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The selectivity of the separation of five antihistamines has been investigated by TLC on silica gel 60 F254 and on aluminium oxide 60 F254 with a variety of mobile phases in horizontal chambers. The best separation selectivity and retention differences for the drugs on the two types of plate were obtained with the mobile phases chloroform–ethyl acetate, 1 + 1 (v/v), ethyl acetate, and butan-2-one–toluene, 7 + 3 (v/v).
The plates were visualized by illumination at l = 254 nm and by reaction with different reagents. The greatest detection sensitivity – 0.06 mg for cetirizine, 0.1 mg for chloropyramine, and 0.2 mg for antazoline, doxylamine, and ketotifene – was obtained by spraying with potassium iodoplatinate reagent.
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| Journal of Planar Chromatography - Modern TLC | |
|---|---|
| Language | English |
| Size | A4 |
| Year of Foundation |
1988 |
| Volumes per Year |
1 |
| Issues per Year |
6 |
| Founder | Akadémiai Kiadó |
| Founder's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Publisher | Akadémiai Kiadó Springer Nature Switzerland AG |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 0933-4173 (Print) |
| ISSN | 1789-0993 (Online) |
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