Authors:
Genowefa Misztal Department of Medicinal Chemistry, Medical Academy, 6 Chodźki, 20-093 Lublin, Poland

Search for other papers by Genowefa Misztal in
Current site
Google Scholar
PubMed
Close
and
Beata Paw Department of Medicinal Chemistry, Medical Academy, 6 Chodźki, 20-093 Lublin, Poland

Search for other papers by Beata Paw in
Current site
Google Scholar
PubMed
Close
Restricted access

The selectivity of the separation of five antihistamines has been investigated by TLC on silica gel 60 F254 and on aluminium oxide 60 F254 with a variety of mobile phases in horizontal chambers. The best separation selectivity and retention differences for the drugs on the two types of plate were obtained with the mobile phases chloroform–ethyl acetate, 1 + 1 (v/v), ethyl acetate, and butan-2-one–toluene, 7 + 3 (v/v).

The plates were visualized by illumination at l = 254 nm and by reaction with different reagents. The greatest detection sensitivity – 0.06 mg for cetirizine, 0.1 mg for chloropyramine, and 0.2 mg for antazoline, doxylamine, and ketotifene – was obtained by spraying with potassium iodoplatinate reagent.

  • [1]

    Ch.R. Craig and R.E. Stitzed (Eds) Modern Pharmacology, Little, Brown and Company, Boston, USA, 1982.

  • [2]

    A.M. ter Laak, M.J. van Drooge, H. Timmerman, and G.M. Danne’op den Kelder, Quant. Struct. Act. Relat. 11 (1992) 348363.

  • [3]

    R. Leurs, M.J. Smit, and H. Timmerman, Pharmacol. Ther. 66 (1995) 413463.

  • [4]

    R. Leurs, H. Vau der Goot, and H. Timmerman, in: B. Testa (Ed.) Advances in Drug Research, Academic Press, London, 1991, p. 217.

  • [5]

    G.R. Ganellin, in: J.C. Schwartz and H. Haas (Eds) The Histamine Receptor, Wiley–Liss, New York, 1992, p. 1.

  • [6]

    D.T. Witiak and R.C. Cavestri, in: M.E. Wolff (Ed.) Burgers’ Medicinal Chemistry, Part III, 4th edn, Wiley–Interscience, New York, 1981, p. 533.

    • Search Google Scholar
    • Export Citation
  • [7]

    K.K. Pamyda, R.A. Bangaru, T,P. Gandi, J.A. Modi, R.J. Modi, and B.K. Chakrawarthy, J. Pharm. Pharmacol. 48 (1996) 510513.

  • [8]

    D. Müller and S. Ebel, J. Planar Chromatogr. 10 (1997) 420426.

  • [9]

    S. Goenechea, J. Chromatogr. 36 (1968) 375377.

  • [10]

    P. Suchocki, S. Tonska, J. Jarzebinski, and T. Piechocki, Acta Pol. Pharm. 2 (1979) 193199.

  • [11]

    R. Bhushan and R. S. Chauhan, Biomed. Chromatogr. 31 (1989) 4647.

  • [12]

    H. Moll and J. Clerk, Pharm. Acta Helv. 62 (1987) 210215.

  • [13]

    O. Ersoy and R. Aydemir, Marmara Univ. Eczacilik Derg. 5 (1989) 107114, Chem. Abstr. 113 (1990) 53w.

  • [14]

    D. DiGregorio and J. Sherma, J. Liq. Chromatogr. Relat. Technol. 22 (1999) 15991606.

  • [15]

    A.P. Argekar and J. G. Sawant, J. Liq. Chromatogr. Relat. Technol. 22 (1999) 20512060.

  • [16]

    B. Borkowski, Thin-Layer Chromatography in Pharmaceutical Analysis, Warsaw, 1973.

  • Collapse
  • Expand

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
6
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Dec 2023 30 1 2
Jan 2024 47 4 1
Feb 2024 55 3 0
Mar 2024 24 0 0
Apr 2024 9 0 0
May 2024 4 0 0
Jun 2024 0 0 0