLRP3 and AIM2 inflammasomes. Further research is needed to explore the molecular mechanisms of these effects of Allium.

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Cover Acta Alimentaria
Acta Alimentaria
Print ISSN:
0139-3006
Online ISSN:
1588-2535

Senior editors

Editor(s)-in-Chief: András Salgó, Budapest University of Technology and Economics, Budapest, Hungary

Co-ordinating Editor(s) Marianna Tóth-Markus, Budapest, Hungary

Co-editor(s): A. Halász, Budapest, Hungary

       Editorial Board

  • László Abrankó, Hungarian University of Agriculture and Life Sciences, Budapest, Hungary
  • Tamás Antal, University of Nyíregyháza, Nyíregyháza, Hungary
  • Diána Bánáti, University of Szeged, Szeged, Hungary
  • József Baranyi, Institute of Food Research, Norwich, UK
  • Ildikó Bata-Vidács, Eszterházy Károly Catholic University, Eger, Hungary
  • Ferenc Békés, FBFD PTY LTD, Sydney, NSW Australia
  • György Biró, Budapest, Hungary
  • Anna Blázovics, Semmelweis University, Budapest, Hungary
  • Francesco Capozzi, University of Bologna, Bologna, Italy
  • Marina Carcea, Research Centre for Food and Nutrition, Council for Agricultural Research and Economics Rome, Italy
  • Zsuzsanna Cserhalmi, Budapest, Hungary
  • Marco Dalla Rosa, University of Bologna, Bologna, Italy
  • István Dalmadi, Hungarian University of Agriculture and Life Sciences, Budapest, Hungary
  • Katarina Demnerova, University of Chemistry and Technology, Prague, Czech Republic
  • Mária Dobozi King, Texas A&M University, Texas, USA
  • Muying Du, Southwest University in Chongqing, Chongqing, China
  • Sedef Nehir El, Ege University, Izmir, Turkey
  • Søren Balling Engelsen, University of Copenhagen, Copenhagen, Denmark
  • Éva Gelencsér, Budapest, Hungary
  • Vicente Manuel Gómez-López, Universidad Católica San Antonio de Murcia, Murcia, Spain
  • Jovica Hardi, University of Osijek, Osijek, Croatia
  • Hongju He, Henan Institute of Science and Technology, Xinxiang, China
  • Károly Héberger, Research Centre for Natural Sciences, ELKH, Budapest, Hungary
  • Nebojsa Ilić, University of Novi Sad, Novi Sad, Serbia
  • Dietrich Knorr, Technische Universität Berlin, Berlin, Germany
  • Hamit Köksel, Hacettepe University, Ankara, Turkey
  • Katia Liburdi, Tuscia University, Viterbo, Italy
  • Meinolf Lindhauer, Max Rubner Institute, Detmold, Germany
  • Min-Tze Liong, Universiti Sains Malaysia, Penang, Malaysia
  • Marena Manley, Stellenbosch University, Stellenbosch, South Africa
  • Miklós Mézes, Hungarian University of Agriculture and Life Sciences, Gödöllő, Hungary
  • Áron Németh, Budapest University of Technology and Economics, Budapest, Hungary
  • Perry Ng, Michigan State University,  Michigan, USA
  • Quang Duc Nguyen, Hungarian University of Agriculture and Life Sciences, Budapest, Hungary
  • Laura Nyström, ETH Zürich, Switzerland
  • Lola Perez, University of Cordoba, Cordoba, Spain
  • Vieno Piironen, University of Helsinki, Finland
  • Alessandra Pino, University of Catania, Catania, Italy
  • Mojmir Rychtera, University of Chemistry and Technology, Prague, Czech Republic
  • Katharina Scherf, Technical University, Munich, Germany
  • Regine Schönlechner, University of Natural Resources and Life Sciences, Vienna, Austria
  • Arun Kumar Sharma, Department of Atomic Energy, Delhi, India
  • András Szarka, Budapest University of Technology and Economics, Budapest, Hungary
  • Mária Szeitzné Szabó, Budapest, Hungary
  • Sándor Tömösközi, Budapest University of Technology and Economics, Budapest, Hungary
  • László Varga, Széchenyi István University, Mosonmagyaróvár, Hungary
  • Rimantas Venskutonis, Kaunas University of Technology, Kaunas, Lithuania
  • Barbara Wróblewska, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences Olsztyn, Poland

 

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Acta Alimentaria
Language English
Size B5
Year of
Foundation		 1972
Volumes
per Year		 1
Issues
per Year		 4
Founder Magyar Tudományos Akadémia    
Founder's
Address		 H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
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Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0139-3006 (Print)
ISSN 1588-2535 (Online)

 

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