Abu-Dabbab area is characterized by high seismicity and complex tectonic setting, for these facts, a local geodetic network consisting of eleven geodetic benchmarks has been established. The crustal deformation data in this area are collected using the GPS techniques. Five campaigns of GPS measurements have been collected, processed and adjusted to get the more accurate positions of the GPS stations. The horizontal velocity vectors, the dilatational, the maximum shear strains and the principal strain rates were estimated. The magnitude of the movements is distributed inhomogeneous over the area and it varies in average between 3 and 6 mm/yr. The results of the deformation analyses indicate a significant contraction and extension across the southern central part of the study area which is characterized by high seismic activity represented by the clustering shape of the microearthquakes that trending NE-SW direction. The north and north-eastern parts are characterized by small strain rates. This study is an attempt to provide valuable information about the present state of the crustal deformation and its relationship to seismic activity and tectonic setting at Abu-Dabbab area.