Ultra-thin layer chromatography (UTLC) — A new dimension in thin-layer chromatography

Heinz Hauck; Olga Bund; Walter Fischer; Michael Schulz

doi:10.1556/jpc.14.2001.4.2

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JPC - Journal of Planar Chromatography - Modern TLC

Volume/Issue:: Volume 14: Issue 4

Ultra-thin layer chromatography (UTLC) — A new dimension in thin-layer chromatography

Authors:

Heinz Hauck

Heinz Hauck Merck KGaA D-64271 Darmstadt Germany

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Olga Bund

Olga Bund Merck KGaA D-64271 Darmstadt Germany

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Walter Fischer

Walter Fischer Merck KGaA D-64271 Darmstadt Germany

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Michael Schulz

Michael Schulz Merck KGaA D-64271 Darmstadt Germany

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Pages:: 234–236

Online Publication Date:: 23 Mar 2007

Publication Date:: 01 Aug 2001

Article Category:: Research Article

DOI:: https://doi.org/10.1556/jpc.14.2001.4.2

Keywords:: Ultra-thin layer chromatography (UTLC); Steroids; Pesticides; Lipophilic dyestuffs

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Miniaturization is general trend in modern analytical methods, with the main targets of increasing sensitivity, shortening analysis times drastically, and reducing the quantity of consumables per analysis. In planar chromatography a first step in this direction was the development of modern high-performance TLC (HPTLC). Compared with conventional TLC, the layers are characterized by smaller adsorbent material particle sizes and a slight reduction in layer thickness. A major final step in the direction of miniaturized planar chromatography are the new ultra-thin layers. In contrast with those on TLC and HPTLC plates, these layers are no longer based on granular adsorbents, but have a monolithic structure based on a silica gel matrix. This means there are no longer separate particles, as in TLC and HPTLC. Furthermore, no binder is needed to fix the layer on the glass plate. To be suitable for chromatographic purposes, the monolithic silica gel of these new ultra-thin layers has meso- and macro pores, with fine capillaries penetrating the layer. The layer thickness of approximately 10 μm is considerably less than that of conventional TLC and HPTLC layers. The exciting properties of these new UTLC silica gel plates, especially their selectivity and separation efficiency, are demonstrated by separations of steroids, pesticides, and some dyestuffs.

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JPC - Journal of Planar Chromatography - Modern TLC

Print ISSN:: 0933-4173

Online ISSN:: 1789-0993

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Journal of Planar Chromatography - Modern TLC
Language	English
Size	A4
Year of Foundation	1988
Volumes per Year	1
Issues per Year	6
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0933-4173 (Print)
ISSN	1789-0993 (Online)